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Destra, Edwin
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Peran Apolipoprotein B, Apolipoprotein A, dan Rasio ApoA/ApoB sebagai Prediktor Terjadinya Demensia pada Kelompok Lanjut Usia Sim, Alfred Sutrisno; Santoso, Alexander Halim; Gunaidi, Farell Christian; Alifia, Khalisya; Aditya, Vincent; Destra, Edwin
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.4891

Abstract

Neurocognitive disorders, particularly dementia, affect various cognitive functions such as memory, attention, language, learning, and problem-solving, with the elderly population being the most impacted. The prevalence of dementia is projected to rise to 131 million cases by 2050, posing significant social and economic implications. This study employed a cross-sectional method to evaluate the role of Apolipoprotein A (APOA) and Apolipoprotein B (APOB) in the diagnosis and prevention of dementia in older adults. The results showed that Apolipoprotein A was not significantly correlated with MMSE scores, indicating no clear relationship between APOA and cognitive function. In contrast, Apolipoprotein B demonstrated a significant negative correlation with MMSE, suggesting that increased APOB levels are associated with cognitive decline. Elevated ApoB, linked to increased LDL and oxidative stress, correlated with reduced cognitive function, whereas ApoA, the main component of HDL, is associated with neuroprotective effects. These findings underscore the importance of monitoring lipid profiles, including ApoA and ApoB, in the prevention and management of dementia in the elderly.    
KORELASI FAKTOR DEMOGRAFI, NUTRISI DAN ANTROPOMETRI TERHADAP KEJADIAN HIPERTENSI PADA PETUGAS KEAMANAN DI UNIVERSITAS TARUMANAGARA JAKARTA Santoso, Alexander Halim; Lontoh, Susy Olivia; Gunaidi, Farell Christian; Istikanto, Ferdian Harum; Destra, Edwin; Kurniawan, Junius; Anggraeni, Natasha; Cahyadi, Stanley Surya; Mayvians, Tizander
Ebers Papyrus Vol. 27 No. 1 (2021): EBERS PAPYRUS
Publisher : Fakultas Kedokteran Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/ep.v27i1.12157

Abstract

Introduction Hypertension is a silent killer and causes various complications and even death. According to World Health Organization (WHO), hypertension causes 9.4 million deaths per year worldwide. Hypertension is more common in countries with low to middle economic status than in high-income countries. Based on the results of the Riskesdas 2018, there was an increase in the prevalence of hypertension in people aged ?18 years, from 23.8% to 34.1%. DKI Jakarta Province is one of the provinces with a high prevalence of hypertension (34%). University security officers are a group of workers who are at risk of hypertension. This may be due to the work style of the University security officers who are mostly standing and sitting. Studies of security personnel are still rare. Methodology This study is an analytical study with a cross-sectional design to see the correlation of demographic, nutritional and anthropometric factors on hypertension. Results In this study, a total of 90 male  subjects were recruited, with an average age of 30.09 years, 84.4% were educated to high school level, 80% smoked, 88.9% consumed coffee, 92,2% exercised regularly. In this study, it was found that the subject's average body weight was 70.56 kg, the average body mass index of the subject was 24.79 kg/m2, 32.2% of the subjects had an waist circumference of more than 90 cm and the average hip circumference was 97.24 cm. In this study, it was found that 48.9% had high blood pressure, where 8.9% of subjects had systolic blood pressure of 140 mmHg and 47.8% of subjects had diastolic blood pressure of ³90 mmHg. There was a positive and significant correlation between age, body weight, BMI, waist circumference and hip circumference with hypertension (p<0.05). Conclusion Increasing age, weight, body mass index, abdominal circumference and pelvic circumference were correlated with hypertension in security officers
SKRINING ANTROPOMETRI PADA PRIA DAN WANITA USIA PRODUKTIF DALAM RANGKA PENCEGAHAN OBESITAS DI KALAM KUDUS II, KELURAHAN DURI KOSAMBI, JAKARTA Limas, Peter Ian; Teguh, Stanislas Kotska Marvel Mayello; Jap, Ayleen Nathalie; Destra, Edwin
Jurnal Serina Abdimas Vol 2 No 3 (2024): Jurnal Serina Abdimas
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jsa.v2i3.32326

