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All Journal JURNAL HUKUM Rotasi UG Journal Animal Agricultural Journal Pharmaciana: Jurnal Kefarmasian Jurnal Kreatif : Jurnal Kependidikan Dasar PIKSEL : Penelitian Ilmu Komputer Sistem Embedded and Logic Jurnal technoscientia Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Fisika Unand Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Nurani: Jurnal Kajian Syariah dan Masyarakat Jurnal Intelektualita: Keislaman, Sosial, dan Sains Jurnal Hukum Novelty Prosiding Forum Studi Transportasi Antar Perguruan Tinggi Isamic Communication Journal JURNAL BIOLOGI INDONESIA TEKNOLOGI LINGKUNGAN The Indonesian Biomedical Journal IDJP (Indonesian Journal of Pharmaceutics) MUDRA Jurnal Seni Budaya Jurnal Bahasa Rupa Ajudikasi : Jurnal Ilmu Hukum Acta Pharmaciae Indonesia : Acta Pharm Indo Publik (Jurnal Ilmu Administrasi) Indonesian Journal of Educational Counseling Sawala : Jurnal Administrasi Negara Rang Teknik Journal Jurnal Bisnis dan Pembangunan Pendas : Jurnah Ilmiah Pendidikan Dasar Scientific Journal of Reflection : Economic, Accounting, Management and Business Compiler Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Reka Buana : Jurnal Ilmiah Teknik Sipil dan Teknik Kimia Proceedings of the International Conference on Applied Science and Health Adabiyyat: Jurnal Bahasa dan Sastra QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Journal of Public Administration Studies Unes Law Review Jurnal Ilmu Fisika Jurnal Ilmiah Mandala Education (JIME) JISIP: Jurnal Ilmu Sosial dan Pendidikan JUPE : Jurnal Pendidikan Mandala Informasi Interaktif JURNAL KAJIAN TEKNIK MESIN The International Journal of Business Review (The Jobs Review) Mashdar: Jurnal Studi Al-Qur'an dan Hadis Jurnal Sistim Informasi dan Teknologi Jurnal Sains Riset PREPOTIF : Jurnal Kesehatan Masyarakat INTEGRITAS : Jurnal Pengabdian Tahdis: Jurnal Kajian Ilmu Al-Hadis Jurnal Administrasi Negara Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Bimbingan Penyuluhan Islam LEGAL BRIEF Ishlah: Jurnal Ilmu Ushuluddin, Adab dan Dakwah Jurnal Syntax Imperatif : Jurnal Ilmu Sosial dan Pendidikan Jurnal Bisnis, Manajemen, dan Ekonomi JURNAL TEKNOLOGI TECHNOSCIENTIA Riwayah : Jurnal Studi Hadis Journal of Judicial Review Wawasan: Jurnal Kediklatan Balai Diklat Keagamaan Jakarta Indonesian Journal of Business and Management Journal of Maritime Empowerment Emphaty Cons : Journal of Guidance and Counseling Narra J Jurnal Res Justitia : Jurnal Ilmu Hukum Journal Corner of Education, Linguistics, and Literature Journal of Information System and Technology (JOINT) Ikhtisar: Jurnal Pengetahuan Islam Indonesian Journal of EFL and Linguistics Al-MIKRAJ: Jurnal studi Islam dan Humaniora Jurnal Penyuuhan dan Pemberdayaan Masyarakat (JPPM) Berita Kedokteran Masyarakat SENTRI: Jurnal Riset Ilmiah Jurnal Manajemen Bisnis dan Organisasi Takwil: Journal of Quran and Hadith Studies Journal of Artificial Intelligence and Digital Business AHKAM : Jurnal Hukum Islam dan Humaniora International Review of Humanities Studies Journal of Constitutional Law Society (JCLS) Religia : Jurnal Ilmu-Ilmu Keislaman JAWI : Journal of Ahkam Wa Iqtishad Moderatio : Jurnal Moderasi Beragama Competitive Pawarta: Journal of Communication and Da'wah Jurnal Pengabdian Masyarakat Journal Of Humanity Dedication IJMA Jurnal Riset Ilmiah TEKNO : Jurnal Penelitian Teknologi dan Peradilan Journal Of Agriculture Sciences (Agrosci) Al Iidara Balad : Jurnal Administrasi Negara SWARNA: Jurnal Pengabdian Kepada Masyarakat Lire Journal (Journal of Linguistics and Literature) Abdurrauf Social Science Jurnal Muria Pengabdian Masyarakat Journal of Law Jurnal Bahasa Rupa Jurnal Jejak Hukum Indonesia (JHI) Journal of Industrial Automation and Electrical Engineering Jurnal Ilmiah Administrasi Publik Jurnal Komputasi
Arif Budiman
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The Effectiveness of Wood Vinegar and Ecoenzyme as Organic Biostimulants on the Growth of Tomato Plants (Solanum lycopersicum L.) Anugrah, Agri; Budiman, Arif; Amini, Zakiyah
Jurnal Agrosci Vol 3 No 3 (2026): Vol 3 No 3 January 2026
Publisher : Ann Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62885/agrosci.v3i3.1020

