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Comparison of Antropometry and Physical Abilities between Trained and Untrained Individuals in Second Growth Phase Akbar, Idzam Kholid; Purwanto, Bambang; Setijono, Hari
Folia Medica Indonesiana Vol. 55, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Evaluations on Plasma Prothrombin Time (PPT) and Activated Partial Thromboplastin Time (APTT) are required in patients with Chronic Kidney Disease (CKD) stage V to determine the risk of bleeding after hemodialysis (HD) using heparin as the anticoagulant. This study aimed to compare the results of PPT and APTT in pre and post-hemodialysis patients with minimum dose of heparin. This was an observational-analytical study with cross-sectional design. The samples were collected in HD wards of Dr. Soetomo Hospital, Surabaya. There were 50 PPT and APTT samples collected from June to August 2017. The samples were evaluated using the tool CoaDATA 501. The examination of coagulation study was conducted in Clinical Pathology Laboratory of Dr. Soetomo Hospital, Surabaya. Paired t-test and Wilcoxon signed-rank test were performed in this study. In the 50 samples, pre-hemodialysis PPT ranged between 10.2-17.6 with the mean of 12.6±2.03 seconds, while for post-hemodialysis, the range was 10.1-20.9 with the mean of 13.41±2.43 seconds. Pre-hemodialysis APPT ranged between 19.5-75.2 with the mean of 30.32±10.43 seconds, while in post hemodialysis the range was 22.21-175 with the mean of 37.52±26.40 seconds. The results of PTT evaluation in pre and post-HD showed no significant difference (p=0.083), while those of APTT showed a significant difference (p=0.035 or p<0.05). Prolongation of APTT in post-HD is due to the use of heparin as an anticoagulant that increases PPT and APTT by inhibiting antithrombin III. HD procedures cause decreased activity of coagulation factors II, IX, X, XII leading to APTT prolongation in post-HD. A significant APTT prolongation was found in post-HD patients with CKD V.
Shoe insole for eccentric activities on daily application prevents muscular damage and improves fasting blood glucose Abdullah, Ahmad; Kusuma, Herdianty; Asnar, Elyana; Purwanto, Bambang
Folia Medica Indonesiana Vol. 53, No. 4
Publisher : Folia Medica Indonesiana

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The eccentric contraction has been proven to improve Glut-1 expression in muscle and fasting glucose levels in mice. The same eccentric contraction occurs in human being when walking or running while wearing high heels. Innovation on the eccentric contraction with high heels can be done by using a specific shoe insole. The design of the rear insole is made thicker than the front. The purpose of this study was to determine the effects of insole use specified for eccentric activities on daily work shoes on the skeletal muscle damage after wearing the specified insole. Skeletal muscle damage was measured based on sTnI level. This was experimental study with pretest-posttest design. The subjects involved were non-diabetic woman workers in Faculty of Medicine of Universitas Airlangga, and were divided into two groups. Each group represented group members who wore 5-degree and 10-degree insoles respectively. The angle used for the shoe insoles were 5° and 10° respectively. These insoles were worn on weekdays for one week. Blood was taken one day after the subjects stop wearing the insoles. Data results showed that the levels of fasting blood glucose (FBG) of subjects who wore the 10-degree insole had a value of p<0.05. The use of insole lead to decreased levels of fasting blood glucose (FBG). This study found that the sTnI levels in the 5-degree and 10-degree insole groups had no significant effect on troponin I skeletal muscle levels before and after treatment.
Glut-1 is a promising target for atp depletion on diabetic energy deficiency syndrome Purwanto, Bambang; Harjanto, Harjanto; Asnar, Elyana
Folia Medica Indonesiana Vol. 53, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.
