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All Journal International Journal of Public Health Science (IJPHS) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan The Journal of Experimental Life Sciences (JELS) Jurnal Vektor Penyakit Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Journal of Degraded and Mining Lands Management Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL PHARMASCIENCE JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) INDONESIAN JOURNAL OF PHARMACY Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran The Indonesian Biomedical Journal Sari Pediatri Padjadjaran Journal of Dentistry Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Ilmiah Kedokteran Wijaya Kusuma Universa Medicina JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Medical Laboratory Technology Journal Jurnal Surya Medika Jurnal Berkala Kesehatan JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) EnviroScienteae Jukung (Jurnal Teknik Lingkungan) BAREKENG: Jurnal Ilmu Matematika dan Terapan SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Media Ilmu Kesehatan JURNAL PENDIDIKAN TAMBUSAI Jurnal Kreativitas PKM Manuju : Malahayati Nursing Journal JKM (Jurnal Kebidanan Malahayati) Acta Biochimica Indonesiana YARSI Medical Journal Jurnal Respirasi (JR) Jurnal Jejaring Matematika dan Sains Jurnal Ners An-Nadaa: Jurnal Kesehatan Masyarakat Science Midwifery Bubungan Tinggi: Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Indian Journal of Forensic Medicine & Toxicology JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Indonesian Journal of Perinatology Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Pengabdian Masyarakat Formosa (JPMF) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Biological Environment and Pollution Homeostasis: Jurnal Mahasiswa Pendidikan Dokter DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Gunung Djati Conference Series Gema Lingkungan Kesehatan Jurnal AGRISEP: Kajian Masalah Sosial Ekonomi Pertanian dan Agribisnis Leuser Journal of Environmental Studies Biosaintifika: Journal of Biology & Biology Education Journal of Advanced Research in Social Sciences and Humanities Journal of Management Practices, Humanities and Social Sciences NMI THE JOURNAL OF Nursing Management Issues Jurnal Abdimas Mahakam Journal of Pharmascience

Eko Suhartono

Departement Of Medical Chemistry/Biochemistry, Faculty Of Medicine, Universitas Lambung Mangkurat, Jl. Ahmad Yani Km.36, Banjarbaru 70712

Author-ID : 258680

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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POTENSI JUS BUAH PARE (Momordica charantia L.) SEBAGAI PENGHAMBAT HEMOGLOBIN TERGLIKASI IN VITRO Muhammad Topan Widyanto; Eko Suhartono; Agung Biworo
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Bitter gourd (Momordica charantia) is a fruit that is potentially has the ability to inhibit glycated hemoglobin thus can reduce blood sugar level. The aim of this study is to test the potency of bitter gourd juice as a glycated hemoglobin inhibitor. This is a quasi experimental study with non randomized posttest-only with control group design method, using a reaction model of diabetes consisted of two groups; bitter gourd juice as the test group and gliclazide as the standard group, divided into 10%, 20%, and 30% concentration. IC50 value is used to determine the potency as a glycated hemoglobin inhibitor. The result of this study shows that the value of r = 0,990 with an IC50 value of 69,239%, whereas for glikazid 17,268%. The positive value of r indicates a positive relation between concentration and its potency as a glycated hemoglobin inhibitor. The result thus indicates that bitter gourd juice has a potency as a glycated hemoglobin inhibitor Keywords: glycated hemoglobin, bitter gourd (Momordica charantia), gliclazide

Efek Pajanan Kadmium (Cd) terhadap Aktivitas Katalase Darah Tikus Putih (Rattus norvegicus) Nuryandi Khairunanda; Eko Suhartono; Triawanti Triawanti
Berkala Kedokteran Vol 10, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.926