Abstract

Background. Wood vinegar is a by-product of the pyrolysis of biomass such as wood. Wood vinegar is also known as liquid smoke/pyroligneous acid. Wood vinegar is formed from the incomplete combustion of lignocellulosic materials. Wood vinegar produces compounds that have antimicrobial, antibacterial, and antioxidant effects. Aims. This study aimed to determine the effect of wood vinegar and ecoenzyme application on the vegetative growth of Servo tomato (Solanum lycopersicum L.) plants. Methods. The study used a Randomized Block Design (RBD) with 9 treatment combinations of wood vinegar (0, 10, and 15 mL/L water) and ecoenzyme (0, 10, and 15 mL/L water) and 3 replicates. The parameters observed included plant height and number of leaves at 10, 17, 27, 37, and 47 days after planting (DAP). The data were analyzed using Analysis of Variance (ANOVA) and followed by Duncan's Multiple Range Test (DMRT) at a 5% level. Result. The results showed that the application of a combination of wood vinegar and ecoenzyme had a very significant effect on the vegetative growth of tomato plants at all observation ages (p < 0.05). The best treatment was P8 (15 mL/L wood vinegar + 15 mL/L ecoenzyme), with the highest average number of leaves (114.67) and plant height (66.83 cm) at 47 DAP. The combination of these two materials worked synergistically to increase nutrient availability, enhance soil microbial activity, and stimulate the production of natural growth hormones (auxin and cytokinin). Conclusion. Meanwhile, the medium concentration at P6 (10 mL/L wood vinegar + 15 mL/L ecoenzyme) also showed a significant increase in leaf number and plant height compared to the control. Implementation. The use of a combination of wood vinegar and an ecoenzyme has been proven to optimally enhance the vegetative growth of Servo tomato plants. It can serve as a potential environmentally friendly organic biostimulant to replace chemical fertilizers.
Delayed percentage attenuation ratio (DPAR) on multiphase CT as a quantitative predictor of early response in hepatocellular carcinoma Supriatna, Yana; Bachtiar, Rifki; Makkaraeng, Muhammad Y.; Budiman, Arif
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.2996

Abstract

Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality, and transarterial chemoembolization (TACE) is the standard therapy for intermediate-stage disease. However, response to TACE is variable, and reliable quantitative imaging biomarkers are needed to support early treatment decision-making. This study aimed to evaluate the predictive value of the delayed percentage attenuation ratio (DPAR) measured from pre-TACE multiphasic computed tomography (CT) in forecasting early therapeutic response. A retrospective cross-sectional study was conducted involving patients with a definitive diagnosis of HCC who underwent their first TACE session and had complete multiphasic CT imaging before and after treatment. Quantitative washout parameters, delayed percentage attenuation ratio (DPAR), absolute washout (WOAbs), and relative washout (WORel) were measured using standardized region of interest (ROI) placement by three radiologists. Treatment response was assessed four to six weeks post-TACE based on modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria and classified into responders and non-responders. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis, and interobserver reliability was assessed using intraclass correlation coefficient (ICC) and Cohen’s κ. A total of 49 HCC patients were included and analyzed. Responders demonstrated significantly higher DPAR values compared with non-responders (median 134.5 vs 113.0; p<0.001). DPAR showed the strongest discriminative performance with an area under the curve (AUC) of 0.898, outperforming WOAbs (AUC 0.689) and WORel (AUC 0.704). The optimal DPAR threshold of ≥120.5 provided 84.4% sensitivity and 88.2% specificity to predict early post-TACE treatment response. Interobserver reliability was excellent for all washout parameters (ICC 0.98–0.99), and agreement for mRECIST classification was also excellent (κ=0.867). In conclusion, pre-TACE DPAR is a robust and reproducible quantitative imaging biomarker that accurately predicts early response to TACE in HCC. A threshold value of ≥120.5 may assist in treatment planning and patient selection in routine clinical practice.
Ternary Solid Dispersion Improves Anti-cancer Activity of Alpha-mangostin Against MCF-7 Breast Cancer Cells Budiman, Arif; Yunita, Ellen Nathania; Rusdin, Agus; Marcelino, Jeremy; Amaliah, Salma; Aulifa, Diah Lia
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3938

