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All Journal HAYATI Journal of Biosciences Humaniora Majalah Kedokteran Bandung Historia: Jurnal Pendidik dan Peneliti Sejarah LITE: Jurnal Bahasa, Sastra, dan Budaya Paramita: Historical Studies Journal Language Circle : Journal of Language and Literature Media Ilmu Keolahragaan Indonesia Althea Medical Journal Majalah Geografi Indonesia Medical Journal of Indonesia Jurnal Kedokteran Indonesia Jurnal Ilmu Sosial dan Ilmu Politik Mozaik Humaniora Jurnal NERS Biomedika Jurnal Sejarah Citra Lekha Jurnal Ilmu Sosial dan Ilmu Politik The Indonesian Biomedical Journal JURNAL ILMU BUDAYA Jurnal Sistem Kesehatan Jurnal Gizi dan Kesehatan Briliant: Jurnal Riset dan Konseptual Al Qodiri : Jurnal Pendidikan, Sosial dan Keagamaan Health Notions Journal of Medicine and Health Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Bina Praja Jurnal SOLMA Bakti Budaya: Jurnal Pengabdian kepada Masyarakat SASDAYA: Gadjah Mada Journal of Humanities Jurnal Keperawatan Muhammadiyah IHiS (Indonesian Historical Studies) Indonesian Journal of Medicine Journal of Maternal and Child Health English Language and Literature International Conference (ELLiC) Proceedings Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Jurnal Ilmu Kedokteran dan Kesehatan Care : Jurnal Ilmiah Ilmu Kesehatan Patrawidya: Seri Penerbitan Penelitian Sejarah dan Budaya Rainbow : Journal of Literature, Linguistics and Cultural Studies YARSI Medical Journal JURNAL ILMIAH MIMBAR DEMOKRASI Jurnal Kesehatan Budi Luhur: Jurnal Ilmu-Ilmu Kesehatan Masyarakat, Keperawatan, dan Kebidanan Jurnal Ners JOSSAE (Journal of Sport Science and Education) Jurnal Riset Akuntansi dan Manajemen Malahayati (JRAMM) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Varia Humanika MAHESA : Malahayati Health Student Journal Narra J Jurnal Telkommil Education and Social Sciences Review Journal of Education Research Indonesian Andrology and Biomedical Journal Proceeding ISETH (International Summit on Science, Technology, and Humanity) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Jurnal Penyakit Dalam Indonesia Physical Therapy Journal of Indonesia Jurnal Pengabdian Masyarakat Kesehatan Indonesia Jurnal Bakti Masyarakat Manajemen Jurnal Kesehatan Metro Sai Wawai Journal of Communication and Public Relations (JCPR) Language Circle : Journal of Language and Literature Midwifery Journal Folia Medica Indonesiana
Bambang Purwanto
Fakultas Ilmu Budaya Universitas Gadjah Mada Yogyakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Narra J

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Aerobic exercise improves spatial memory in a rat model of meningitis Zaidah, Lailatuz; Soetrisno, Soetrisno; Purwanto, Bambang; Kristiyanto, Agus; Wasita, Brian; Widyaningsih, Vitri
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.977

Abstract

Infections of the nervous system, such as acute bacterial meningitis, pose serious health problems that require immediate intervention. In experimental animals, exposure to lipopolysaccharide (LPS) is used to induce meningitis. Aside from drug intervention to reduce inflammation in meningitis, aerobic exercise helps to maintain the regulatory mechanisms of brain homeostasis through anti-inflammatory mechanisms. The aim of this study was to evaluate the effect of aerobic exercise on malondialdehyde (MDA), nuclear factor-kappa B (NF-κB), insulin-like growth factor 1 (IGF-1), endothelial nitric oxide synthase (eNOS), brain-derived neurotrophic factor (BDNF), apoptosis, and spatial memory. A four-week experimental study was conducted using 18 rats, which were randomly divided into three different groups (six rats per group): healthy rats as negative controls (non-meningitis), a treatment group treated with antibiotic treatment (meningitis group), and a third group (aerobic exercise group) treated with antibiotics and aerobic exercise following LPS-induced meningitis. Data were analyzed using a one-way analysis of variance (ANOVA) test, and the comparison between groups used the Bonferroni post-hoc test. The results showed that aerobic exercise significantly reduced MDA (p<0.001), NF-κB (p=0.035), and apoptosis (p=0.020) while increasing the serum levels of IGF-1 (p<0.001), eNOS (p=0.011), and BDNF (p=0.001) levels. Improvement in spatial memory was significant in the aerobic exercise group (p<0.001). This study suggested that aerobic exercise could be a promising adjunct therapy in meningitis management strategies, particularly due to its effect on improving spatial memory. Further clinical trials are needed to confirm these findings for clinical use.
Impacts of Phyllanthus niruri extract on biomarker levels, macrophage count, and lesion area in an endometriotic rat model Wulandari, Eka T.; Soetrisno, Soetrisno; Purwanto, Bambang; Reviono, Reviono; Wasita, Brian; Laqif, Abdurrahman
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1002

