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All Journal Jurnal Sain Veteriner Jurnal Veteriner Majalah Kedokteran Bandung Media Kedokteran Hewan Indonesian Journal of Tropical and Infectious Disease JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Medik Veteriner Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Ovozoa: Journal of Animal Reproduction Journal of Applied Veterinary Science and Technology journal of Basic Medical Veterinary Jurnal Kedokteran Hewan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Current Biomedicine Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Jurnal Medika Veterinaria Jurnal Agro Veteriner
Hani Plumeriastuti
Divisi Patologi Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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Acute and Subchronic Toxicity Assessment of 70% Ethanol Extract of Gendarusa Leaves In Vivo Luthfiatu Kanina; Mabluhatus Solehah; Hani Plumeriastuti; Retno Widyowati; Bambang Prajogo Eko Wardoyo
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.39-47

Abstract

Background: Justicia gendarussa Burm. f., has been used traditionally in Indonesia for antifertility. Nowadays, a capsule containing 70% ethanol extract of J. gendarussa leaves has been studied for safety. Objective: This study aimed to determine the acute and sub-chronic toxicity of 70% ethanol extract of J. gendarussa leaves in vivo. Methods: In the acute toxicity study, a single dose of 2,000"‰mg/Kg BW was orally administered to mice (n = 10), which were monitored for 24"‰days. For the subchronic toxicity study, rats were randomly divided into four groups (n = 10). The control group received distilled water, while the treatment groups received a repeated dose of 40, 200, and 1,000 mg/Kg BW orally for 90 days. Blood samples were collected for hematological and biochemical evaluations. Gross pathology and histopathology of liver and kidneys were assessed. Results: No mortality and non-observed adverse effect level (NOAEL) were observed in the acute toxicity study. The hematological analysis did not show significant differences in the subchronic toxicity study. The SPGT, SGOT, and creatinine values showed no change in groups 2 and 4, but the level of SGPT increased in groups 3. The increasing level of BUN was observed in all treated groups. Abnormalities or histopathological changes were observed in the liver and kidney in groups 3 and 4. Conclusions: Using 70% ethanol extract of J. gendarussa leaves at a therapeutic dose is safer, but it needs attention at a higher dose.
Co-Authors AA Sudharmawan, AA Abdul Samik, Abdul Adiana Mutamsari Witaningrum Adikara, Tatang Santanu Akbar Wijaya Putra Purnama Al arif, Mohammad Anam Al-Anshori, Akhmad Afifudin Aldin Akbar Rahmatullah Amaris, Aulia Puspa Anastasya, Jelita Andriani, Ratna Anggreani Desi Ramadhani Rahajeng Anindya, Afifatus Annisa Nur Fitria Rahma Annise Proboningrat Anwar Ma'ruf Arimbi Arimbi Arimbi Ayang Mahindra Ayu, Zerlinda Dyah Azizatun Nimah Bachtiar, Harris Yudhanta Bambang Prajogo Eko Wardoyo Batubara, Agung Setia Benjamin Christoffel Tehupuring, Benjamin Christoffel Boedi Setiawan