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Iswandi Iswandi
Bina Nusantara University
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Journal : Science Midwifery

 1 
Efectiveness of kenitu leaf extract (chyrysophyllum cainito l.) on bone density and histopathology osteoblast-osteoklast in female mice Pare, Nurdiana Tandi; Widodo, Gunawan Pamudji; Iswandi, Iswandi
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1950

Abstract

Osteoporosis is a systemic bone disease characterized by a decrease in bone density and deterioration of bone microarchitecture so that bones become brittle and break easily. Osteoporosis due to long-term use of glucocorticoids causes osteoporosis. There is a lot of clinical evidence about the role of phytoestrogens in the treatment of osteoporosis. Kenitu (Chrysophyllum cainito) contains isoflavone phytoestrogen compounds. The aim of this research was to determine the anti-osteoporosis effect of ethanol extract of kenitu leaves (Chrysophyllum cainito L.), by looking at the increase in bone density as well as the number of osteoblast cells and the number of osteoclast cells in the femur trabecular bone of female mice induced by dexamethasone. In this study, 49 female mice were grouped into 7 groups, namely normal control, negative control, positive control with cabone naturindo, and groups treated using 70% ethanol extract of kenitu leaves with varying doses of 100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW and 800 mg/kg BW. An increase in femur trabecular bone density, the number of osteoblast cells and the number of osteoclast cells were observed using the Histomorphometry method. The results showed that the ethanol extract of kenitu leaves has anti-osteoporosis activity. The ethanol extract of kenitu leaves has a dose of 400 mg/kg BW which is the optimal dose as anti-osteoporosis which is indicated by an increase in bone density, an increase in the number of osteoblast cells and a decrease in the number of osteoclast cells.
Evaluation of the drug management system at the pharmaceutical supplies installation of the Tegal City Health service in 2019 Wibawa, Anggun Setya; Widodo, Gunawan Pamudji; Iswandi, Iswandi
Science Midwifery Vol 13 No 4 (2025): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i4.2096

Abstract

Drug management involves a series of interconnected activities, including planning, procurement, receipt, storage, distribution, control, recording, reporting, disposal, monitoring, and evaluation. This study aimed to evaluate the drug management system, identify challenges and solutions, and assess its compliance with the 2010 Ministry of Health standards at the Pharmaceutical Supply Installation of the Tegal City Health Office. A descriptive design was used, with retrospective data collected from 2019 documents. Primary data were obtained through direct observation and in-depth interviews to identify obstacles, while secondary data were sourced from drug management records based on ten indicators and compared with the 2010 standards. The results revealed several discrepancies: in the planning stage, drug conformity with the Fornas Level I reached 92.54% and planning accuracy was 184.22%; in procurement, drug availability was 92.04%, generic drugs 88.97%, and budget allocation 98.14%. Storage met standards, with 0% expired or damaged drugs. In distribution, the proportion of drugs in the safe category was 46.27% and average stock-out duration was 27.40%, while distribution accuracy reached 100%. Key challenges include the presence of non-Fornas drugs, disruptions in the e-logistics reporting system, and procurement delays due to an underdeveloped e-catalogue system. Recommended solutions include regular training for drug management staff, improved coordination with the TPOT team based on clinical and pharmacoeconomic considerations, and the addition of pharmacist personnel.
Evaluation of Covid-19 vaccination in 2021 in nganjuk regency Mariyah, Mariyah; Satibi, Satibi; Iswandi, Iswandi
Science Midwifery Vol 11 No 6 (2024): February: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i6.1417

