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All Journal Medula Juke Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya JITEK (Jurnal Ilmiah Teknosains) Jurnal Ilmu Kedokteran dan Kesehatan Acta Biochimica Indonesiana Jurnal Medika Malahayati SRIWIJAYA JOURNAL OF MEDICINE Jurnal Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Indian Journal of Forensic Medicine & Toxicology Jurnal Kedokteran Raflesia Jurnal Pengabdian kepada Masyarakat Prosiding Konferensi Nasional PKM-CSR JCOMENT (Journal of Community Empowerment) Jurnal Informatika Polinema (JIP) Medic Nutricia : Jurnal Ilmu Kesehatan Majority JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Journal of Pharmaceutical and Natural Resources
Syazili Mustofa
Department Biochemistry, Molecular Biology And Physiology, Faculty Of Medicine, Universitas Lampung, Bandar Lampung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Complex Case Of Copd Exacerbation With Lung Cancer And Paraneoplastic Syndrome: A Case Report Mustofa, Syazili; Sidik, Faizah Zahrah; Kurniawaty, Evi; Rohman, Miftahur; Karima, Nisa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 4 (2026): Volume 13 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i4.22914

Abstract

Managing Chronic Obstructive Pulmonary Disease (COPD) alongside advanced lung cancer is highly complex, especially when complicated by multiple paraneoplastic syndromes. We present a 70-year-old male with shortness of breath, hemoptysis, and significant weight loss. Evaluation revealed an acute COPD exacerbation unmasking a metastatic right lung cancer with a rare combination of concurrent paraneoplastic syndromes (anemia, hyponatremia, and hypocalcemia). The uniqueness of this case lies in how these overlapping systemic manifestations masked the acute respiratory exacerbation, creating a profound diagnostic dilemma. Clinically, this implies that physicians must maintain a high index of suspicion for underlying malignancies when treating atypical or refractory COPD exacerbations. The key lesson learned is that managing such intertwined conditions requires prompt, individualized, and multidisciplinary coordination to prevent delayed interventions and optimize patient outcomes.
Indonesian Medicinal Plants for Anticancer Syazili Mustofa
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 2 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i2.pp1-10

