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All Journal Medula Jurnal Kesehatan Masyarakat JITEK (Jurnal Ilmiah Teknosains) Hasanuddin Law Review SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JFL : Jurnal Farmasi Lampung Jurnal Dunia Kesmas Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati JURNAL ILMIAH KESEHATAN SANDI HUSADA Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Jurnal Ilmiah Kesehatan JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Abdi Insani Jurnal Peduli Masyarakat JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Jurnal Kesehatan Tambusai Jurnal Pengabdian Dharma Wacana Buguh: Jurnal Pengabdian Kepada Masyarakat Fox Justi : Jurnal Ilmu Hukum Jurnal EduHealth Indonesian Journal of Biological Pharmacy Prosiding Konferensi Nasional PKM-CSR Jurnal Ilmiah Bakti Farmasi Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Farmasetis Sains Medisina Indonesian Journal of Pharmacy and Natural Product FASKES : Jurnal Farmasi, Kesehatan, dan Sains Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Majority Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Kesehatan Sandi Husada JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Sanitas: Journal of Health, Medical, and Psychological Studie International Journal of Health Science
Rasmi Zakiah Oktarlina
Program Studi Farmasi, Fakultas Kedokteran, Universitas Lampung
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Gen-Gen yang Berperan dalam Mekanisme Epilepsi Resisten terhadap Obat Shinta Nurhaliza; Roro Rukmi Windi Perdani; Intan Kusumaningtyas; Rasmi Zakiah Oktarlina
Journal of Health, Medical, and Psychological Studies Vol 1 No 2 (2025): December: Sanitas: Journal of Health, Medical, and Psychological Studies
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/b1bg2p24

Abstract

Drug-resistant epilepsy represents a major clinical challenge due to its complex and multifactorial biological mechanisms. This condition is not solely driven by inadequate pharmacological efficacy but is strongly influenced by genetic alterations affecting drug transport, neuronal excitability, and neuroinflammatory regulation. Genes encoding drug transporters such as ABCB1 and ABCC2 limit antiepileptic drug penetration across the blood–brain barrier, reducing therapeutic concentrations within epileptogenic regions. Meanwhile, mutations in sodium channel genes, particularly SCN1A, SCN2A, and SCN8A, disrupt neuronal excitability by altering action potential dynamics and synaptic balance. In parallel, neuroinflammatory genes including IL1B, TNF, and TLR4 promote chronic inflammatory responses that sustain epileptogenesis and further reduce drug responsiveness. The interaction among these genetic pathways creates a self-reinforcing pathological network that underlies persistent seizure activity despite optimal treatment. Understanding these molecular mechanisms highlights the necessity of precision-based approaches, including pharmacogenetic screening and targeted adjunctive therapies, to improve clinical outcomes in patients with drug-resistant epilepsy.  
Evaluasi Pengelolaan Obat Antibiotik di Puskesmas dalam Mendukung Program Pengendalian Resistensi Antimikroba Aisyah Qinthara Nabila Putri; Rasmi Zakiah Oktarlina; Ayu Tiara Fitri; Juspeni Kartika
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 1 (2026): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i1.9537

