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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Ilmiah Farmasi Jurnal Kebijakan Kesehatan Indonesia Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Kesehatan Suara Forikes Jurnal Surya Medika Jurnal Wiyata : Penelitian Sains dan Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmaseutik Pharmasipha Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Media Ilmu Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) JFL : Jurnal Farmasi Lampung JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Jurnal Farmasi Indonesia Oceana Biomedicina Journal JFIOnline JURNAL MEDIA KESEHATAN PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Journal of Pharmaceutical and Health Research Jurnal Insan Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Ilmiah Kesmas-IJ (Indonesia Jaya) Riset Informasi Kesehatan Journal of Health Economic and Policy Research (JHEPR) Academic Hospital Journal Kartika : Jurnal Ilmiah Farmasi Jurnal Ilmiah Multidisiplin Keilmuan Mandira Cendikia (JIMK-MC) Journal of Tropical Pharmacy and Chemistry Jurnal Ekonomi Kesehatan Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Pharmacology and Therapy Strada Jurnal Ilmiah Kesehatan (SJIK) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Tri Murti Andayani

Universitas Gadjah Mada

Author-ID : 227268

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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The correlation of clinical pathway compliance implementation on clinical outcome and sectio caesarian patient costs in a type c private hospital in Lampung Joko Sunowo; Tri Murti Andayani; Dwi Endarti; Eka Tri Wulandari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No S1: Supplement
Publisher : Universitas Aisyah Pringsewu

