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PENGARUH GEN Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) TERHADAP PERKEMBANGAN PENYAKIT KARDIOVASKULAR Setiawati, Tri; Jumriana; Rabiatul Adawiyah; Ryka Marina Walanda
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 2 (2024): Agustus
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i2.217

Abstract

ABSTRAK Gen PGC-1α sebagai pengatur metabolisme sel, biogenesis mitokondria, mempengaruhi regulasi sel endotel dan sel otot polos yang berkaitan dengan perkembangan penyakit vaskular terutama penyakit aterosklerosis. PGC-1α dapat mengontrol beberapa aspek fungsi otot terkait dengan olahraga, karena PGC-1α dapat mengontrol paralisis otot, menekan respon inflamasi yang luas dan memediasi efek baik akibat olahraga. Peningkatan PGC-1α dapat mencegah dan mempengaruhi regresi lesi penyakit terutama aterosklerosis. Ekspresi PGC-1α yang rendah berhubungan dengan kejadian gagal jantung akibat stres dan kematian sel kardiomiosit. Disfungsi PGC-1α kemungkinan mendasari patologi penyebab berbagai penyakit degerenratif, termasuk kardiovaskular, penyakit degenerasi saraf, dan kanker. ABSTRACT Gene of PGC-1α functions as a regulator of cell metabolism, mitochondrial biogenesis, affects the regulation of endothelial cells and smooth muscle cells that are related to the development of vascular diseases, especially atherosclerosis. PGC-1α can control several aspects of muscle function related to exercise, as PGC-1α can control muscle paralysis, suppress extensive inflammatory responses and mediate exercise-induced good effects. Increased PGC-1α may prevent and influence regression of disease lesions especially atherosclerosis, whereas lack of PGC-1α levels are associated with the incidence of stress-induced heart failure and cardiomyocyte cell death. PGC-1α dysfunction likely underlies the causative pathology of various degenerative diseases, including cardiovascular, neurodegenerative diseases, and cancer.
Implementasi Dana Corporate Social Responsibility (CSR) terhadap Kesejahteraan Masyarakat dan Kelestarian Lingkungan: (Studi Kasus PT. Bumi Daya Agrotamas Kota Subulussalam) Syukri Syukri; Rabiatul Adawiyah; Muhaddis Muhaddis
Gemawisata: Jurnal Ilmiah Pariwisata Vol. 20 No. 3 (2024): Jurnal Ilmiah Pariwisata
Publisher : Sekolah Tinggi Ilmu Ekonomi Pariwisata Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56910/gemawisata.v20i3.415

Abstract

PT. Bumi Daya Agrotamas aims to put pressure on the world of work to be better in carrying out all its production activities so that companies not only think about achieving maximum financial profits but also participate in preserving the environment around which the company is established... these impacts can be in the form of beneficial impacts and detrimental impacts. For companies, the various impacts are that companies oriented towards the economic aspect (profit) are also required to have a responsibility, both to the social aspect and to the environmental aspect. Based on the research background above, the author is interested in conducting research with the title "implementation of PT corporate social responsibility (CSR) funds. Bumi Daya Agrotamas towards community welfare and environmental sustainability. This research was conducted to analyze the implementation of PT's corporate social responsibility (CSR) funds. Bumi Daya Agrotamas towards community welfare and environmental sustainability. This research uses qualitative with descriptive research type, data collection techniques are observation, interviews and documentation. The data obtained was analyzed using a qualitative analysis model. The results of the research show that the implementation of corporate social responsibility (CSR) funds impacts community welfare and environmental sustainability in PT case study. Bumi Daya Agrotamaskota Subulussalam. There are still many things lacking in being able to provide maximum results for the community and good cooperation between the company and the assisted community so there is still something that needs to be improved by the PT. Bumi Daya Agrotamas so that in the future there will be no social jealousy towards the PT and also here, openness is needed by the PT. Bumi Daya Agrotamas to the community so that the closeness becomes more positive and nothing undesirable happens in the future. Furthermore, corporate social responsibility (CSR) is a form of company activity in managing business to produce positive actions in the community to create a quality community.
Penerapan Aplikasi Sicantik Cloud Terhadap Kualitas Pelayanan di Dinas Penanaman Modal, Pelayanan Terpadu Satu Pintu dan Tenaga Kerja Kota Lhokseumawe Rabiatul Adawiyah; Saiful Bahri; Syukri Syukri; Muhaddis Muhaddis
Gemawisata: Jurnal Ilmiah Pariwisata Vol. 20 No. 3 (2024): Jurnal Ilmiah Pariwisata
Publisher : Sekolah Tinggi Ilmu Ekonomi Pariwisata Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56910/gemawisata.v20i3.418