ABSTRACT: Cadmium (Cd) is a heavy metal compound which is often founded in the environment and food. It has a wide variety of negative effects on target exposed organs, such as blood. Cd increases the Reactive Oxygen Species (ROS) which will lead to an increase in catalase (CAT) activity. The aim of this study was to determine the effect of Cd exposure on CAT activity in the rat ovary (Rattus norvegicus). It was an experimental laboratory using 2 groups. Control group P (0) was given 2 mL aquadest and treatment group P (1) was given Cd with 1,2 x 10-2 mg daily for 4 weeks. The results showed that the mean of the activity of CAT in the control group P(0) was 0,382 + 0,225 μU/mg while in the treatment group P(1) was 0,458 + 0,393 μU/mg. The statistical analysis test using unpaired t test showed an insignificant differences between those two groups with p = 0,599 (p > 0,05). It can be concluded that Cd does not have effect on activity of CAT in the rats’ blood. Keywords: cadmium, catalase activity, oxydative stress..ABSTRAK: Kadmium (Cd) adalah suatu senyawa logam berat yang sering terdapat pada lingkungan dan makanan. Cd memiliki berbagai efek negatif pada organ target yang terpajan, salah satunya adalah darah. Mekanisme Cd untuk merusak jaringan yang terpajan adalah dengan meningkatkan Reactive Oxygen Species (ROS) yang akan menyebabkan peningkatan aktivitas katalase (CAT). Penelitian ini bertujuan untuk mengetahui efek pajanan Cd terhadap aktivitas CAT pada darah tikus putih (Rattus norvegicus). Penelitian ini bersifat laboratorik eksperimental yang dilakukan pada 2 kelompok, yakni kelompok kontrol P(0) yang diberi akuadest sebanyak 2 mL dan kelompok pajanan P(1) yang diberi Cd dengan dosis 1,2 x 10-2 mg setiap hari selama 4 minggu. Hasil penelitian didapatkan rerata pada kelompok kontrol P (0) sebesar 0,382 + 0.225 µU/mg dan pada kelompok perlakuan P(1) sebesar 0,458 + 0,393 µU/mg. Pada uji t tidak berpasangan didapatkan tidak ada perbedaan yang bermakna dari kedua kelompok dengan p = 0,037 (p < 0,05). Dapat disimpulkan bahwa Cd tidak memiliki efek pada aktivitas CATpada darah tikus putih. Kata-kata kunci: kadmium, aktivitas katalase, stres oksidatif.

Perbedaan Kadar Methylglyoxal (MG) Ovarium Tikus Putih (Rattus Norvegicus) Terpajan Kadmium dan Tidak Terpajan Kadmium Annisa Halida Husna; Eko Suhartono; Meitria Syahadatina Noor
Berkala Kedokteran Vol 10, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.956

ABSTRACT: Cadmium (Cd) is a heavy metal nonessensial that can pollute the environment and if it is included into the food chain and fish or plant indirectly also tainted Cd. If fish or plant that is contaminated with Cd consumed persistently by human beings in a long time will accumulate in the body and be chronic toxic by changing structural also functional an organ of the ovary. Determine the level Cd toxic in the ovary with measures level of methylglyoxal (MG). This research using the ovaries of white rats age of 2-3 months. This research to know the difference in the levels of MG of rat ovaries exposed and unexposed Cd. This study is experimental laboratory on the two groups, the control group P(0) that are aquadest as much as 2 ml per day for 4 weeks an exposure group P(1) who is given a Cd with a concentration of 6 mg/L are given as much as 2 ml for 4 weeks. The research results obtained average in the control group P(0) of 0,005 and treatment group P(1) by 0,016. Then to test normality Shapiro-wilk, after a normal, then do a non parametric tests Mann-whitney and meaningful differences between the results obtained by the control group p<0,005. There is a meaningful difference between the control group MG level of P(0) with the treatment group P(1) where the presence of increased levels of MG on Cd exposure groups. Keywords: cadmium, methylglyoxal, ovarium, stress oksidatif ABSTRAK: Kadmium (Cd) adalah logam berat nonessensial yang dapat mencemari lingkungan dan jika masuk ke dalam rantai makanan maka ikan ataupun tanaman secara tidak langsung juga tercemar Cd. Jika ikan atau tanaman yang tercemar Cd dikonsumsi terus-menerus oleh manusia dalam jangka waktu lama akan terakumulasi di tubuh dan berakibat toksiksitas kronis dengan mengubah struktural juga fungsional dari organ ovarium. Untuk mengetahui tingkat toksiksitas Cd di dalam ovarium dengan mengukur kadar methylglyoxal (MG). Penelitian ini menggunakan ovarium tikus putih yang berumur 2-3 bulan. Tujuan penelitian untuk mengetahui perbedaan kadar MG ovarium tikus putih yang terpajan Cd dan tidak terpajan Cd. Penelitian laboratorik eksperimental dilakukan dengan 2 kelompok, yaitu kelompok kontrol P(0) yang diberi akuadest 2 ml setiap hari selama 4 minggu dan kelompok perlakuan P(1) yang diberi Cd konsentrasi 6 mg/L sebanyak 2 ml selama 4 minggu. Hasil penelitian didapatkan rerata kelompok kontrol 0.005 dan kelompok perlakuan P(1) 0.016. Data kemudian di uji normalitas Shapiro-Wilk menunjukan p=0,000 (p<0,005). Kemudian dilakukan uji non-parametrik Mann-Whitney p=0,000 (p<0,005). Dapat disimpulkan bahwa terdapat perbedaan bermakna kadar MG antara kelompok kontrol P(0) yang tidak terpajan Cd dengan kelompok perlakuan P(1) yang terpajan Cd. Kata-kata kunci: kadmium, methylglyoxal, ovarium, stress oksidatif

