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Sari Mutiara Indonesia International Conference on Health Jurnal Ilmu Keperawatan Jiwa Jurnal Perempuan ComTech: Computer, Mathematics and Engineering Applications CSRID (Computer Science Research and Its Development Journal) Unnes Journal of Public Health MANAGERIA: Jurnal Manajemen Pendidikan Islam JURNAL MEDIA HUKUM DAN PERADILAN Menara Ilmu Jurnal Suara Keadilan Jurnal Madani SPORTIVE: Journal Of Physical Education, Sport and Recreation Jurnal Penelitian IPTEKS E-Prodenta Journal of Dentistry JURNAL MUTIARA KESEHATAN MASYARAKAT Jurnal Pendidikan Teknologi Pertanian Jurnal Sains dan Teknologi Reaksi JCER (Journal of Chemistry Education Research) Kappa Journal Jurnal Keperawatan Priority Jurnal Ekonomi Manajemen Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Kesehatan Masyarakat dan Lingkungan Hidup Jurnal Pendidikan dan Konseling Contagion: Scientific Periodical Journal of Public Health and Coastal Health Jurnal Pengembangan Penyuluhan Pertanian Health Information : Jurnal Penelitian Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bearing : Jurnal Penelitian dan Kajian Teknik Sipil Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Agrium Akbis: Media Riset Akuntansi dan Bisnis PREPOTIF : Jurnal Kesehatan Masyarakat JSR : Jaringan Sistem Informasi Robotik Journal of Artificial Intelligence and Innovative Applications (JOAIIA) Jurnal Doppler JOURNAL OF INFORMATICS AND COMPUTER SCIENCE Indonesian Journal of Pharmaceutical and Clinical Research Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Jurnal Scientia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Edunomics Journal Caring : Indonesian Journal of Nursing Science JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Sylva: Jurnal Ilmu-ilmu Kehutanan KLIK: Kajian Ilmiah Informatika dan Komputer PRIMER (Prima Medical Journal) JAGO TOLIS : Jurnal Agrokompleks Tolis Jurnal EduHealth Jurnal Ekonomi Jurnal Info Sains : Informatika dan Sains Ahmar Metastasis Health Journal (AMHJ) Empiricism Journal Humantech : Jurnal Ilmiah Multidisiplin Indonesia International Archives of Medical Sciences and Public Health International Archives of Medical Sciences and Public Health BERKAT: Jurnal Pemberdayaan Masyarakat Nurse and Holistic Care Suloh : Jurnal Fakultas Hukum Universitas Malikussaleh Jurnal Ekonomi dan Bisnis Digital (MINISTAL) Jurnal Multidisiplin Madani (MUDIMA) International Journal of Islamic Education, Research and Multiculturalism (IJIERM) JAMAIKA: Jurnal Abdi Masyarakat KOMMAS: Jurnal Pengabdian Kepada Masyarakat Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP) Abdi Jurnal Publikasi Yuris: Journal of Court and Justice Jurnal Mosfet Jurnal Sosial dan Sains Journal of Islamic Economics Lariba J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Journal of Community Health Provision Jurnal Natural Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Innovative: Journal Of Social Science Research Jurnal Pengabdian Masyarakat Bangsa Estudiante Law Journal Journal of Economics and Management Scienties Jurnal Mahasiswa Ilmu Kesehatan IJRETINA - International Journal of Retina LOGIC : Jurnal Ilmu Komputer dan Pendidikan Biner : Jurnal Ilmu Komputer, Teknik dan Multimedia OKTAL : Jurnal Ilmu Komputer dan Sains APPA : Jurnal Pengabdian Kepada Masyarakat Indatu Journal of Management and Accounting Haga Journal of Public Health (HJPH) Malahayati International Journal of Nursing and Health Science Journal on Pustaka Cendekia Informatika Lentera: Multidisciplinary Studies Ashlach : Journal of Islamic Education MCSIJ (Marine, Coastal and Small Islands Journal) : Jurnal Tugas Akhir Mahasiswa Ilmu Kelautan Folia Medica Indonesiana
Nasution, Ali Napiah
Universitas Prima Indonesia
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Test of the Effectiveness of Bilalo Sea Cucumber (Actinopyga Mauritiana) in Pancreatic Beta Cell Repair in Aloxan-Induced Mice (Mus Musculus) Aris, Anita; Girsang, Ermi; Nasution, Ali Napiah
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.1982