Abstract

BACKGROUND: Alpha-mangostin (AM) exhibits potent anti-breast cancer activity but its therapeutic effectiveness is constrained due to low aqueous solubility and poor bioavailability. Ternary solid dispersions (TSDs) were developed by adding another excipient to address these challenges. Nevertheless, limited studies have systematically evaluated whether improvements in dissolution and stability achieved through TSD systems are translated into enhanced in vitro cytotoxicity of AM. Therefore, TSD system of AM with Eudragit (EUD) and Poloxamer (POL) was developed, and in vitro cytotoxicity activity was evaluated as a preliminary proof-of-concept in MCF-7 breast cancer cells.METHODS: TSD of AM was prepared by solvent evaporation and characterized by Power X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) Spectroscopy. The pharmaceutical properties were evaluated by in vitro dissolution test using a standard paddle apparatus, while physical stability was assessed under two relative humidity environments. The in vitro anticancer efficacy was examined in MCF-7 breast cancer cell using an MTT assay.RESULTS: Amorphization of TSD was confirmed by a halo pattern with PXRD measurements and the absence of an AM melting peak in the DSC curve. FT-IR analysis revealed hydrogen bond interactions between the carbonyl group of AM and EUD/POL protons. TSD system significantly improved the dissolution profile and enhanced cytotoxic effects, reducing cell viability to 1.17% at 16 µg/mL with an IC50 of 7.11 μg/mL (CI 95%: 6.626-7.591).CONCLUSION: The TSD system significantly improved dissolution profile and in vitro cytotoxicity in MCF-7 breast cancer cells, providing proof-of-concept for enhancing the biological performance of AM. KEYWORDS: alpha-mangostin, ternary solid dispersions, dissolution, MCF-7, cytotoxicity
HIDROGEN: SOLUSI INOVATIF UNTUK PENYIMPANAN ENERGI BERKELANJUTAN DI MASA DEPAN Budiman, Arif
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01, Maret 2026 Release
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.43197

Abstract

Hydrogen, with its environmentally friendly characteristics, high energy density, and versatile utilization, offers a promising solution for future energy storage systems. This paper discusses various hydrogen storage technologies, their operating principles, advantages and disadvantages, application examples, and usage trends. Despite several challenges, such as storage complexity, high costs, and safety issues, current trends indicate that hydrogen adoption continues to grow. This development is driven by the decreasing cost of green hydrogen production, advancements in more efficient storage technologies, integration of hydrogen into renewable energy systems, expansion of hydrogen refueling infrastructure, and increased collaboration among industries and governments. Hydrogen holds significant potential as a sustainable energy source for the future. With the development of more effective and efficient storage technologies, along with supportive policies and infrastructure, hydrogen can play a crucial role in the transition toward a cleaner and more environmentally friendly energy system.
RECONSTRUCTING THE JUDICIAL SUPERVISION PARADIGM IN INDONESIA: ANALYSIS OF CONSTITUTIONAL COURT DECISION NO. 39/PUU-XIII/2015: REKONSTRUKSI PARADIGMA SUPERVISI DI INDONESIA: ANALISIS KEPUTUSAN MAHKAMAH KONSTITUSIONAL NO. 39/PUU-XIII/2015 Budiman, Arif; Arifin, Firdaus
Constitutional Law Society Vol. 5 No. 1 (2026): March
Publisher : Pusat Studi Konstitusi dan Perundang-undangan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36448/jcls.v5i1.146