STUDY OF INTERACTION BETWEEN LEAD AND GASTRIC MUCOSAL PROTEIN OF RATS WITH FORENSIC TOXICOLOGY APPROACH Iwan Aflanie; Iskandar Thalib; Eko Suhartono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Recently, forensic toxicology has been an interesting concern, especially in exposing the phenomena associated with the law. Using the forensic toxicology approach, several cases of lead (Pb) poisoning have been widely revealed. In this present study will be investigate the interaction between Pb and amino acid gastric mucosal constituent proteins, especially cysteine and tyrosine groups. This research is a pure experimental research with posttest control group design, which is divided into 4 groups with 6 rats (Rattus novergicus) in each group. Treatment in each group as follows; P0 was control group were given 2 ml of distilled water; P1 = administration of Pb 0.1 g/L; P2 = Pb administration of 1 mg/L; and P3 = Pb administration of 10 g/L for 4 weeks repectively. According to the results, it can be concluded that Pb-Protein interaction tends to binding of Pb-Cysteine rather than Pb-Tyrosine Keywords: Gastric Mucosa, Lead, Protein

EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS Iskandar Thalib; Windy Yuliana Budianto; Eko Suhartono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats. The subjects that used in this study are 15 male rats (Rattus novergicus) with normal activity, 2-3 months old, and weighing 300±10 gram. The research subjects the divided into 3 groups; P0 group are given commercial fed rats diets only; P1 are given commercial fed rats + Cd with a concentration of 3 mg/l in drinking water for 1 day (acute); and P2 are given commercial fed rats+Cd with a concentration of 3 mg/l in drinking water for 4 weeks (subacute). The results of this present study shows that treatment with Cd significantly increase the levels of blood glucose (P < 0,05). The result also showed that treatment with Cd can increase the Km value of liver glucokinase, and it means Cd exposure can decrease the affinity between glucose and glucokinase. The present study demonstrated that Cd exposure could increase the risk of DM through increased the blood glucose and decrease the activity of liver glucokinase. Keywords: Cadmium, glucose metabolism, glucose, glucokinase

Biotoxic of Gemor (Nothaphoebe coriacea) Leaves from Peat Swamp Tumbang Nusa Research Forest, Central Kalimantan, Indonesia Iskandar Thalib; Purwanto Budi Santosa; Eko Suhartono
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: The study aimed to evaluate the sub-acute toxicity effect of aqueous N. coriacea leaves extract to kidney and liver function. The biotoxic study was conducted using male rats. In this study, the experimental animals received five different doses of aqueous N. coriacea leaves extract (0.1 mg, 1 mg, 10 mg, 100 mg, and 1000 mg per day) for 4 weeks via oral route. After treatment, the level of plasma ureum, creatinine, Aspartate Transaminase (AST) and Alanine Transaminase (ALT) level were measured. The results show that most of dose treatments of aqueous extract of N. coriacea leaves had not statistically effect on the level of the plasma ureum and creatinine except for dosage of 1000 mg. Similarly, the dose treatments of that extract did not statistically change the plasma AST and ALT, except on 100 and 1000 mg/kg of b.w extract dose. In conclusion, a short-term intake of N. coriacea leaves extract via oral route was not toxic to kidney and liver. Keywords: N. coriacea, Kidney, Liver, Toxicity.

