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Journal : Narra J

Acceptance and willingness to purchase a hypothetical COVID-19 vaccine in a region under Shariah law: A cross-sectional study in Aceh, Indonesia Rayhan, Muhammad A.; Mudatsir, Mudatsir; Nurjannah, Nurjannah; Ichsan, Ichsan; Amir-Behghadami, Mehrdad; Khader, Yousef S.; Koyanagi, Ai; Sah, Ranjit; Viveiros-Rosa, Sandro G.; Mamun, Mohammed A.; Lemu, Yohannes K.; Bouchra, Assarag; Linguissi, Laure SG.; Ikram, Aamer; Sallam, Dina E.; Parperis, Konstantinos; Wollina, Uwe; Rademaker, Marius; Vento, Sandro; Usman, Said
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.85

Abstract

Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to determine the acceptance of and willingness to purchase a hypothetical COVID-19 vaccine in the general population of Aceh, a holistic Shariah law implementation province in Indonesia. An online cross-sectional study was conducted using a quota sampling technique between 1 to 24 September 2021. To determine hypothetical vaccine acceptance, respondents were asked if they were willing to accept vaccines with combinations of either 50% or 95% effectiveness and either 5% or 20% risk of adverse effects. Willingness to purchase was assessed by asking whether the participants would pay for such vaccines at certain price points. Logistic regression analysis was used to assess the associated determinants. Out of 377 respondents included in the final analysis, 86.5% were willing to accept a COVID-19 vaccine with 95% effectiveness and 5% adverse effects. The acceptance rate dropped to 45.1% if the risk of adverse effects was 20%. Vaccines with 50% effectiveness and 5% adverse effects were acceptable to 42.2% but the acceptance went down to 17.2% if the risk of adverse effects increased to 20%. Multivariate analysis found that men were twice as likely to accept a vaccine with 95% effectiveness and 5% adverse effects compared to females (aOR: 2.01; 95% CI 1.05–3.86). We found that 156/377 (41.3%) of respondents were willing to purchase a COVID-19 vaccine and of these participants 71.1% were willing to pay between Indonesian Rupiah (IDR) 50,000–150,000 (US$ 3.33–10.00). In conclusion, the acceptance rate of a hypothetical COVID-19 vaccine varied based on effectiveness and the risk of adverse effects.
Risk factors of MDR-TB and impacts of COVID-19 pandemic on escalating of MDR-TB incidence in lower-middle-income countries: A scoping review Ichsan, Ichsan; Redwood-Campbell, Lynda; Mahmud , Nissa N.; Dimiati, Herlina; Yani, Muhammad; Mudatsir , Mudatsir; Syukri, Maimun
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.220

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is affecting tuberculosis (TB) treatment in many ways that might lead to increasing the prevalence of multi-drugs-resistance tuberculosis (MDR-TB), especially in lower-middle-income-countries (LMICs). This scoping review aimed to identify the risk factors of MDR-TB and to determine the impacts of the COVID-19 pandemic on MDR-TB prevalence in LMICs. This study was reported according to the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) guideline. The relevant keywords were used to search studies in three databases (PubMed, ScienceDirect and SpringerLink) to identify the related articles. The English-written articles published from January 2012 to December 2022 that explored risk factors or causes of MDR-TB in LMICs were included. Out of 1,542 identified articles, 17 retrospective, prospective, case-control and cross-sectional studies from ten LMICs met were included in this scoping review. Twenty-one risk factors were discovered, with prior TB treatment (relapsed cases), diabetes, living area, living condition, smoking and low socioeconomic status were the main factors in developing MDR-TB during COVID-19 pandemic. The pandemic increased the MDR-TB prevalence through drug resistance transmission inside households, the distance between home and healthcare facilities and low socioeconomic status. This scoping review demonstrates how the COVID-19 pandemic has affected the rising incidence of MDR-TB in LMICs.
Comparative study of anti-SARS-CoV-2 receptor-binding domain total antibody titer before and after heterologous booster with mRNA-based COVID-19 vaccine Kamil, Qatrunnada; Putri, Widia; Ayulinda, Arianisah P.; Maelani, Imelda; Anwar, Samsul; Ichsan, Ichsan; Pranata, Agung; Mudatsir, Mudatsir; Syukri, Maimun; Rizal, Samsul; Kurniawan, Rudi; Sofyan, Sarwo E.; Harapan, Harapan
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.788