Abstract

Obesity is a condition that occurs when the body has too much fat and is not balanced with the amount of muscle it has. Obesity is an increasing health problem and has a major impact on mortality and morbidity. Anthropometrics has an important role in screening a person's health status, one of which is obesity, so that by carrying out anthropometric screening, it is hoped that prevention and management of a person's health status can be correlated with obesity. This community service activity is carried out using the PDCA method which focuses on anthropometric screening and health education. Anthropometric screening measures parameters such as body weight, height, waist circumference, and hip circumference, which are important indicators for evaluating the risk of developing obesity. Therefore, anthropometry plays an important role in identifying risks and enabling the rapid and effective implementation of early interventions. Education regarding the importance of physical activity and healthy eating habits is included in this activity, so it is hoped that it can become a basis for maintaining and improving the quality of life and long-term health for the community. ABSTRAK Obesitas adalah kondisi yang muncul saat tubuh memiliki jumlah lemak yang terlalu tinggi dan tidak seimbang dengan jumlah otot yang dimiliki, obesitas merupakan masalah kesehatan yang semakin meningkat dan mempunyai dampak besar terhadap mortalitas dan morbiditas. Antropometri memiliki peran penting dalam skrining status kesehatan seseorang, yang salah satunya adalah obesitas, sehingga dengan dilakukannya skrining antropometri, diharapkan dapat dilakukan pencegahan dan tatalaksana terhadap status kesehatan seseorang yang terkorelasi dengan obesitas. Kegiatan pengabdian masyarakat ini dilaksanakan dengan metode PDCA yang berfokus pada skrining antropometri dan edukasi kesehatan. Skrining antropometri mengukur parameter seperti berat badan, tinggi badan, lingkar pinggang, dan lingkar pinggul, yang merupakan indikator penting untuk mengevaluasi risiko terjadinya obesitas. Oleh karena itu, antropometri berperan penting dalam mengidentifikasi risiko dan memungkinkan penerapan intervensi dini secara cepat dan efektif. Edukasi mengenai pentingnya aktivitas fisik dan kebiasaan makan sehat diikutsertakan dalam kegiatan ini, sehingga diharapkan dapat menjadi landasan bagi menjaga dan meningkatkan kualitas hidup dan kesehatan jangka panjang bagi masyarakat
Role of Dermatoporosis as Mediating Factors: Impact of Systemic Health Parameters on Dermatology Life Quality Index in The Elderly W., Linda Julianti; Destra, Edwin; Firmansyah, Yohanes; Moniaga, Catharina Sagita; Tan, Sukmawati Tansil; Wijaya, Bryan Anna; Gunaidi, Farell Christian
MAHESA : Malahayati Health Student Journal Vol 6, No 2 (2026): Volume 6 Nomor 2 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i2.20813

Abstract

ABSTRACT Dermatoporosis, an emerging concern in geriatric dermatology characterized by pronounced skin fragility and chronic skin atrophy, significantly impacts the quality of life among the elderly. This study delves into the complex interactions between various health parameters such as albumin, glucose, lipid profiles, uric acid, vitamin D, insulin resistance, uric acid, renal functions, and liver functions, assessing their cumulative effect on the Dermatology Life Quality Index (DLQI) in an elderly population, with dermatoporosis serving as a pivotal mediating factor. This study included 31 individuals who met the specified inclusion criteria. The selection process was designed to ensure the relevance of analyzed health parameters and to minimize selection bias, thereby enhancing the validity and applicability of the findings. Descriptive and inferential statistical methods were employed, along with Partial Least Squares (PLS) path modeling, to control for potential confounding variables and explore the multifactorial relationships among the measured variables. Regression analysis indicated that dermatoporosis significantly mediates the relationship between these health parameters and the DLQI, evidenced by R² values of 0.691 for dermatoporosis and 0.842 for DLQI. This study confirms that skin health in the elderly is multifactorial and strongly influenced by systemic health parameters. A multidisciplinary approach is essential to holistically manage dermatological conditions, addressing not only skin symptoms, but also systemic health factors that exacerbate skin disorders and diminish the quality of life in older adults. Keywords: Dermatoporosis, Dermatology Life Quality Index (DLQI), Geriatric Dermatology, Health Parameters, Systemic Health Influences.
Hubungan Antara Kadar GDP, HBA1C, Insulin Puasa, Obesitas, dan Kondisi Kelemahan Otot terhadap Risiko Infeksi Saluran Kemih pada Kelompok Lanjut Usia S., Donatila Mano; Ernawati, Ernawati; Santoso, Alexander Halim; Destra, Edwin; Gunaidi, Farell Christian; Goh, Daniel; Kusuma, Kanaya Fide
MAHESA : Malahayati Health Student Journal Vol 6, No 2 (2026): Volume 6 Nomor 2 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i2.20717