Abstract

Corona Virus Disease 2019 (COVID-19) is an infectious disease that has never been identified before in humans, in severe cases it can cause pneumonia, acute respiratory syndrome, kidney failure, and even death which has been declared a non-natural disaster as a public health emergency. The purpose of this study is to determine and evaluate the implementation of COVID-19 vaccination which includes planning needs, distribution, storage, recording and reporting, monitoring and overcoming adverse events after COVID-19 vaccination, and monitoring evaluation in accordance with the Minister of Health Regulation Number HK.01.07 / MENKES / 4638 / 2019. This research method uses observational research with a descriptive approach. This research is conducted to assess a program that is being or has been implemented. The results of this research are used to improve and/or refine the program or system. In managing the results of this evaluation research, simple statistical analysis is usually used. The implementation of COVID-19 vaccination in Nganjuk Regency includes planning needs, distribution, storage, recording and reporting, monitoring and overcoming adverse events after COVID-19 vaccination, as well as monitoring and evaluation in accordance with Minister of Health Regulation Number HK.01.07/MENKES/4638/2021. The evaluation of the implementation of COVID-19 vaccination in 2021 in Nganjuk District includes several components, namely planning, organizing, mobilizing, monitoring, and output. However, at the planning stage, the need for COVID-19 vaccination stocks is not in accordance with the achievement target. The distribution and storage of SOPs have been carried out well, SOPs are carried out with references in accordance with their respective technical instructions along with recording AEFI reporting and monitoring.
Co-Authors A. Zarkasi, A. Zarkasi Abdurrofi, Akrom Adellia, Triva Afrinovera Agnita Yolanda, Agnita AGUS AGUS Ahmad Ahmad Akmal, Fauzi Al Rasyid, Al Rasyid Al Yaqut, Muhammad Arto Alatas, Uying Hapid Albizar, Albizar Aldhori, Yopan Rahmad Alfalah Alfalah Alfarisi, Rabani Rashif Saniy Alfiana, Ina Alfiander, Dodon Alfianti Alfianti Alfianti Alwizra Alwizra, Alwizra Aminuddin Aminuddin Amuharnis Ananda, I Made Govardana Andi Yaqub Andri Priyoherianto Andriani, Diyan Andriyansah . Anggun Setya Wibawa, Anggun Setya Anita Nilawati Anjani, Tsabita Putri Annisa Annisa Annisa Anrisal, Ahmad Ansorullah , Ansorullah Antarissubhi, Antarissubhi Ardat, Muh. Achyar Arfa'i, Arfa'i Arif Arisman Arifin, Sadriwanti Arifmiboy, Arifmiboy Ariska, Firli Arrie Budhiartie Asman Asman Asri Dewi, Asri Azis, Lasman Azmi, Fikri Azwar, Zainal Basyar, Taufik Qul Bobby Umroh Budi L, Deny Budio, Sesra Bukhari Bukhari Cahyadi, Irwan Chaterji, Katia Chintara Wanda, Aulia Christian Tallu Karaeng Dadang Mashur Dahlan Abdullah Danindra, Fuad Darianto, Darianto Darmansah, Darmansah Darmita, Darmita Darwin, Felix Deded Chandra Desrianto, Desrianto Dewi Fikra, Aksul Dewi Fikra, Asul Dian Adhetya Arif Dina Septiana, Yulda Elfarezi, Febri Elfitri, Riza EMRI, EMRI ERNA FITRIANY, ERNA Eswanto, Eswanto Eswanto, Eswanto Fajri, Helfikra Fausia, Fausia Febrian, St. Ade Moon Fendi, Azmi Fikra, Aksul Dewi Fikri, Nurfajrian Ahmad Firdaus Firdaus Firman Firman Fitria, Mita Fitriyah Fitriyah Gaditia Gunawan Pamudji Widodo Gunawan, Lucia Sincu Guruh Hidayat Hafizah, Dila Auli