Abstract

The waning immunity following the COVID-19 vaccination become a significant concern and the immunological dynamics of vaccine-induced antibodies after vaccination need to be explored. The aim of this study was to compare anti-SARS-CoV-2 receptor-binding domain (RBD) antibody levels before and after a booster dose with heterologous COVID-19 vaccine and to identify factors influencing the levels after receiving the booster dose. A cross-sectional study was conducted in which individuals who received primary doses of CoronaVac and a booster dose with an mRNA-based vaccine were recruited using a purposive sampling technique. The titers of anti-SARS-CoV-2 RBD antibodies were measured using an enzyme-linked immunosorbent assay (ELISA), and plausible associated factors were collected using a questionnaire-assisted face-to-face interview. The Wilcoxon test was used to compare the titers before and after the booster dose, while the Kruskal-Wallis and Mann-Whitney tests, followed by multivariate linear regression, were used to assess the factors associated with RBD total antibody titers. The results showed that there was a significant increase of anti-SARS-CoV-2 RBD total antibody titers before and after receiving the booster dose (1,558.7 BAU/mL vs 140.6 BAU/mL, p<0.001). The analysis revealed that age (p=0.555), sex (p=0.254), type of vaccine (p=0.914), presence of hypertension (p=0.541), diabetes (p=0.975), chronic obstructive pulmonary disease (COPD, p=0.620), and gout (p=0.364) were not associated with anti-SARS-CoV-2 RBD total antibody titers. However, the titers of anti-SARS-CoV-2 RBD total antibody were significantly different between those with and without hyperlipidemia (p=0.021). This study suggests that a booster dose with a heterologous COVID-19 vaccine could significantly enhance immune responses against COVID-19, and therefore, this strategy may be recommended as part of preventive measures to strengthen immunity against COVID-19.
Co-Authors Abbas, Damanhur Abdul Hadi Abdun Nasir, Muhammad Fikri Adi Hermansyah, Adi Adi Marjani, Adi Marjani Afnan, Afnan Agung Pranata Agus Hendra Al Rahmad Al Azhar Alam, M. Syahrul Qhodi Alamin, Nurul Alfian G. M, Aji Alfridsyah Alfridsyah Aliyah, Hikmatul Aliyah, ambartiasari, Geta Amir-Behghadami, Mehrdad Ampera Miko Andi Bustan Didi Andian, Andian Andini, Enjelin Okta Annisyaa', Nur Aprih Santoso Aprilisia, Sanju Ardian Ardian Arief Boediono Arief, Abdul Samad Arif Saefudin Arnawan Hasibuan Assingkily, Muhammad Shaleh Aulia, Muhammad Ghozil Aurillia, Silvianda Ayulinda, Arianisah P. Bahrun Bahrun Bintoro, Yudha Bouchra, Assarag Budiarti, Novita Bulkaini (Bulkaini) Cakranegara, Pandu Adi Chalirafi, Chalirafi D, Damanhur Damanhur, Damanhur Danyl Mallisza Darmawan Daud, Muslem Debi Masri Deby Anggraini, Deby Desi Astuti Dewi Maya Sari Dewi, Anjar Kusuma Dewi Dini Rahmawati Djoko Kisworo Dodi Iskandar, Dodi Dody Radiansah, Dody Radiansah Eisenring, Moh. Abraham Akbar Elha Rimah Dani, Dita Elia, Elia Enny Yuliani F, Falahuddin F, Fuadi Fadila, Utin Triyana Fajarrini, Arsyia Fauzul Hakim Hasibuan, Ahmad Febiyanto, Angga Febtysiana, Nur Fajar Febyarum, Lintang Fendy Yogha Pratama Fikriyah, Adela Tsamrotul