Efek Pajanan Kadmium (Cd) terhadap Kadar Malondialdehyde (MDA) pada Ovarium Tikus Putih (Rattus norvegicus) Muhammad Hendy Arizal; Eko Suhartono; Mohammad Bakhriansyah
Berkala Kedokteran Vol 10, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.953

ABSTRACT: Cadmium (Cd) is heavy metal that pollutant in the environment. Chronic intake of Cd induces toxicity on liver, kidney, and ovary. Cd could damage the tissue with stress oxidative damage mechanism. Malondyaldehyde (MDA) is the product of lipid peroxidation used as a measure of lipid peroxidation and stress oxidative damage. This was an experimental laboratoric using two groups. The control group P(0) was given aquadest 2 ml per day for 4 weeks and the exposure group P(1) was given a solution of Cd with a concentration of 1.2 x 10-2 mg for 4 weeks. The results showed the mean of MDA level in the P(0) and the P(1) were 214.80 μM and 232.00 μM, respectively. Statistical analysis using Unpaired Test-T obtained the result p = 0.016 (p<0.05). It can be concluded that Cd causes increased MDA levels in rats ovary. Keywords: Cadmium, malondialdehyde, ovarium, oxidative stress, rats. ABSTRAK : Kadmium (Cd) merupakan logam berat bersifat polutan yang mencemari lingkungan. Paparan kronik Cd berefek toksik terhadap hati, ginjal, dan ovarium. Cd merusak jaringan melalui mekanisme stres oksidatif. Malondialdehyde (MDA) merupakan produk akhir dari peroksidasi lipid yang menjadi parameter dalam mengukur kerusakan oksidatif. Penelitian ini bertujuan untuk mengetahui efek pajanan Cd terhadap kadar MDA ovarium tikus putih. Penelitian ini bersifat eksperimental laboratorik yang dilakukan pada 2 kelompok, yakni kelompok kontrol P(0) yang diberi aquadest sebanyak 2 ml selama 4 minggu dan kelompok perlakuan P(1) yang diberi Cd dengan konsentrasi 1,2 x 10-2 mg dalam 2 ml aquadest setiap hari selama 4 minggu. Hasil penelitian didapatkan rerata pada kelompok kontrol P(0) sebesar 214,80 ± 22,90 μM dan pada kelompok perlakuan P(1) sebesar 232,00 ± 20,40 μM dengan nilai p = 0,016 (p<0,05). Dapat disimpulkan bahwa Cd menyebabkan peningkatan kadar MDA pada ovarium tikus putih. Kata-kata kunci: Kadmium, malondialdehyde, ovarium, stres oksidatif, tikus putih.

UNDERSTANDING THE INTERACTION BETWEEN GLUTATHIONE AND ACETAMINOPHEN: A DOCKING STUDY APPROACH Mohammad Rizki Fadhil Pratama; Eko Suhartono
Dentino : Jurnal Kedokteran Gigi Vol 3, No 2 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i2.5381

Background:Acetaminophen (PCT) is known for its pro-oxidant properties, which neutralized by the presence of internal antioxidants such as glutathione (GSH). GSH has two forms: monomers and dimers, mainly distinguished by the presence of thiol group. Purpose:This study aims to see the difference in interaction between PCT with both forms of GSH. Method:Molecular docking was performed using Autodock Vina 1.1.2 on whole GSH surfaces. The main parameter used was the free energy of binding as affinity marker, as well as the position of PCT toward GSH. Result:The docking results show that PCT has a slightly higher affinity to the dimeric form of GSH than its monomeric form with the free energy of binding -2.7 kcal/mol and -2.2 kcal/mol, respectively. The interesting thing is the acetyl group of PCT is in a position far from the thiol group in the monomeric form of GSH, in contrast to its dimeric form. Conclusion:These results show that difference in affinity of PCT to both GSH forms is influenced by the position of the acetyl group against the thiol group of cysteine in GSH. The proximity of the pro-oxidant group to the thiol group leads to an increase in the affinity of the pro-oxidant to GSH.