Nanocurcumin Enhances Antioxidant Defense through GPx Upregulation in Ovarian Granulosa Cells of Endometriosis Mouse Model Handini, Haspita Rizki Syurya; Hendarto, Hendy; Purwanto, Bambang; Widjiati, Widjiati
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3846

Abstract

BACKGROUND: Endometriosis impairs female reproductive function through oxidative stress and apoptosis, reducing oocyte quality and causing infertility. Current therapies are limited by suboptimal efficacy and side effects, including ovulation suppression. Curcumin offers antioxidant and anti-inflammatory benefits but has low bioavailability and poor solubility, which can be improved through nanoparticle formulation. Although nanocurcumin is suggested to act through multiple pathways, its mechanisms remain unclear. This study was conducted to evaluate the antioxidant and anti-apoptotic effects of nanocurcumin in a mouse model of endometriosis.METHODS: Thirty-five mice were allocated into five groups and induced to develop endometriosis using cyclosporine A, ethinyl estradiol, and human endometrial tissue. Nanocurcumin was formulated at three particle sizes (3.71; 3.98; and 25.60 nm) and administered orally at doses of 50, 100, or 200 mg/kg/day for 14 days. After treatment, the mice were euthanized, and ovarian tissues were collected for immunohistochemical analysis of glutathione peroxidase (GPx) and B-cell lymphoma-2 (Bcl-2) expression.RESULTS: The highest GPx expression was observed in the group receiving 50 mg/kg/day nanocurcumin (mean±SD= 6.31±1.97; p=0.042). The lowest expression of Bcl-2 was observed in control group with no treatment (mean±SD=4.15±2.48; p=0.582). Nanocurcumin administration significantly increased GPx expression in a dose-dependent manner compared with the untreated group, while no significant differences were found in Bcl-2 expression.CONCLUSION: Nanocurcumin increases GPx expression, particularly at 50 mg/kg/day, indicating its potential as an antioxidant in reducing oxidative damage associated with endometriosis. However, nanocurcumin did not significantly influence Bcl-2 expression. These findings support nanocurcumin’s role as an effective antioxidant agent in protecting ovarian granulosa cells in endometriosis.KEYWORDS: nanocurcumin, GPx, Bcl-2, endometriosis, granulosa cells
The Effect of Prenatal Yoga on The Intensity of Lower Back Pain Among Third-Trimester Pregnant Women: A True-Experimental Study at Namlea Community Health Center Mentari; Frety, Endyka Erye; Dwilda, Euvanggelia; Purwanto, Bambang
Jurnal Kesehatan Budi Luhur: Jurnal Ilmu-Ilmu Kesehatan Masyarakat, Keperawatan, dan Kebidanan Vol. 18 No. 2 (2025): July 2025
Publisher : STIKes Budi Luhur Cimahi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62817/jkbl.v18i2.480

Abstract

Background: Low back pain is common among pregnant women, particularly in the third trimester, and is mainly associated with physiological changes, including hormonal fluctuations affecting connective and supportive soft tissues, leading to reduced muscle flexibility and elasticity. Pain management during pregnancy involves pharmacological and non-pharmacological approaches, with this study focusing on prenatal yoga as a non-pharmacological intervention. Objective: To examine the effect of prenatal yoga on reducing the intensity of low back pain in women during the third trimester of pregnancy. Methods: This study employed a true experimental pretest–posttest control group design with 32 samples equally assigned to an intervention group (n = 16) and a control group (n = 16). The intervention was conducted four times over two weeks, with each session lasting 30–60 minutes. Data were collected using a structured checklist and the Numeric Rating Scale (NRS). Statistical analysis used the Wilcoxon signed-rank test and the Mann–Whitney U test. Results: The prenatal yoga group demonstrated a statistically significant reduction in low back pain intensity following the intervention (p = 0.001), with mean pain scores decreasing from 2.00 to 1.29, indicating a mean difference of 0.71. In contrast, the pregnancy gymnastics group showed a smaller reduction, with mean scores declining from 2.06 to 1.82, yielding a mean difference of 0.24. Between-group analysis confirmed a statistically significant difference in pain intensity (p = 0.001). Conclusion: Prenatal yoga significantly reduces the intensity of low back pain in women during the third trimester of pregnancy.