Abstract

Introduction diabetes mellitus (DM) is a degenerative disease that occurs due to abnormal carbohydrate metabolism. DM conditions occur when the pancreas is unable to produce insulin or the sensitivity of cell receptors to insulin is very low. The increase in DM occurs when the pancreatic beta cells are unable to produce insulin or the sensitivity of cell receptors to insulin is very low. Damage to pancreatic beta cells can be caused by diabetogenic substances such as alloxan. Teripang bilalo (Actinopyga mauritiana) is a marine animal that has been used as food and medicine. Contains many secondary metabolites, namely flavonoids, alkaloids, glycosides, steroids, and saponins. active compound flavonoids and saponins., research objectives to know the effectiveness of oral administration of teripang billion in reducing blood sugar levels and the ability to repair tissue in pancreatic beta cells seen from hispatology, materials, and methods is an experimental study with 25 mice as subjects. Oral administration of sea teripang bilalo ethanol extract at doses of 100, 200, and 400 mg/kg, positive control by oral administration of glibenclamide, and negative control by administration of Na-CMC then a histopathological examination of the pancreas was performed, research results in the administration of teripang bilalo ethanol extract 400 mg / kg proved to be able to reduce blood sugar levels to 179.4 mg / dl and proved to have an effect on the improvement of pancreatic histology, which is a picture of damage to peripheral islands of langerhans by 1, damage to islands of langerhans less than 50% by 2.4 and damage, conclusions administration of teripang bilalo ethanol extract is proven to reduce blood sugar levels and have an effect on improving pancreatic histology.
Important Strategies for Preventing Hypertension Through Risk Factor Approaches Nasution, Ali Napiah; Ginting, Chrismis Novalinda; Siregar, Reza Arfan
Indonesian Journal of Global Health Research Vol 6 No 1 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i1.2689

Abstract

Hypertension causes high morbidity (sickness) and mortality (death). Hypertension occurs as a result of interactions and various risk factors that a person has. Multiple studies have linked various risk factors to the emergence of hypertension. The research aims to determine the Essential Hypertension strategy through a risk factor approach at the Asy-Asyifa Clinic. The research design used was an analytical study with a case-control study design by selecting cases who suffered from essential hypertension and controls who did not suffer from essential hypertension. Primary data collection was carried out directly by researchers using research instruments in the form of questionnaires. In fact, the results of this study determined that age is related to the incidence of hypertension. The higher the age group, the more often the incidence of hypertension. The results of the Chi-Square statistical test with a value of p = 0.06 mean that there is a significant relationship between obesity and the incidence of hypertension. The results of the Chi-Square statistical test with a value of p = 0.048 mean that there is an essential relationship between people who smoke and the incidence of hypertension. In this study, there was no significant relationship with the Chi-Square statistical test with a value of p = 0.020, meaning that there was a meaningful relationship between people who consumed much salt and the incidence of hypertension. The variables influencing essential hypertension are obesity, salt consumption, and age. The dominant variable that influences essential hypertension at the Asy-Asyifa Clinic in Medan is the obesity variable. Regular exercise and a balanced diet are crucial to maintaining a healthy weight.
Effectiveness Test of Ethanol Extract of Red Betel Leaves (Piper Crocatum Ruiz & Pav) Against Histopathological Features of The Pancreas and Blood Sugar Levels of Alloxan-Induced Male Mice (Mus Musculus L) Sembiring, Mahral Effendi; Nasution, Ali Napiah; Chiuman, Linda
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