Abstract

Antimicrobial resistance (AMR) represents a serious global health threat caused by the irrational use of antibiotics. In Indonesia, this issue has become more complex due to the high rate of antibiotic purchases without prescriptions and weak distribution control. This study aims to evaluate the effectiveness of antibiotic management in community health facilities, particularly Puskesmas, and to identify factors influencing antibiotic use practices in support of the national antimicrobial resistance control program. A qualitative method with a literature study approach was used, reviewing national and international scientific sources, including WHO reports, the Indonesian Ministry of Health, and the National Action Plan for Antimicrobial Resistance Control (RAN-PRA) 2020–2024. The findings show that approximately 41% of antibiotics are still obtained without prescriptions, and 70.75% of pharmacies in Indonesia continue to sell antibiotics freely. Both public and healthcare workers’ awareness of AMR remains low, as antibiotics are often misused for viral infections. Although national policies such as RAN-PRA adopt a One Health approach, their implementation still faces challenges, including limited resources, weak monitoring, and regional disparities. Puskesmas plays a strategic role in education, supervision, and reporting on antibiotic use but requires capacity strengthening and intersectoral collaboration. This study concludes that AMR control demands synergy among government, medical professionals, academics, and the public through enhanced education, stricter antibiotic distribution control, and evidence-based policymaking. Continuous efforts are essential to preserve antibiotic effectiveness and strengthen Indonesia’s national health resilience against global antimicrobial resistance threats.
Pengaruh Pemberian Pill Card terhadap Kepatuhan Minum Obat Antihipertensi pada Pasien Hipertensi Rawat Jalan Puskesmas Rawat Inap Satelit Bandar Lampung Audry Lintang Hasanuddin; Rasmi Zakiah Oktarlina; Dwi Aulia Ramdini; Oktafany Oktafany
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2004

Abstract

Hypertension is one of the most common non-communicable diseases in Indonesia. Hypertensive patients must have high self-efficacy to comply with antihypertensive medication so that blood pressure can be controlled and complications prevented. Therefore, intervention is needed to improve therapy compliance. One intervention that can be given is the provision of pill cards. This study was a quasi-experimental design with a pre-intervention post-intervention control group design. Sampling was conducted using non-probability purposive sampling from July to September 2025. A total of 106 respondents were divided into two groups, with 53 respondents in the control group and 53 respondents in the intervention group. The control group was only given the MMAS-8 questionnaire, while the intervention group was given pill cards and the MMAS-8 questionnaire. In the intervention group, prior to intervention, 25 patients (47.2%) had low compliance, 21 patients (39.6%) had moderate compliance, and 7 patients (13.2%) had high compliance. After the intervention, there was a significant increase, with 21 patients (39.6%) showing high compliance, 26 patients (49.1%) showing moderate compliance, and 6 patients (11.3%) showing low compliance. Providing pill cards to outpatients with hypertension can improve patient medication adherence. Based on the results of the Wilcoxon Signed Ranks Test, a value of (p<0.001) was obtained, indicating that H0 was rejected and there was a significant effect.
EDUKASI DAN INOVASI PRODUK ALBUMIN IKAN GABUS SEBAGAI NUTRISI TAMBAHAN BAGI PENDERITA LUKA DAN PASCAOPERASI Oktarlina, Rasmi Zakiah; Pardilawati, Citra Yuliyanda; Sutarto, Sutarto; Amelia, Dinda; Riyanto, Rahmadani Putri; Bahri, Syaiful
Jurnal Abdi Insani Vol 12 No 12 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i12.3390

Abstract

Snakehead fish (Channa striata) is a natural source of albumin that plays a vital role in wound healing and post-operative recovery. Despite its high nutritional potential, its utilization in Hanura Village, Teluk Pandan District, Pesawaran Regency, Lampung, Indonesia, remains limited. The main challenges include its strong fishy odor and the lack of product innovation. This condition highlights the need for developing more innovative and acceptable snakehead fish-based products. To address this issue, the community service program aimed to enhance the knowledge and skills of local partners in producing snakehead fish albumin capsules through training in manufacturing, packaging, and marketing. The program employed a modified extractor and a freeze-drying method to obtain high-quality albumin extract. It also included education on efficient and simple extraction procedures and training on capsule production processes that can be easily implemented by the community. The program successfully designed and developed a modified extractor unit for albumin extraction. The extraction process produced 500 mL of liquid albumin with a yield of 27.37%, which was subsequently freeze-dried into 35.70 g of yellow albumin powder with a distinctive odor. The Biuret test yielded positive results, indicated by a color change to purple, while heating at 90 ºC caused coagulation, confirming the presence of albumin. The training involved 20 participants and resulted in a significant improvement in understanding, with average scores increasing by 71.7%, from 32.8 to 80.5. Overall, the program successfully improved participants’ knowledge and skills in producing snakehead fish albumin capsules and promoted the sustainable utilization of local resources in Hanura Village.
Kandungan Bahan Aktif Daun Sirih Hijau (Piper betle L.) dan Pemanfaatannya di Bidang Kesehatan Asyifa, Nisa; Sibero, Hendra Tarigan; Ratna, Maya Ganda; Oktarlina, Rasmi Zakiah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.937