Abstract

ABSTRACT Urinary tract infection (UTI) is a common disease among the elderly, especially in nursing homes. Knowing the individual risk factors that impact the incidence of UTIs is essential for the development of prevention strategies. This study aims to identify the relationship between fasting blood sugar (FBG), HbA1c, fasting insulin levels, upper arm circumference (MUAC), and calf circumference (CC) on the incidence of UTIs in the elderly group conducted at Bina Bhakti Nursing Home in 2024. A cross-sectional study was conducted using a total sampling method. UTI diagnosis was based on urinalysis findings of positive leukocytes, nitrites, or leukocyte esterase. HbA1c, fasting blood glucose, and insulin levels were measured from venous blood samples and analyzed in a laboratory. MUAC and calf circumference were measured using a measuring tape. Statistical analysis included descriptive statistics, and regression analysis was performed to evaluate the relationship between numerical variables. The study involved 93 respondents with an average age distribution of 74.19 years (61-97 years) and the majority were female (82.8%). Diagnosis of UTI was based on urine examination with findings of positive leukocytes, positive nitrite, or positive leukocyte esterase. The average HbA1c value of the respondents was 7.59% which was predominantly moderate as many as 52 respondents (55.9%), the average MUAC value was 23.61 cm, and the calf circumference was 28.72 cm. Most respondents had optimal insulin levels (mean 4.83 ng/mL) and normal FBG values (mean 86.54 mg/dL). Regression analysis showed a significant correlation (p0.05) between age and HbA1c values with the incidence of UTI. However, no significant correlation was found between gender, FBG, fasting insulin levels, MUAC, and calf circumference with the incidence of UTI. The results of this study conclude that increasing age and HbA1c values correlate with an increase in the incidence of UTIs in the elderly. Further research is needed to better understand the causal relationship between these factors and the incidence of UTI in nursing homes. Keywords: Calf Circumference, Fasting Blood Sugar, HbA1c, Nursing Home, Upper Arm Circumference, Urinary Tract Infection.  ABSTRAK Infeksi saluran kemih (ISK) merupakan penyakit yang umum terjadi pada kelompok lanjut usia, terutama di lingkungan panti werdha. Mengetahui faktor risiko individu yang berdampak terhadap kejadian ISK sangat penting untuk pengembangan strategi pencegahan. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara kadar gula darah puasa (GDP), HbA1c, kadar insulin puasa, lingkar lengan atas (LiLA), serta lingkar betis terhadap kejadian ISK pada kelompok lanjut usia yang dilakukan di Panti Werdha Bina Bhakti pada tahun 2024. Penelitian ini menggunakan desain potong lintang dengan metode pengambilan sampel total. Diagnosa ISK ditegakkan berdasarkan pemeriksaan urin dengan temuan leukosit positif, nitrit positif, atau leukosit esterase positif. Kadar HbA1c, gula darah puasa, dan insulin diukur melalui pengambilan darah vena dan diperiksa di laboratorium. Lingkar lengan atas dan lingkar betis diukur menggunakan pita pengukur. Analisis statistic mencakup penyajian deskriptif dan analisis regresi diterapkan untuk mengevaluasi hubungan antara variabel numerik. Penelitian ini melibatkan 93 responden dengan distribusi usia rata-rata 74,19 tahun (61-97 tahun) dan mayoritas berjenis kelamin perempuan (82,8%). Rata-rata nilai HbA1c responden adalah 7,59% yang didominasi derajat sedang sebanyak 52 responden (55,9%), Rata-rata nilai LiLA sebesar 23,61 cm dan lingkar betis sebesar 28,72 cm. Sebagian besar responden memiliki kadar insulin yang optimal (rata-rata 4,83 ng/mL) dan nilai GDP yang normal (rata-rata 86,54 