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All Journal Jurnal Veteriner Majalah Kedokteran Bandung Media Kedokteran Hewan Indonesian Journal of Tropical and Infectious Disease JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Medik Veteriner Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Ovozoa: Journal of Animal Reproduction Journal of Applied Veterinary Science and Technology journal of Basic Medical Veterinary Jurnal Kedokteran Hewan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Current Biomedicine Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Jurnal Medika Veterinaria Jurnal Agro Veteriner
Hani Plumeriastuti
Divisi Patologi Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : Journal of Applied Veterinary Science and Technology

 1 
Nephroprotective Effect of Dayak Onion (Eleutherine palmifolia) Against Monosodium Glutamate-Induced Renal Toxicity in Mice (Mus musculus) Anggreani Desi Ramadhani Rahajeng; Aldin Akbar Rahmatullah; Cindy Ercha Aulia Putri; Rahmi Sugihartuti; Endang Suprihati; Hani Plumeriastuti; Mohammad Sukmanadi; Iwan Sahrial Hamid
Journal of Applied Veterinary Science And Technology Vol. 5 No. 2 (2024): October 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V5.I2.2024.129-134

Abstract

Background: The toxicological impacts of monosodium glutamate (MSG), a commonly used food additive, present a significant public health concern. Excessive MSG consumption will increase radical oxidative species, inducing a stress oxidative condition that ultimately results in kidney damage. Purpose: This study aimed to explore the nephroprotective effects of ethanol extracts from Dayak onion (Eleutherine palmifolia) against MSG-induced renal toxicity in mice (Mus musculus). Method: Twenty-five 11 week-old male mice, weighing approximately 20 g each, were divided into five research groups. Group C- received only CMC-Na 0.5%, Group C+ received 4000 mg/kg BW MSG, while Groups T1, T2, and T3 were administered 4000 mg/kg BW MSG along with Dayak onion extract at doses of 30 mg/kg BW, 60 mg/kg BW, and 120 mg/kg BW respectively. All treatments were carried out orally for 52 days. The mice were euthanized by cervical dislocation, and their kidneys were extracted for the examination of any histopathological changes. The data underwent analysis utilizing the Kruskal-Wallis test, followed by the Mann-Whitney test. Results: The results as indicated by the histopathological evaluation of the mice’s kidneys revealed significant improvements in the histo-architecture of the kidneys. Supplementation of Dayak onion extract in mice induced with MSG decreased the degeneration and necrosis of the tubule epithelium, and it also repaired the glomerular necrosis. Conclusion: Oral administration of Dayak onion extract to mice exposed to monosodium glutamate demonstrated a notable reduction in kidney damage and helped maintain renal health significantly.
A Comparative Study Between E-Cigarette Vapor and Cigarette Smoke Exposure on the Lungs of Mice (Mus musculus) Putri, Mirtanti Kiswandi; Hestianah, Eka Pramyrtha; Kuncorojakti, Suryo; Widiyatno, Thomas Valentinus; Sukmanadi, Mohammad; Santoso, Kuncoro Puguh; Plumeriastuti, Hani; Hidayatik, Nanik; Khairullah, Aswin Rafif
Journal of Applied Veterinary Science And Technology Vol. 6 No. 2 (2025): October 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V6.I2.2025.102-108