Abstract

The management information system applied in the government is known as the term electronic government (e-government) which is interpreted as the user of information technology transforming government activities with the aim of increasing the effectiveness and efficiency of government administration. SiCantik Cloud is a smart application for integrated public cloud-based licensing services that can be used by government agencies independently. SiCantik Cloud or an intelligent application system for integrated licensing services for the public, is intended for the public to make it easier to manage online licensing. The purpose of this study is to determine the application of the Sicantik Cloud application to Services at the PMPTSP and Naker Office and the inhibiting factors for the application of the Sicantik Cloud application to Services at the PMPTSP and Naker Office of Lhokseumawe City. This study is a study using a qualitative descriptive approach. The application of the SiCantik application to the quality of service at the Investment, One-Stop Integrated Service and Manpower Office of Lhokseumawe City is quite good, as known from several benchmarks of service quality from the Sicantik Cloud application, namely Accountability, Transparency, Effectiveness, and Efficiency. The lack of public awareness of the importance of using information technology means that many people have not been able to optimize the Sicantik application.
PENINGKATAN GAYA BELAJAR PESERTA DIDIK DALAM PEMBELAJARAN JARAK JAUH DI ERA NEW NORMAL Rabiatul Adawiyah
Jurnal Pendidikan dan Sastra Inggris Vol. 2 No. 3 (2022): Desember: Jurnal Pendidikan dan Sastra Inggris
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jupensi.v2i3.917

Abstract

This study aims to analyze the increase in the transition to distance learning in the new normal era which is able to develop an increase in learning styles for students from various cycles of the learning process. This research uses a qualitative descriptive approach, a qualitative descriptive research type. The findings of this research study are confused with the fact that the success of the teaching and learning process is still doubtful until now, because each student's learning style depends on the arrangement of the class, and the delivery of material from the educator. readiness and competence that teachers need to have to support effective and quality learning in the new normal era during the Covid-19 pandemic.
PENERAPAN PRINSIP KEADILAN PADA PERJANJIAN KERJASAMA ANTARA PEMILIK LAHAN PERSAWAHAN DENGAN PENGELOLA WISATA BIDADARI DI DUSUN PAMAH SIMELIR DESA TELAGAH KECAMATAN SEI BINGAI, KABUPATEN LANGKAT Rabiatul Adawiyah; Suhaidi; Jelly Leviza; Dedi Harianto
Jurnal Media Akademik (JMA) Vol. 2 No. 3 (2024): JURNAL MEDIA AKADEMIK Edisi Maret
Publisher : PT. Media Akademik Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62281/v2i3.216