Abstract

This study examines fundamental weaknesses in judicial supervision in Indonesia following Constitutional Court Decision Number 39/PUU-XIII/2015. Using normative legal research with statutory, case-based, conceptual, and comparative approaches, the research identifies a critical research gap: the absence of comprehensive frameworks that integrate oversight of judicial technical reasoning with ethical evaluation in ways that maintain judicial independence while strengthening institutional accountability. This study theoretically contributes to the development of balanced independence-accountability theory by reconceptualizing judicial supervision as a system that enables rather than constrains judicial professionalism. The findings indicate three central issues. First, Constitutional Court Decision Number 39/PUU-XIII/2015 has significantly narrowed the authority of the Judicial Commission by restricting oversight related to judicial technical matters, creating institutional vulnerability. Second, both internal and external supervisory mechanisms failed to detect early indications of bribery in the acquittal verdict of Gregorius Ronald Tannur, despite striking inconsistencies between the court's legal reasoning and the evidentiary record, demonstrating critical gaps in monitoring systems. Third, judicial supervision in Indonesia remains predominantly reactive rather than proactive, addressing issues only after they surface in criminal proceedings. This study recommends regulatory reform through the enactment of the Judicial Office Bill, revision of the Judicial Commission Law, and integration of artificial intelligence systems with appropriate safeguards to identify anomalous judicial decisions. These measures aim to strengthen preventive mechanisms while preserving judicial independence and ensuring institutional accountability.
EFEKTIVITAS PROGRAM POSYANDU REMAJA DALAM MENINGKATKAN STATUS KESEHATAN REMAJA PUTRI DI DESA PANDAMAAN KECAMATAN DANAU PANGGANG KABUPATEN HULU SUNGAI UTARA Fauzan, Ahmad; Budiman, Arif; Sari, Ratna
Al Iidara Balad Vol. 7 No. 2 (2026): Al Iidara Balad
Publisher : PPPM STIA Amuntai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36658/aliidarabalad.7.2.1713

Abstract

Penelitian ini berangkat dari kenyataan bahwa Program Posyandu Remaja di Desa Pandamaan belum berjalan secara optimal. Hal tersebut tampak dari rendahnya kesadaran sebagian remaja putri dalam menjaga kesehatan, yang tercermin dari kurangnya kedisiplinan saat kegiatan berlangsung, seperti tidak fokus ketika penyuluhan dan kurang tertib dalam pemeriksaan kesehatan. Padahal, Posyandu Remaja merupakan upaya promotif dan preventif yang sangat penting untuk mendukung peningkatan derajat kesehatan remaja sejak usia dini. Penelitian ini bertujuan untuk menganalisis tingkat efektivitas program tersebut serta mengidentifikasi faktor-faktor yang mendukung maupun menghambat pelaksanaannya. Pendekatan yang digunakan adalah deskriptif kualitatif melalui observasi, wawancara, dan dokumentasi, dengan pemilihan informan secara purposive sampling. Hasil penelitian menunjukkan bahwa efektivitas program masih belum tercapai sepenuhnya. Dukungan program tampak melalui pemanfaatan grup WhatsApp dan media informasi desa serta pemberian doorprize untuk mendorong partisipasi remaja. Namun, pelaksanaan program masih terhambat oleh rendahnya kesadaran kesehatan remaja dan jadwal kegiatan yang tidak selaras dengan jam sekolah. Temuan ini menegaskan perlunya peningkatan edukasi, pengelolaan kegiatan yang lebih teratur, serta koordinasi yang lebih kuat antar pihak terkait agar program dapat berjalan lebih efektif dan berkelanjutan.
IMPLEMENTASI PROGRAM TRIBINA DI KELURAHAN ANTASARI KECAMATAN AMUNTAI TENGAH KABUPATEN HULU SUNGAI UTARA Novitasari, Novitasari; Budiman, Arif; Fahmi, Yusran
Al Iidara Balad Vol. 7 No. 2 (2026): Al Iidara Balad
Publisher : PPPM STIA Amuntai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36658/aliidarabalad.7.2.1744