Fitriani, Ari Deca Fuadi Fuadi Fuadi Hakim, A’us Arief Ikhwani Handayani, Mila Sri Harapan Harapan Harianti, Putri Hasibuan, Ahmad Fauzul Hakim Heikal, Mohd. Hendy Tannady Henny Purnama Dewi Herlina Dimiati, Herlina Herri Mahyar Heruwansah, Heruwansah Hijri Juliansyah Hillary, Janne Hilmi Hilmi Ida Nurhaida Ikram, Aamer Imran, Herry Irma Suryani Jayawarsa, A.A. Ketut Jhon Rinaldo Kamil, Qatrunnada KARTINI ERIANI Khader, Yousef S. Khairisma, Khairisma Khamaludin, Khamaludin Kharisma, Kharisma Khasanah, Yuli Nur Khasanah, Yuli Nur Khazanah, Wiqayatun Koyanagi, Ai La Iba, La Larisu, Zulfiah lbs, Freddy Hermansyah Lemu, Yohannes K. Lestari Lestari Linguissi, Laure SG. Lubis, Hikmah Adelia Zuhri M, Munandar Maelani, Imelda Mahdalena, Sonia Santa Mahmud , Nissa N. Maimun Syukri, Maimun Mamun, Mohammed A. Maria Ulfa Marjani, Adi Masruri Masruri Mauliza, Mauliza Meilasari, Devi Mela, Lita Mela Mila Hasanah Moch, Rully Mohamad Agung Rokhimawan Muammar Khaddafi Mudatsir , Mudatsir Mudatsir Mudatsir Mufalakhah, Kurnia Muflihah Ramadhia Muhammad Daud Muhammad Nur, Mukhlis Muhammad Rajab Muhammad Yani, Muhammad Munandar Munandar Munardi Murtala, Murtala Mustofa, Fuadul Musyaffa, A A Muzayanati, Apriliyanti Najol, Priska Vivinda Nashi Widodo Nazimah Nazimah Nilahayati Ningsih, Putri Dewi Fitria Ningtyas, Mustika Wati Alfia Novita Loka Nugraha, Ardi Maulana Nunung Sri Mulyani Nur Anisa Nur Munajat, Nur NURHASNAWATI NURHASNAWATI Nurjannah Nurjannah Nurkhasyanah, Alfiyanti Nurmalita Sari, Dina Nurramadani, Lilia Nursanti, Risa NURUL AZIZAH NURUL HIDAYAH Pahimah, Nurul Parperis, Konstantinos Permatasari, Lina Perwitasari, Erni Pratiwi Phanichharath, Samoth Prihatin, Ayu Umi Puspitaningrum, Rani Putri, Hesty Pradita Putri, Luqyana Azmiya Putri, Widia Putro, Khamim Zarkasih Rademaker, Marius RADIANSAH, DODY Rahmadana, Jati Rahmawati, Rahmawati Rayhan, Muhammad A. Redwood-Campbell, Lynda Rico Nur Ilham Ridani Alifah, Syarifah Rifai, Ikhsan Rifkiya, Adiba Rini Handayani Rizkia, Rini Rizkiyah, Maulidah Rohim, Fahmi Rollando, Rollando Rosyidi, A. Rozalina, Rozalina Rozalina Rudi Kurniawan Safrizal Safrizal Sah, Ranjit Sallam, Dina E. Samsul Anwar Santosa, Sedya Santosa, Tomi Apra Saragih, Negi Prianda Sari, Putri Sekar SEFRIYANTI, SEFRIYANTI Septiaji, Muhammad Haryo Sesario, Revi Sholihah, Nafi’atus Sibawaihi Sibawaihi Sigit Somadiyono, Sigit SILMI MARIYA Siregar, Muhammad Randha Siregar, Widyana Verawaty Siti Aisyah Siti Nurjannah Siti Nurjannah Sofyan, Sarwo E. Srinawati, Wawat Sugiono Sugiono Sujani, Elfara Hajjar Sukma, Hanum Hanifa Sulastri, Susi Supardi, R Suryati Suryati Susatyo Adhi Pramono, Susatyo Adhi Susianto, Tri Endar Sutiye, Sutiye Suyadi Suyadi Syauki, Ahmad Th. Candra Wasis Agung Sutignya Togatorop, Angelina Ulfa, Nadia Ulya, Nadiya Umairoh, Siti Umairoh, Siti Usman, Said Vensy Vydia Vento, Sandro Viveiros-Rosa, Sandro G. Wahdini, Wahdini Warsito Warsito Wartinah Wartinah Wasis, Th. Candra Wasis, Thomas Candra Winarti Winarti Wollina, Uwe Wulandari, Rizki Isma Yadi Ardiawan Yayat Suharyat Yuhan, Ulfatul Yuli Setianto, Akbar Yuliansyah, Hafidz Yulianti, Junari Yulius Dharma Yupinus, Lusius Yusrizal Yusrizal Zainuddin Harahap Zulfahmi Zulfahmi Zulyusri Zulyusri