Aplikasi IJEN (Infeksi Jamur Entomopatogen pada Nyamuk) : Jamur Metarhizium anisopliae pada Nyamuk Aedes aegypti Liestiana Indriyati; Salamiah Salamiah; Lutfhi Fatah; Eko Suhartono; Muhammad Rasyid Ridha; Abdullah Fadily; Paisal Paisal; Dicky Andiarsa
Jurnal Vektor Penyakit Vol 13 No 1 (2019): Edisi Juni
Publisher : Balai Penelitian dan Pengembangan Kesehatan Donggala, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan RI

Abstract Dengue hemorrhagic fever is one of the main problems in Indonesia, its handling on chemical insecticides with insecticide resistance constraints that can inhibit vector control efforts. Entomopathogenic fungi especially Metarhizium anisopliae is one of bioinsecticides that has been widely used in agriculture for controlling insect attacks, effective in killing mosquitoes, safe for vertebrates, humans and the environment and has a small risk of resistance. Appropriate methods of formulation and application for M. anisopliae infection to mosquitoes suitable for mosquito bionomic and fungus characteristics are required. Experimental research with complete randomized design was conducted to test the efficacy of. M.anisopliae solution mixed olive oil and honey formula applied to ovitrap, plant trap and black cotton trap in infecting adult female Ae. aegypti. The death of Ae.a egypti and fungal growth on kadaver was observed everyday. 100% Ae. aegypti death was obtained in the ovitrap method with mixed formulation of M.anisopliae and olive oil. This method was also capable of infecting Ae.aegypti in various phases of both adults, eggs and larvae so that in this study ovitrap olive oil method was the most effective method for infecting M.anisopliae on Ae.aegypti. Abstrak Demam berdarah dengue merupakan salah satu masalah utama di Indoneisa. Penggunaan insektisida kimia sebagai upaya pengendalian DBD saat ini memiliki kendala resistensi insektisida yang dapat menghambat upaya pengendalian vektor. Jamur entomopatogen khususnya Metarhizium anisopliae adalah salah satu bioinsektisida yang telah digunakan secara luas di bidang pertanian untuk pengendalian serangan serangga efektif membunuh nyamuk, aman bagi vertebrata, manusia dan lingkungan serta memiliki risiko resistensi yang kecil. Diperlukan metode yang tepat baik dari formulasi maupun cara aplikasi untuk penginfeksian M.anisopliae kepada nyamuk yang sesuai dengan bionomik nyamuk dan karakteristik jamur. Penelitian eksperimental dengan rancangan acak lengkap dilakukan untuk menguji efektivitas formula M.anisopliae. Larutan M.anisopliae dicampur minyak zaitun dan madu yang diaplikasikan pada ovitrap, plant trap dan black cotton trap dalam menginfeksi Ae.aegypti betina dewasa. Pengamatan dilakukan pada kematian Ae.aegypti dan pertumbuhan jamur pada kadaver setiap hari. Kematian Ae.aegypti 100% didapatkan pada metode ovitrap dengan formulasi campuran M.anisopliae dan minyak zaitun. Metode ini juga mampu menginfeksi Ae.aegypti pada berbagai fase baik dewasa, telur maupun larva sehingga pada penelitian ini metode zaitun ovitrap dinyatakan metode yang paling efektif untuk penginfeksian M.anisopliae pada Ae.aegypti.