Abstract

Perjanjian kerjasama pengusahaan lahan pertanian/sawah sebagai objek wisata memberikan keadilan dan kepastian hukum. Ini memposisikan Dusun Pamah Simelir, Desa Telagah, Kecamatan Sei Bingai, Kabupaten Langkat dalam pengelolaan obyek wisata. Perjanjian ini di luar KUHPerdata, berdasarkan Pasal 1338 KUHPerdata. Adapun rumusan masalah dalam penelitian ini, yaitu: Bagaimana Pengaturan Kerjasama pengelolaan Obyek wisata bidadari di Dusun Pamah Simelir Desa Telagah Kecamatan Sei Bingai Kabupaten Langkat; Bagaimana bentuk kesepakatan tidak tertulis yang dilakukan antara pemilik lahan persawahan dengan pengelola wisata bidadari di Dusun Pamah Simelir Desa Telagah Kecamatan Sei Bingai Kabupaten Langkat dilihat dari hukum kontrak di Indonesia; Apakah kesepakatan antara pemilik lahan persawahan dengan pengelola Obyek wisata bidadari di Dusun Pamah Simelir Desa Telagah Kecamatan Sei Bingai Kabupaten Langkat Telah Menerapkan Prinsip Keadilan bagi Menjamin Kepentingan para pihak. Metode penelitian yang digunakan di dalam penelitian ini adalah jenis penelitian yuridis empiris, yang didukung dengan sumber data primer dan sekunder, serta dilakukan analisis secara kualitatif. Hasil penelitian dan pembahasannya yaitu pengaturan kerjasama pengelolaan obyek wisata bidadari di Dusun Pamah Simelir dalam pelaksanaan pengelolaannya memberikan kuasa kepada pengelola wisata. Pemberian hak pengelolaan ini didasari atas perjanjian tidak tertulis dan tidak dituangkan dalam akta tertulis antara kedua belah pihak tersebut. Bentuk kesepakatan tidak tertulis yang dilakukan antara pemilik lahan persawahan dengan pengelola wisata bidadari di Dusun Pamah Simelir dimana setelah melalui proses perundingan, tercipta kesepakatan mengenai hak dan kewajiban pemilik lahan persawahan dengan pengelola wisata bidadari beserta pelaksanaan pembagian hasil dari pengelolaan wisata bidadari. Kesepakatan antara pemilik lahan persawahan dengan pengelola wisata bidadari di Dusun Pamah Simelir berdasarkan hak dan kewajiban di antara kedua belah pihak sudah tercermin keadilan walaupun sesungguhnya perlu terdapat perubahan yang harus dilakukan demi tercapainya suatu keadilan secara utuh.
Desain Ekstrakurikuler Al-Qur’an Di SMP Pertiwi Medan Arlina Arlina; Rabiatul Adawiyah; Salsabila Syfa Siregar; Alfina Azisi Br Purba; Fadila Hasibuan
Jurnal Pendidikan, Bahasa dan Budaya Vol. 2 No. 3 (2023): September : Jurnal Pendidikan, Bahasa dan Budaya
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpbb.v2i3.2004

Abstract

Studying the Qur'an is an obligation for every Muslim, because the Qur'an is the main guideline for Muslims in worship and muamalah. Reading and writing the Qur'an is a lesson that must be taught to students, starting from the elementary school level to the high school level. One way is to hold an extracurricular reading of the Qur'an. This research was conducted to find out how the Al-Qur'an extracurricular design at SMP Pertiwi Medan and its relation to improving students' ability to read the Al-Qur'an. This was done to find out whether the Al-Qur'an extracurricular provision had a significant effect on improving the ability to read and memorize the Al-Qur'an in students who took part in the extracurricular activities at Pertiwi Middle School, Medan. The method used in this study is a qualitative descriptive method, in which the descriptive method is used to describe the conditions in the field as they are. Based on the research conducted, the extracurricular design at SMP Pertiwi Medan is good, with the right methods and real support from the school. So that students who take part in extracurricular activities are on average in the good category, in which in this category students are able to read or memorize the Al-Qur'an properly and in accordance with the rules of tajwid science, even though they are not fully good in terms of sound.
ANALISIS KECELAKAAN LALU LINTAS DAN PENANGANAN DAERAH RAWAN KECELAKAAN JALAN AHMAD YANI (RUAS KM 37 – KM 82) KABUPATEN BANJAR Lestari, Utami Sylvia; Yasruddin; Rabiatul Adawiyah
Jurnal Teknik Sipil Vol 6 No 2 (2022): Jurnal Gradasi Teknik Sipil - Desember 2022
Publisher : P3M Politeknik Negeri Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31961/gradasi.v6i2.14400

