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Firdawati Firdawati
Andalas University
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Analysis of bile acid in saliva of patients with laryngopharyngeal reflux and non-laryngopharyngeal reflux Ade Asyari; Refi Amalia Utami; Eti Yerizel; Andani Eka Putra; Firdawati Firdawati
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.561

Abstract

ABSTRACT — Background: Laryngopharyngeal reflux (LPR) is the backflow of gastric and or duodenal fluid into the larynx, pharynx, trachea, and bronchi. The prevalence of LPR is difficult to determine due to the limited gold standard and the large variety of LPR symptoms. Damage can occur due to the decrease in pH value and also because of exposure to harmful enzymes in reflux, including bile acid. Purpose : This study was conducted to analyze bile acid levels in the saliva of LPR patient and non LPR subject. Methods:  This study is an observational study with a case-control design. The study was conducted in the ORL-HNS Department of Dr. M. Djamil Hospital, Padang, West Sumatra, Indonesia. The total sample size was 44 people. We enrolled 22 healthy subjects as the control group and 22 patients suspected of having LPR. Result: LPR patients are more common in women than in men, with 12 women and 10 men. Bile acid in the LPR group means of is 25.08±7.67µM, meanwhile, in the healthy group, the mean was 18.99±8.26 µM. There is a statistically significant in the incidence of LPR with the bile acids (p = 0.015) based on t- independent test. Conclusion: Our study confirmed that bile acids in saliva play a major role in diagnosing LPR. 
Co-Authors Abdiana Abdiana Abdiana Abdiana, Abdiana Adang Bachtiar Ade Asyari Ade Rahmadini Adhima Indriyani Adrial Adrial Adrial Adrial Afdal Afdal Afdal, Afdal Afrah, Rahmayani Al Hafiz Aladin Aladin ALADIN ALADIN Amir, Arni Amri, Dudi Andani Eka Putra Anisa Ulfah Antonius, Puja Agung Aprila, Prety Zinta Arde Hidayat Ariadi Ariadi Arni Amir Assyura, Fazhladia Asterina, Asterina Bobby Indra Utama David Perdana Defrin Defrin Defrin, Defrin Delmi Sulastri Deswinda Deswinda Dewi Ayu Ningsih Dia Rofinda, Zelly Dia Dolly Irfandy Dwiesfiza Muharawita Edison Edison Eka Nofita Enda Gusnita Erda Mutiara Halida Erkadius Erkadius Eryati Darwin Esinelya Esinelya Eti Yerizel Eva Decroli Fahmelia, Diva Fauzan F Fauzan Junanda Putra Fiandra, Yudha Fika Tri Anggraini Finny Fitry Yani Genia Alda Fitria Gestina Aliska Gusti Revilla Gustina Lubis Halida Halida Hanum, Fathiya Juwita Hardisman Hasmiwati Helmi Helmi Hendra, Gabriel Septian Hendriani, Berliana Husna Yetti Husni, Lailatul Ida Rahma Burhan Ida Rahma Burhan Ida Rahmah Burhan Iffah, Uliy Ilma Nuria Sulrieni Indah Lisfi Ismul Ismul Laras Surakusuma Laura Suciono Lisma Evareny Lubis, Siska Ilannur M. Fadil Maharani, Rifty Zhafira Mahata, Liganda Endo Marwis Marwis Masrul Masrul Masrul Masrul Masrul Masrul Masrul Masrul Meka Melani Sari Merri Syafrina Miftah Irrahmah Milano, Ryan Suheil Mohamad Reza Muhammad Luthfi Muhammad Zaldy Rasyid Putra Mutiara Miftahul Jannah Nelmi Silvia Netti Suharti, Netti Nice Rachmawati Masnadi Nita Afriani Nizwardi Azkha Nora Harminarti Novizar Nazir Nur Afrainin Syah Nur Indrawati Lipoeto Nurhayati Nurhayati Nurhayati, Nurhayati Nuzulia Irawati Nuzulia Irawati Hasmiwati Oktavia, Mutiara Pom Harry Satria Putri Azzahroh Putri, Biomechy Oktomalio Putri, Viorika Marsafa Rahmadian, Rizki Rahmadini Faricha Hakim Rahman, Andio Ratu Fawwaz Efendi Rauza Sukma Rita Refi Amalia Utami Rina Gustia Rinang Mariko Rizal, Wadratul Jannah Rosfita Rasyid Rosfita Rasyid Russilawati, Russilawati Sakinah Sakinah Salsabila Dhiyaa Syifa Sari, Fitri Yunita Selfi Renita Rusjdi Selian, Rada Almina Siti Nurhajjah, Siti Sri Melda Br Bangun Suradi, Asy Syfa Syandrez Prima Putra Teguh Widodo Tuti Ernawati Ulfa Badri Ulfa Esterina Ulfa Farrah Lisa, Ulfa Farrah Utama, Bobby Indra Vera Pujani Wetra Fauza Wiwit Fetrisia Yanti, Farah Sevnell Yanti, Roza Sri Yantri Maputra Yonariza Yonariza Yosi Aguslida Yulia Fitriani Yulia, Dwi Yulika, Marzatia Yulistini, Yulistini Yulizawati, Yulizawati Yuniar Lestari Yuniar Lestari Yuniar Lestari Zelly Dia Rofinda Zul'afiyati Huwaida