Sectio caesaria births are around 17.6% of all births (Riskesdas, 2018), this figure is higher than the figure recommended by WHO. The high incidence and cost of sectio caesaria can cause problems if they are not managed properly. CA clinical pathway (CP) as a multi-disciplinary management plan for patients with certain diagnoses can be used to improve the quality and efficiency of excellent health services for each individual according to the law’s mandate. This research is research (observational analytic) with cross-sectional design and retrospective method for data collection. The data in this research were all BPJS patients who underwent sectio caesaria for the period of 1 January 2020 to 30 June 2020 according to the inclusion and exclusion criteria in a type C private hospital in Lampung Province. The observations were made on CP forms and patient medical record documents as well as details of treatment costs from BPJS claim data. To see the correlation of compliance implementation with CP and clinical outcomes, the Chi-square test was carried out, the average analysis of CP implementation compliance with costs was carried out using a non-parametric regression test, the correlation of confounding variables on clinical outcomes was tested using Chi-square and Somers tests, and the correlation between confounding variables and total real costs was tested using the ANOVA test. The descriptive analysis found that the average CP implementation compliance of 145 patients (63%) had an average good adherence score (more than 85%) and 85 patients (37%) had low adherence (less than 85%). The points of care education and nutrition counseling as well as treatment or medical intervention have the highest score of 99.57% and the lowest is 0.34% in nursing mobilization/rehabilitation. The description of clinical outcomes of 230 patients with sectio caesaria Length of Stay (LOS) according to CP (less than 3 days) as many as 95 patients and 185 patients with pain scale (VAS 2) and no patients had ILO. The results of the statistical analysis showed that there was no correlation of compliance implementation of CP on clinical outcomes based on the pain scale, LOS, and total real costs (p more than 0.05). The result of the statistical analysis of the confounding variables Age (p 0.015) and treatment class (p 0.00) showed that there was a correlation on the total real costs (p less than 0.05). The conclusion of this research is that there is no correlation of compliance implementation with CP on clinical outcomes and the total real cost of sectio caesaria patients, and there is a correlation between age and class of care on the total real cost of sectio caesaria patients. Abstrak: Kelahiran sectio caesaria sekitar 17, 6% dari seluruh kelahiran (Riskesdas, 2018), angka ini lebih tinggi dari angka yang direkomendasikan WHO. Tingginya angka kejadian dan biaya sectio caesaria dapat menimbulkan permasalahan jika tidak dikelola dengan baik. Clinical pathway (CP) sebagai suatu rancangan penatalaksanaan multi disiplin untuk pasien dengan diagnosis tertentu dapat digunakan dalam upaya meningkatkan kualitas dan efisiensi pelayanan kesehatan yang prima kepada setiap individu sesuai amanat Undang Undang. Penelitian ini adalah penelitian (observasional analitik) dengan desain cross sectional dan metode retrospektif untuk pengambilan data. Data pada penelitian ini adalah seluruh pasien BPJS yang menjalani sectio caesaria periode 1 Januari 2020 sampai 30 Juni 2020 sesuai kriteria inklusi dan eksklusi di sebuah RS swasta tipe C di Provinsi Lampung. Pengamatan dilakukan pada form CP dan dokumen rekam medik pasien serta rincian biaya perawatan dari data klaim BPJS. Untuk melihat hubungan kepatuhan pelaksanaan CP terhadap outcome klinik dilakukan uji Chi square, analisis rata-rata kepatuhan pelaksanaan CP terhadap biaya dilakukan menggunakan uji regresi non parametrik , hubungan variable perancu terhadap outcome klinik diuji menggunakan uji Chi square dan somers serta hubungan variable perancu terhadap total biaya riil diuji menggunakan uji anova. Analisis deskriptif didapatkan, rata-rata kepatuhan pelaksanaan CP sebanyak 145 pasien (63%) memiliki nilai rata-rata kepatuhan baik (85%) dan 85 pasien (37%) untuk kepatuhan rendah (kurang dari 85%). Poin asuhan edukasi dan konseling gizi serta tatalaksana atau intervensi medis memiliki nilai tertinggi sebesar 99,57% dan terendah sebesar 0,34% pada mobilisasi / rehabilitasi keperawatan. Deskripsi outcome klinik dari 230 pasien sectio caesaria Length of Stay (LOS) sesuai CP (kurang dari 3hari) sebanyak 95 pasien dan 185 pasien dengan skala nyeri (VAS 2) serta tidak didapati pasien yang mengalami ILO. Hasil analisis statistik menunjukkan tidak adanya hubungan kepatuhan pelaksanaan CP terhadap outcome klinik yang berdasarkan skala nyeri, LOS,dan total biaya riil (p lebih dari 0,05 ). Hasil analisis statistik variable perancu usia (p 0,015) dan kelas perawatan (p 0,00) menunjukan ada hubungan terhadap total biaya riil (p kurang dari 0,05). Kesimpulan pada penelitian ini adalah tidak terdapat hubungan antara kepatuhan pelaksanaan CP terhadap outcome klinik dan total biaya riil pasien sectio cesaria, serta terdapat hubungan usia dan kelas perawatan terhadap total biaya riil pasien sectio caesaria.

Analisis Biaya dan Luaran Klinik Terapi Remdesivir dibandingkan Favipiravir pada COVID-19 Derajat Sedang: Perspektif Provider Aniq, Laduna; Andayani, Tri Murti; Endarti, Dwi
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.87168

The COVID-19 pandemic cases affect health and the economy and have become a burden for the global community. Effective and specific antiviral for COVID-19 is still controversial and has yet to be found. Antiviral use is the main mitigation strategy that tends to be more cost-effective but varies in effectiveness and cost depending on various factors. This study aims to evaluate the effectiveness, safety, and cost of antiviral therapy in moderate COVID-19. This observational-analytic study used a retrospective cohort design. Subjects were hospitalized patients with moderate COVID-19 who received antivirals in July-October 2021 and January-March 2022. Therapy effectiveness was measured by lowered NLR (Neutrophil-to-Lymphocyte Ratio) to a normal level and length of stay (LOS). Drug safety includes adverse drug events. The cost of therapy was calculated based on the hospital’s perspective (provider), using direct medical costs. A total of 170 patients were divided into two groups (94 patients remdesivir and 76 patients favipiravir). In this arm, there were 45 patients with lowered NLR (21 patients reached the target and 24 patients did not). The effectiveness of favipiravir and remdesivir was 70.6% and 32.1%. Remdesivir may lower NLR (2.92) versus favipiravir (1.55). Favipiravir had a shorter LOS than remdesivir (8 vs 9 days). Adverse drug events observed in remdesivir were nausea (47.9%) and abdominal pain (22.3%), while in favipiravir nausea (53.9%) and vomiting (22.4%). The average total cost of remdesivir is higher than favipiravir (IDR 19,772,985 vs IDR 13,819,727). Favipiravir has higher efficacy and a shorter LOS with a lower average total cost than remdesivir.