Hamrah, Desi Haniza Harahap, Uun Novalia Hasan, Mohammad Tohirin Hasibuan, Samsul Abdul Rahman Sidik Helfia Edial Herdalia, Ni Nyoman Ayu Hetdianti, Dian Hoyroyyarah Ida Royani Ika Purwidyaningrum Ikhsan, Masrul Ilham Kuncahyo, Ilham Iltavia Iltavia Indahsari, Indahsari INDRA HERMAWAN Islahuddin Ismal, Dien M. Iwan Setiawan Jamaluddin Jamaluddin Januariyansah, Sapitri Jasiro, Affandri Jason Merari Peranginangin Joko Purnomo Jufri Jufri Jufrizal Jufrizal Juliawati, Ni Kadek Dewi Juliwis Kardi Jusuf Zulfikar, Achmad Kamaruddin Kamaruddin Kartini Kartini Khoiroh, Hadiatul Kristanti Kristanti Kusumawati, Mulyaningtyas Ayu Lasman Azis Lestari, Puja Lestari, Sri Putrani Lisdayanti Loravianti, Susas Rita Lubis, Ismi Saydina Lubis, Pramdya A.T. Lubis, Wilmansyah Lutfiyani, Lutfiyani M. Hatta Mahamadaree Waeno Mahayana, Argoto Mahdiana, Yana Malfiandri, Malfiandri Manullang, Leonardo Mardhatillah, Mardhatillah Mariyah Mariyah, Mariyah Masduki Maya, Maya Mentari Dian Pertiwi Metananda, Arya Arismaya Mimin Sundari Nasution Muh. Nuzul Muhammad Idris Muhammad Idris Muhammad Ridha Muhammad Yusuf Rahmansyah Siahaan Muji Gunarto Mutazam, Mutazam Nadilla, Nadilla Nasrodin Nasrodin, Nasrodin Nasution, Soibatul Aslamiah Niarman, Abdurrahman Nilawati, Anita Nilda Nilda, Nilda Novalia, Cindi Novi Susanti Novialdi . Noviandri, Dian Nuchraha Alhuda Hasnda Nuha, Uli Nur 'Adillah Nur Hidayati Nurul Hidayat Otu, Larasati Rambu Pangaribuan, Rhenaldy Primananda Pare, Nurdiana Tandi Pasaribu, Muhamamd Nuh Hudawi Pradhan, David Prasasti, Anin Pratama, Suprayuandi Purba, Jepriadi Purwantari, Yuniarsih Purwidyanigrum, Ika Putra, Tomy Nanda Putri, Hadisa Putri, Hana Maylinda Putri, Sri Kandi Putri, Sukma Oktafiani Putri, Vera Darasni Rahayu, Eny Sukani Rahmadi Rahmadi Rahmi Safitri, Rahmi Rahmi, Lidya Ratna Wilis Ratnawilis Risa Oktarina Rizki Muliono Rojia, Rojia Roshinta Wulandari, Sasongko Rosta, Fitria Ruhadi Ruhadi ryansyah, mrizkyfajar Sahninda, Sepri Salman Salman Santi Santi Santjuu, Amanda Santosa, Tito Hadji Agung Saputra, Ilham Sarah Astiti S.Kom., M.MT Sari Nova Sari, Arum Mayang Sari, Erlinda Novita Sari, Riazmi Yusma Sartika Arifin Sartika, Lili Satibi Satibi Sepriani, Nur Astri Septiana, Yulda Dina Setiyadi, Henki Sevtian, Andre Shobirin, Khairulis Shofia Nurun Alanur S Sholehah, Faza Putri Farihatus Siagian, Alfonsius Siagian, Tony Silvia Sucianti, Diva Silviana, Mery Sinaga, Stefani Siregar, Irma Suryani Sitepu , Frans Sinatra Soebiyanto, Soebiyanto Sri Mariya Sri Rezki, Sri Sri Utami Sri Wahyuni, Lidia Sriwardona, Sriwardona Sugiyarmasto Sugiyarmasto, Sugiyarmasto Sukma Wira, Andre Sukmawati Sukmawati Sukmawati, U. Sulia Sumardiyono Sumardiyono Sunardi Sunardi Suprapto Suprapto Supriatno Supriatno, Supriatno Supriyadi Supriyadi Suryani Suryani Susilawati, Susilawati Syamsir Syamsir Syarnubi, Syarnubi Syofrianisda Syofrianisda, Syofrianisda Tambusay, M. Ibnu Taufik Hidayat Thoharudin, Thoharudin Tino Hermanto Tresna, Tresna Trisno, Andi Trisno Trisya Septiana Triyatno Triyatno Turdiyanto, Totok Utami, Dila Wahyu Wagisri, Wagisri Wan Rizca Amelia, Wan Rizca Warman, Arifki Budia Wibakti, Aji Restu Widya Rahmawati Widyasti, Jena Hayu Wulandari, Destik Y, Eva Yani, Ni Nyoman Feny Gita Yanti, Masyitah Novia Yeni Erita Yenni Yenni Yopan Rahmad Aldori Yuliana, Ika Yuslim Yuslim Zahri, Mustafa Zanniaty, Iva Zukhroini Zulfarina, Zulfarina zulfikar, Achmad Jusuf