Abstract

Peningkatan jumlah penduduk dan jumlah kendaraan dapat menimbulkan permasalahan baru dalam berlalu lintas, seperti kebutuhan struktur jalan yang lebih baik, meningkatnya pelanggaran lalu lintas dan risiko kecelakaan lalu lintas. Tujuan dari penelitian ini adalah untuk menganalisis daerah rawan kecelakaan pada ruas jalan Ahmad Yani Km 37 – Km 82 Kabupaten Banjar. Metode yang digunakan untuk mengidentifikasi daerah rawan kecelakaan adalah dengan menghitung Tingkat Kefatalan (TF) dan UCL (Upper Control Limit). Dari hasil analisis data, terdapat 14 ruas jalan yang teridentifikasi sebagai daerah rawan kecelakaan (blacksite) dan yang memiliki tingkat nilai TF tertinggi di Jl. A. Yani km 63 – Jl. A. Yani km 64, yaitu TF = 137.342 dan nilai UCL = 76.464. Selain itu, didapatkan 44 titik ruas jalan yang teridentifikasi sebagai Blackspot. Titik ruas jalan yang memiliki nilai TF tertinggi adalah titik Jl. A. Yani km 47- km 47,25 yaitu TF = 457.808 dan nilai UCL = 93.720. Rekomendasi untuk mengurangi tingkat kecelakaan lalu lintas yang dianjurkan yaitu dengan memasang rambu-rambu lalu lintas, lampu penerangan jalan, guardrail untuk tikungan serta sosialisasi keselamatan berkendara
Peningkatan Kemampuan Membaca Al Quran Santri TPQ Al Azhar dengan Bimbingan Ilmu Tajwid Di Desa Bakan Kecamatan Janapria Kabupaten Lombok Tengah Husaen Sudrajat; Syamsul Hadi; Hadlun; Ala Purnawati; M. Kamari; Intoriqatul Khairiyah; Fathurrahman; Zainal Arifin; Zainal Abidin; Rabiatul Adawiyah; Martini; Nurin Kumala Dewi; Khairul Muzakki; Muhammad Aminudin; Nisrokyah
Jurnal Pengabdian Kepada Masyarakat Al-Amin Vol. 2 No. 1 (2024): January 2024
Publisher : STAI Al-Amin Gersik Kediri Lombok Barat-NTB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54723/jpa.v2i1.129