Abstract

Abstrak Pendahuluan: Daun sirih hijau (Piper betle L.) merupakan salah satu tanaman obat tradisional yang banyak digunakan di Asia Tenggara, termasuk Indonesia, dan mengandung beragam senyawa bioaktif yang berpotensi untuk pengembangan fitofarmaka. Metode: Metode penelitian ini menggunakan pendekatan scoping review berbasis bibliometrik, di mana data bibliografis terkait Piper betle L. dikumpulkan dari basis data Scopus dan dianalisis menggunakan perangkat R-Biblioshiny untuk memetakan tren publikasi, kolaborasi penulis, serta tema penelitian yang relevan. Pembahasan: Hasil penelitian in vitro menunjukkan aktivitas antimikroba yang luas, baik terhadap bakteri Gram positif maupun Gram negatif, serta sifat antiinflamasi dan antioksidan yang mendukung penyembuhan luka. Inovasi formulasi, seperti nanoemulsi berbasis ekstrak sirih, terbukti meningkatkan kelarutan, stabilitas, dan efektivitas bioaktif sehingga efektif diaplikasikan pada kesehatan mulut, khususnya sebagai obat kumur alami untuk pencegahan karies. Perbandingan lintas studi nasional dan internasional memperlihatkan konsistensi manfaat daun sirih hijau sebagai agen terapeutik, meskipun masih diperlukan penelitian lanjutan dalam bentuk uji klinis berskala besar. Kesimpulan: Dengan demikian, daun sirih hijau dapat dipandang sebagai sumber potensial untuk mendukung inovasi produk kesehatan berbasis herbal yang aman, efektif, dan terstandar.                Kata Kunci: Bahan Aktif; Piper betle L.; Daun Sirih Hijau; Implementasi Kesehatan
Peran Pemantauan HbA1c dalam Menilai Rasionalitas Terapi Obat Antidiabetes Oral di Pelayanan Kesehatan Primer: Literature Review Siboro, Erwi Saulina Venezia; Sukohar, Asep; Kusumaningtyas, Intan; Oktarlina, Rasmi Zakiah
Jurnal Kesehatan Ilmiah Aufa Royhan Vol 10 No 2 (2025): Vol. 10 No. 2 Desember 2025
Publisher : Universitas Aufa Royhan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51933/health.v10i2.2355

Abstract

Diabetes melitus tipe 2 merupakan gangguan metabolik kronis yang ditandai oleh resistensi insulin dan disfungsi sel β pankreas menyebabkan peningkatan glukosa darah serta meningkatkan risiko komplikasi mikrovaskular dan makrovaskular. Pada pelayanan kesehatan primer, pengelolaan diabetes menuntut penggunaan terapi rasional untuk mencapai kontrol glikemik optimal dan mencegah progresivitas penyakit. Obat Antidiabetes Oral (OAD) menjadi pilihan utama berdasarkan efektivitas, keamanan, dan ketersediaan. Tinjauan pustaka ini bertujuan mengevaluasi peran pemeriksaan HbA1c dalam menilai rasionalitas terapi OAD di layanan kesehatan primer. Metode yang digunakan adalah literature review melalui Google Scholar, Science Direct, Scopus, dan Pubmed sesuai kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan pemeriksaan HbA1c merupakan parameter utama yang mencerminkan kontrol glikemik rata-rata dalam 2–3 bulan terakhir dengan target HbA1c <7% sebagai indikator keberhasilan terapi. HbA1c membantu menentukan efektivitas terapi, kebutuhan penyesuaian regimen maupun intensifikasi jika target tidak tercapai setelah tiga bulan yang dapat mengevaluasi kerasionalan pengobatan. Namun, pelaksanaan pemantauan HbA1c masih terkendala biaya, keterbatasan alat, dan sistem pencatatan yang belum terintegrasi. Literature review ini menyimpulkan bahwa pemantauan HbA1c yang terintegrasi dengan POR mampu meningkatkan efektivitas terapi OAD dan membantu mewujudkan pengelolaan Diabetes Melitus Tipe 2 yang lebih efisien di pelayanan kesehatan primer.
Literature Review: Evaluation of the Performance of the Pharmacy Management Information System (SIM-Farmasi) Using the HOT-Fit Model Dzakiya Alya Musyafa Satriad; Rasmi Zakiah Oktarlina; Citra Yuliyanda Pardilawati
International Journal Of Health Science Vol. 6 No. 1 (2026): March: International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v6i1.6778