Abstract

Program Tribina yang mencakup Bina Keluarga Balita, Bina Keluarga Remaja, dan Bina Keluarga Lansia merupakan salah satu bentuk kebijakan pemerintah dalam memperkuat peran keluarga. Program ini dilaksanakan melalui kegiatan pembinaan yang berkelanjutan dan disesuaikan dengan tahapan perkembangan keluarga, dengan tujuan mendorong terciptanya ketahanan serta peningkatan kesejahteraan keluarga. Pada pelaksanaan program Tribina di Kelurahan Antasari Kecamatan Amuntai Tengah Kabupaten Hulu Sungai Utara ditemukan fenomena masalah yaitu, kurangnya sosialisasi program Tribina di Kelurahan Antasari, kurangnya kemampuan dan sumber daya kader, serta waktu pelaksanaan program yang tidak menetap. Penelitian ini menggunakan pendekatan kualitatif dengan tipe deksriptif kualitatif. Teknik pengambilan data yang digunakan adalah observasi, wawancara dan dokumentasi. Sumber data diambil melalui penentuan secara purposive sampling berjumlah 14 orang. Setelah data terkumpul kemudian dianalisis dengan teknik reduksi data, penyajian data, penarikan kesimpulan, dan verifikasi. Hasil Penelitian ini menunjukkan bahwa implementasi program Tribina di Kelurahan Antasari Kecamatan Amutai Tengah Kabupaten Hulu Sungai Utara cukup baik diukur melalui model George Charles Edwards III dalam Leo Agustino (2022:154-158) yaitu: Pertama Sub-variabel Komunikasi indikator Penyaluran Informasi (Sosialisasi) masih kurang optimal, Kejelasan sudah baik, dan Konsistensi waktu masih kurang konsisten. Kedua sub-variabel Sumber Daya indikator Sumber Daya Manusia kurang memadai, Sarana Prasarana memadai, dan Anggaran sudah memadai. Ketiga sub-variabel Disposisi indikator Komitmen/ Tanggung Jawab cukup baik, Pengaturan Birokrasi/Kesesuaian Penempatan Kader cukup sesuai, dan Insentif cukup memadai. Keempat sub-variabel Struktur Birokrasi indikator Standar Operasional Prosedur (SOP) cukup sesuai, Koordinasi sudah baik, dan Evaluasi cukup baik. Adapun faktor pendukung implementasi program Tribina di Kelurahan Antasari Kecamatan Amuntai Tengah Kabupaten Hulu Sungai Utara adalah Pertama, ketersediaan sarana dan prasarana yang memadai; Kedua, anggaran yang cukup memadai; Ketiga, dukungan pemerintah dan instansi terkait. Sedangkan faktor penghambat yaitu Pertama, kurangnya inisiatif dan peran kader dalam menyebarluaskan informasi adanya program Tribina di Kelurahan Antasari; Kedua, penyesuaian jadwal/waktu yang sulit untuk ditentukan; Ketiga, kurangnya pelatihan dan pembinaan berkelanjutan bagi kader dalam mengelola kegiatan Tribina ini.
The Implementation of the Complete Systematic Land Registration (PTSL) Program in Malang Regency Land Office Budiman, Arif
Jurnal Ilmiah Administrasi Publik Vol. 6 No. 3 (2020): Jurnal ilmiah Administrasi Publik (JIAP)
Publisher : Badan Penerbitan Jurnal (BPJ) FIA-UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jiap.2020.006.03.17

Abstract

Pendaftaran Tanah Sistematis Lengkap (PTSL) or Complete Systematic Land Registration is a program under the Ministry of Agrarian Affairs and Spatial Planning/ National Land Agency (ATR/ BPN) in response to new directives from President Joko Widodo in 2016 to register all yet 79 million unregistered land parcels before 2025. The organization and its officers are still adapting to the sudden change in work rhythm from the usual target of 1 million land parcels per year to 5 million land parcels that gradually increases every year further. This research employs the descriptive method with the qualitative approach to study the process of PTSL program implementation in Malang Regency Land Office during the year of 2017 and 2018. By measuring success of the PTSL program implementation, it can be concluded that the goal of PTSL program in Malang Regency Land Office was achieved and PTSL program was delivered as expected.
Transformasi Digital Sistem Pembimbing Akademik Berbasis Web Menggunakan Metode Rapid Application Development (RAD) Siska, Sri Tria Siska; Budiman, Arif; Mustaqim, Muhammad Al
Jurnal Komputasi Vol. 14 No. 1 (2026)
Publisher : Jurusan Ilmu Komputer Fakultas MIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/komputasi.v14i1.349

