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Journal : Journal of Multidisciplinary Applied Natural Science

Caesalpinia bonduc (L) Roxb Seed Extract Dosage and Sex Effects on Pathobiological Changes in A Rat Model of Diabetes Mellitus Sopianti, Densi Selpia; Doewes, Muchsin; Sumandjar, Tatar; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita; Nurwati, Ida
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.349

Abstract

Caesalpinia bonduc (L) Roxb is a medicinal plant commonly utilized in traditional Indonesian medicine, particularly for the treatment of diabetes mellitus (DM). This study examined the effects of varying doses C. bonduc extract on fasting blood sugar (FBS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and pancreatic histology in male and female wistar rats with diabetes. The study design included six groups of 18 male and female rats (Wistar strain) each. To develop diabetes, nicotinamide (NA) (110 mg/kg) and streptozotocin (STZ) (45 mg/kg) were supplied, followed by oral administration of C. bonduc extract at dosages of 200, 400, and 600 mg/kg for 21 days. We utilized ELISA to analyze biochemical parameters and employed H&E staining to evaluate histological changes. A factorial design was employed for the statistical analysis to examine the effects of both dosage and sex. This study offers a unique comparative examination of the antidiabetic efficacy of C. bonduc across genders, a dimension seldom explored in experimental diabetes research. The findings indicated that C. bonduc markedly reduced levels of FBS, MDA, TNF-α, and TGF-β (p < 0.05) enhanced the structural integrity of the pancreas. There were no significant differences between males and female (p > 0.05). The dosage and sex influenced MDA and TGF-β. The extract of C. bonduc shown the ability to lower blood sugar, fight free radicals, and reduce inflammation; however, the intensity of these benefits depended on the dosage given. This means that it might assist persons with diabetes minimize oxidative stress and damage to the pancreas.
Co-Authors -, Kartika . Zulfan ?Arub, Lathifah Abd. Rasyid Syamsuri Achmad Arman Subijanto, Achmad Arman Addini, Ragil Aidil Fitriasari Adelita, Sela Putri Adi Prayitno Adita, Kingkin Aditya Nanda Priyatama Afriyanti, Neta Agus Kristiyanto Agus, Yuliana Agus, Yuliana Aini, Zahratul Aisy, Jihan Rohadatul Aisyiyah, Farida Nur Akmala, Jatu Kartika Amalia Choirunnisa Amalia, Ade Amalia, Zuliana Ambar Mudigdo Anak Agung Gede Sugianthara Anggraini, Wella Anik Lestari Annisaa, Salwa Argyo Demartoto, Argyo Ari Natalia Probandari Ari Probandari Arief Nurudhin Arifin Arifin Arwiyantasari, Wida Rahma Astari, Rahmi Windhy Astuti, Fitriyani Dwi Aviandari, Tifa Aziza, Triana Ulfa Nur Azizah, Fikri Dian Dinu Azzahro, Asri Wahyu ‘Arub, Lathifah Bachtiar, Erlangga Yusa Bakrie, Saekhol Bambang Purwanto Baroroh Barir Bhisma Murti Brian Wasita Budhiastuti, Uki Retno Budiastuti, Veronika Ika Bulan Kakanita Hermasari Chatarina Umbul Wahyuni Christanto, Antonius Cynara, Ailsa Clarissa Dania, Samara Rahma Devi Eka Ratnasari Deviasti, Rindra Dewi, Arddha Maha Pawitra Dwi Puspita Dewi, Dian Puspita Dewi, Rizka Amalia Dewi, Rizqa Kartika Dian Handayani Diana Nur Afifah, Diana Nur Diani Octaviyanti Handajani Dilma’aarij, Dilma’aarij Dwi Handayani Dwiantini, Feby Endang Lestari Endang Sutisna Sulaeman Ernawati, Dwi Arini Erynda, Revina