Cost-Effectiveness of Length of Stay of Intravenous Aminophylline and Nebulized Salbutamol in Asthma Exacerbations Lorensia, Amelia; Ikawati, Zullies; Andayani, Tri Murti; Maranatha, Daniel
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.435

Asthma is a heterogeneous disease which is also one of the major health problems in the world. Uncontrolled asthma symptoms will exacerbate asthma, which is the biggest cause of the patient into the ER. Salbutamol is a bronchodilator that belonged to the short-acting beta-2 agonist (SABA), which is an obligatory choice in the management of asthma exacerbations. Unlike the aminophylline group in Indonesia which is still often used widely and rarely appear in the side effects of its use. The main objective of this study was to evaluate the cost-effectiveness of nebulized salbutamol versus intravenous aminophylline for reduction in asthma symptoms, improvement in lung function, and a long hospital stay. The study involved 57 adults asthma exacerbation patients without complication who received treatment in the ER, were studied by using quasi-experimental methods in this study cost-effectiveness analysis to compare intravenous aminophylline (n:27) versus nebulized salbutamol (n:30) therapy to determine the most cost-effective. Intravenous aminophylline therapy was more cost-effective than nebulized salbutamol in reducing the symptoms of asthma and PEF value improvement. Clinical outcome of the length of hospital stay outcome both had the same effective, and cost analysis results showed intravenous aminophylline (US$5.38) cheaper than nebulized salbutamol (US$5.71). intravenous aminophylline was more effective in reducing asthma symptoms than nebulized salbutamol (Pvalue=0.001). Meanwhile, the average decrease in lung function intravenous aminophylline than nebulized salbutamol, although not significantly different (Pvalue=0.507). Aminophylline therapy was more cost-effective in reducing asthma symptoms and improvement in lung function compared nebulized salbutamol in exacerbations asthma patients. But cost-effectiveness researchers need to measure substance abuse outcomes in terms of Quality-Adjusted Life Years (QALY), as this will make their findings more relevant to the development of treatment policy.

Adverse effects of fentanyl/midazolam among patients of intensive care unit (ICU): a narrative review Septiyanti, Windy; Puspita Sari, Ika; Murti Andayani, Tri
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11232

Patients of intensive care unit (ICU) have a complicated condition due to disease, comorbid, and other risk factors. Some ICU patients need to get an invasive process to reduce pain, anxiety, and support their condition. During an invasive process, including mechanical ventilation which causes pain or anxiety, the patient is givensedative and analgesic agents to support the procedure and reduce the patient’s pain and anxiety. However, the use of fentanyl/midazolam has the potential to cause adverse effects, for instance, hypotension, hypoxia, and delirium in several ICU patients. Several risk factors that can lead to adverse effects are aging, obesity, underlying cardiac disease, and the amount of dosage. Therefore, it is essential to recognize the risk factors and monitor the use of fentanyl/midazolam to prevent the worsening condition of patients.