Effect of Coal Dust Exposure on the SOD Activity and the Oxidative DNA Damage in Asthmatic Mice Windy Yuliana Budianto; Husnul Khotimah; Eko Suhartono
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.579

BACKGROUND: Coal dust is known to trigger hypersensitivity and inflammation of the respiratory tract as it increases oxidative stress leading to asthma. To date, the relationship of coal dust exposure in the pathomechanism of asthma remains unclear. This study was aimed to examine the effect of coal dust exposure on the superoxide dismutase (SOD) activity and the oxidative DNA damage indicated by increased serum 8-hydroxy-2' -deoxyguanosine (8-OHdG) in asthmatic mice.METHODS: Twenty-four female balb/c mice were divided into four groups. The first group was the control group. The second group was the negative control group which composed of mice exposed to coal dust particles. The third group was composed of ovalbumin (OVA)-sensitized mice. The fourth group was composed of OVA-sensitized mice and exposed to coal dust particles. The inflammatory process was identified by serum interleukin (IL)-13 concentration using Enzyme-linked Immunosorbent Assay (ELISA) method. Meanwhile, the oxidative stress was examined by measuring the SOD activity using the Nitro Blue Tetrazolium (NBT) method, and the 8-OHdG concentration was quantified by ELISA method.RESULTS: There was an increasing IL-13 in OVAtreated coal dust exposed group along with the increment of 8-OHdG (statistically not significant). SOD activity measured in serum was decreased in all groups (p>0.05). Combination of OVA and coal dust showed the worst effect on IL-13, 8-OHdG and SOD activity.CONCLUSION: Coal dust exposure for four weeks does not adequately induce the oxidative DNA damage in asthmatic mice.KEYWORDS: asthma, coal dust, IL-13, SOD, 8-OHdG