Gambaran Penerapan Perilaku Hidup Bersih Dan Sehat Ditatanan Rumah Tangga Pada Penderita Diare Damayanti, Novita; Masra, Ferizal; Barus, Linda; Purwanto, Bambang
MIDWIFERY JOURNAL Vol 5, No 4 (2025): Volume 5 No 4 Desember 2025
Publisher : Universitas Malahayati Bandar Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mj.v5i4.24164

Abstract

ABSTRACT: Clean and Healthy Living Behavior among Diarrhea Patients in the Labuhan Ratu Working Area, Bandar Lampung City in 2024Background: Diarrhea is an environment-based disease caused by infections, including bacteria and viruses, and is commonly transmitted through the fecal–oral route. Diarrhea can affect all age groups, including toddlers, children, and adults from various social backgrounds. It is characterized by defecation with a more liquid stool consistency than usual, occurring three or more times within a 24-hour period.Objective: This study aimed to describe the availability of clean water, handwashing with soap (HWWS) habits, and the use of healthy latrines in the Labuhan Ratu working area, Bandar Lampung City, in 2024.Methods: This study employed a descriptive research design, which aimed to objectively describe a situation. The study focused on identifying and describing Clean and Healthy Living Behavior (PHBS) among diarrhea patients.Results: The results showed that 36.5% of respondents used clean water that did not meet health requirements, while 63.4% used clean water that met the requirements. Handwashing with soap (HWWS) practices that did not meet the requirements were found in 53.7% of respondents, whereas 46.2% practiced proper handwashing with soap. In addition, 31.1% of respondents used latrines that did not meet health standards, while 68.8% used healthy latrines.Conclusion: The study indicates that a considerable proportion of diarrhea patients still experience inadequate clean water availability, poor handwashing with soap habits, and the use of unhealthy latrines, which may contribute to the occurrence of diarrhea.Recommendation: It is recommended that the Labuhan Ratu Health Center and related institutions strengthen health education for the community, particularly diarrhea patients and their families, regarding the importance of using safe clean water, proper handwashing with soap (HWWS) practices, and the use of healthy latrines. In addition, continuous promotion of Clean and Healthy Living Behavior (PHBS) through education, assistance, and regular monitoring is needed to reduce the risk of diarrhea incidence in the Labuhan Ratu working area, Bandar Lampung City. Keywords: Clean and Healthy Living Behavior, Diarrhea, Clean Water, Handwashing with Soap, Healthy Latrines  Latar Belakang: Diare merupakan penyakit berbasis lingkungan yang disebabkan oleh infeksi, termasuk bakteri dan virus, serta penularan melalui jalur fekal–oral. Penyakit diare dapat menyerang semua kelompok usia, mulai dari balita, anak-anak, hingga orang dewasa dari berbagai latar belakang sosial. Diare ditandai dengan buang air besar dengan konsistensi tinja lebih cair dari biasanya yang terjadi tiga kali atau lebih dalam kurun waktu 24 jam.Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran ketersediaan air bersih, kebiasaan cuci tangan pakai sabun (CTPS), dan penggunaan jamban sehat di wilayah kerja Puskesmas Labuhan Ratu Kota Bandar Lampung Tahun 2024.Metode: Jenis penelitian ini adalah penelitian deskriptif yang bertujuan untuk menggambarkan secara objektif kondisi yang ada. Penelitian ini berfokus pada penggambaran perilaku hidup bersih dan sehat (PHBS) pada penderita diare. Hasil: Hasil penelitian menunjukkan bahwa sebanyak 36,5% responden menggunakan air bersih yang tidak memenuhi syarat, sedangkan 63,4% menggunakan air bersih yang memenuhi syarat. Kebiasaan cuci tangan pakai sabun (CTPS) yang tidak memenuhi syarat ditemukan pada 53,7% responden, sementara 46,2% responden memiliki kebiasaan CTPS yang memenuhi syarat. Selain itu, sebanyak 31,1% responden menggunakan jamban yang tidak memenuhi syarat, sedangkan 68,8% responden menggunakan jamban sehat.Kesimpulan: Penelitian ini menunjukkan bahwa masih terdapat proporsi responden yang cukup besar dengan ketersediaan air bersih, kebiasaan CTPS, dan penggunaan jamban sehat yang belum memenuhi persyaratan kesehatan, sehingga berpotensi berkontribusi terhadap kejadian diare.Saran: Disarankan kepada pihak Puskesmas Labuhan Ratu dan instansi terkait untuk meningkatkan edukasi kesehatan kepada masyarakat, khususnya penderita diare dan keluarganya, mengenai pentingnya penggunaan air bersih yang memenuhi syarat, kebiasaan cuci tangan pakai sabun (CTPS) yang benar, serta penggunaan jamban sehat. Selain itu, perlu dilakukan penguatan program promosi perilaku hidup bersih dan sehat (PHBS) secara berkelanjutan melalui penyuluhan, pendampingan, dan pemantauan rutin guna menurunkan risiko kejadian diare di wilayah kerja Puskesmas Labuhan Ratu Kota Bandar Lampung. Kata Kunci: Perilaku Hidup Bersih dan Sehat, Diare, Air Bersih, Cuci Tangan Pakai Sabun, Jamban Sehat
Co-Authors A.A. Ketut Agung Cahyawan W AA Subiyanto, AA Abdul Wahid Abdurachman Abdurachman Achmad Munjid Adam James Fenton Adi Prayitno Agung Dinasti Permana Agung Dwi Nurcahyo Agus Kristiyanto Agustina Indri Hapsari Agustinus Agustinus Ahmad Abdullah Ahmad Fikri Akbar, Idzam Kholid Ali Djamhuri Aliyanto, Warjidin Anandani, Esti Tantri Andriati Andriati Angguntur, Wayan Anindita, Rahma Ansyori, Ansyori Arif Akhyat, Arif Arsyad, Mehmek Ali Akza Arya H Dharmawan Assegaf, Aswin Rizal Atik Swandari, Atik Atika Atika Atmoko, Warigit Dri Ayu Kusuma Dewi Ayubi, Novadri Azhari Muslim Baehaqi Bambang Wirjatmadi Bogi Soeseno Brian Wasita Budi Susetyo Pikir Budianto, Pepi Budiningsih, Fatichati Budiyanti Wiboworini Damayanti Tinduh Damsir, Damsir Deden Kamaludin Dedi Irwanto Dewi Purwaningsih Dewi, Dinda Luciana Diah Kurnia Mirawati Didik Prasetyo Didik T Subekti Diding Heri Prasetyo Dindy Samiadi Djaja Hendra Djoko Suryo Djoko Suryo DODY KURNIAWAN Dono Indarto Dwi Purwanti Dwi Putra, Kartika Wahyu Dwilda, Euvanggelia Edy Mintarto, Edy Elyana Asnar Eman Sulaiman, Eman Endriatmo Soetarto Endyka Erye Frety Erna Listyaningsih Erwanda, Setrian Eti Poncorini Pamungkasari Fachrudin, Irfan Farabi Fakih Faruk Fatma Hetami Febrina, Irma Ferizal Masra Giani, Maia Thalia Gusliana, Ali Hadi Sabari Yunus Hambarsari, Yetty Hamidi, Baarid Luqman Handini, Haspita Rizki Syurya Hari Setijono, Hari Hariyanto, Budhi