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Journal : Science and Technology Indonesia

Oral Immunization with Recombinant Lactococcus lactis and Retinoic Acid Boost Immune Response in Mice Nugroho, Inggil Cahyo; Amalia, Maulida Nisa; Juniardi, Muhamad Rizki; Marhendra, Eunike Berliana; Yanma, Nadifa Almira; Adianingsih, Oktavia Rahayu; Winarsih, Sri; Widodo, Nashi; Yurina, Valentina
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.55-64

Abstract

The COVID-19 vaccine is one of the most important approaches for preventing SARS-CoV-2 virus transmission and spread. Oral vaccines are a promising option for preventing SARS-CoV-2 infection because it can activate both the mucosal and cellular immune systems. Previous research has shown that administering oral and intranasal vaccines can induce an immune response in mice. The effectiveness of the SARS-CoV-2 oral vaccine was evaluated in this study by combining spike protein with a carrier of food-grade recombinant Lactococcus lactis bacteria and a retinoic acid adjuvant. Mice were divided into three groups: a negative control (no treatment), a positive control (L. lactis recombinant), and a third group (L. lactis recombinant plus 300 μg retinoic acid). The vaccines were given three times, with a three-week interval between each. The serum levels of IgG, IgA, and IgE were determined using the ELISA method at the end of the study. CD4 and CD8 cellswere detected using immunofluorescence. While not statistically significant, the results showed that the retinoic acid groups had the highest anti-spike antibody levels of the three groups. In comparison to the control group, CD4 and CD8 cells increased in the spleens of mice given retinoic acid. There was no difference in temperature or IgE levels between vaccinated and non-vaccinated mice, indicating that the vaccine caused no allergic reaction. This study’s findings suggest that retinoic acid adjuvant can stimulate the cellular and humoral immune system.
Co-Authors -, Kusdianti A, Aulanniam Abd. Haris Abd. Rasyid Syamsuri Ade Zakiya Tasman Munaf Adisty Dwi Treasa Ahmad Alim Bachri Ajeng Maharani Putri Akbariyanto, Fahrizal Akhid Yulianto Alfatah, Abu Hasan Alfian Wika Cahyono Alluza, Hamid Hunaif Dhofi Almira, Rehan Amalia, Maulida Nisa Amelia, Putri Nurhidayati Amir, Nayla Nabilla Tahta Avwina Anastasia Shinta Wardhani Andy Soegianto Anggawirya, Arin Mantara Anggita Maharani ANISYAH ACHMAD Ariel, Dio Giovanni Arif Widagdo Arsy Arundina Aulanni'am, Aulanni'am Aulia, Aida Salsabila Ayangsari Cahyaningrum Ayu Nirmala Sari Ayuk Lawuningtyas Hariadini Azzahra, Ika Prima Bambang Rahardjo Burhan, M. Cahyaningtyas, Tita Dwi Cahyono, Alfian Wika Chatarina Umbul Wahyuni Daely, Brian Fo’era-era Danik Agustin Purwantiningrum, Danik Agustin Derisna, Anak Agung Dewi Indiastari DEWI SARTIKA Dhany Efita Sari Diningrat, Diky Setya Dio Giovanni Ariel Doris Noviani Dwi Yuni Nur Hidayati Elfi Anis Saati Ema Dianita Mayasari Ema P. Yunita Ema Pristi Yunita Ema Pristi