Co-Authors - Edyson - Haudhiya - Mashuri - Mashuri, - Abd Rahman, Sunarti Abdullah Fadily Achmad Syamsu Hidayat Adelia Anggraini Utama Adenan Adenan, Adenan Adi Kristanto Adi Nugroho Adi Nugroho Adi Nugroho Agianto Agung Biworo Agung Biworo Agung Biworo Ahmad Hidayat Ahmad Husairi Akhmad Rizali Ali Assagaf Amin Setyo Leksono Aminuddin Prahatama Putra Aminuddin Prahatama Putra Aminuddin Prahatama Putra Anang Kadarsah Anang Kadarsah, Anang Anes Fikri Haekal Angga Praditya Anggraini, Farida Anindya Anindya Anindya, Anindya Anni Nurliani Annisa Halida Husna Annisa Halida Husna, Annisa Halida Aranda, Viren Lolita Ardik Lahdimawan, Ardik Arfan Eko Fahrudin Arganita, Fidya Rahmadhany Ari Yunanto Ari Yunanto Ari Yunanto Arifin Syamsul Arjan Arkasi Arrifah Noer Emma Asdar Gani, Asdar Asnawati Asnawati Assyfa, Nadia Salma Nazwa Aurenada, Syabita Azka Lahdimawan Badaruddin Badaruddin Bahrul Ilmi Bahrul Ilmi Bakhriansyah, Bakhriansyah Bakhriansyah, M. Bambang Setiawan Bambang Setiawan Bambang Setiawan Basir Achmad Budu - Cahyadi, Herry Deni Fakhrizal Denny Margono Denny P.N.H. Margono Denny P.N.H. Margono, Denny P.N.H. Dewi Anggraini Dewi Hariyani Dewi Indah Noviana Pratiwi, Dewi Indah Noviana DEWI SARTIKA Dewi Sri Susanti Dewi, Renie Kumala Diani, Holly Dicky Andiarsa Didik Triwibowo Dita Apriliana Sari Dona Marisa, Dona Donna Marisa Donna Marisa, Donna Edi Hartoyo Edi Hartoyo Edyson Edyson Edyson Edyson, Edyson Edyson, - Efrilia Tanjung Eka Santi Eko Suhartono Eko Suhartono Emmy Sri Mahreda Endah Ayu Rahmadhani Endah Ayu Rahmadhani, Endah Ayu Endah Rusdiana Eria Sartika Erida Widyamala Erlena, Erlena Erliyanti, Emmi Ermina Istiqomah Essy Dwi Damayanthi Fahira, Nurul Savira Faisal, Muhammad Ali Fakhrur Razie Fakhrurrazy Fakhrurrazy Farizka Erianti Farizka Erianti, Farizka Fatimah, Husnul Fatmawati Fatmawati Fauzi, Rahman Fauzi Fauzie Rahman Febrianti, Helma Febriyasy, Fathia Ferdinand Aprianto Tannus Fujiati ., Fujiati Fujiati Fujiati Ganesh, Rajendran Ghazi Mauer Idroes Gunawan Gusti Muhammad Perdana Putera Gusti Muhammad Perdana Putera Gusti Muhammad Perdana Putera Hafifah, Ifa Hafiz Al Farizi Hamrun, Nurlinda Handayani, Rini Hapsari Lintang Sekartaji Hapsari Lintang Sekartaji Hardyan Sauqi Haryati Haryati Haryati Haryati Haudhiya, - Heny Arwati Herawati Herawati Heru Cahjono Husaini Husaini Husaini Husaini Husaini Husaini Husaini Husaini Husaini Husaini Husaini Husna, Hanna Dwi Aprilia Husnul Khotimah Ibrahim, Sayed Ida Yuliana Idroes, Ghalieb Mutig Ika Kustiyah Oktaviyanti Illiandri, Abdullah Oski Insanul Kamilah Ira Nurrasyidah Irham Taufiqurrahman Isa Ansori Isa, Mohamad Iskandar Iskandar Isna Syauqiah Isna Syauqiah Isnasyauqiah, Isnasyauqiah Istiana Istiana Istiana Istiana Iwan Aflanie Izaak Zoelkarnain Akbar, Izaak Zoelkarnain Joneks Aldianto Kabes June Astri Nijka Juniarti, Maya Kadarsah , Anang Kamilah, Insanul Karantika, Ellsa Anggun Kasmasari, Kasmasari Khairan Khairan Khairina Khairina Khairina Khairina, Khairina Khairiyadi Khairiyadi Krisdianto Krisdianto Krisdianto Kusumaningtyas, Prabandari Kusumawardhani, Erna Kusumo, Fitranto Lenie Marlinae Lenie Marlinae Lenie Marlinae Lenie Marlinae Lenie Marlinae Liestiana Indriyati Liling Triyasmono Lisda Hayatie, Lisda Lutfhi Fatah M Irwan Setiawan M Surya Hermawan M. Bakhriansyah, M. Madargerong, Vincentius Adrian Maharani Laillyza Apriasari Mahmudah Marhaeni, Wulandewi Maria Ulfah Maria Yosephine Himawan Martiani Martiani, Martiani Mashuri Mashuri Mashuri Mashuri Mashuri Mashuri Mashuri Mashuri Mashuri, Mashuri Masniah Masniah Maula, Ni’mal Maulana, Aga Maya Juniarti Medyan Riza Meitria