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All Journal HAYATI Journal of Biosciences Majalah Kedokteran Bandung MEDISAINS BERITA BIOLOGI The Indonesian Biomedical Journal Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kesehatan Komunitas Buletin Farmatera Indonesian Journal of Medicine JOURNAL OF SCIENCE AND SOCIAL RESEARCH SCIENTIA JOURNAL Journal of Humanities and Social Studies Unnes Journal of Public Health Media Karya Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Maternitas Kebidanan Jurnal Keperawatan Priority Contagion: Scientific Periodical Journal of Public Health and Coastal Health Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains An-Nadaa: Jurnal Kesehatan Masyarakat Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan INFOKUM Indonesian Journal of Global Health research Jurnal Scientia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Ilmiah METADATA International Journal Of Science, Technology & Management (IJSTM) JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal JURNAL MITRA PRIMA Journal of Multidisciplinary Applied Natural Science Interdisciplinary Social Studies Jurnal Info Sains : Informatika dan Sains JIDAN (JURNAL ILMIAH KEBIDANAN) International Archives of Medical Sciences and Public Health International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Jurnal Locus Penelitian dan Pengabdian Pharmaceutical Sciences and Research (PSR) International Journal of Health and Pharmaceutical (IJHP) JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Jurnal Pengabdian Masyarakat dan Riset Pendidikan Haga Journal of Public Health (HJPH) Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics Folia Medica Indonesiana
Ginting, Chrismis Novalinda
Faculty Of Medicine, University Of Prima Indonesia, Medan, North Sumatera, Indonesia
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Autologous Dendritic Cell Immunotherapy Modulates Renal Perfusion and Hemodynamics in Diabetic Kidney Soekardi, Adi; Chiuman, Linda; Ginting, Chrismis Novalinda
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3878

Abstract

BACKGROUND: Diabetic kidney disease (DKD) is driven by chronic inflammation and endothelial dysfunction, which often persist despite standard pharmacological treatments. Autologous dendritic cell (DC) immunotherapy offers a novel approach to restore immune homeostasis and improve renal vascular function. While the use of autologous DC for immune homeostasis has been previously discussed, not many studies have explicitly reported on the modulation of renal perfusion parameters, such as peak systolic velocity (PSV) and resistive index (RI), following DC immunotherapy. Therefore, this study was conducted to evaluate the effect of autologous DC administration on renal hemodynamics, including PSV and RI, as well as inflammatory biomarkers, including tumor necrosis factor (TNF)-α and vascular cell adhesion molecule (VCAM-1) in DKD patients.METHODS: Thirty-one DKD patients were selected via simple random sampling. All subjects underwent autologous DC therapy, which was administered via intravenous infusion at a concentration of approximately 1×107 cells suspended in 100 mL of normal saline. PSV and RI were measured using Renal Doppler Ultrasonography, while TNF-α and VCAM-1 were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) method. All measurements were conducted before intervention and 60 days after intervention to evaluate the therapeutic efficacy.RESULTS: DC therapy led to significant alterations in renal hemodynamic parameters. The mean PSV decreased from 52.74 to 38.21 cm/s (p=0.016), while RI showed a modest increase from 0.7350 to 0.7550 (p=0.028). Greater hemodynamic effects were observed in patients with well-controlled glycemia, lower serum urea, and microalbuminuria. In contrast, no significant changes were detected in TNF-α and VCAM-1 levels.CONCLUSION: Autologous DC therapy delivers measurable, statistically significant benefits in renal vascular parameters for DKD, particularly in early-stage disease and metabolically stable patients. These findings may support DC therapy as a promising adjunctive strategy to improve renal microcirculation in DKD. KEYWORDS: diabetic kidney disease, dendritic cell therapy, TNF-α, VCAM-1, PSV, RI
Implementasi Program Rujuk Balik pada Pasien DM Tipe 2 di Puskesmas Lalang Kabupaten Batubara Aqilah Yafa, Wafi; Ginting, Chrismis Novalinda; Nasution, Sri Wahyuni
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 4 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i4.5478