Abstract

Endometriosis is a gynecological disorder characterized by chronic inflammation, anatomical changes, prolonged pain, and infertility. On the other hand, Phyllanthus niruri is recognized for its pharmacological effects, which might be beneficial in managing endometriosis. The aim of the study was to investigate the pharmacological effects of P. niruri as a potential therapy for endometriosis by using an animal model. An experimental laboratory study with randomized, controlled trial, pre-test, and post-test design using 40 female Wistar rats (Rattus norvegicus) was conducted at the Integrated Research and Testing Laboratory (LPPT) of Universitas Gadjah Mada, Yogyakarta, Indonesia, from February to June 2023. Endometriosis was induced in female Wistar rats by suturing a 0.5 cm2 flap from the uterine horn to the peritoneal cavity. Changes in serum interleukin 1β (IL-1β), malondialdehyde (MDA), and matrix metalloproteinase 9 (MMP-9), before and after the treatment, were analyzed using enzyme-linked immunosorbent assay. Hematoxylin and eosin (HE) staining were used to evaluate lesion size and macrophage quantity. The results suggested that the P. niruri extract with a dose of 196 mg/200 g body weight (BW) could significantly attenuate serum IL-1β (p=0.004), MMP-9 (p=0.021), and MDA (p=0.021). Rats receiving the P. niruri extract (196 mg/200 g BW) had significantly higher macrophage counts (p=0.003), but similar lesion area (p=0.093) as compared with the negative control. In conclusion, P. niruri demonstrated promising therapeutical effects on endometriosis by modulating IL-1β, MDA, and MMP-9 levels, although the effect was not pronounced on macrophage counts and lesion area.
Effect of walking and bone joint exercise on enhancing bone remodeling in menopausal women: A randomized controlled trial Pasa, Chusairil; Pamungkasari, Eti P.; Doewes, Muchsin; Purwanto, Bambang; Hartono, Hartono; Cilmiaty, Risya; Dirgahayu, Paramasari
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1321

Abstract

Osteoporosis increases fracture risk and reduces quality of life in menopausal women. Although physical activity, such as walking and bone joint exercise, is known to help maintain bone health, its effectiveness needs further examination. The aim of this study was to analyze the effects of physical activity, in particular walking and bone joint exercise, on enhancing bone remodeling in menopausal women. A randomized controlled trial was conducted among menopausal women and allocated into three groups: walking, bone joint exercise, and control groups. The intervention was provided for eight weeks, with the outcomes measured before and after the intervention. The study assessed five bone remodeling biomarkers: estrogen, parathyroid hormone (PTH), receptor activator of nuclear factor kappa-β ligand (RANKL), tumor necrosis factor-alpha (TNF-α), and bone mineral density (BMD). The paired sample student t-test and ANOVA were used to assess the effects of the interventions. The results indicated that, compared to pre-intervention, both walking and bone joint exercise significantly increased the estrogen (p=0.026 and p=0.023, respectively), decreased RANKL (p=0.019 and p=0.002, respectively), decreased PTH levels (p=0.022 and p=0.048, respectively) and increased the BMD scores (p=0.001 and p<0.001, respectively). In the control group, none of the remodeling biomarkers significantly changed except the mean level of TNF-α, which was increased significantly (p=0.001). This study highlights that structured exercise, such as walking and bone joint exercise, can significantly enhance bone remodeling markers in menopausal women. Therefore, implementing such physical activities into management may provide benefits to menopausal women.
Effects of Moringa oleifera extract on inflammaging markers, muscle mass, and physical endurance in geriatric mice model Budiningsih, Fatichati; Purwanto, Bambang; Wasita, Brian; Poncorini, Eti
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2052