Abstract

Introduction: The use of information technology has become a necessity and an increasing demand for public service providers, including hospital pharmacy departments. The pharmacy department plays a vital role in supporting patient recovery through the provision of pharmaceutical services oriented toward patient and community needs. To enhance service quality, an effective management information system is required. SIM Farmasi (Pharmacy Management Information System) is designed to improve drug distribution management, ensure medicine availability according to patient needs, and support accurate inventory control. This study applied the HOT-Fit model to evaluate the performance of SIM Farmasi in hospital pharmaceutical services. Methods: This study employed a literature review method by collecting and analyzing previous research articles selected based on predetermined inclusion and exclusion criteria. The selected studies were evaluated and synthesized to strengthen the theoretical foundation, identify knowledge gaps, and support the development of a conceptual framework. Results and Discussion: The effectiveness of SIM Farmasi implementation is strongly influenced by human factors (staff competence and training), organizational factors (management support and standard operating procedures), and technological factors (system quality and data accuracy). Major challenges include limited human resource skills, inadequate system features, and weak organizational policies. Continuous training, system enhancement, and strengthened management commitment are therefore essential to optimize system performance. Conclusion: Overall, the HOT-Fit evaluation indicates that the implementation of SIM Farmasi has not yet been optimal. The main obstacles include insufficient staff training, weak management support, and data accuracy issues within the system.
Manejemen Farmakologis Herpes Labialis : Tinjauan Pustaka Isaura Dewi Fauzi; Rasmi Zakiah Oktarlina
Malahayati Nursing Journal Vol 7, No 10 (2025): Volume 7 Nomor 10 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i10.20325