Abstract

Sinkronisasi jadwal bimbingan dan pengelolaan administrasi akademik konvensional masih menjadi hambatan utama dalam interaksi antara dosen pembimbing dan mahasiswa di institusi pendidikan tinggi. Ketidakefisienan sistem manual ini berdampak pada kurang maksimalnya pengawasan terhadap perkembangan studi mahasiswa secara real-time. Penelitian ini bertujuan untuk merancang dan mengimplementasikan transformasi digital pada sistem pembimbing akademik melalui aplikasi berbasis web. Metode yang digunakan adalah Rapid Application Development (RAD), yang dipilih karena kemampuannya dalam mempercepat siklus pengembangan sistem melalui keterlibatan pengguna secara intensif dalam pembuatan prototipe. Sistem ini mencakup fitur manajemen jadwal bimbingan, dokumentasi hasil konsultasi, serta pemantauan progres nilai mahasiswa. Hasil penelitian menunjukkan bahwa penggunaan metode RAD berhasil mempercepat proses pengembangan sistem sesuai dengan kebutuhan pengguna. Implementasi sistem ini mampu meningkatkan efisiensi proses bimbingan, meminimalisir risiko kehilangan data bimbingan, dan mendukung akselerasi transformasi digital di lingkungan institusi pendidikan.
Delayed percentage attenuation ratio (DPAR) on multiphase CT as a quantitative predictor of early response in hepatocellular carcinoma Supriatna, Yana; Bachtiar, Rifki; Makkaraeng, Muhammad Y.; Budiman, Arif
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.2996