Abstract

Program Rujuk Balik (PRB) bertujuan memindahkan pemantauan pasien penyakit kronis yang stabil dari rumah sakit ke fasilitas kesehatan tingkat pertama. Namun, pelaksanaannya masih menghadapi hambatan seperti kepatuhan pasien yang rendah, keterbatasan edukasi, serta ketidakkonsistenan obat. Penelitian ini bertujuan menganalisis implementasi PRB pada pasien Diabetes Melitus tipe 2 di Puskesmas Lalang Kabupaten Batubara berdasarkan aspek masukan, proses, dan keluaran. Penelitian menggunakan desain kualitatif dengan wawancara mendalam terhadap tenaga kesehatan, petugas rujukan, apoteker, dan pasien. Analisis dilakukan melalui reduksi data, kategorisasi, dan triangulasi untuk memastikan keabsahan data. Hasil penelitian menunjukkan bahwa SDM dan proses layanan sudah berjalan sesuai prosedur, serta fasilitas dinilai cukup memadai. Namun, ketersediaan obat PRB masih kurang stabil dan tidak tersedianya media edukasi tertulis menghambat pemahaman pasien. Kepatuhan kunjungan ulang hanya mencapai 58%, menunjukkan perlunya penguatan edukasi dan perbaikan koordinasi program. Penelitian menyimpulkan bahwa implementasi PRB di Puskesmas Lalang cukup efektif, tetapi belum optimal karena dukungan informasi dan ketersediaan obat belum konsisten. Peningkatan edukasi, stabilitas obat, dan koordinasi lintas layanan diperlukan untuk meningkatkan keberhasilan program.
Promotive Health Interventions Through Environmental Sanitation and Water Quality Education for Diarrhea Prevention Among Children in the Medan Sunggal Community Health Center Area Fauziah, Dinda; Ginting, Chrismis Novalinda; Nasution, Sri Wahyuni
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 4 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i4.5736

Abstract

This study aims to assess the effectiveness of promotive health interventions through environmental sanitation and water quality education for diarrhea prevention among children in the Medan Sunggal Community Health Center area on the knowledge and practices of PHBS among families with toddlers, as well as its relationship with the incidence of diarrhea in toddlers in the working area of the Medan Sunggal Health Center. The study used a quasi-experimental design with a one-group pretest–posttest approach involving 50 families with toddlers selected purposively. Interventions in the form of environmental sanitation and water quality education were provided through structured counseling. Data analysis was conducted using the Wilcoxon signed-rank test and the chi-square test. The results showed a significant increase in maternal knowledge of PHBS after the intervention (p < 0.001), while the increase in maternal PHBS practices was not statistically significant (p = 0.073), although descriptively it improved. The chi-square test analysis indicated no significant relationship between maternal knowledge and the incidence of diarrhea (p = 0.529) or between maternal PHBS practices and diarrhea incidence (p = 0.636). These findings suggest that educational interventions effectively improve cognitive aspects but are insufficient to reduce diarrhea incidence without improvements in physical environmental factors. Environmental sanitation and water quality education increase mothers’ knowledge of Clean and Healthy Living Behaviors; however, they alone are inadequate to reduce diarrhea incidence in toddlers, as factors such as access to clean water, proper sanitation facilities, and environmental hygiene also play a critical role.
The Effectiveness of Clean and Healthy Lifestyle Behavior Education in Preventing Scabies among Children at the Medan Juvenile Correctional Institution Lubis, Anisa Taqwa; Ginting, Chrismis Novalinda; Nasution, Sri Wahyuni
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 4 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i4.5743