Abstract

A comprehensive approach to managing frailty is required due to the increasing number of elderly. Physical frailty, associated with inflammatory processes and a loss of muscle mass, can significantly impair health status. The aim of this study was to determine the effect of Moringa oleifera Lam. leaf extract on frailty in geriatric mice model. An experimental study was conducted using a post-test-only control group design using  Mus musculus Balb/C mice aged eight weeks. The animals were divided into five groups: negative control group received intraperitoneal injections of normal saline (0.5 cc/day) for eight weeks, positive control group received D-galactose (150 mg/kg body weight (BW)/day) only, and three treatment groups treated with 150 mg/kg of D-galactose intraperitoneally for eight weeks followed by 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW of M. oleifera leaf extract orally for five weeks. At the end of the study, the blood levels of malondialdehyde (MDA), transforming growth factor-beta (TGF-β) and caspase-3, as well as caspase-3 expression in skeletal muscle, skeletal muscle mass fibrosis, and physical endurance were measured. The results showed that a dose of 400 mg/kg/day of M. oleifera leaf extract had the most significant effect on lowering MDA, TGF-β, and caspase-3 expression in skeletal muscle tissue, skeletal muscle fibrosis, and improved physical endurance compared to other groups (p<0.001). This study highlights that M. oleifera leaf extract reduced frailty in geriatric mice model-induced using D-galactose by reducing inflammaging factors, thereby improving physical endurance.
Co-Authors A.A. Ketut Agung Cahyawan W AA Subiyanto, AA Abdul Wahid Abdurachman Abdurachman Achmad Munjid Adam James Fenton Adi Prayitno Agung Dinasti Permana Agung Dwi Nurcahyo Agus Kristiyanto Agustina Indri Hapsari Agustinus Agustinus Ahmad Abdullah Ahmad Fikri Akbar, Idzam Kholid Ali Djamhuri Aliyanto, Warjidin Anandani, Esti Tantri Andri Rezano Andriati Andriati Angguntur, Wayan Anindita, Rahma Ansyori, Ansyori Arif Akhyat, Arif Arsyad, Mehmek Ali Akza Arya H Dharmawan Assegaf, Aswin Rizal Atik Swandari, Atik Atika Atika Atmoko, Warigit Dri Ayu Kusuma Dewi Ayubi, Novadri Azhari Muslim Baehaqi Bambang Wirjatmadi Bogi Soeseno Brian Wasita Budi Susetyo Pikir Budianto, Pepi Budiningsih, Fatichati Budiyanti Wiboworini Damayanti Tinduh Damsir, Damsir Deden Kamaludin Dedi Irwanto Dewi Purwaningsih Dewi, Dinda Luciana Diah Kurnia Mirawati Didik Prasetyo Didik T Subekti Diding Heri Prasetyo Dindy Samiadi Djaja Hendra Djoko Suryo Djoko Suryo DODY KURNIAWAN Dono Indarto Dwi Purwanti Dwi Putra, Kartika Wahyu Dwilda, Euvanggelia Edy Mintarto, Edy Elyana Asnar Eman Sulaiman, Eman Endriatmo Soetarto Endyka Erye Frety Erna Listyaningsih Erwanda, Setrian Eti Poncorini Pamungkasari Fachrudin, Irfan Farabi Fakih Faruk Fatma Hetami Febrina, Irma Ferizal Masra Giani, Maia Thalia Gusliana, Ali Hadi Sabari Yunus Hambarsari, Yetty Hamidi, Baarid Luqman Handini, Haspita Rizki Syurya Hari Setijono, Hari Hariyanto, Budhi Hariyanto, Olivia Ramadhanty HARJANTO HARJANTO Hartono Hartono Hendy