Abstract

Background: Cigarettes are tobacco products processed with or without additives and are known to contain addictive substances that pose serious health risks to individuals and the public. Inhaled cigarette smoke directly stimulates the activation of macrophage cells in the respiratory tract. Among the affected cells, type II alveolar cells which produce pulmonary surfactant to reduce alveolar surface tension are particularly vulnerable to smoke-induced damage. Purpose:  This study aimed to compare the effects of conventional cigarette smoke and e-cigarette vapor exposure on the number of alveolar macrophages and type II alveolar cells in male mice (Mus musculus). Method: A total of 28 male mice were randomly divided into seven groups. The control group (C) was exposed to ambient air only. Groups A1, A2, and A3 were exposed to 1, 2, and 3 conventional cigarettes per day, respectively, while groups B1, B2, and B3 were exposed to 0.7 mL, 1.3 mL, and 2 mL of e-liquid vapor per day, respectively. All exposures were conducted for 36 consecutive days. Results: A significant difference (p<0.05) was observed in the number of alveolar macrophages among groups C, A1, A2 , A3 , B2 , and B3 , whereas no significant difference was found between A1 and B1. The number of type II alveolar cells significantly differed (p < 0.05) across all groups: C, A1, A2, A3, B1, B2, and B3. Conclusion: Both conventional cigarette smoke and e-cigarette vapor increase alveolar macrophage counts and reduce type II alveolar cell numbers compared to controls. Although both exposures pose health risks, e-cigarette vapor appears to cause milder pulmonary effects than conventional cigarette smoke.
Co-Authors AA Sudharmawan, AA Abdul Samik, Abdul Adiana Mutamsari Witaningrum Adikara, Tatang Santanu Akbar Wijaya Putra Purnama Al arif, Mohammad Anam Al-Anshori, Akhmad Afifudin Aldin Akbar Rahmatullah Amaris, Aulia Puspa Anastasya, Jelita Andriani, Ratna Anggreani Desi Ramadhani Rahajeng Anindya, Afifatus Annisa Nur Fitria Rahma Annise Proboningrat Anwar Ma'ruf Arimbi Arimbi Arimbi Ayang Mahindra Ayu, Zerlinda Dyah Azizatun Nimah Bambang Prajogo Eko Wardoyo Batubara, Agung Setia Benjamin Christoffel Tehupuring, Benjamin Christoffel Boedi Setiawan BUDI UTOMO Budiarto Budiarto Cahyono, Shahani Azpriyanne Chairul A. Nidom Chairul Anwar Christian Marco Hadi Nugroho Christy, Rachella Chusniati, Sri Cindy Ercha Aulia Putri Dadik Rahardjo, Dadik Daniel Leonardo Darsono, Roesno Dayanti, Efin Windi Dewita Dewita Dhesy Kartikasari Didik Handijatno Djoko Legowo Dwi Puspa Sukma Viranda Eka Pramyrtha Hestianah Eka Pramyrtha Hestianah Eka Pramyrtha Hestianah, Eka Pramyrtha Endang Suprihati ERMA SAFITRI Erma Safitri Estoepangestie, Agnes Theresia Soelih Fedik Abdul Rantam Fiqih, Adam Fahmi Fitri, Paraswita Eindah Galaxy Guardian Galuh Swa Ardhya Habibi, Muhammad Afif Hana Eliyani Hariadi, Mas'ud Hendarti, Gracia Angelina Heni Puspitasari Hermin Ratnani Hernanda, Ary Setya Hidajati, Nove Hidanah, Sri Hidayatik, Nanik Imam Mustofa IMAM MUSTOFA Ira Sari Yudaniayanti Irfannur, Irfannur Ismi, Alif Noviana Ismudiono Ismudiono, Ismudiono Iwan Sahrial Hamid Iwan Sahrial Hamid Iwan Sahrial Hamid Kabayo, Fierda Kadek Rachmawati Kadek Rachmawati Kartikasari, Dhesy Khairullah, Aswin Rafif Kinasih, Kurnia Nisa Kuncorojakti, Suryo Kusnoto Kusnoto Kusnoto Lake, Werenfridus Kono Legowo, Djoko Lilik Maslachah Lucia Tri Suwanti, Lucia Tri Lukman, Epy Muhammad Luqman, Epy Muhammad Luthfiatu Kanina Mabluhatus Solehah Mafruchati, Maslichah Mardatillah, Meidy Mirni Lamid Mochamad Lazuardi Mohammad Sukmanadi Muchammad Yunus Mufa, Ramy Inas Mahirah Mufasirin Muhammad Thohawi Elziyad Purnama Muliari Muliari Mustika, Yolla Rona Mustofa Helmi Effendi Nawangwulan, Tantri Nidom, Chairul Anwar Niluh Selly Frantika Nisa, Hanifah Khairun Nove Hidajati Novitasari, Seline Putri Nursadida, Milla Nusdianto Triakoso Palupi, Tantri Dyah Widhi Paramita, Chici Ayu Poedji Hastutiek Prameswari, Febriana Hawa Prastiya, Ragil Angga Prestalia Dwi Rachmawati Primarizky, Hardany Pudji Srianto Putri, Anandia Nafisah Putri, Mirtanti Kiswandi Rachmani, Sartika Dewi Rahadi, Yustisiane Ruth Rahaju Ernawati Rahmahani, Jola Rahmaniabdi, El Roy Achmad Rahmi Sugihartuti Rahmi Sugihartuti Rahmi Sugihartuti, Rahmi Retno Widyowati Retno Yuli Rezady, Ganeswara Muharam Hazmi Rimayanti Rimayanti Rina Vitriasari Ritonga, Mudhita Zikkrullah Rochmah Kurnijasanti S Ravi, Vishantheni Santoso, Kuncoro Puguh Saputro, Amung Logam Sari, Dian Ayu Kartika Sarmanu, Sarmanu Sarudji, Suryanie Setiawan Koesdarto Sherina Lashita Candrakirana Soeharsono Soeharsono Sofyan, Miayu Soneta Solikhah, Aviatus Sri Mulyati Sri Mulyati Sri Pantja Madyawati, Sri Pantja Suherni Susilowati Suhud, Mohamad Kharis Sukmanadi, Mohammad Sunarso, Agus Supranianondo, Koesnoto Suzanita Utama Tatik Hernawati Tjuk Imam Restiadi Tony Hartono Tri Wahyu Suprayogi Trilas Sardjito Tyasningsih, Wiwiek Weliyani, Trima Wibawati, Prima Ayu Widisuputri, Ni Komang Aprilina Widiyatno, Thomas Valentinus Widjiati w Widjiati Widjiati, Widjiati Widya Paramita Lokapirnasari Wiwik Misaco Yuniarti Wurlina, W Xin, Irene Teh Kai Yeni Dhamayanti Yonatan Dimascahyo Budianto Yudhana, Aditya Yulianna Puspitasari Yunita, Maya Nurwartanti Yunus, Muchammad Yusrizal Akmal Yustinasari, Lita Rakhma Zahro, Vida Seanita Zhaza Afililla Zulkifli, Arief Hidayat