Abstract

ABSTRACT Herpes labialis caused by herpes simplex virus type 1 (HSV-1) infection is a latent infectious disease with high prevalence globally, where socioeconomic changes and hygiene levels affect its transmission patterns. This study aims to evaluate the pharmacological management of herpes labialis through analysis of treatment methods and stages of HSV-1 infection to determine the optimal intervention strategy. The study was conducted using a literature study method on 281 articles from the PubMed, ScienceDirect, Garuda, and Google Scholar databases, which were systematically selected and analyzed. The results of the analysis showed that Acyclovir administration was most effective in the prodromal phase, with a combination of corticosteroids able to accelerate healing. Supplementation of vitamins B12 and D contributed to supporting the immune system, while the use of 0.2% chlorhexidine gluconate was effective in preventing secondary infections. Stress factors were identified as a predisposition to recurrence, so stress management education based on the 4M concept (Avoiding, Changing, Adapting, Accepting) is important. It was concluded that optimal management of herpes labialis requires an integrated pharmacological approach and psychosocial interventions. Further research is needed for the development of an HSV-1 vaccine and the improvement of community-based prevention education programs. Keywords: Herpes Labialis, Antiviral, HSV ABSTRAK Herpes labialis yang disebabkan oleh infeksi virus herpes simpleks tipe 1 (HSV-1), merupakan penyakit menular laten dengan prevalensi tinggi secara global, di mana perubahan sosial ekonomi dan tingkat kebersihan memengaruhi pola transmisinya. Penelitian ini bertujuan untuk mengevaluasi manajemen farmakologis herpes labialis melalui analisis metode pengobatan dan tahapan infeksi HSV-1 guna menentukan strategi intervensi yang optimal. Penelitian dilakukan dengan metode studi pustaka terhadap 281 artikel dari database PubMed, ScienceDirect, Garuda, dan Google Scholar, yang diseleksi dan dianalisis secara sistematis. Hasil analisis menunjukkan bahwa pemberian Acyclovirpaling efektif pada fase prodromal, dengan kombinasi kortikosteroid mampu mempercepat penyembuhan. Suplementasi vitamin B12 dan D berkontribusi dalam mendukung sistem imun, sedangkan penggunaan klorheksidin glukonat 0,2% efektif dalam mencegah infeksi sekunder. Faktor stres diidentifikasi sebagai predisposisi kekambuhan, sehingga edukasi manajemen stres berbasis konsep 4M (Menghindari, Mengubah, Mengadaptasi, Menerima) menjadi penting. Disimpulkan bahwa pengelolaan herpes labialis yang optimal memerlukan pendekatan farmakologis terpadu dan intervensi psikososial. Penelitian lanjutan diperlukan untuk pengembangan vaksin HSV-1 dan peningkatan program edukasi pencegahan berbasis masyarakat. Kata Kunci: Herpes Labialis, Antivirus, HSV
Penatalaksanaan Impetigo : Infeksi Bakteri Kulit yang Paling Umum Komang Ria Yuliana Santhi; Rasmi Zakiah Oktarlina
Malahayati Nursing Journal Vol 7, No 8 (2025): Volume 7 Nomor 8 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i8.21089

Abstract