Abstract

Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality, and transarterial chemoembolization (TACE) is the standard therapy for intermediate-stage disease. However, response to TACE is variable, and reliable quantitative imaging biomarkers are needed to support early treatment decision-making. This study aimed to evaluate the predictive value of the delayed percentage attenuation ratio (DPAR) measured from pre-TACE multiphasic computed tomography (CT) in forecasting early therapeutic response. A retrospective cross-sectional study was conducted involving patients with a definitive diagnosis of HCC who underwent their first TACE session and had complete multiphasic CT imaging before and after treatment. Quantitative washout parameters, delayed percentage attenuation ratio (DPAR), absolute washout (WOAbs), and relative washout (WORel) were measured using standardized region of interest (ROI) placement by three radiologists. Treatment response was assessed four to six weeks post-TACE based on modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria and classified into responders and non-responders. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis, and interobserver reliability was assessed using intraclass correlation coefficient (ICC) and Cohen’s κ. A total of 49 HCC patients were included and analyzed. Responders demonstrated significantly higher DPAR values compared with non-responders (median 134.5 vs 113.0; p<0.001). DPAR showed the strongest discriminative performance with an area under the curve (AUC) of 0.898, outperforming WOAbs (AUC 0.689) and WORel (AUC 0.704). The optimal DPAR threshold of ≥120.5 provided 84.4% sensitivity and 88.2% specificity to predict early post-TACE treatment response. Interobserver reliability was excellent for all washout parameters (ICC 0.98–0.99), and agreement for mRECIST classification was also excellent (κ=0.867). In conclusion, pre-TACE DPAR is a robust and reproducible quantitative imaging biomarker that accurately predicts early response to TACE in HCC. A threshold value of ≥120.5 may assist in treatment planning and patient selection in routine clinical practice.
Co-Authors -, Sukamta -, Sukamta -, Sutijan -, Sutijan . Subeno A'yun, Qurrota A.A. Ketut Agung Cahyawan W A.K Patra Suwanda A’yun, Qurrota Abdul Mahsyar Abdulah, Nubal Ansori Abdullah, Yogi Abdurrohman, Fauzy Adi Prasetyo Adilansyah, Adilansyah Afdal Afdal, Afdal Afdhal Muttaqin Afriyadi, Afriyadi Agustiawan, M. Nassir Ahmad Fauzan Aisali, Ledyta Asa Aisyah, Tesyalia Zara Aji Abdillah Kharisma Ajie, Bintang Wicaksono Al Firdaus, Al Firdaus Alhasbi, Faruq Alimin Mahyudin Amaliah, Salma Amelia, Radika Anam, ⁠Muhammad Ghousul Angga Permana Anggi, Joseph Fide Anggraeni, Rani Aning Ayu Kusumawati, Aning Ayu Anis Khoirunisa, Anis Anjar Mahardian Kusuma Anjasmari, Ni Made Musiyani Anna Yuliana, Anna Antonius Hintono Anugrah, Agri Anwar, M. Choerul An’Nur, M.Yusuf Kahfi Ardian Putra ARDYANSAH, ADY Ari Wulandari, Ari Arief Budiono Arif Budiarto Ariyadi, Ariyadi Arlando, Arlando Armeli, Rifka Resti Arpandi, Arpandi Arsal, Muryani Ashadi, Andri Astuti - Ayodduki, Zahra Noor Silmi Hermawan Azima, Muhammad Fauzhan Bachtiar, Rifki Baihaqi, Ahmad Beny Ramdani, Beny Berkatillah, Akhmad Bin Abdul Aziz, Abdul Rashid Budiharto, Segar Budiharto, Segar Chalimah Girsang, Nova Ckhotimah, Husnul Dedi Mardiansyah Derajah, Alawiah Dhani, Alvan Diah Lia Aulifa Dian Fitriyani Dian Ranggina Donny Kristanto Mulyantoro Dwi Pujiastuti Dwi Puryanti Dwita, Dea Effendi, Sundari Fatma Eko Prasetyo Eko Risdianto Eldrin, Nadya Eka Handayani Elistia Liza Namigo, Elistia Ening Herniti Erman Gani Fadhila, Zulham Nurul Fadillah, Ahmad Fahmi, Yusran Fakhruddin Z Fakhrur Rozi, Fakhrur fatimah Fatimah Fatmawati, Fatmawati fatonah, siti nur Faturohman, Faturohman Fauziah, Nafiza Fernando, Harley fikri firmansyah Firdaus Arifin, Firdaus Firdaus Hafidz As Shidieq Firmansyah Firmansyah Firmansyah Firmansyah Firmansyah, Firmasnyah Fitra Fitra, Fitra Fitri Sari, Fitri Fitriana Murriya Ekawati Fitryantica, Agnes Genatrika, Erza Hadiwijaya, Nathannael Adrya Hafizah, Noor Hana Budi Prativi, Hana Budi Hargiani, Fransisca Xaveria Harries Madiistriyatno, Harries Hartono, Sugianto Ayudha Haslina Haslina Hateyaningsih, Hateyaningsih Hayadi , B. Herawan Hegandari, Hegandari Helmi