Abstract

This activity to improve the ability to read the Qur'an at TPQ Al Azhar students is one of several activities that have been compiled by friends of the STAI Al Amin KKN group in Bakan Village by looking at the state of the level of understanding about reading the Qur'an which is mostly lacking so that on that basis friends of the STAI Al Amin KKN group are enthusiastic to realize it and are supported by the institution,  Of course, the hope and desire of a program like this for students or female students can add insight into understanding knowledge about good and correct procedures in reading the Qur'an, and gratitude and enthusiasm in teaching provide a little understanding, students increase understanding and there are changes both in letter recognition, letter makhorijul and reading law in the science of tajweed,  and can also help TPQ caregivers in educating / teaching students to be more like before.
POTENSI PARIWISATA DESA BAGENDANG HILIR Zainap Hartati; Rifani Shobari; Indah Fitria Ningsih; Kartini Kartini; Nur Arinda; Muhammad Ridho Aulia Irawan; Rabiatul Adawiyah; Rinawati Rinawati; Rani Sabrani; Salsabila Githa Zahratunnisa; Wiwin Wiwin
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) 2021
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pariwisata menjadi salah satu sumber pendapatan bagi daerah otonom yang sedang meningkatkan tata kelola, pembangunan yang merata, dan pelayanan publik yang memadai. Dengan adanya destinasi pariwisata di suatu daerah dapat mendongkrak perekonomian daerah tersebut. Tidak tercuali di Kabupaten Kotawaringin Timur yang memilki berbagai tujuan pariwisata. Di Daerah Timur Kabupaten Kotawaringin Timur, tepatnya di Desa Bagendang Hilir terdapat berbagai potensi pariwisata yang sangat memadai untuk dikembangkan dalam mendongkrak Pendapatan Asli Daerah dari sektor pariwisata. Desa Bagendang Hilir dapat menjadi tujuan pariwisata dengan adanya berbagai potensi pariwisata yang dapat dikembangkan di desa ini. Bagian desa Bagendang Hilir yang memiliki potensi dan dapat dikembangkan sebagai desa wisata, yaitu: (1) Wisata Religi Masjid Lama Bara’atul Istihlal; (2) Wisata Penangkaran Buaya; (3) Susur Sungai Mentaya (Endapan Gosong, Pulau Lepeh, dan Pulau Baru); (4) Agrowisata Porang Desa Bagendang Hilir; (5) Wisata Kuliner Desa Bagendang Hilir; (6) Wisata Sejarah Kerajaan Sungai Sampit. Setiap potensi pariwisata memiliki kesempatan menjadi lebih besar untuk meningkatkan pendapatan baik bagi warga desa maupun dan daerah
Model Regresi Nonparametrik dengan Pendekatan Spline (Studi Kasus: Berat Badan Lahir Rendah di Rumah Sakit Ibu dan Anak Siti Fatimah Makassar) Wahidah Sanusi; Rahmat Syam; Rabiatul Adawiyah
Journal of Mathematics, Computations and Statistics Vol. 2 No. 01 (2019): Volume 02 Nomor 01 (April 2019)
Publisher : Jurusan Matematika FMIPA UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The non-parametric approach is an approach that is used if the form of the relationship between the response variable and the predictor variable is unknown or the absence of information about the shapes of regression functions. The Spline is a technique performed to estimate the parameters in the nonparametric regression. This study aims to determine the model of the relationship between low birth weight and the factors that affect the based on the spline model. Such factors are maternal age, gestational age, and pregnancy distance. The Data is obtained from the mother and child hospital siti Fatimah Makassar 2017. Where to get a spline model best the initial step is to determine the knots with the value of the Generalized Cross Validation (GCV) which is a minimum. Based on the research that has been done, the two variables stated effect against low birth weight, namely age of mother, and gestational age. Nonparametric regression Model with the approach of the Spline that is formed has a coefficient of determination of 78.19 to%, as well as the value of the GCV with a three-point knot that is 0.0117.