ABSTRACT Bacterial skin infections are among the most frequently encountered health problems, particularly affecting pre-school and school-aged children. One of the most common superficial skin infections is impetigo, caused by Staphylococcus aureus and Streptococcus pyogenes, and characterized by fragile pustular lesions that form honey-colored crusts. Transmission occurs through direct skin contact or indirectly via contaminated objects. Effective management of impetigo requires accurate diagnosis, proper selection of both topical and systemic antibiotic therapies, and preventive measures to halt further transmission. This study employed a Systematic Literature Review (SLR) method by analyzing scientific journals focusing on the effectiveness and safety of antibiotic treatments, challenges related to resistance, and relevant prevention strategies. The review reveals that topical antibiotics such as mupirocin, fusidic acid, retapamulin, and ozenoxacin are effective for mild to moderate cases, while systemic antibiotics are reserved for more severe or widespread infections. Preventive efforts that emphasize personal hygiene and environmental sanitation also play a crucial role in breaking the chain of transmission. A comprehensive and rational approach to impetigo management can enhance treatment outcomes and reduce complications across various levels of healthcare services. Keywords: Impetigo, Skin Infections, Staphylococcus aureus, Streptococcus pyogenes, Antibiotics  ABSTRAK Infeksi kulit akibat bakteri merupakan salah satu masalah kesehatan yang sering ditemui, terutama pada anak-anak usia pra-sekolah hingga usia sekolah. Salah satu bentuk infeksi kulit superfisial yang paling umum adalah impetigo, yang disebabkan oleh Staphylococcus aureus dan Streptococcus pyogenes, dengan gejala khas berupa lesi pustularyang mudah pecah dan membentuk krusta berwarna madu. Penularan terjadi melalui kontak langsung maupun tidak langsung dengan benda yang terkontaminasi. Penatalaksanaan impetigo membutuhkan diagnosis yang akurat, pemilihan terapi antibiotik yang tepat baik topikal maupun sistemik, serta langkah-langkah pencegahan untuk menghindari penyebaran lebih lanjut. Penelitian ini menggunakan metode Systematic Literature Review (SLR) dengan menganalisis jurnal ilmiah yang membahas efektivitas dan keamanan terapi antibiotik, tantangan resistensi, serta strategi pencegahan yang relevan. Hasil kajian menunjukkan bahwa antibiotik topikal seperti mupirocin, asam fusidat, retapamulin, dan ozenoxacin efektif untuk kasus ringan hingga sedang, sementara antibiotik sistemikdigunakan pada kasus yang berat atau meluas. Strategi pencegahan berbasis kebersihan diri dan lingkungan juga memainkan peran penting dalam memutus rantai penularan. Dengan pendekatan yang komprehensif dan rasional, impetigo dapat ditangani secara efektif dan komplikasi dapat diminimalkan di berbagai tingkat layanan kesehatan. Kata Kunci: Impetigo, Infeksi Kulit, Staphylococcus Aureus, Streptococcus Pyogenes, Antibiotik
Efektifitas NSAID, Opioid dan Antibiotik pada Fraktur Terbuka dan Tertutup: TINJAUAN PUSTAKA Najwa Ulinnuha; Muhammad Nazher; Rasmi Zakiah Oktarlina
Malahayati Nursing Journal Vol 7, No 8 (2025): Volume 7 Nomor 8 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i8.21083