Pola dan Konsumsi Antibiotik pada Pasien Pneumonia RSUD Abdul Wahab Sjahranie Samarinda Normakiyah; Murti Andayani, Tri; Endarti, Dwi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 12 No. 2 (2025): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v12i2.7296

Antibiotik merupakan terapi utama dalam pengobatan pneumonia. Resistensi antibiotik dapat disebabkan oleh penggunaan antibiotik yang tidak tepat. Penelitian penggunaan antibiotik perlu dilakukan sebagai salah satu langkah mengurangi resistensi antibiotik. Penelitian ini bertujuan untuk memberi gambaran pola dan konsumsi antibiotik pada pasien pneumonia di RSUD Abdul Wahab Sjahranie Samarinda. Penelitian ini merupakan penelitian observasional deskriptif dengan rancangan penelitian cross sectional. Pengambilan data pasien penyakit pneumonia rawat inap secara retrospektif dilakukan berdasarkan catatan rekam medis pasien di RSUD Abdul Wahab Sjahranie Samarinda selama periode 1 Januari 2021 sampai dengan 31 Desember 2022 dengan menggunakan teknik total sampling. Hasil penelitian menunjukkan pola konsumsi antibiotik dengan konsumsi terbanyak periode tahun 2021 dan 2022 yaitu penggunaan antibiotik tunggal yaitu levofloxacin IV. Konsumsi antibiotik pada pasien pneumonia terbanyak adalah levofloxacin dan ceftriaxonee. Nilai DDD levofloxacin berturut-turut adalah 47,01 DDD/100 hari rawat inap dan 32,2 DDD/100 hari rawat inap dan ceftriaxonee dengan nilai DDD berturut-turut 12,26 DDD/100 hari rawat inap dan 20,74 DDD/100 hari rawat inap. Kesimpulan dari penelitian ini adalah pola antibiotik terbanyak adalah antibiotik tunggal yaitu levoflovacin IV dan antibiotik yang termasuk dalam segmen DU 90% pada tahun 2021 dan 2022 meliputi levofloxacin, ceftriaxonee, azithromycin, moxifloxacin dan meropenem.

Karakteristik Pengobatan dan Biaya Medis Langsung Kanker Payudara pada Kemoterapi Rawat Jalan di RSUD Dr. M. Yunus Tahun 2023 Utami, Dika Aryan; Andayani, Tri Murti; Endarti, Dwi
Majalah Farmaseutik Vol 21, No 4 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i4.103487

Kanker payudara merupakan jenis kanker dengan prevalensi tertinggi di Indonesia dan secara global, yang memerlukan analisis biaya pengobatan untuk mencapai efektivitas terapi. Penelitian ini bertujuan untuk menganalisis karakteristik pengobatan kanker payudara pada pelayanan kemoterapi rawat jalan di RSUD Dr. M. Yunus selama periode 1 Januari hingga 31 Desember 2023 dan merupakan penelitian deskriptif dengan desain penelitian cross-sectional. Data yang digunakan dalam penelitian ini diambil dari SIM RS dan rekam medis pasien, yang kemudian dianalisis menggunakan perangkat lunak RStudio. Hasil penelitian menunjukkan bahwa terdapat 2.268 pelayanan kemoterapi rawat jalan untuk 386 pasien, mayoritas berusia 40–44 tahun. Pengobatan diberikan melalui tiga rute: intravena (IV), oral (PO), dan kombinasi (injeksi dan oral), dengan total 31 regimen pengobatan. Total biaya medis langsung mencapai Rp 5.719.995.986, dengan rata-rata biaya per pasien sebesar Rp 2.522.044. Rute intravena (IV) paling sering digunakan (49,87%), sementara regimen EC-T (Epirubicin, Cyclophosphamide, dan Docetaxel) paling banyak diberikan (32,80%). Regimen Paclitaxel-Trastuzumab memiliki biaya medis langsung tertinggi, yaitu Rp 9.002.322. Penelitian ini memberikan wawasan tentang karakteristik pengobatan kanker payudara di RSUD Dr. M. Yunus dan diharapkan dapat menjadi dasar perancangan kebijakan berbasis data untuk meningkatkan efektivitas pelayanan kesehatan.