Fiandany Fajriyani, Fanny Kartika Fardhiasih Dwi Astuti Fatikhu Yatuni Asmara Firmansyah, Gusti Fathoni Fitria Wulandari Fitriani, Sufia Flora, Viola Holly Gaurinindi, Melinda Febianca Handariati, Atik Handayani, Anggun Fitri Handriani, Winei Haniah, Alfi Zamilul Hanifa, Ainun Hanifah, Ainun Hanifah, Nita Layli Hanifah, Siti Nur Hapsari, Dini Hardilla, Dinda Septiani Hariyadi, Agustin Mahardika Harsono Salimo Harumi, Linda Hastami, Yunia Hernanda R, Annisa Istighfari Hidayah, Siti Shafridha Ida Nurwati Ilma, Nabilah Nurul Indriani, Frida Indriasih, Merlita Indriasih, Merlita Indriastuti, Latty Irfandi, Julhan Jannah, Putri Isriyatil Karim, Muhammad Yusuf Khairunnisa, Lia Khoirunnisa, Luthfiana Nadhiifa Kristiani, Shinta Kumalaningrum, Melda Kurnianingsih, Mayasari Kurrniati, Era Kusumawati, Ima Larasati, Meirina Dwi Lestari, Esti Lestari, Esti Loekito, Cindy Lestyani Luthfiana, Lia Ulfah Luthfianasari, Luthfianasari Luturmas, Antina MAFTUHAH, ATIK Manggandhi, Yuyun Maranata, Maranata Marliana, Wiwit Maryana, Dyan Maryani ., Maryani Maryani Maryani Maung, Yuzana Mawardi, Fitriana Mayaningrum, Yulita Endah Mayarestya, Nita Putriasti Muchsin Doewes Muhammad Rifqi Azhary Mulya Tarmidi, Mulya Mustara, Mustara Mutiara, Bunga Nabilah Nurul Ilma Natalia, Vinda Nawangwulan, Diyah Novia Zuriatun Solehah Novika, Revi Gama Hata Novika, Revi Gama Hatta Novitasari, Isnaini Novitasari, Ratih Nugroho, Dian Nuralita, Ayunda Yonik Nurhayati, Happy Nurindahsari, Yespy Anna Wahyu Nurkholifa, Ferda Fibi Tyas Nursani, Anggia Rahmah Oktaviani oktaviani Oktaviyani, Feny Paramasari Dirgahayu Pawito Pawito Prabowo, Puspita Mayangsari Prasetya, Hanung Primaningtyas, Widana Purnama, Hanif Wildan Putri, Anggi Resina Putri, Azilla Edsa Putri, Diani Fadmi Putri, Dominika Risnanda Alfinsia Qomariah, Nur Laili Rahardjo, Setyo Sri Rahayu, Ria Muji Rahmah Rahmah Ramli, Muhammad Rizaldi Randhita, Amandha Boy Timor Ratih Puspita Febrinasari Ravi Masitah RB. Soemanto Reviono, R Rini, Arum Kusuma Rismawati, Normalia Levi Risna Widowati Risya Cilmiaty, Risya Rita Adriani Benya Adriani Rohaniyati, Retno Dwi Rosid, Sultonnur Rosyidah Alfitri RUBEN DHARMAWAN Rusnoto, R Safitri, Diyanti Sakinah Sakinah Sari, Prafista Wulan Sari, Putri Yunita Selviana, Tasya Ardia Septianawati, Linda Wahyu Setiamika, Made Setiowati, Tri Ayu Setiyarini, Dwi Wahyu Setyo Sri Raharjo Shalih, Ahmad Sabiq Sinta, Prabawati Siti Munawaroh Soetrisno Soetrisno Sopianti, Densi Selpia Sri Darnoto Sri Mulyani Suci Arsita Sari SUGIARTO - Sugiarto S Sulastomo, Heru Sumandjar, Tatar Sumardiyono Sumardiyono suminah ., suminah Suminah Suminah, Suminah Suprapti Suprapti Supriyadi Hari Respati Susanti, Nadya Sutiman Sutiman, Sutiman Syamsiar, Syamsiar Syetiawinanda, Amriansyah Titah Pujangkara, Ajeng Ayu Tri Nur Kristina Triyanta Yuli Pramana Tunurrohmin, Zela Uki Retno Budihastuti Ulhaq, Muhammad Zia Ulul Azmi Zuhaira Ummah, Hafari Fajria Nuril Usmaningrum, Desif Upix Utomo, Asrori Ibnu Vitri Widyaningsih VIVIN EKA RAHMAWATI Wati, Emita Dewi Lilis Angkasa Wayanshakty, Janur Putri Wekadigunawan, CSP Widiyaningrum, Alfiati Nanda Widiyawati, Rina Widyandana Widyandana Widyaningsih , Vitri Widyawardani, Tri Nyantosani Widyawati Widyawati Wulandari, Umianita Risca Yanuari, Ridha Rossela Yanuarini, Triatmi Andri Yuana, Nabila Amartya Yudhani, Ratih Dewi yulia lanti retno dewi Yulia Sari Yusup Subagio Zakiyah, Nisaus Zauma, Luthfia