Abstract

ABSTRACT Open and closed fractures are common bone injuries caused by trauma such as traffic or occupational accidents. Management involves not only bone stabilization but also pain control and infection prevention. Antibiotics, opioids, and NSAIDs are the main classes of drugs used in fracture therapy, though their effectiveness and associated risks remain important subjects of ongoing study. This study is a literature review of 17 articles published between 2016 and 2024, sourced from PubMed, NCBI, and Google Scholar. The analysis was conducted to evaluate the effectiveness and safety of these three drug classes. Antibiotics such as cefazolin and ceftriaxone are effective in preventing infection when administered within the first three hours post-injury. Opioids are highly effective for managing severe pain but carry risks of addiction and systemic side effects. NSAIDs are suitable for moderate pain management but may impair bone healing by inhibiting multimodalprostaglandin synthesis. Antibiotics, opioids, and NSAIDs each play a critical role in the management of open and closed fractures. Treatment choices should be based on fracture type, clinical condition, and a careful assessment of the risks and benefits of each drug. Evidence-based clinical guidelines and further research are needed to support safer and more effective therapeutic practices. Keywords: Fracture, NSAIDs, Opioids, Antibiotics, Pain Management, Infection  ABSTRAK Fraktur terbuka dan tertutup merupakan cedera tulang yang sering terjadi akibat trauma seperti kecelakaan lalu lintas dan kerja. Penanganan tidak hanya fokus pada perbaikan tulang, tetapi juga pengendalian nyeri dan pencegahan infeksi. Antibiotik, opioid, dan NSAID adalah kelompok obat utama yang digunakan dalam terapi fraktur, namun efektivitas dan risikonya masih menjadi bahan kajian penting. Studi ini merupakan tinjauan literatur terhadap 15 artikel dari tahun 2016 hingga 2024 yang diakses melalui PubMed, NCBI, dan Google Scholar. Analisis dilakukan untuk mengevaluasi efektivitas dan keamanan tiga kelompok obat tersebut. Antibiotik seperti Sefazolin dan seftriakson efektif mencegah infeksi jika diberikan dalam tiga jam pertama pasca kecelakaan. Opioid bekerja baik untuk nyeri berat namun berisiko adiksi dan gangguan sistemik. NSAID efektif untuk nyeri sedang, tetapi dapat menghambat penyembuhan tulang. Ketiga kelompok obat, yaitu antibiotik, opioid, dan NSAID, memiliki peran penting dalam penanganan fraktur terbuka dan tertutup. Pemilihan terapi harus mempertimbangkan jenis fraktur, kondisi klinis pasien, serta risiko dan manfaat masing-masing obat. Diperlukan pedoman klinis berbasis bukti dan penelitian lanjutan untuk mendukung penggunaan yang lebih tepat, aman, dan efektif dalam praktik kedokteran. Kata Kunci: Fraktur, NSAID, Opioid, Antibiotik, Manajemen Nyeri, Infeksi
Co-Authors A.P, Afna Nur Adela Putri Agata Afna Nur Afni Palogan Afra Rahmania Santi oktarlina Afriyana, Regi Agung Abadi Kiswandono Agustina, Mezza agustyas tjiptaningrum Aisyah Qinthara Nabila Putri Alfina Indah Nabila Ali Hasymi Romanov Alicia Rahma, Cinta Aloysius Krishartadi Damar Bawono Alvira Balqis Soraya Amanda, Fadyla Ambarwati, Yuli Amelia, Dinda Andi Nafisah Andrifianie, Femmy Annisa Nurul Sa'diah Antika Sintia, Nova Aqil, Faiq Akhmad Ari Wahyuni Ari Wahyuni ari wahyuni Aryanti, Sri Asep Sukohar Asep Sukohar Asnah Tarigan Aspita Laila Asyifa, Nisa Asyraf Vivaldi Wardoyo Atri Sri Ulandari Audry Lintang Hasanuddin Augesti, Gita Aulia Nur Fadilah Aulia Ramdini, Dwi Axcellia Theresa Ayu Tiara FItri Bayu Anggileo Pramesona Berlyantama Afifaldo Chyntia Saputri Citra Yuliyanda Pardilawati Citra Yuliyanda Pardilawati Citra Yuliyanda Pradilawati Damayanti, Ervina Danang hafizfadillah Daulay, Suryani Agustina Deandra Athaayaa Iswari Desi Astri Dewi Nur Fiana Dheti Efrilia Dheti Efrilia - Dika Pratiwi Adifa Disaputera, Alfafa Tsalaatsa Diva Meylia Dwi Anjani, Galuh DWi Aulia Ramdini