Abstract

Scabies is a contagious skin disease that remains a public health problem, particularly among children living in communal settings with high population density, such as Juvenile Correctional Institutions (Lembaga Pembinaan Khusus Anak/LPKA). Clean and Healthy Living Behavior (Perilaku Hidup Bersih dan Sehat/PHBS) plays an important role in preventing the transmission of scabies through changes in individual behavior. This study aimed to analyze the effectiveness of a community health promotive intervention through PHBS education in preventing scabies among children at LPKA Class I Medan. This study employed a quasi-experimental design with a pre-test and post-test group design. The research sample consisted of all 125 children residing at LPKA Class I Medan, selected using total sampling technique. The intervention comprised PHBS education delivered using PowerPoint presentation media. Data were collected before and after the intervention using a structured questionnaire assessing knowledge, attitudes, and practices related to PHBS for scabies prevention. Data analysis was performed using univariate and bivariate analyses, with the Wilcoxon Signed Rank Test applied due to non-normal data distribution. The results showed a significant increase in respondents’ knowledge and attitudes following the PHBS educational intervention (p < 0.001), as well as a significant improvement in scabies prevention practices (p = 0.010). The greatest improvement was observed in the knowledge aspect, while changes in practice were relatively lower, possibly influenced by limitations in facilities and environmental conditions within the LPKA.
An Impact Analysis Of The Stunting Handling Program In Anambas Islands Regency In 2023 Rahayu Rahayu; Chrismis Novalinda Ginting; Sri Wahyuni Nasution
JHSS (JOURNAL OF HUMANITIES AND SOCIAL STUDIES) Vol 8, No 3 (2024): JHSS (Journal of Humanities and Social Studies)
Publisher : UNIVERSITAS PAKUAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jhss.v4i3.11221

Abstract

Abstract. In 2013, the prevalence of stunting in Indonesia reached 34.1% and only decreased to 31% in 2022. Therefore, the Indonesian Government is targeting a reduction in the prevalence of stunting to 14% in 2024 through national policies and various programs at various levels of government. One of the areas that has a program to accelerate the reduction of stunting is the Anambas Islands Regency which has a stunting prevalence of 21.7% in 2021. This study aims to determine the impact of the implementation of the prevention and acceleration program for reducing stunting in the Anambas Islands Regency. This study is a qualitative study conducted at the Tarempa Health Center and the Siantan Selatan Health Center. Information in this study was obtained from three Key Informants (Head of the Health, Population Control, and Family Planning Office, Head of the Siantan Selatan Health Center, and Tarempa Health Center Posyandu Cadres) and four Ordinary Informants (mothers of stunted children). Data collection in this study was carried out through in-depth interviews and analyzed by triangulation and matching with secondary data. In addition, communication between implementing actors is carried out routinely through both face-to-face and online, implementation resources are well available, all implementing actors have good dispositions, and have a clear bureaucratic structure. It can be concluded that the implementation of prevention and acceleration of stunting reduction is running well and has succeeded in reducing the prevalence of stunting in Anambas Islands Regency.
Effectiveness Of Incision Wound Healing Of Pandanus Amaryllifolius Roxb In Wistar Rats Muna Soraya Putri; Ermi Girsang; Linda Chiuman; Chrismis Novalinda Ginting
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 2 (2022): May 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (747.609 KB) | DOI: 10.51601/ijhp.v2i2.33