Septaria Herlin Helvy Trilismana, Helvy Hendar Sudrajat Hendra H Hendrawan, Donni Hendry Gunawan, Hendry Hidayat, Heru HR, Yuliani Husaini, M. Idham, Muhamad Hairil Idraswara, Redhatama Arya Iip Sarip Hidayana Ilyasa Indah Etika Indah Puji Rahayu Indri Hapsari Insan Sunan Kurniawansyah, Insan Sunan Insi Farisa Desy Arya Irham, Rahim Irianto, Kartika Dewi Iskandar Muda Janna, Miftahul Jasman , Jeffri Ardiyanto Jhoni, I Made Juliantio, Juliantio Junianto, Kendy junita, amelinda karni, awis Kasman, Suf Khairunnisa, dewi hanifah Kharisma, Maltha Khasanah, Kusnia Nikmatul Khristianto Khristianto, Khristianto Koeswandi, Tika Kristie, Harry Jamatul Kumaidi, Muhamad Kurniawan, Insan S. Kusrahayu Kusrahayu Kusumadevi, Nurwulan Laila Kholid Alfirdaus Latief, Abdillah Choirul Leny Latifah Lestari MS, Suci Lestari, Azhar Nur Dini Liawardi, Petra Pahlawanda Chrisanto Lies Anggi Puspita Dewi Lukman Hakim M Hamzah, M M. Irfan Maharani, Intan Suri Mahmudin, Rinaldy Makkaraeng, Muhammad Y. Marcelino, Jeremy mardyan, muhammad zacky Maria Veronika Halawa Martha, Yulistio Maulida, Lusi Melina Faulina, Melina Meydiyati, Yusrina Mia Lasmi Wardiyah, Mia Lasmi Mochammad Imron Awalludin Mohammad Ali Shafii Monita Sholeha Mu'in, Fathul Muchtaridi Muchtaridi mufrod mufrod Muhamadong, Muhamadong Muhammad Iqbal Sy Muhammad Nur Muhammad Rizki Muhammad Taufiq Muhammadon, Muhammadon Mulyani, Fitria Muskhir, Mukhlidi Mustaqim, Muhammad Al Mustofa Mustofa Mutya Vonnisa Nahariyah, St. Rohmani Naldi, Febri Nazar, Taufid Hidayat Nedy, Yohanes Hans Nelson, Endi Neneng Yanti Khozanatu Lahpan Nengsi, Sisri Wahyu Nibas A, ⁠Vierel Maulana Ningsih, Afrilia Setia Nofriadel - Noor, Muhammad Fahrian Norman, Frizky Novitasari Novitasari Nugraha, Erfan nugraha, jajang Nur Inayah nur'aeni, aliya Nur, Muhammad Hajid An Nurdidayati, Safitri Nurhidayat Nurhidayat Nursa, Irfan Nursuhud Nurul Fatonah, Nurul Nurulaini, Siti Nunung Nurvianto, Sandy Nurvianto, Sandy Nuryani Nuryani Oktafitria, Rita Oktavia, Ayunda Pajri, Panji pajrin, apwa Palkrisman -, Palkrisman Pambudi, ⁠Priyo Pamekas, Bondan Wahyu Paradise, Paradise Pebrianti, Zenny pramawijaya, daffa Pratama, Deva Angga Pratama, Wildan Pratiwi, Ayu Rizky Pratomo, Muhammad Fadhil Putra, Bagas Dwipantara Putri, Abhista Emilia putri, Nurhazar Indriani Putri, Ramadhayani Putri, Rosyie Sahara R. Rusli Rafiani, Amia Putri Rahmadani, Tri Rahmah Ningsih, Rahmah Rahmatil Hayati, Rahmatil Rakhmalaely, Andien Aulia Ramacos Fardela Ramadhan, Nur Fajri Rangkuti, Bagindo Ichsan Rasyid, Rosidah Ratna Sari Richa Mardianingrum Rifai Rifai Rifai Rijal, Muhammad Nur Rinaldi Rinaldi Rindiantika, Yokaniza Rindu Twidi Bethary, Rindu Twidi Rini Indrati, Rini RIZKIANI, FIRLIA Rizkiani, Firliah Rizkya, Ria Rolandio, Falzi Romi, Audrey Ananda Rosa, Ariane Ruby, Mahlil Rumahlatu, Alvaro Rusdin, Agus Ryan Bakry, Mohammad Safri, Edi Salim, Afdal Fajri Salim, Steven Salsabila, Deffania Samudra, Dian Sandi Sandi Sanjaya, Eka Wahyu Saputra, Adyan Reza Saputra, Indrian Saputra, Toha Achmad Saputri, Ester Dwi Sarjon Defit Satyawan Pudyatmoko Saudjhana, Audrey Sembiring, Berlian Garuda Setianingsih, Cahyani Ayu Setiawan , Irza Setiawan, Lukman Setyawati, Luthfi Utami Shely Nasya Putri Siddiq, Andhika Mochamad Sinarti, Sinarti Siregar, Dedy Revalino Siti Raudah Sitompul, Elizabeth Giovanni Sri Endah Susilowati Sri Handani Sri Handayana, Sri Sri Tria Siska Suaibah Siregar, Suaibah Subarkah, M. Hari Subarkah, M. Hari Sucianti, Cita Sudiyono Sudiyono Sukandar, Warlan Sukatin, Sukatin Sulvia, Sulvia SUMIYATI SUMIYATI Supriatna, Yana Surip Surip Susmiatun Susmiatun, Susmiatun Susyanti, Susi sutansah, ahmad rifai Sutrisni, I Gusti Ayu Mirah Syaiful . Syamsudin, Wa Ode Fithrah Az-zalia Syerlie Annisa Syukriani, Helfi Tatang Shabur, Tatang Tiyurma, Anna Tomy Tomy udayana, wasman Ulfa, Yesi Srihandani Umalihayati Umalihayati Venessa, Kisusyenni Vini Aristianti, Vini W, Akhmad Bening W, Akhmad Bening Wahyudi Wahyudi Wanda Nugroho Yanuarto Wawandono, Novianto Bambang Wawandono, Novianto Bambang Widoyo, Agus Fatuh Wijaya, Nadiah Azizah Arisa Wijaya, PG. Wisnu Yordan Gunawan Yudiansyah, Ridwan yudiardi, dodi Yuhandri Yuhandri, Yuhandri yulia, sapitri Yunita, Ellen Nathania Yunus, Kafrawi Yusuf , Furtasan Ali Yuwanto Yuwanto Zaini , Muhammad Zakiyah Amini Zubaidah, and Zulfara, Shananta Rizki