Syahadatina Noor Meitria Syahadatina, Meitria Mijani Rahman, Mijani Mirza Maulana Ahmad Mohamad Isa Mohammad Bakhriansyah Mohammad Bakhriansyah Mohammad Rizki Fadhil Pratama Muchamad Arief Soendjoto Muhammad Abdan Shadiqi Muhammad Abdan Shadiqi Muhammad Abdan Shadiqi Muhammad Hafidz MS Muhammad Hendy Arizal Muhammad Hendy Arizal, Muhammad Hendy Muhammad Pahruddin, Muhammad Muhammad Rasyid Ridha Muhammad Rizky Tri Aditya Muhammad Rizky Tri Aditya, Muhammad Rizky Tri Muhammad Topan Widyanto Muhammad Topan Widyanto, Muhammad Topan Multiansyah, Multiansyah Musafaah Musafaah Muthaminah, Noor Muthia Elma Muthmainah, Noor Muthmainah, Noor Nabila Rahman Nadia Eka Pratiwi Nadila, Nadila Nanda Bagus Wibisono Nastiti, Titis Nelly Al Audhah Nelly Al Audhah Nia Kania Nia Kania Niarsari Anugrahing Putri Nikmah, Elok Hikmatun Nila Nirmalasari Nila Nirmalasari, Nila Nindya Tresiana Putri Nisa Nur Agistni Eriana Noer Komari Noor Muthaminah Noor Muthmainah Noor, Ihsan Noor, Meitria Syahdatina Nopi Stiyati Prihartini Nopi Stiyati Prihatini Nova Eka Wondasari Novie Aprianti Novie Aprianti, Novie Novita Hidayati Nugi Maulana Nur Azizah Nur Qamaliah Nur Qamariah Nur Yulia Sari Nur, Radian NURUL HIDAYAH Nurul Hidayah Nurul Salsabila Yasmina Nuryandi Khairunanda Nuryandi Khairunanda, Nuryandi Nusni Nusni Olivia Sari, Devi oni Soesanto Patricia Sator Perdana Putera, Gusti Muhammad Perdana, Muhammad Ricky Pradito, Syaifullah Akbar Prahatama Putra, Aminuddin Prasetio, Rasi Prastricia, Meily Andini Pratama, Muhammad Noor Aditya Pricilia Gunawan H Pricilia Gunawan Halim Prihartini, Nopi Stiyati Purwakaning Agung Purwanto Budi Santosa Putera, Gusti Muhammad Perdana Rahayu, Istuning Puji Rahmiyati Rahmiyati Rima Permata Sari Rinawati Rino Rino Rismia Agustina Rizka Maulida Rizki Amalia Sari Rizki Perdani Rizqi Puteri Mahyudin ROBIATUL ADAWIYAH Rony Riduan Rosalia Friska Ananda Roselina Panghiyangani Rosihan Adhani Rosihan Adhani, Rosihan Ruslan Muhyi Ruslan Muhyi, Ruslan Ruslan Ruslan Salamiah . Salamiah Salamiah Saldy Rizky Saputra Saldy Rizky Saputra, Saldy Rizky Salmon Charles P.T. Siahaan Salmon Charles Pardomuan Tua Siahaan Salmon Siahaan Salsabila, Nur’aien Istiqayani Salsabila, Salsabila Samsul Hadi Samsul Hadi Samsul Hadi Sanyoto, Didik Dwi Sapphira, Nadira Sari, Nur Yulia Sartika, Eria Savira Angelia Sekartaji, Hapsari Lintang Setiawan, Bambang Setiawaty, Endang Silvia Kristanti Tri Febriana Silvia Kristanti Tri Febriana Silvia Kristanti Tri Febriana Siti Arika Bulan Siti Juliati Siti Juliati Soesanto, Bayu Sri Cahyo Wahjono Sri Oktawati, Sri Suciati Suciati Suhastinah, Suhastinah Suhendrayatna Suhendrayatna Sumi Kartika Sunardi Sunardi, Ph.D., Sunardi Supianur, Supianur Susantu Susantu Susilawati Susilawati Susilo, Tanto Budi Syachrumsyah, Muchlisch Syafa’ah, Irmi Syamsiar, Syamsiar Syamsul Arifin Syamsul Arifin Tamtama, Tatang Taupik Rahman Tazkia Safarina Tenri Ashari Wanahari Teuku Rizky Noviandy Trang, Ha Thi Thu Triawanti Triawanti Triawanti Triawanti Triawanti Triawanti Triawanti Triawanti Triawanti Trisnu Satriadi Vini Yulia Anhar Wardani, Hesti Sasmila Warih Anggoro Mustaqim, Warih Anggoro Waty, Marsela Umbar Wenda Fitriati Noor Wenda Fitriati Noor, Wenda Fitriati Wenny Wulandani Wijaya, Herman Wiji Cahyadi Windy Budianto Windy Yuliana Budianto, Windy Yuliana Wiwied Ekasari Wydiamala, Erida Yaliza, Nella Yosef Dwi Cahyadi Salan Yosef Dwi Cahyadi Salan Yuni Yulida Yusanto Nugroho Yuyun Hidayat Zahriah, Zahriah Zairin Noor Zoelkarnain Akbar, Izaak Zuchra Helwani, Zuchra Zulfikar Ali As, Zulfikar Ali

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