p-Index From 2021 - 2026
10.015
P-Index
This Author published in this journals
All Journal International Journal of Public Health Science (IJPHS) Jurnal Veteriner Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Pendidikan Administrasi Perkantoran Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ketahanan Nasional Jurnal Ilmu Ternak Veteriner Indonesian Journal of Tropical and Infectious Disease Journal of Tropical Biodiversity and Biotechnology INVOTEC Universa Medicina Mimbar Agribisnis: Jurnal Pemikiran Masyarakat Ilmiah Berwawasan Agribisnis Health Notions Omni-Akuatika BIOEDUSCIENCE Jurnal Biologi Tropis Aquasains : Jurnal Ilmu Perikanan dan Sumberdaya Perairan Jurnal Pengabdian Magister Pendidikan IPA Jurnal Kreativitas PKM Jurnal Pro Hukum : Jurnal Penelitian Bidang Hukum Universitas Gresik Unes Law Review Journal of Aquaculture Science Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Journal of Aquaculture and Fish Health Jurnal Pemberdayaan Masyarakat Universitas Al Azhar Indonesia Neo Teknika: Jurnal Ilmiah Teknologi INTEGRITAS : Jurnal Pengabdian Jurnal Pendidikan Teknologi Informasi dan Vokasional Journal of Vocational Education Studies (JOVES) Kontribusia : Research Dissemination for Community Development Grouper: Jurnal Ilmiah Perikanan Jurnal Abdi Insani Jurnal Sisfotek Global BERDAYA: Jurnal Pendidikan dan Pengabdian Kepada Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Journal of Marine and Coastal Science Jurnal Pengabdian kepada Masyarakat Nusantara REKA ELKOMIKA: Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Agribios International Journal of Health, Economics, and Social Sciences (IJHESS) Indonesian Journal of Multidiciplinary Research (IJoMR) Jurnal Abmas Merdeka Indonesia Jurnal International Jurnal Suara Pengabdian 45 International Journal of Health and Pharmaceutical (IJHP) Jurnal Akta Notaris Jurnal Indonesia Sosial Sains MIMBAR INTEGRITAS Jurnal Agrifoodtech Ranah Research : Journal of Multidisciplinary Research and Development Media Pendidikan Gizi dan Kuliner WASATHON MANGGALI PAPUMA: Journal of Comunnity Services Journal of Fisheries & Marine Akselerasi Luaran Pengabdian Masyarakat Jurnal Teknik Sipil Unpand Jurnal Agribest Jurnal Ilmu-Ilmu Pertanian Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Universa Medicina

Toxic compounds of Curcuma aeruginosa causes necrosis of mice hepatocytes Eka Pramyrtha Hestianah; Idha Kusumawati; Lucia Tri Suwanti; Sri Subekti
Universa Medicina Vol. 33 No. 2 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.118-125

Abstract

BACKGROUNDPeople have been using Curcuma aeruginosa rhizome as a traditional herbal medicine as appetite stimulant, without realizing its side effects. Herbal plants contain tens to hundreds of compounds, some of which are toxic. The aim of this research was to determine which toxic compound of Curcuma aeruginosa rhizome has an impact on apoptosis and PARP-1 expression of hepatocytes in male mice.METHODSEighty eight male Balb C mice were divided into 10 groups treated respectively with Curcuma aeruginosa rhizome cloroform extract, methanol extract, essential oil, infusion, and press juice, at dosages of 0.004g/kgBW and 0.06g/kgBW, and 1 control group. The treatment was given orally once a day for 10 days and on the 11th day, the research animals were sacrificed, and their liver taken for histopathologic slide preparation with Apopteq Detection Kit, and immunofluorescence. Compounds in Curcuma aeruginosa rhizome were analyzed with gas chromatography/mass spectrometry. The data obtained were analyzed by one-way ANOVA, and Partial Least Squares to determine which compounds had an impact on murine hepatocytes.RESULTSThe result of one way ANOVA showed that the chloroform groups at dosages of 0.004g/kgBW and 0.06g/kgBW showed the highest apoptosis of mice’s hepatocytes (p<0.05). There were significant differences in PARP-1 expression between control and treatment groups. The highest PARP-1 expression was in the essential oil group at a dosage of 0.06g/kg BW (p<0.05).CONCLUSIONCurcuma aeruginosa rhizome given to mice orally causes necrosis of mice’s hepatocytes.