mg/dL). Analisis regresi menunjukkan adanya korelasi signifikan (P0,05) antara usia dan nilai HbA1c dengan kejadian ISK. Namun, tidak ditemukan korelasi signifikan antara jenis kelamin, GDP, kadar insulin puasa, LiLA, dan lingkar betis dengan kejadian ISK. Hasil penelitian ini menyimpulkan bahwa peningkatan usia dan nilai HbA1c berkorelasi dengan peningkatan kejadian ISK pada lansia. Penelitian lanjutan diperlukan untuk memahami lebih dalam hubungan kausal antara faktor-faktor tersebut dengan kejadian ISK di panti werdha. Kata Kunci: Gula Darah Puasa, HbA1c, Infeksi Saluran Kemih, Lingkar Betis, Lingkar Lengan Atas, Panti Werdha.
Co-Authors Adhim, Laudza Al Aditya Pratama Aditya, Vincent Adjie, Eko Kristanto Kunta Afladhanti, Putri Mahirah Alexandro, Cristian Alexin, Corry Calista Alifia, Khalisya Alifia, Tosya Putri Alvianto, Fidelia Alwini, Muhammad Rifat Umar Amanda, Shelma Tria Amertha, Anak Agung Ngurah Putrayoga Andria Priyana Anggraeni, Natasha Angtoni, Miranda Anthony, Louis Ashil , Rafidah Hanina Astari, Pristia Averina, Friliesa Averina, Frilliesa Bachri, Fiqi Afrizal Biromo, Anastasia Ratnawati Cahyadi, Stanley Surya Christian, Farell Dewanto, Naomi Esthernita F. Dewanto, Paulus Gegana Thery Edbert, Bruce Edbert, Juan Emilda, Emilda Enike, Syilvia Cendy Ernawati , Ernawati Ernawati Ernawati Evelyn EVELYN EVELYN Fadhila, Arni Ismi Fajarivaldi, Kresna Bambang Febriastuti, Abebi Felicia, Ivana Frisca Frisca Gaofman, Brian Albert Ghina, Andini Goh, Daniel Gracienne Gracienne Gracienne, Gracienne Gunaid, Farell Christian Gunaidi, Farell Christian Gunawan, Paskalis Andrew HalimSantoso, Alexander Hari Sutanto, Hari Hariesti, Ribka Anggeline Harjono, Johan Lucas Harsono, Axsel Hartono, Eric Hartono, Vincent Aditya Budi Haryanto, Ines Hawari, Irawati Hendsun Herdiman, Alicia Herdiman, Julia Herlina Uinarni Hidayat, Fadil Ismi, Arni Istikanto, Ferdian Harum Jamaludin , Jamaludin Jamaludin . Jap, Ayleen Nathalie Jaya, I Made Satya Pramana Jeffrey ., Jeffrey Jeffrey Jeffrey Johan Johan Johan, Richver Framanto JuliantiWijayadi, Linda Juliastina , Mika Jaya Kasvana Khatimah, Gita Khusnul Khoto, Anthon Eka Prayoga Kosasih, Robert Kurniawan, Joshua Kurniawan, Junius Kusuma, Kanaya Fide Lontoh, Susy Olivia Lumintang, Valentino Gilbert Mahendri, Ryan Daffano Putra Martin, Alfianto Mashadi, Fladys Jashinta Mayvians, Tizander Moniaga, Catharina Sagita Permatasari, Nabila Jingga Peter Ian Limas Philo, Andrew Prakoso, Ariel Bagoes Pranata, Catherine Christiana Pratama, Muhammad Kevin Dava Pratomo, Farhan Purnomo, Yonathan Adi Putra, Feri Yanto Putra, Muhammad Dzakwan Dwi Rafi, Muhammad Adam Abizar Ramadhani, Kenzie Rafif Ramadhanty, Prajnya Kamila Rayhan , Naufal Riadi, Seravin Janet Ruslim, Daniel Ruslim, Welly Hartono S., Donatila Mano Santoso, Alexander Halim Sari, Anna Rahmania Sarijuwita, Alicia Sartono, Stefanny Satyanagara, William Gilbert Satyanegara, William Gilbert Satyo, Yovian Timothy Septrisya, Shiera Setia, Nicholas Setiawan, Fiona Valencia Sidarta, Erick Sim, Alfred Sutrisno Singh, Arwinder Sitorus, Ribka Angeline Hariesti Sitorus, Ribka Anggelline Hariesti Siufui Hendrawan Soebrata, Linginda Soeltanong, Dianova Soni, Yulfitra Sugiarto, Hans Sugiharto, Hans Sukianto, Louise Audrey Suros, Angel Sharon Susilo, Muhammad Farhan Pratama Sutedja, Gina Triana Syarifah, Andini Ghina Tamaro, Anggita Tan, Sukmawati Tansil Tara, Audina Alianda Dimas Teguh, Stanislas Kotska Marvel Mayello Triyana Sari Ulinuha, Ulinuha Valdes, Angeline Florencia W., Linda Julianti Waltoni, Bobby Marshel Ancheloti Warsito, Jonathan Hadi Wijaya, Bryan Anna Wijaya, Christian Wijaya, Dean Ascha Wijayadi, Linda Julianti yanto, heri YantoPutra, Heri Yeni Wulandari Yogie, Giovanno Sebastian Yohanes Firmansyah Yulishaputra, Muhammad Daffa Alghifari Yunita, Fenny