Budi Utomo BUDI UTOMO Budiarto Budiarto Cahyono, Shahani Azpriyanne Chairul A. Nidom Chairul Anwar Christian Marco Hadi Nugroho Christy, Rachella Chusniati, Sri Cindy Ercha Aulia Putri Dadik Rahardjo, Dadik Daniel Leonardo Darsono, Roesno Dayanti, Efin Windi Dewita Dewita Dhesy Kartikasari Didik Handijatno Djoko Legowo Dwi Puspa Sukma Viranda Eka Pramyrtha Hestianah Eka Pramyrtha Hestianah Eka Pramyrtha Hestianah, Eka Pramyrtha Endang Suprihati Erma Safitri ERMA SAFITRI Estoepangestie, Agnes Theresia Soelih Fedik Abdul Rantam Fiqih, Adam Fahmi Fitri, Paraswita Eindah Galaxy Guardian Galuh Swa Ardhya Habibi, Muhammad Afif Hana Eliyani Hariadi, Mas'ud Hendarti, Gracia Angelina Heni Puspitasari Hermin Ratnani Hernanda, Ary Setya Hidajati, Nove Hidanah, Sri Hidayatik, Nanik Imam Mustofa IMAM MUSTOFA Ira Sari Yudaniayanti Irfannur, Irfannur Ismi, Alif Noviana Ismudiono Ismudiono, Ismudiono Iwan Sahrial Hamid Iwan Sahrial Hamid Iwan Sahrial Hamid Kabayo, Fierda Kadek Rachmawati Kadek Rachmawati Kartikasari, Dhesy Khairullah, Aswin Rafif Kinasih, Kurnia Nisa Kuncorojakti, Suryo Kusnoto Kusnoto Kusnoto Lake, Werenfridus Kono Legowo, Djoko Lilik Maslachah Lucia Tri Suwanti, Lucia Tri Lukman, Epy Muhammad Luqman, Epy Muhammad Luthfiatu Kanina Mabluhatus Solehah Mafruchati, Maslichah Mardatillah, Meidy Mirni Lamid Mochamad Lazuardi Mohammad Sukmanadi Muchammad Yunus Mufa, Ramy Inas Mahirah Mufasirin Muhammad Thohawi Elziyad Purnama Muliari Muliari Mustika, Yolla Rona Mustofa Helmi Effendi Nawangwulan, Tantri Nidom, Chairul Anwar Niluh Selly Frantika Nisa, Hanifah Khairun Nove Hidajati Novitasari, Seline Putri Nursadida, Milla Nusdianto Triakoso Palupi, Tantri Dyah Widhi Paramita, Chici Ayu Poedji Hastutiek Prameswari, Febriana Hawa Prastiya, Ragil Angga Prestalia Dwi Rachmawati Primarizky, Hardany Pudji Srianto Putri, Anandia Nafisah Putri, Mirtanti Kiswandi Rachmani, Sartika Dewi Rahadi, Yustisiane Ruth Rahaju Ernawati Rahmahani, Jola Rahmaniabdi, El Roy Achmad Rahmi Sugihartuti Rahmi Sugihartuti Rahmi Sugihartuti, Rahmi Retno Widyowati Retno Yuli Rezady, Ganeswara Muharam Hazmi Rimayanti Rimayanti Rina Vitriasari Ritonga, Mudhita Zikkrullah Rochmah Kurnijasanti S Ravi, Vishantheni Santoso, Kuncoro Puguh Saputro, Amung Logam Sari, Dian Ayu Kartika Sarmanu, Sarmanu Sarudji, Suryanie Setiawan Koesdarto Sherina Lashita Candrakirana Soeharsono Soeharsono Sofyan, Miayu Soneta Solikhah, Aviatus Sri Mulyati Sri Mulyati Sri Pantja Madyawati, Sri Pantja Suherni Susilowati Suhud, Mohamad Kharis Sukmanadi, Mohammad Sunarso, Agus Supranianondo, Koesnoto Suzanita Utama Tatik Hernawati Tjuk Imam Restiadi Tony Hartono Tri Wahyu Suprayogi Trilas Sardjito Tyasningsih, Wiwiek Weliyani, Trima Wibawati, Prima Ayu Widisuputri, Ni Komang Aprilina Widiyatno, Thomas Valentinus Widjiati w Widjiati Widjiati, Widjiati Widya Paramita Lokapirnasari Wiwik Misaco Yuniarti Wurlina, W Xin, Irene Teh Kai Yeni Dhamayanti Yonatan Dimascahyo Budianto Yudhana, Aditya Yulianna Puspitasari Yunita, Maya Nurwartanti Yunus, Muchammad Yusrizal Akmal Yustinasari, Lita Rakhma Zahro, Vida Seanita Zhaza Afililla Zulkifli, Arief Hidayat