Impact of platinum-based and non-platinum chemotherapy on quality of life in non-small cell lung cancer: A narrative review Yuditha Astarina, Davinda; Rahmawati, Fita; Murti Andayani, Tri
Indonesian Journal of Pharmacology and Therapy Vol 7 No 1 (2026)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.27318

Chemotherapy remains one of the main therapeutic options for patients with advanced non-small cell lung cancer (NSCLC), a disease that continues to contribute significantly to global cancer-related mortality. The selection of platinum-based or non-platinum chemotherapy regimens has important clinical implications, as these approaches differ not only in antitumor efficacy but also in their impact on patients’ health-related quality of life (HRQoL). This narrative review aimed to synthesize recent evidence regarding the effects of platinum-based and non-platinum chemotherapy on HRQoL among patients with NSCLC. Relevant studies published between 2020 and 2025 were identified through systematic searches of major scientific databases, including PubMed, Scopus, and Web of Science. The findings were narratively synthesized across commonly reported HRQoL domains using validated assessment instruments, such as the Functional Assessment of Cancer Therapy–Lung (FACT-L), the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Lung Cancer Module (QLQ-LC13), as well as the EQ-5D-5L. Overall, platinum-based chemotherapy was associated with better disease control but also with greater toxicity-related deterioration in physical and emotional functioning. In contrast, non-platinum regimens demonstrated improved tolerability and more stable HRQoL outcomes. These differences have important implications for shared clinical decision-making, particularly in patients with advanced disease for whom symptom relief and quality of life often represent primary treatment goals. This review highlights the need to integrate HRQoL considerations alongside clinical efficacy when individualizing chemotherapy strategies for patients with advanced NSCLC.

Cost of Illness Analysis in Total Knee Replacement at Public Hospital Jenderal Ahmad Yani, Lampung, Indonesia Alia, Dina Fatma; Endarti, Dwi; Andayani, Tri Murti
Jurnal Ekonomi Kesehatan Indonesia Vol. 10, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Total knee replacement (TKR) is one of the most economical and frequently successful orthopedic procedures. Cost-of-illness studies of TKR in Indonesia are scarce and lack an analysis of the relationship between characteristics and costs. This study aims to examine the cost-of-illness of TKR from a social perspective and explore the relationship between the characteristics and the cost of TKR. This is an observational cross-sectional study of all patients who underwent TKR from 1st January 2022-31 st December 2023. The characteristics were collected from the medical records. Cost of illness was conducted from a social perspective with a bottom-up approach. Hospital cost on the JKN ECLAIM System was obtained as direct medical cost. Direct non-medical and indirect costs were collected through a phone interview with the patient or caregiver. Indirect cost was defined as income loss from the patient and caregiver. The relationship between characteristics and cost was analyzed bivariately using the Mann–Whitney U test and Kruskal–Wallis test. Of a total 54 patient were obtained. Median direct medical cost was 51,769,675 IDR; direct non-medical cost was 850,000 IDR; and indirect cost was 750,000 IDR. None of the characteristics had a direct relationship with medical cost. Age (p = 0.043), Caregiver (p <0.001), and distance traveled (p <0.001) were known as characteristic related to direct non-medical costs. Indirect cost was related to age (p = 0.053) and employment status (p = 0.005). This study only examined the cost of TKR in the hospital. Costs of post-surgery recovery steps, including costs for revisit consultations, wound care, and physiotherapy, need to be carried out in the future.

Pharmacy Strategy Formulation Based on Integration of Balanced Scorecard and SWOT Analysis: A Case Study Ahmad Suriyadi Muslim; Titik Sunarni; Tri Murti Andayani
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.7664

