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Modulation of AR-FGF-2-TGF beta Axis by Cosmos caudatus Suppresses Prostatic Epithelial Proliferation in a BPH Rat Model: A Comparative Study with Finasteride Sahara, Nita; Mudigdo, Ambar; Wasita, Brian; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Cilmiaty, Risya
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.370

Abstract

Benign prostatic hyperplasia (BPH) progression is critically influenced by the androgen receptor (AR), Fibroblast growth factor-2 (FGF-2), and transforming growth factor-β (TGF-β) signaling axis. Although finasteride (FIN) is the standard therapeutic agent, its use is limited by adverse effects. This study evaluated the efficacy of Cosmos caudatus (CC) extract, administered alone or in combination with FIN, in modulating the AR–FGF-2–TGF-β axis in a testosterone-induced BPH rat model. Rats were divided into five groups (n = 6): Normal (N), BPH control (KN), FIN (KP; 0.44 mg/kg), CC extract (P1; 250 mg/kg), and combination (P2; CC 250 mg/kg + FIN 0.44 mg/kg). Prostatic AR, FGF-2, and TGF-β expression was analyzed using immunohistochemistry (IHC) with H-score quantification. Both KP and P1 significantly reduced AR (KP: 112 ± 15; P1: 105 ± 12 vs KN: 195 ± 18, p < 0.05) and FGF-2 (KP: 98 ± 14; P1: 92 ± 11 vs KN: 180 ± 20, p < 0.05), approaching normal values (AR N: 90 ± 10; FGF-2 N: 85 ± 9). In contrast, combination therapy (P2) failed to suppress AR (188 ± 17, p = 0.936) and FGF-2 (175 ± 19, p = 0.870) and induced a significant increase in TGF-β (P2: 145 ± 16 vs KN: 110 ± 12, p < 0.05). All treatment groups showed reduced epithelial thickness and prostate index (p < 0.05). These findings indicate that CC extract alone exerts therapeutic effects comparable to FIN by modulating the AR–FGF-2 axis, whereas combining it with FIN disrupts pathway regulation and promotes a pro-fibrotic response. The study supports the potential of CC extract as an effective alternative for BPH management without pharmacologic complications.
Co-Authors -, Kartika . Zulfan ?Arub, Lathifah Abd. Rasyid Syamsuri Achmad Arman Subijanto, Achmad Arman Addini, Ragil Aidil Fitriasari Adelita, Sela Putri Adi Prayitno Adita, Kingkin Aditya Nanda Priyatama Afriyanti, Neta Agus Kristiyanto Agus, Yuliana Agus, Yuliana Aini, Zahratul Aisy, Jihan Rohadatul Aisyiyah, Farida Nur Akmala, Jatu Kartika Amalia Choirunnisa Amalia, Ade Amalia, Zuliana Ambar Mudigdo Anak Agung Gede Sugianthara Anggraini, Wella Anik Lestari Annisaa, Salwa Argyo Demartoto, Argyo Ari Natalia Probandari Ari Probandari Arief Nurudhin Arifin Arifin Arwiyantasari, Wida Rahma Astari, Rahmi Windhy Astuti, Fitriyani Dwi Aviandari, Tifa Aziza, Triana Ulfa Nur Azizah, Fikri Dian Dinu Azzahro, Asri Wahyu ‘Arub, Lathifah Bachtiar, Erlangga Yusa Bakrie, Saekhol Bambang Purwanto Baroroh Barir Bhisma Murti Brian Wasita Budhiastuti, Uki Retno Budiastuti, Veronika Ika Bulan Kakanita Hermasari Chatarina Umbul Wahyuni Christanto, Antonius Cynara, Ailsa Clarissa Dania, Samara Rahma Devi Eka Ratnasari Deviasti, Rindra Dewi, Arddha Maha Pawitra Dwi Puspita Dewi, Dian Puspita Dewi, Rizka Amalia Dewi, Rizqa Kartika Dian Handayani Diana Nur Afifah, Diana Nur Diani Octaviyanti Handajani Dilma’aarij, Dilma’aarij Dwi Handayani Dwiantini, Feby Endang Lestari Endang Sutisna Sulaeman Ernawati, Dwi Arini Erynda, Revina Fiandany Fajriyani, Fanny Kartika Fardhiasih Dwi Astuti