Abstract

The incision is a condition of tissue discontinuity that is commonly encountered with the risk of prolonged healing time, imperfect wound healing, infection, etc. Assessment of the wound healing activity of the incision is the purpose of this research, which includes an examination of wound contraction, the thickness of collagen fibers, and the number of new blood vessels formation. In total, 25 rats will be divided into 5 test groups, each consisting of 5 rats; the control group (cream base treated), standard group (Povidone Iodine), followed by the treated group with 10%, 20%, and 30% pandan leaf extract ointment. The preliminary screening of phytochemical analysisshowed the presence of alkaloids, saponins, flavonoids, tannins, triterpenoids, and steroids and glycosides, with the total content of phenols and flavonoids from the ethanolic extract of Pandan Wangi is 20.95 GAE mg/gram extract, and 23.57 TAE mg/gram extract. Wound contraction examination result showed a significant difference between the treatment groups on day 16 and a sign the pairs of groups after being given the ointment with each concentration (p <0.05), especially in the group with 30% fragrant leaves extract and the standard group. Examination of new blood vessels showed a significant difference (p <0.05), especially with 30% of the leaves extract ointment. There was also a significant difference in collagen density in the group given pandanus ethanol ointment, especially at the 30% pandanus extract content against the group that was only given the ointment base. This research strongly suggests that the fragrant pandan leaf extract ointment is effective in healing incisional wounds and promises the potential for further studies on the pharmacological aspects.
OPTIMALISASI PENGETAHUAN PASIEN TERKAIT DENGAN SURAT IZIN OPERASI DI RUMAH SAKIT NATAMA TEBING TINGGI Muhammad Chairul; Chrismis Novalinda Ginting; Sri Lestari Ramadhani Nasution
JOURNAL OF SCIENCE AND SOCIAL RESEARCH Vol. 9 No. 2 (2026): April 2026
Publisher : Smart Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54314/jssr.v9i2.6178

Abstract

Patient understanding of the Surgical Consent Letter (SIO) is a crucial aspect in ensuring patient safety, rights, and involvement in medical procedures. However, limited patient knowledge remains, potentially leading to misunderstandings and legal and ethical risks in hospitals. This study aims to optimize patient knowledge regarding the Surgical Consent Letter through a systematic educational approach. The method used is descriptive quantitative, with data collected through questionnaires from patients undergoing surgery. Analysis was conducted by comparing the level of patient knowledge before and after the education. The results showed a significant increase in patient knowledge after the educational intervention, with most patients previously in the low to moderate knowledge category improving to the good category. Direct education provided using communicative media has proven effective in improving patient understanding. Thus, optimizing patient knowledge regarding the Surgical Consent Letter can be achieved through planned and ongoing education, thereby supporting patient safety and strengthening the principle of informed consent in healthcare.
THE RELATIONSHIP OF ORGANIZATIONAL CITIZENSHIP BEHAVIOR, ORGANIZATIONAL COMMITMENT, AND JOB SATISFACTION WITH NURSES’ PERFORMANCE IN INPATIENT CARE SETTINGS Sri Wahyuni Nasution; Saud Parulian Harianja; Chrismis Novalinda Ginting
International Archives of Medical Sciences and Public Health Vol. 6 No. 2 (2025): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v6i2.911