X Pharmacy Yogyakarta faces increasingly intense competition from growing competitor pharmacies in its operating area. Performance evaluation using the Balanced Scorecard (BSC) method has been conducted, but has not been comprehensively integrated with SWOT Analysis for strategic development formulation. Objective: This study aims to formulate a development strategy for X Pharmacy Yogyakarta through integration of Balanced Scorecard performance evaluation results with SWOT Analysis. This study employed a non-experimental case study design with an exploratory descriptive approach. Data were collected prospectively and retrospectively at X Pharmacy Yogyakarta during the period 2017-2020. A total of 65 patient respondents were recruited using purposive sampling for the customer perspective, and all pharmacy employees were included as respondents for the learning and growth perspective. Financial data were retrieved retrospectively for 2017-2019, while prescription data were observed prospectively over 14 working days. Data were analysed descriptively using IFAS and EFAS matrices to determine the pharmacy’s strategic position based on BSC performance evaluation covering four BSC performance evaluation showed that financial performance (GPM, NPM, ITOR) met established standards. Customer satisfaction was high, but patient growth declined. Average drug availability was 93.87% and Drug Related Problems (DRP) were still identified. Employee satisfaction and morale were high, but productivity was low. SWOT analysis yielded a total IFAS score of 2.94 and EFAS score of 2.57, with SO (Strength-Opportunity) as the primary strategy. Recommended strategies include enhanced patient-oriented pharmaceutical services, human resource development, service innovation, and drug management optimisation. Integration of BSC and SWOT analysis produced a comprehensive strategy map that can serve as a reference for X Pharmacy management in improving competitiveness and quality of pharmaceutical services.

Review: Cost-Effectiveness Analysis Metformin dan Dipeptidyl Peptidase-4 Inhibitor Dibandingkan dengan Metformin dan Sulfonilurea pada Pasien Diabetes Melitus Tipe 2 Nuring Novita Kusumawati; Tri Murti Andayani
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.91911

Prevalensi diabetes melitus tipe 2 (DMT2) meningkat, sehingga manajemen terapi yang efektif dan cost-effective sangat penting. Kombinasi metformin dengan dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) dan metformin dengan sulfonilurea (SU) merupakan terapi lini kedua pada pasien DMT2, masing-masing memiliki kelebihan dan kekurangan terkait biaya dan efektivitas. Review ini bertujuan untuk membandingkan hasil penelitian cost-effectiveness dari kedua kombinasi tersebut guna membantu praktisi kesehatan dalam membuat keputusan pemilihan terapi dalam pengelolaan DMT2. Review ini menganalisis temuan dari berbagai jurnal yang dipublikasikan secara online, menggunakan database SCOPUS dan PubMed serta mengikuti skema PRISMA dan PICO. Penelitian yang memenuhi kriteria pencarian adalah 75 studi, 35 di antaranya berasal dari Scopus dan 40 PubMed. Terdapat beberapa artikel dikecualikan dan didapatkan 5 studi yang memenuhi kriteria akhir kemudian dilakukan penilaian kualitas berdasarkan standar CHEERS 2022. Analisis menunjukkan bahwa kombinasi DPP-4 inhibitor dan metformin lebih efektif dibandingkan kombinasi sulfonilurea dan metformin dalam mengelola diabetes melitus tipe 2, temuan ini didukung oleh pemelitian dari berbagai negara, menunjukkan pengurangan risiko hipoglikemia dan peningkatan kualitas hidup pasien. Tinjauan sistematis ini menunjukkan bahwa kombinasi DPP-4 inhibitor dengan metformin adalah terapi lini kedua yang cost effective dibandingkan dengan kombinasi sulfonilurea dan metformin untuk penderita diabetes melitus tipe 2.