Abstract

The potential of Indonesia's natural wealth of plants to be developed as anticancer agents is enormous, thanks to its abundant biodiversity. Indonesia has become a "natural laboratory" with various plants traditionally used for treatment, including cancer, by local communities. This potential is supported by several primary factors: extensive biodiversity, bioactive compound content, and empirical use in traditional medicine. Several studies have identified several Indonesian plants that show potential as anticancer agents: Tapak Dara (Vinca rosea), Taxol (Taxus sp), Lempuyang Wangi (Zingiber zerumbet), Temu Kunci (Boesenbergia pandurata), Melinjo/Tangkil (Gnetum gnemon), Soursop leaves (Annona muricata), Cloves (Syzygium aromaticum), and Typhonium flagelliforme (Typhonium flagelliforme). Despite its great potential, developing anticancer drugs from Indonesian plants faces several challenges: scientific proof, standardization, high research and development costs, and regulatory and patent aspects. To address these challenges, a comprehensive development strategy is needed, including: Enhancing collaboration between research institutions, universities, the pharmaceutical industry, and the government; Conducting ethnobotanical studies to document traditional knowledge of medicinal plants; Developing standardized herbal formulas (phytopharmaceutics) that have supporting scientific data; Strengthening basic research to identify and test specific bioactive compounds; and Encouraging innovation in the extraction and purification of active compounds.
Co-Authors A.P, Gadila Achmad Gozali Ade Yonata Adityo Wibowo, Adityo Adli, Farhan Kamali Afriyana, Regi Agung Kurnia, Ahmad Fadila Agus Dwi Susanto Agus Wantoro Agustia Pratiwi Agustyas Tjiptaningrum agustyas tjiptaningrum Ahmad A Anindito Aisyah A Putri Aisyah Ramadhani Alissa Zahara Anggelika Amanda Febby Amanda Febby Febrina Amani Raya, Latansa Ananta, Yoga andestya nanda pratama Andika Ridwan Nugraha Harahap Anggi Adelia Anggraeni Janar Wulan Anggraeni Janar Wulan, Anggraeni Janar Anggraeni, Liza Annisa Adietya Pratama Antoni Antoni Apga Repindo Asep Sukohar Asyifa, Takhfa Nur Aviv Fitria Yulia Ayu Tiara Fitri Ayu Tiara Fitri Ayu, Putu Ristyaning Benny Syahputra Gumay Betta Kurniawan Betta Kurniawan, Betta Budhi Antariksa Caesaria Sinta Zuya Caesarridha, Dhaifany Karissa Chicy WIdya Morfi Choerunnisa, Nida Christi Natalia Sirait Dansen Frans Louise Draven Rudyanto David Tongon Silaen Dewi Nur Fiana Dewi, Meidiana Kartika Dheti Efrilia Dheti Efrilia - Dimas Trend PB Dorisman, Hari Dwi Indria Anggraini Dwi Sarwindah Dyah Wulan Sumekar Rengganis Wardani Ekawati, Diyan Eksa, Dwi Robbiardy Elman Dani Firdaus Endah Setyaningrum Endah Setyaningrum, Endah Ersa, Rakhmigasti Citra Erumbia, Ilham Akbar Ety Apriliana Evi Kurniawaty Evy Kurniawaty Faisal Rohmadhiyaul Haq Faisal Yunus Faisol Rohmadhiyaul Haq Fauziah Hanif Fayza Syachrani Febrianti, Arlin Febrihartati, Isura Feby Aulia Hasanah Femmy Andrifianie Fikri Muhammad Rifai Patongai Firantika Dias Puteri Fitri, Reggina Annisa Fitria Saftarina Fitriyah . Fitriyah Fitriyah Fitriyah Fitriyah Fransisca Sinaga Fredison, Fredison Gerliandi, Egi Oktarian Gigih Setiawan Gilang Kukuh Megantoro Ginting, Bisart Giska Tri Putri Giska Tri Putri Giska Tri Putri Gusti Agung Putu Yogy Veda Ananta Gusti Wahyu, Pratiwi Hakim Alhaady Juhana Hakim Alhaady Juhana, Hakim Alhaady Hanna Mutiara, Hanna Helmi Ismunandar Hendra Tarigan Sibero Hendri Busman Hendri Busman Hendri Busman Hendri Busman Herdato, M. Junus Didiek I Made Afryan SL I Made Galih Fradiva Giantara Idzni Mardhiyah Ifan Aulia Candra Ilma Puteri Hutami Indri Windarti Infianto, Andreas Intan Kusumaningtyas Intanri Kurniati Isnamurti Ciptaningrum Isura Febrihartati Izzati, Marwah Aulia Jamsari Jamsari Jati, Pandu Kumaya Jhons Fatriyadi Suwandi Jordy Oktobiannobel Karima, Nisa Karina, Salwa Al Kevin Jeremia Purba Khairun Nisa Khairun Nisa Khoiri, Ratu Kirana Siva Kholis Abdurachim Audah Kurniawaty, Evi Kusumajati, Pusparini Latansa Amani Raya Linda Septiani Listiandoko, Raden Dicky Wirawan Lucky Togihon M. Rakha Gerizha M., Tria Mallarangeng, Andi Nafisah Tendri Adjeng Maulana, Rifadly Yusril Mayasari, Diana Meiwa Rizky Ardhi Blla Putri Mentariasih Maulida Mia Esta Poetri Afdal Faisal Mirza Purwitasari Mohamad Sadikin Morfi, Chicy Widya Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Maulana Muhammad Ricky Ramadhian Muhammad Ricky Ramadhian Muhartono Muhartono Muhartono NA, Ahmad Mufid Nadhifa, Farin Nadya Febriani Namdes, Fitri Cyntya Naufal Rivo Aditya Ni Sayu Putu Desya Laksmi Putri Nicholas Alfa Nickyta Yolandita Rosti Novita Carolia Novita Carolia Novita Carolia Nuriah Nuriah Nuriah, Nuriah Nursidiq, Iqbal Muhammad Rafi Oktadoni Saputra, Oktadoni Pinaka Baladika, Dimas Trend Poty, Pitha Maykania Pralia Winda Sari Pratama, Arianda Puan Raissa Lenka Puteri, Vadiyani Fricillya Putra, Andika Chandra Putranata, Naufal R. 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Sinaga, Fransisca TY Sindika Amertavia Sirait, Felicya Rosari Hasianna Siti Hazrina Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza S Soemarwoto, Retno Ariza Soeprihatini Soeprihatini Soemarwoto, Retno Ariza Soeprihatini, Retno Ariza Soraya Rahmanisa Soraya Rahmanisa Soraya Rahmanisa Sri Janahtul Hayati Sri Janahtul Hayati Sri Puji Hartini Suharyani Suharyani Suharyani Suharyani Sukarti Sukarti Suryadi Islami Suryani Agustina Daulay Susianti Susianti Sutarto Sutarto Sutyarso Sutyarso Sutyarso Suwarno, Sukarti San Syahrani, Fitri Aulia Syaka, Muthiiah Khodista Syakir, Muhammad Addin Syiefa Renanda Surya Tarigan, Clara Yulianti Terza Aflika Happy Tito Tri Saputra Tito Tri Saputra Tito Tri Saputra Tiwuk Susantiningsih Tri Putri, Giska Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Veny Anisya Victoria Hawarima Virginia, Nur Ayu W Bahagia Wawan Abdullah Setiawan Wayan Ferly Aryana Winda Trijayanthi Utama Winda Trijayanthi Utama, Winda Trijayanthi Wisnugroho, Cahyo Wulan, Anggraini Janar Yana Ayu, Dwi Yandri Yanwirasti Yuningrum, Hesti Zulia Yasminanindita Fahmi Zulkifli