Fatikhu Yatuni Asmara Firmansyah, Gusti Fathoni Fitria Wulandari Fitriani, Sufia Flora, Viola Holly Gaurinindi, Melinda Febianca Handariati, Atik Handayani, Anggun Fitri Handriani, Winei Haniah, Alfi Zamilul Hanifa, Ainun Hanifah, Ainun Hanifah, Nita Layli Hanifah, Siti Nur Hapsari, Dini Hardilla, Dinda Septiani Hariyadi, Agustin Mahardika Harsono Salimo Harumi, Linda Hastami, Yunia Hernanda R, Annisa Istighfari Hidayah, Siti Shafridha Ida Nurwati Ilma, Nabilah Nurul Indriani, Frida Indriasih, Merlita Indriasih, Merlita Indriastuti, Latty Irfandi, Julhan Jannah, Putri Isriyatil Karim, Muhammad Yusuf Khairunnisa, Lia Khoirunnisa, Luthfiana Nadhiifa Kristiani, Shinta Kumalaningrum, Melda Kurnianingsih, Mayasari Kurrniati, Era Kusumawati, Ima Larasati, Meirina Dwi Lestari, Esti Lestari, Esti Loekito, Cindy Lestyani Luthfiana, Lia Ulfah Luthfianasari, Luthfianasari Luturmas, Antina MAFTUHAH, ATIK Manggandhi, Yuyun Maranata, Maranata Marliana, Wiwit Maryana, Dyan Maryani ., Maryani Maryani Maryani Maung, Yuzana Mawardi, Fitriana Mayaningrum, Yulita Endah Mayarestya, Nita Putriasti Muchsin Doewes Muhammad Rifqi Azhary Mulya Tarmidi, Mulya Mustara, Mustara Mutiara, Bunga Nabilah Nurul Ilma Natalia, Vinda Nawangwulan, Diyah Novia Zuriatun Solehah Novika, Revi Gama Hata Novika, Revi Gama Hatta Novitasari, Isnaini Novitasari, Ratih Nugroho, Dian Nuralita, Ayunda Yonik Nurhayati, Happy Nurindahsari, Yespy Anna Wahyu Nurkholifa, Ferda Fibi Tyas Nursani, Anggia Rahmah Oktaviani oktaviani Oktaviyani, Feny Paramasari Dirgahayu Pawito Pawito Prabowo, Puspita Mayangsari Prasetya, Hanung Primaningtyas, Widana Purnama, Hanif Wildan Putri, Anggi Resina Putri, Azilla Edsa Putri, Diani Fadmi Putri, Dominika Risnanda Alfinsia Qomariah, Nur Laili Rahardjo, Setyo Sri Rahayu, Ria Muji Rahmah Rahmah Ramli, Muhammad Rizaldi Randhita, Amandha Boy Timor Ratih Puspita Febrinasari Ravi Masitah RB. Soemanto Reviono, R Rini, Arum Kusuma Rismawati, Normalia Levi Risna Widowati Risya Cilmiaty, Risya Rita Adriani Benya Adriani Rohaniyati, Retno Dwi Rosid, Sultonnur Rosyidah Alfitri RUBEN DHARMAWAN Rusnoto, R Safitri, Diyanti Sahara, Nita Sakinah Sakinah Sari, Prafista Wulan Sari, Putri Yunita Selviana, Tasya Ardia Septianawati, Linda Wahyu Setiamika, Made Setiowati, Tri Ayu Setiyarini, Dwi Wahyu Setyo Sri Raharjo Shalih, Ahmad Sabiq Sinta, Prabawati Siswahyudianto Siti Munawaroh Soetrisno Soetrisno Sopianti, Densi Selpia Sri Darnoto Sri Mulyani Suci Arsita Sari SUGIARTO - Sugiarto S Sulastomo, Heru Sumandjar, Tatar Sumardiyono Sumardiyono suminah ., suminah Suminah Suminah, Suminah Suprapti Suprapti Supriyadi Hari Respati Susanti, Nadya Susanto, Agung Sutiman Sutiman, Sutiman Syamsiar, Syamsiar Syetiawinanda, Amriansyah Titah Pujangkara, Ajeng Ayu Tri Nur Kristina Triyanta Yuli Pramana Tunurrohmin, Zela Uki Retno Budihastuti Ulhaq, Muhammad Zia Ulul Azmi Zuhaira Ummah, Hafari Fajria Nuril Usmaningrum, Desif Upix Utomo, Asrori Ibnu Vitri Widyaningsih VIVIN EKA RAHMAWATI Wati, Emita Dewi Lilis Angkasa Wayanshakty, Janur Putri Wekadigunawan, CSP Wibowo, Yogo Pardi Widiyaningrum, Alfiati Nanda Widiyawati, Rina Widyandana Widyandana Widyaningsih , Vitri Widyawardani, Tri Nyantosani Widyawati Widyawati Wijaya, Bayu Basuki Wulandari, Umianita Risca Yanuari, Ridha Rossela Yanuarini, Triatmi Andri Yuana, Nabila Amartya Yudhani, Ratih Dewi yulia lanti retno dewi Yusup Subagio Zakiyah, Nisaus Zauma, Luthfia