Co-Authors Abda Abda Achmad Amarudin Adam Sultoni Ade Fitri Noor Inaya Adelina Grace Aditya Gita Rohmatullah Adriana Monica Sahidu Agustien Zulaidah Agustin, Niyar Candra Agustina Agustina Agustine Zulaidah Agustono - Ahmad Syahrul Mubarak Aji, Joni Murti M Akhmad Taufiq Mukti Aksono HP., Eduardus Bimo Al Rasyid, Lalu Zainul Alfath, Muhammad Badar Aliffiansyah Rizky E Amadeus Michel Goein Ana, A Andriani, Devin Dwi Anggraeni, Rosmayniar Anggun Mayang Sari Anief Rufiyanto Annisa Nur R. P. Apipaturohmah, Pipa Apriyanti, Eny Arifin, Riyadhil Haqqy Arini Arini Arrosyid, Muchson Arya Witantama Aryati Aryati Aryo Fajar Sunartomo Asradinto, Faris Fathan Aulia, Aviva Baswendro, Baswendro Baswindro Berliana, Suci Wahyu Budi Utomo Candra Agustin, Niyar Candra Wahyu Sportyawan Chasanah , Ummi Choirunisa, Safa Fayza Olivia Christian Simarmata, Thesalonica Christine J K Ekawati Cica Yulia Cicilia Dyah Sulistyaningrum Indrawati Damayanti, Wilda Ayu Devy Rahmawati Putri Dewi, Sutan Cadena Kusuma Diah Ayu Puspitarini Dian A, Shallomita Diky Zakaria Diwangkara, Naufal Kresna Dr. Woro Hastuti Satyantini, Ir., M.Si Dwi Yuli Pujiastuti Dwirahmadi, Feby Dwitha Nirmala Dyah Purwaningrum, Shintawati Dzati Utomo Edy Sudrajat, Agus Sarwo Eka Pramyrtha Hestianah Eka Saputra Ellis Endang Nikmawati Elroy A.W, Mada Endang Dewi Masithah Eny Apriyati Fathmawati Fathmawati Fauziah, Diana Fauziah, Dini Fa’adilla A, Nashwa Feby Dwirahmadi Ferlyn Hendra Wiyatno Florentina Sustini Franch Dalahi Galih Candra Prakosa Yudha Giovani Agnelli Susanti Gunanti Mahasri Halimatus Sa'diyah Hari B. Notobroto Hari Basuki Notobroto Harsasi Setyawati Hebert Adrianto Heny Arwati Herliana Arsianingtyas Hervina Benazir Ardiyanti Hutama Putra, Windra Ida Ayu Made Mahayani Ida Ayu Puspitasari Idha Kusumawati Iip Saripah, Iip Ike Nur Firdhayani Ilham Harlan Amarullah Indah S Tantular Jamilah, Dewi Siti January Jefry Prasetya Jefry, January Joni Murti Mulyo Aji Jumiyanto Widodo Juniastuti Juniastuti katiah, katiah Khairul Bariyah, Khairul Khuril Zaqyyah Kismiyati , Kismiyati, Kismiyati Kris Cahyo Mulyatno, Kris Cahyo Kurnia, Kiki Adi Kusnoto Kusnoto Kusumawardani, Yustika Lailatul Lutfiyah, Lailatul Laksmi Sulmartiwi Lenny Widjayanthi Liliana Tedjo Saputra Lina Wafia Asmi Lindarto, Wira Widjaya Lucia Tri Suwanti, Lucia Tri Ludira Sari Luh Putu Suciati Maosul, Asep Mardiah Rahma Umami Mariana, Arni Retno Marina hasan Markus Suryo Utomo Masanori Kameoka, Masanori Mirni Lamid Mochammad Amin Alamsjah Mohamad Akmal A.H. Mohammad Rondhi Mohd Fazrul Hisam Abd Aziz Mohd Ihwan Zakariah Mokhamad Syaom Barliana Muhammad Aiman Yudarana Yudarana Muhammad Amin Muhammad Arief Muhammad Herman Muktiarni, Muktiarni Mupita, Jonah Mustapit , Mustapit Mustapit