Yunita, Ema Pristi Erwan, Nabila Erina Eviana Norahmawati Eviana Norahmawati Fachrul Islam, Ruckmana Febriani, Amelia Dwi Fitria Febriliani Putri Fitria Jannatul Laili Florensy Sauhenda, Angla Floriani, Rosalia Frenty Hadiningsih, Eka Frista, Ardaleni Hamid Hunaif Dhofi Alluza Hamida, Maretha Hanif Alamudin Manshur Hanur, Binti Su’aidah Harahap, Novita Sari Hariyani, Tintin Harjoni Harjoni Hasrun, Andi Hastuti, Nur Aini Retno Heidir, Hilwa Hidayah, Eva Nur Huwae, Thomas Erwin C.J I Nengah Kundera Iin Tri Marlinawati Ika Ratnaningrum Insania, Chika Janah, Uzlifatul Juniardi, Muhamad Rizki Kalsumy, Umi Kana Mardhiyyah Karfin Kartika, Bintang Karyono Mintaroem Kesuma, Suryanata Khasanah, Putri Yatun Kinasih, Anggraini Kurotul Aeni Kuswanto Kuswanto Lanlan Muhria Lenggana, Rinaldi Lia Sawitri Loeki Enggar Fitri Louise Panggabean, Helena Maemunah Maemunah Majid, Muhammad Abdul Manuhutu, Natalia Mardhiyyah, Kana Marhendra, Eunike Berliana Marini . Marni Bawawa Marnina Marnina Maulota, Sally Inggrid Mayasari, Ema Dianita Melati Puspita Sari Muchammad Subali Noto Mukaromah, Lisa Aminatul Mukhamad Nooryanto Mukhlisah, Rafikah Munayarokh Munayarokh, Munayarokh Murdiono, Jatmiko Murtiningsih Murtiningsih Musa, Pabali Nabila Erina Erwan Nabilah, Aviana Zuhrotun Narahawarin, Margaretha F Narahawarin, Margaretha F. Nashi Widodo Nikmawati, Nuril Nisa R. Deasury Noorhamdani Novanda, Shabilla Caesar Nugraha, Rivo Yudhinata Brian Nugroho, Inggil Cahyo Nur komalasari Nurhakim Nurhakim Nursodik, Tabah Nurul Istiqomah Oktavia Rahayu Adianingsih Palastri, Aisha Rifda Pande Made Dwijayasa Permana, David Galuh Prawiro, Sumarno Reto Prihannensia, Maydia Purwantiningrum, Danik Agustin Purwati, Ajeng Budi Putri Ardela, Mayasari Putri, Ajeng Maharani Putri, Fitria Febriliani Rahman, Chientya Annisa Rahmani, Nuraida Fara Ratnasari, Aprilya Seruni Retty Ratnawati Ribkha Itha Idhayanti Rinaldi Lenggana Riny Natalina Ririn Handayani Rista, Nadia Rivo Yudhinata Brian Nugraha Rosalia Rusli Sanarto Santoso Sani, Indra Santoso, Putu Adi Santy Monika Saputra, Hendriek Farhan Saputra, Ridwan Cahya Saputra, Wahyu Joko Sari, Nurul Husnah Mustika Sarnita Septiana, Celsy Citra Setyono Yudo Tyasmoro Shafira, Hanna Sijabat, Survey Siti Candra Windu Baktiyani Siti Candra Windu Baktiyani Siti Chunaeni Siti Nurhidayah Sri Andarini Sri Poeranto, Sri Sri Sukasih, Sri Sulistiyani Sulistiyani Sultanah Zahariah Sumarno Reto Prawiro SURYANTI Susanto Nugroho Susanto Nugroho Sutrisno Sutrisno Tamara Gusti Ebtavanny Tatit Nurseta Tatit Nurseta Tatit Nurseta Tatong Harijanto, Tatong Thomas Erwin Christian Junus Huwae Tita Hariyanti Tri Ardyati Tri Yudani Mardining Raras Triana, Salma Ayuning VALENTINA YURINA Wachid, Moch. Wahyuniar Wardhani, Anastasia Shinta Wibowo, Fiska Almayda Widayanti, Isyania Widya, Reta Anggraeni Wirayuda, Rangga Wiyasa, I Wayan Arsana Yanma, Nadifa Almira Yogi Sugito Yohanes Kristantyo Yudhistira Ardana, Yudhistira Yudi Arimba Wani Yulistiani Yulistiani, Yulistiani Zahariah, Sultanah