Dwi Aulia Ramdini Dwi Indria Anggraini Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Dzakiya Alya Musyafa Satriad Ebti Rizki Utami Elisa, Syavira Ety Apriliana Ety Apriliana Evi Kurniawati, Evi Exsa Hadibrata Exsa Hadibrata Falamy, Ryan Fathia Sa'adah Fatimah Azzahra Femmy Andrifianie Femmy Andrifianie Fernandya Sylvia Nurindi Fonna, Maulida Puteri Fragil Khoirul Basyar Fredison, Fredison Gasela Zalianti Balqis Happy, Terza Aflika Hasta Hendarto Helmi Ismunandar Helmi Ismunandar Hendra Tarigan Sibero Hidayat, Rizqi High Boy Karumulborg Hutasoit Humaira, Nayarani Ilyas Prabamukti Inas Salsabila Indri Windarti Indriyani, Reni Intan Kusumaningtyas Intan Kusumaningtyas Intanri Kurniati Isaura Dewi Fauzi J, Zayatri Nurul Jeffrey Surya Jessy Dewi Awali Jezmy, Beby Kelidia Jihan Siti Muthmainah Joni, Agnesia Priskila Josua Tumpal Haloman Junando, Mirza Juspeni Kartika Karima, Nisa Khairun Nisa Khairunnisa Komang Ria Yuliana Santhi Kurniawaty, Evi Kusumaningrum, Desy L.P, Eka Ananda Lani Hartanti Lathifah, Dina Silmi Letifa Rahmadani Letifa Rahmadani Lia Qelina Liana Sidharti, Liana Lina Marlina M. Bintang Al Farrel M. Fitra Wardhana M. Fitra Wardhana M. Ricky Ramadhian M. Rizky Fathurrohim Magdalena Yosefin Saputra Magdalena Yosefin Saputra Mallarangeng, Andi Nafisah Tendri Adjeng Marcelia, Selvi Mayasari, Diana Melia Megawati Mirza Junando Muhammad Aditya, Muhammad Muhammad Aditya, Muhammad Aditya Muhammad Fakih Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Iqbal Muhammad Kaisar Febriantara Muhammad Maulana Muhammad Miraj Mirza, Isroni Muhammad Nazher Mukhlis Imanto Mukhlis Imanto, Mukhlis Mulyono Mulyono Mutiara Nauli Br. Sitinjak Najwa Ulinnuha Nara Safitri Natamiharja, Rudi Nathasya Karren Zeta Nathasya Karren Zeta Naza Tsasbita Hayuning Adila Noldy Masyitha Nora Ramkita Norbertus Marcell Prayogi Novita Carolia Novita Carolia Novita Carolia Novriana, Dina NUR AFRIYANI Nurul Islamy4 Nurul Utami Oktafany Oktafany Oktafany Oktafany, Oktafany Oktoba, Zulpakor P, Cindy Ivana P, Cutra Yuliyanda Pardilawati, Citra Yulianda Pardilawati, Citra Yuliyanda Patricia Cristina Wati Pius Ave Rafael Silalahi Prabamukti, Ilyas Pratama, Andre Arya Puteri, Vadiyani Fricillya Putik Titian Cipta Hening Putri Ria Ariyanti Putri Ulan Sari Putri, Oka Mahila Gustia Putri, Syalika Dianisa Radita Dewi Prasetyani Rahma, Cinta Alicia Rahmania Santi, Afra Rahmasari, Fania Asfi rahmawati, selvi Ramadhana Komala Ramdini, Dwi Aulia Rani Himayani Rani Himayani Ratna Dewi Puspita Sari Ratna, Maya Ganda Ratu, Sarih Reffilia Irfa Rena Roy Reni Indriyani Reni Zuraida Reva Dwi Yanty Rika Lisiswanti Rika Lisiswanti Risal Wintoko Risti Graharti Riyanto, Rahmadani Putri Rodiani, Rodiani Romulya, Ari Irawan Roro Rukmi Windi Perdani Roro Rukmi Windi Perdani Roro Rukmi WP Rossa, Putri Emylia Roviq Umam S Rr Astri Nur Azizah Utama Utama Rudiyanto, Waluyo Safitri, Nara Sahab Sibuea Salsabila Dzakiyyah Zahra Salsabila Nurislami Salsabila Nurislami Salsabila, Lyansaputri Salsabilla, Riefa Ayu Salshabilla, Annisa Sangging, Putu Ristyaning Ayu Saputra, Kurnia Hadi Saputra, Magdalena Yosefin Sari, Tri Anti Permata Septiani, Linda Setiawan, Muhamad Rizky Setiorini, Anggi Shinta Nareswari, Shinta Shinta Nurhaliza Siboro, Erwi Saulina Venezia Silalahi, Pius Ave Rafael Siti Khalimatus Sa&#039;diah Sofyan Musyabiq Wijaya Soraya Rahmanisa Suharmanto Suri, Nurma Susianti Susianti Sutarto . Sutarto Sutarto Sutarto Sutarto Sutyarso Suwaib Amiruddin Syaiful Bahri SYAIFUL BAHRI Syavira Elisa Syazili Mustofa T. Adjeng, Andi Nafisah T.A. Larasati TA Larasati Tiara Aninditha Tias Adhe Setyaningrum Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Vania Putri Risyhade Verizka, Talitha Wardani, Dyah Wulan S.R Wardani, Dyah Wulan S.R. Wardani, Farah Dwi Widyaningrum, Diah Ayu Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani yusran Zada Amalia Agatha Sari Zada Amalia Agatha Sari Zahra Wafiyatunisa Zeta, Nathasya Karren Zetira, Zihan Zunando, Mirza