Mustapit Mustofa, Chairil Hana Musyafa, Muhammad Zainal Ali Naisah, Naila Hijrotin Nastiti, Amayliana Ajeng Nathania Disa Ariesta Andriani Ni Komang Ayu Artiningsih Nia Lestari, Nia Nina Herlina Novi Krishatno Putera Novy Prasetya Nugraha, Rifki Destrizal Nunuk Dyah Retno Lastuti Nur Fitriani Nurfauziana, Tazkia Nurines Oktavia Ayuningtiaz Nurul Dwi Novikarumsari, Nurul Dwi Nurul Kumalasari Nuzuluddin, Taufiq Rizza Oktofianus Sila P, January Jefry Paqih, Khaidir Imam Patmawati Patmawati Patmawati Patricia Sembiring Meliala, Susan Barbara Patricia, Susan Barbara Permatasari, Nanda Prabawa, Dewa Gede Benny Raharja Pradiptya Ayu Harsita Puji Basuki Purwaningrum, Shintawati Dyah Puspa Wardhani Puspaningrum , Diah Puspaningrum, Diah Puteri, Whimas Jessica Ayudia Putri, Chairunnisa Ramadhani R. Wahid Nur Yusuf R.TD Wisnu Broto Rachmi Masnilah Ragu Harming Kristina Ragu Harming Kristina Rahadianti, Dian Rahayu Kusdarwati Rahmadany, Deya Nathasya Rani Frisca Christiana Refi, Refi Rengga Eko Pradipta Renyta Andini, W. Retno Mawarini Sukmariningsih RHJ. Wedyowibowo Ririh Yudhastuti Ririh Yudhastuti Ririn Agustiya Riswanda, Andri Rizhar Eman Karunia Akbar Robi M.A Yahya Rohsarifuddin, Fadiya Furuujihim Rr. Juni Triastuti Sahrun Salsabila, Salsabila Sampurna, Insan Cita Santi Martini Sapto Andriyono Sari, Dini Yurindiana Sari, Putri Desi Wulan Sarwo Edy Sudrajat, Agus Sasmitaningtyas, Maulidya Tri Sasmito, Adi Selvi Lely Rosanti Sembiring Meliala, Susan Barbara Patricia Septi Septi Setyawati, Febri Shifa Fauziyah Shifangi, Shifangi Shintawati Shintawati Sila, Oktofianus Siti Churrotin, Siti Sitti R. Umniati Soegeng Soegijanto Soehartono Soehartono Soehartono Sri Kiswati Sri Sumarsih Sri Susilogati Sumarti Subagyo Yotopranoto Sudarko Sudarko Sudarno, Sudarno Suhartiningsih Dwi Nurcahyanti Sukaryo Sukaryo Sukaryo Sukaryo Sukaryo Sulistyowati, Jeni SUPRIYONO . Susiyanti, Rosi Sutrisno, Sutrisno Tanzilia, May Fanny Tegar Putra Purnayudha Teguh Hari Sucipto, Teguh Hari Tjahjaningsih, Wahju Tjahjaningsih, Wahju Tomohiro Kotaki, Tomohiro Tri Budhi Murdiarti Tri Budhi Murdiati Tri Budhi Murdiati Tumangkar, Totok Tutik Juniastuti Ueda, Shuhai Ulia Fajriah Ummi Chasanah Ummi Chasanah, Ummi Valentina, Virliana Titus Vemas, Vemas W, Rico Kusuma Wahyu Wahyu Wanti Wanti Wanti Wanti Wardana, Elizia Flauren Wardhani, Puspa Wasmen Manalu Wedyowibowo, RHJ Widi Astuti Widya Kristiyanti Putri WIHARDJO, EDY Wijoyono, Alvin Putra Wiranda G Piliang Wiranda G Piliang Wulandari Suryaningtyas, Endang Wulanndari, Wahyu Yadi Ruyadi Yarin Dwi Monica Yoes Prijatna Dachlan Yuli Pujiastuti, Dwi Yulia Rahmawati, Yulia Yuniar, Fahdia Maulita Yuristianti Utami, Aisyah Yuwono Marta Dinata Zahira, Naswa Alfina Zahra, Amanatta Zamawi, Irvan