Hendarto HERAWATI, LILIK herdianty kusuma, herdianty Heri Dwi Santoso, Heri Dwi Herinanto, Dwi Herlina, Intan Hutabarat, Ervina Arta Jayanti I Gde Raka Widiana Ida Liana Tanjung Ida Nurwati Iing Lukman Indriani, Wiewiek Irwadi, Irfiansyah Isa Mahfudi Issy Yuliasri Istikomah, I I’tishom, Reny Jatmiko Susilo Jayawarsa, A.A. Ketut Jongky Hendro Prajitno Karbito Karbito, Karbito Ketut Suega Kumara, Kusuma Arum Diana Kusnanto Kusnanto Kusumawati, Made Dian La Ode Rabani Laqif, Abdurrahman Larasati, Amilia Putri Lina Lasminingrum Linda Barus Mangesti, Rini Dwi Maria Johana Ari Widayanti Maryono, Sumardi Maryono, Suradi Ma’sumah, Fithriyatul Melati Sudiro Mentari Merryana Adriani Mesah, Winny Misbakhul Munir Miswan Gumanti Muchsin Doewes Muhammad Rifqi Muhammad Zainal Arifin, Muhammad Zainal Muhammad Zaki Pahrul Hadi Muhammad, Faizal Muhammad, Muaz Muhimatul Ifadah Mutiah Amini Nanda Fadhilah Witris Salamy Ni Wayan Winarti Novita Damayanti Nugroho, Ardi Setyo Nuha, Putri Ulin Nur Aini Setiawati Nur Aini Setyawati Nur Inayah Nur Shani Meida Nur, Nahdia Nurinasari, Hafi Olivia Cindowarni Padhil Hudaya Pamungkasari, Eti P. Pandu Putra Harsarapama, Pandu Putra Pangesti, Devia Regita Paramasari Dirgahayu pasa, chusairil Paulus Kusnanto Paulus Liben, Paulus Poernomo, Gigih Rahmadanu Poncorini, Eti Prabaningtyas, Hanindia Riani Pradana, E Pramesti, MPBD Pranadyan, Rizki Pratama, Yuan Guruh Pratiwi, Wahyu Nur Prayuda, Prayuda Priaminda, M Dodi F Priatmojo, Arif Suryo Pryla Rochmahwati Pudji Lestari Purnama, Siswanta Jaka Purwani, Deni Purwoto, Septyaningrum Putri Putranto, Wachid Putri, Arum Cahyaning Rachmat Setiawibawa Rachmawati, Anindita Rachmi Fauziah Rahayu Raden Mohammad Budiarto Rahmi Syarifatun Abidah, Rahmi Syarifatun Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Rejeki, Purwo Sri Reviono Reviono RINA YUDIWATI BM, RINA Ristinawati, Ira Risya Cilmiaty, Risya Rivan Danuaji Rohaeni, Rohaeni Rosida, Silvi Dina Rosita, Hanna Eka Rosyidi, Mohamad Ikhwan Rudi Hartono Ruliyandari, Rochana S, Gadis Meinar S.Pd. M Kes I Ketut Sudiana . Sa'adi, Ashon Sajidan Salimah, Kun Sally Mahdiani Sandhi Cahyani, Maria Benedictin Saputro, Yosia Puri Sari, Gadis Meinar Seful Bahri Senyum Indrakila Septian, Muhammad Raditia Setiabudi, Narendra Arya Setiadi, Hafid Setyawan, Ravinda Dharma Shinta Nurmasari Siahaan, Paulus Parholong Siam, Rambu Nurul Simanjuntak, Nela Soetrisno Soetrisno Soetrisno Soewondo, Widiastuti Sri Margana Sugiarto S Sukiman, Djoko Sulistiawati Sulistiawati SUROTO Susanto, Agung Susanto, Tri Hardi Suseno, Aryo Susiana, Okta Margarita Syafardan, R.M. Doni Syetiawinanda, Amriansyah Tedjo, Raden Andi Ario Tejomukti, Teddy Teti HS Madiadipoera Thaufiq S. Boesoirie Tonang Dwi Ardiyanto, Tonang Dwi Uji Nugroho Winardi Utami, Bernadhita Herindri Samodera Utami, Tri Setyo Vitri Widyaningsih Wahyuni, Ardianti Wasngadiredja, Pupu Fujriani Wibi, Bagas Ardytyan Wibowo, Diki Prayugo Widjiati Widjiati, Widjiati Wildan Sena Utama Woro Setia Ningtyas Wulandari, Eka T. Wuryanti, Lestari YANTO YANTO Yenny Kandarini Yoda, Vincensius Arga Yuliawati, Tri Hartini Yuniarto, Haryono Yussy Afriani Dewi Zaidah, Lailatuz