Abstract

This study investigates the relationship of organizational citizenship behavior, organizational commitment, and job satisfaction, with the performance of inpatient nurses at RSU Royal Prima Medan (RPMH). Aquantitative correlational (explanatory) design was employed, involvinga total sample of 151 nurses in 2024. Data analysis was conducted using univariate, bivariate, and multivariate techniques. The findings reveal that organizational citizenship behavior, rganizational commitment, and job satisfaction are significantly associated with nurse performance, with job satisfaction demonstrating the strongest correlation. Theseresults underscore the importance of strengthening job satisfaction and organizational factors to enhance nurse performance and improve overall hospital service quality.
Co-Authors Ade Irma Suryani Adek Amansyah Adrian Adrian Adrian Khu Afni Kartika, Ajeng Agatha, Yuti Paramitha Ahmad Faried Alya Mardhotillah Azizah Andre, Johannes Anggraini, Livia Anggraini, Suhelis Angnes, Odri ANITA SARI, DEVI Annisa Amalia Anton Timur Jailani Harahap Aqilah Yafa, Wafi Aritonang, Murni Armansyah, Adek Arna Fransisca Mp Awaluddin Ziad Azah, Yunita Wannur Bawean, Popi Latifah Butter Samin Chandra Wilim Chintya Darma, Gladys Chiuman, Linda Chiuman, Veranyca Daniel Prem Raj Pandid Dewi Riastawaty Dewi Sartika DEWI SARTIKA Diana Krisanti Jasaputra Duha, Sonya Marsela Pieta Dwi Astuti Manullang Edy Fachrial Eliani, Eliani Elis Anggeria Emilia Laia, Maria Ermi Girsang Ermi Girsang Ernes, Audrina Eva Latifah Nurhayati Fauziah, Dinda Ferdinand, Sahna Feri irawan Finna Piska Fiska Maya Wardhani Frederick Frederick gan, claris cyntha deninta Geeta, Girsang, Ermi Gultom, Yohania Premita Gusbakti Rusip Hafifah Hafifah Halim, Michael Handayani, Rr. Anisa Siwianti Handoko, Erwin Handriani, Wita Hanna Sari Widya Kusuma Harahap, Viora Rezky Harmileni Hasibuan, Nasyidah Hannum Hasya, Muhammad Nawal Hondo, Alfarikus Hsb, Khairiyani Asri Hutapea, Dwight Mahaputera Marulitua I Nyoman Ehrich Lister I Nyoman Ehrich Lister IKHTIARI, REFI Iksen, Iksen irza Haicha Pratama Johannes Bastira Ginting Karmila Br. Kaban Laurenxius, Vanessa Sinana Linda Chiuman Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, Nyoman Ehrich Lubis, Anisa Taqwa Lumbantobing, Salomo Lydia Ernawati Rahayu Makdalena, Makdalena Manalu, Andika Prianto Mangatas Silaen Manik, Rayani Mariana Mariana Masryna Siagian Maswarni Maulidwina Bethasari Mawarni, Evi Mendrofa, Leli Angelita Mendrofa, Trisman Basri Mendrofa, Tuho Konsultasi Muhammad Chairul Muna Soraya Putri Mustika, Rani Mutia, Maya Sari Nabila, Siti Napiah, Ali Nasution, Ali Napiah Nasution, Isna Gita Amalia Nella Vista Purba, Agnes Nerissa Nasriza Noflita, Noflita Noviawati Noviawati Nurhayati, Evalatifah Oni Fatmala, Cut Panggabean, Dini Desita Panjaitan, Dian Permata Khaira, Azzuhra Pesta Ria, Anna Maria Pinem, Sabriela Br Pulungan, Ica Yulianti Putranto Manalu Rahayu Rahayu Rahmadani, Rani Raif, Martinus Ahmad Ramadhan Efendi Rapael Ginting Razoki, Razoki Rica Tri Septinora Rizal Rizal Rizky, Muhammad Irvan Sahna Ferdinand Ginting Sahna Ferdinand Ginting Santy Deasy Siregar saragih, jean Sari, Laura Kartika Satrio Wibowo Saud Parulian Harianja Siahaan, Destri Safhira Siahaan, Nurisa Tri Ayu Sianturi, Reksaudi Sihombing, Bungaran Sihombing, Nadia Deva Silaen, Mangatas Sinaga, Widya Oktaviani Siregar, Reza Arfan Siti Hardianti, Siti Soekardi, Adi Sri Lestari Ramadhani Nasution Sri Mulyati Sri Ulina, Evita Sri Wahyuni, Devi Subangkit, Mawar Suhartomi Sunarti Suriani Suriani Suyono, Tan Syahputra, Hariyadi Dharmawan Syahrian, Muhammad Faridz Telaumbanua, Rizky Anditino Teresa Liliana Wargasetia The Fransiska Eltania Tiarnida Nababan Tjiawi, Midoro Tobing, Madeline Angeline Tresun Br Turnip, Malna Umar, William Vera Estefania Kaban Wahyu Widowati Wahyu Widowati Wahyu Widowati WAHYU WIDOWATI Wau, Herbert Widodo, Wahyu Setia Widya Yanti Sihotang Widyastari, Elisa Wienaldi, Wienaldi Wijaya, Johanna Fransiska Winda Sari Winvi, Feli Clarisa Yanti, Ratmi Yolanda Eliza Putri Lubis Yuliansyah, Jeri Yulizal, Ok Yusmaini, Yusmaini Zebua, Sawato Zerry All Vindo Tarigan