Hariyanto, Olivia Ramadhanty HARJANTO HARJANTO Hartono Hartono Hendy Hendarto HERAWATI, LILIK herdianty kusuma, herdianty Heri Dwi Santoso, Heri Dwi Herinanto, Dwi Herlina, Intan Hutabarat, Ervina Arta Jayanti I Gde Raka Widiana Ida Liana Tanjung Ida Nurwati Iing Lukman Indriani, Wiewiek Irwadi, Irfiansyah Isa Mahfudi Issy Yuliasri Istikomah, I I’tishom, Reny Jatmiko Susilo Jayawarsa, A.A. Ketut Jongky Hendro Prajitno Karbito Karbito, Karbito Ketut Suega Kumara, Kusuma Arum Diana Kusnanto Kusnanto Kusumawati, Made Dian La Ode Rabani Laqif, Abdurrahman Larasati, Amilia Putri Lina Lasminingrum Linda Barus Mangesti, Rini Dwi Maria Johana Ari Widayanti Maryono, Sumardi Maryono, Suradi Ma’sumah, Fithriyatul Melati Sudiro Mentari Merryana Adriani Mesah, Winny Misbakhul Munir Miswan Gumanti Muchsin Doewes Muhammad Rifqi Muhammad Zainal Arifin, Muhammad Zainal Muhammad Zaki Pahrul Hadi Muhammad, Faizal Muhammad, Muaz Muhimatul Ifadah Mutiah Amini Nanda Fadhilah Witris Salamy Ni Wayan Winarti Novita Damayanti Nugroho, Ardi Setyo Nuha, Putri Ulin Nur Aini Setiawati Nur Aini Setyawati Nur Inayah Nur Shani Meida Nur, Nahdia Nurinasari, Hafi Olivia Cindowarni Padhil Hudaya Pamungkasari, Eti P. Pandu Putra Harsarapama, Pandu Putra Pangesti, Devia Regita Paramasari Dirgahayu pasa, chusairil Paulus Kusnanto Paulus Liben, Paulus Poernomo, Gigih Rahmadanu Poncorini, Eti Prabaningtyas, Hanindia Riani Pradana, E Pramesti, MPBD Pranadyan, Rizki Pratama, Yuan Guruh Pratiwi, Wahyu Nur Prayuda, Prayuda Priaminda, M Dodi F Priatmojo, Arif Suryo Pryla Rochmahwati Pudji Lestari Purnama, Siswanta Jaka Purwani, Deni Purwoto, Septyaningrum Putri Putranto, Wachid Putri, Arum Cahyaning Rachmat Setiawibawa Rachmawati, Anindita Rachmi Fauziah Rahayu Raden Mohammad Budiarto Rahmi Syarifatun Abidah, Rahmi Syarifatun Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Rejeki, Purwo Sri Reviono Reviono Rezano, Andri RINA YUDIWATI BM, RINA Ristinawati, Ira Risya Cilmiaty, Risya Rivan Danuaji Rohaeni, Rohaeni Rosida, Silvi Dina Rosita, Hanna Eka Rosyidi, Mohamad Ikhwan Rudi Hartono Ruliyandari, Rochana S, Gadis Meinar S.Pd. M Kes I Ketut Sudiana . Sa'adi, Ashon Sajidan Salimah, Kun Sally Mahdiani Sandhi Cahyani, Maria Benedictin Saputro, Yosia Puri Sari, Gadis Meinar Seful Bahri Senyum Indrakila Septian, Muhammad Raditia Setiabudi, Narendra Arya Setiadi, Hafid Setyawan, Ravinda Dharma Shinta Nurmasari Siahaan, Paulus Parholong Siam, Rambu Nurul Simanjuntak, Nela Soetrisno Soetrisno Soetrisno Soewondo, Widiastuti Sri Margana Sugiarto S Sukiman, Djoko Sulistiawati Sulistiawati SUROTO Susanto, Agung Susanto, Tri Hardi Suseno, Aryo Susiana, Okta Margarita Syafardan, R.M. Doni Syetiawinanda, Amriansyah Tedjo, Raden Andi Ario Tejomukti, Teddy Teti HS Madiadipoera Thaufiq S. Boesoirie Tonang Dwi Ardiyanto, Tonang Dwi Uji Nugroho Winardi Utami, Bernadhita Herindri Samodera Utami, Tri Setyo Vitri Widyaningsih Wahyuni, Ardianti Wasngadiredja, Pupu Fujriani Wibi, Bagas Ardytyan Wibowo, Diki Prayugo Widjiati Widjiati, Widjiati Wildan Sena Utama Woro Setia Ningtyas Wulandari, Eka T. Wuryanti, Lestari YANTO YANTO Yenny Kandarini Yoda, Vincensius Arga Yuliawati, Tri Hartini Yuniarto, Haryono Yussy Afriani Dewi Zaidah, Lailatuz