Co-Authors . Inayati A.M Wara Kusharwanti Abdul Khodir Jaelani Abdul Mahmud Yumassik Achmad Fudholi Achmad Fudholi Achmad Fudholi Achmad Fudholi admaja, wika Agung Endro Nugroho Agustini, Tiara Tri Ahmad H. Asdie Ahmad Suriyadi Muslim Ahmad, Irfan Aisyah, Noor Akuba, Jusnita Ali Ghufron Mukti Ali Gufron Mukti Alia, Dina Fatma Amalia Amalia Amalia Amalia Amalia Amalia Ambar Yunita Nugraheni Amelia Lorensia Anak Agung Gede Sugianthara Ani Pahriyani Aniq, Laduna Anisa Zulfa Fatihah Anna Wahyuni Widayanti Anni Anni, Anni Aqnes Budiarti Ari Dwidayati Arief Nurrochmad Arini, Yovita Dwi Arissa Dwiningrum Artemisia, Rahma Astuti, Rini Budi Atsna, Zafria Avrilya Iqoranny Susilo Ayunda Nur Hidayatiningsih Ayuning Siwi, Mayang Aditya Azalea, Metty Bekti Meilani Nurcahya Belinda Arbitya Dewi Candra Eka Puspitasari Candraningrat, I Dewa Agung Ayu Diva Cecep Kusmana Chairun W Chairun W Chairun Wiedyaningsih Chinthia Sari Yusriana Desy Purnamasari Dewi, Mahmud Carica dharmika wijaya sakti Dhiyan Kusumawati Didik Setiawan Dina Fatma Alia Dinaryanti, Pratiwi Dini Okyaviani Dini, Intan Rahmania Eka Diyan Ajeng Rossetyowati Djoko Wahyono Djoko Wahyono Dwiningrum, Arissa Dyah, Ria Istamining Eka Kartika Untari Eka Tri Wulandari Elsa Zhenita, Albela Endang Suparniati Endang Suparniati, Endang Endang Yuniarti Endang Yuniarti erna prasetyaningrum Etikasari, Ria Farida Munawaroh Farida, Yeni Ferdinan Jalung Ferdinan Jalung Ferdy Firmansyah Fidiawan, Arie Firda Ridhayani Fita Rahmawati Fita Rahmawati Fitri, Elny Fredie Irijanto Fredie Irijanto Fridly Manawan Gita Mayasari Gunawan Pamudji Widodo Hafizah, Ilmi Nur Halimah Hayul Halimah Hayul Handi Mukti Fahrizal Handi Mukti Fahrizal Haninditya, Beta Hari Kusnanto Hari Kusnanto Haris, Restu Nur Hasanah Herri S. Sastramihardja Hidayaturahmah, Rizky Hilmy Irsyadi Hanif Hutahaean, Amsaline Vingky I Dewa Putu Pramantara I Dewa Putu Pramantara I Dewa Putu Pramantara S Ibrahim Arifin Ika Alfinnisa Majida Ika Norcahyanti Ika Purwidyaningrum IKA PUSPITA SARI Ika Puspita Sari Ika Puspitasari Ika Puspitasari Ika Puspitasari Ika Trisnawati Ika Trisnawati, Ika Ikakusumawati, Novita Dhewi Imaniar Noor Faridah Imaniar Noor Faridah Inayati Inayati Inayati, Inayati Indriyati Hadi Sulistyaningrum Ingenida Hadning Intan Rahmania Eka Dini Irfanianta Arif Setyawan Irnayanti Irnayanti Irnayanti, Irnayanti Ivanka, Luna Iwan Dwiprahasto Iwan Dwiprahasto Jaelani, Abdul Khodir Jaelani, Abdul Khodir Jaelani, Abdul Qadir Jarir At Thobari Jason Merari Peranginangin Joko Sunowo Kartika Widayati Taroeno Hariadi Kusharwanti, A.M Wara Kusumawati, Dhiyan L. Endang Budiarti, L. Endang Larasati, Laksmy Anggun Lering, Maria Nona Adriani Liliany Fatonah Lingga Ikaditya Lingga Ikaditya, Lingga Listyana, Yanverty Idda Lukman Hakim Luthfan Budi Purnomo Magistasari, Dewi Makmur, Rahmat Maranatha, Daniel Mariana Wahyudi Mariska Sri Harlianti Mariska Sri Harlianti Marlina, Ni Ketut