Co-Authors . Muhammad Ramli Buhari Abdullah Alim Musaddik Agnes Nelciani Rindu Ahmad Mulyadi Kosim Ahmad Zulfahmi Aida Sapitri Akhmad Sukron Haekal Ramdani Ala Purnawati Alfina Azisi Br Purba Algis Ekselen Naibaho Alimuddin A. Djawad Allisa Munawarrah Amniatin Naqiyah Andi Martina Kamaruddin Anggrita Sari Annisa Zuhra Anti Larici Arlina Arlina Arma Sentia Lestari Asrar Mabrur Faza Ayu Lestari Ayu Vidyaningrum Bahri, Salmi Yuniar Baiq Elda Dinisa Putri Baiq Rahmatul Paraeni Barus, Siti Khadijah Bq. Meli Reksa Heriani Bq. Rani, DW Bulkaini (Bulkaini) Ceria Hermina Dea Alifah Dedi Harianto Dela Fitriana Deti Destiani Dewi Ratnatih Dhiza Aliffia Diana Rizky Lubis Dina Sukma Dinda Anisa Yuliana Dita Lestari Djoko Kisworo Dwi Wahyuni Eka Kasymir Elvara Norma Aroyandini Emeliya Sukma Dara Damanik Eva Iryani Fachry Abda El Rahman Fadila Hasibuan Fahrullah Fahrullah Fathurrahman Febry Amirullah Febry Amirullah Benny Guntar, Elsita Lisnawati Gusti Ayu Diantha Dara Puspita Hadlun Hani Fitria Anggraini Hanifah Hartati Agustin HARYANTO Hasibuan, Ahmad Jasa Hasibuan, Nur Asiah Hayatun Thoybah Herning Indriastuti Hesti Hajah Hety Diana Septika Hikmawati Hikmawati Husaen Sudrajat Ibnu Kharis Alfauzi Iga Syarlah Ikrimatul Ulya Imam Ahmad Abi Abdillah Indah Fitria Ningsih Indra Indra Intan Paramiarta Ningrum Intoriqatul Khairiyah Irni Cahyani Jeffrey Jelly Leviza Jihan Hafidzah Juliana Astuti Jumriana Kartini Kartini Khaerani Khaira Zahra Nasution Khairul Muzakki Khairun Na’imah KHOIRUNNISA Kurniawan . Lalu Puji Indra Kharisma Lalu Rudyat Telly Savalas Lestari, Dyah Aring Hepiana Lestari, Utami Sylvia Lubis, Nurhidayah M. Kamari Mahyuddin Mahyuddin MARA UNTUNG RITONGA, MARA UNTUNG Marlian Arif Nasution MARTINI Mar’ie Muhammad Mawadah Mawadah Megawati Megawati Merlinda Suryati Jitung Mohammad Basit Muh Said Muhaddis Muhaddis Muhammad Al Fisah Muhammad Albadar Adren Muhammad Aminudin Muhammad Faizuddin Muhammad Jailani Alkadri Muhammad Rafi’i Muhammad Ridho Aulia Irawan Muhammad Saleh Mire Muhhammad Husni Thamrin Muhlis Mukhlis Mukhtar Muhammad Salam Mumpuniarti Mumpuniarti Munifah Munifah Wahyuddin Naheri Najwa Nadhira Harahap Nara Puan Majid Nazli Badrul ‘Aini Ramdhani Ni Luh Nanik Puspadi Nisrokyah Norhaliza Norhaliza Novi Rizki Nurlaili Nur Arinda nur hafizah Nurfarhanah Nurfarhanah Nurhalisa Nurin Kumala Dewi Nurshalati Tahar Nurul Humairah Nurul Ikrimah Opi Andriani Panggabean, Rizky Mubarok Pepita Sari Putri Ramadani R Hanung Ismono Rahma, Aufa Rahmadani Rahmadani Rahman Ambo Masse Rahmat Syam Raihan Randi Boang Manalu Raja Ritonga Ramlan Padang Rangkuti, Rosipa Rahmi Rani Sabrani Ratih Puspita Sari Refani Pramunita Riannur Riannur Richo Kais Threza Fauzi Ridwan Sholeh Rifani Shobari Rinawati Rinawati Riska Afifah Riska Amira Zahrotunnisa Riska Ayu Purnama Dewi Riska Tri Listiani Rita Nofianti Rizqi Nailul Baroroh Romat Efendi Sipahutar Ryka Marina Walanda Saiful Bahri Salsabila Githa Zahratunnisa Salsabila Hasibuan Salsabila Syfa Siregar Sari Wulan Satriyadi Sendhy Krisnasari Shanty Komalasari Sholatiah Hannum SITI LATIFAH Siti Maisarah Soeci Izzati Adlya Srg, Kartina SRI RAHAYU Suhaidi Suhartini Sujaya, Ketut Ary Sukiyat, Sukiyat Sukriadi Sumper Mulia Harahap, Sumper Mulia Syamsul Ph.D M.A. Hadi Syukri Syukri Taharuddin Teguh Endaryanto Timbul Surya Akbar Lubis Tri Asihati Ratna Hapsari Tri Setiawati Tri Setyawati Umi Kalsum Veronica Lia Andriani Wafiq Azizah Wahidah Sanusi Wardah Syafirah Wiwin Wiwin Wuryaningsih Dwi Sayekti Yaktiworo Indriani Yasruddin Yayuk Andayani Yudi Sutaryana Yudo Dwiyono Yulianti Hidayah Yulianto, W Yuni Sahara Yuniar Affandy Zahra Nur Oktaviani Zainal Abidin Zainal Arifin Zainap Hartati Zakiyah Rangkuti