Martodiharjo, Suwaldi Maulidia, Shofia Siza Mawaqit Makani Maya Arfania Mayasari, Gita Megawati Parmasari Metty Azalea Milda Rianty Lakoan Milda Rianty Lakoan Mohamed Izham Mohamed Ibrahim Mohammad Robikhul Ikhsan Mpila, Deby Afriani Mufarrihah Mufarrihah Mufarrihah, Mufarrihah Mukhamad Najib Mukti, Ali Gufron Mulyani, Risya Munawaroh, Farida Murni, Siti Olega Adawiyah Muslimah Muslimah Mustofa Mustofa Nafiah Adiningrum Nanang Munif Yasin Nanang Munif Yasin Nanang Munif Yasin Natalia Gilarsih Natalia Gilarsih Nawang Wulan Nago Pitasari Neneng Ratnasari Normakiyah Novena Adi Yuhara Novia Ariani Dewi Novianti, Feby Galuh Nur Rasdianah Nurcahya, Bekti Meilani Nurifahmi, Rahmaningtyas Nuring Novita Kusumawati Nurul Adzkia Ghearizky Nurul Ambianti Nurul Hikmah Nurul Latifah Nurul Qiyaam, Nurul Nurul Safitri Nuryanti, Tety Nutrisia Aquariushinta Sayuti, Nutrisia Aquariushinta Octavia, Mega Oetari Oetari Oetari Oetari Okke Putri Shera Oktaviani, Devi Okti Ratna Mafruhah Pahriyani, Ani Pamungkas, Kumbang Nirbhaya Pande Made Desy Ratnasari Parmasari, Megawati Partini Partini Partini Partini, Partini Pramana, Facetha Intan Pratiwi, Woro Rukmi Primadiamanti, Annisa Purnamasari, Vina Purnomo, Luthfan Budi Purwoko, Agus Puspita Sari, Ika Putri Dina Mahera Laily Rahajeng, Bangunawati Rahayu, Asri Rahma, Nazulanita Rahmawati, Anindya Rahmawati, Fita Rahmawati, Fita Rastiti, Liza Ratnasari, Pande Made Desy Renni Simorangkir Ria Etikasari Ria Istamining Dyah Rina Herowati Rina Triasih Riskayanti Riswaka Sudjaswadi Riyanta Aribawa Rizaldy Pinzon Rizaldy T Pinzon Rizka Humardewayanti Asdie Rizky Danang Susetyo Rokhman, Rifqi Rukminingsih, Fef Ryan Astaruddin S, I Dewa Putu Pramantara Safnurbaiti, Dwi Putri Saharuddin, Tria Saputra Sammulia, Suci Fitriani Sampurno Sampurno Sampurno Sampurno Sampurno, Sampurno Santi Andriani Saputra, Andy Kurniawan Saputri, Erlika Sari, Maya Dwi Wulan Sari, Rafika Mutia Sarifudin, Barbara Azalya Satibi Satibi Satibi Satibi Satibi Satibi Satibi Satibi Selamet, Ni Made Dwi Antika Septiyanti, Windy Setiyaningsih, Hermawati Setyawan, Irfanianta Arif Simanullang, Raymon Siradjuddin, Ammar Sri Haryanti Starlista, Viva Sudewi Mukaromah Khoirunnisa Suffiana, Yunita Sugiyanto - Sugiyanto Sugiyanto Sukengtyas, Dyah Atmi Tri Sulistiawaty, Endang Sunarti Sunarti Supanji, Supanji Susi Ari Kristina Susi Ari Kristina Suwendar Syahrizal Ramadhani Syaiful Katadi Tety Nuryanti Titik Nuryastuti Titik Sunarni Titik Sunarni Tri Wijayanti Tria Saputra Saharuddin Tuangrat Phodha Umi Athijah Utami, Dika Aryan Venanti, Bernadeta Setyo Vo Quang Trung widi astuti r Widiastuti Widiastuti Willi Wahyu Timur Winarni Winarni Wirawan Adikusuma Wulandari, Aprilla Ayu Yance Anas Yeni Farida Yopi Rikmasari, Yopi Yovita Dwi Arini Yuditha Astarina, Davinda Yusriana, Chinthia Sari Zullies Ikawati Zullies Ikawati Zullies Ikawati ZULLIES IKAWATI

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