Diabetes Mellitus induces hyperglycemia. Low insulin production causes insulin resistance and altered protein, fat, and carbohydrate metabolism. Much research has shown that traditional herbal treatments can treat diabetes. Diabetes increases free radical production. Secondary metabolic plants include antioxidants that treat extreme illnesses like diabetes. This study examines the efficacy of ethanol extract from red betel leaves (EERBL) in lowering blood glucose levels in vivo, the optimal dose, secondary metabolite content based on phytochemical screening, and alloxan-induced pancreatic hyperglycemia histopathology. Mouse. Six 20-30 gram groups of mice were treated. Group III got 0.65 mg/kgBW glibenclamide, and Groups IV, V, and VI received oral gavage EERBL 100, 300, and 500 mg/kgBW. Group I was in standard control without alloxan, and Group II was in alloxan control. Hyperglycemic mice received 150 mg/kg BW intraperitoneal alloxan. Red betel is 96% ethanol-macerated. Oral red betel leaf extract was given for 21 days to monitor blood glucose and pancreatic function. Splitting red betel leaves to male mice significantly altered blood glucose and pancreatic histology. Red betel goes low cuts close and pancreatic histology by 58.4%. Blood glucose readings were Kruskal-Wallis significant at 0.004 or 0.05. Red betel leaf extract reduced blood glucose and enhanced pancreatic histology in male mice.
The BPJS Patient Medical Services on Doctor Work Satisfaction at Public Hospital Royal Prima Medan Ali Napiah Nasution; Daniel Prem Raj Pandid; Chrismis Novalinda Ginting
Jurnal Scientia Vol. 13 No. 04 (2024): Education and Sosial science, September-December 2024
Publisher : Sean Institute

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Abstract

A health worker who has an important role in the service at a hospital is a doctor. At RSU Royal Prima Medan, the medical services received by doctors are considered insufficient which causes dissatisfaction with doctors at work. Based on the results of the performance evaluation of doctors in December 2017, the percentage decreased from 80% to 76.3%. This study was to analyze perceptions about the distribution of the amount of medical services, the timeliness of providing medical services, the compatibility of medical services with performance, the distribution system, transparency, work environment, co-worker relations, and promotion opportunities on doctor's job satisfaction. This study uses a type of survey. All 48 specialist doctors at RSU Royal Prima Medan are the population as well as the sample in this study. Analysis was performed on bivariate data using chi-square and then for multivariate data using logistic regression test α = 0.05. The doctor's satisfaction level is influenced by the distribution system and promotion opportunities. The opportunity for promotion has a regression coefficient (B) of 2,887 so that it is the main factor influencing the level of doctor satisfaction.
An Analysis Of The Stunting Prevention Program At The Batang Quiz Village Health Center Deli Serdang District In 2022 Asri Widiya Sitompul; Ermi Girsang; Ali Napiah Nasution
Jurnal Scientia Vol. 13 No. 04 (2024): Education and Sosial science, September-December 2024
Publisher : Sean Institute

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Abstract

Stunting is a linear growth disorder in children due to a chronic lack of nutritional intake. The consequences of malnutrition in children will have a major impact on future generations. The prevalence of stunting in Indonesia is 30.8%. This means that three out of ten children under the age of five experience growth disorders which will result in delays in thinking abilities and reduced levels of intelligence. Based on the map of the distribution of stunting in Deli Regency, it shows that there has been a decrease in the percentage of stunted toddlers in Deli Serdang Regency from 6.70% in 2019 to 2.64% in 2020. This shows that the convergence of programs/interventions in efforts to accelerate stunting prevention has been able to reduce percentage of stunted toddlers in Deli Serdang Regency. The research used in this research is quantitative research. The sample taken was 315 people using purposive sampling technique. The independent variables in the research are behavior, level of education, social status, p erceived benefits and perceived barriers to action. The dependent variable in this research is efforts to prevent stunting. In this study, it was found that 74.51% had a level of stunting prevention behavior. Stunting prevention in children aged 2 -5 years is influenced by behavior, while education level, social status, perceived benefits and barriers to action influence stunting prevention in children aged 2 -5 years.
The K3 Policy Strategy To Improve Worker Safety In PT. Nusa Raya Cipta TBK Medan In 2023 Eva Kristina Pelawi; Ermi Girsang; Ali Napiah Nasution
Jurnal Scientia Vol. 13 No. 04 (2024): Education and Sosial science, September-December 2024
Publisher : Sean Institute

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Abstract

Labor has an important role and position as actors and development goals. To improve the quality of the workforce, employment development is needed aimed at increasing protection for workers. Occupational safety and health (K3) has a very important role in every organization. Data shows that there are still many companies that have not implemented an effective K3 policy strategy, as evidenced by the high numbe r of work accidents and fatalities in Indonesia. This research combines several methods, namely interviews and library or literature studies. Data collection uses in - depth interview techniques, observation and documentation. The validity and reliability of the data was carried out by source triangulation. The data analysis used in this research uses inductive qualitative data analysis techniques. Activities in data analysis include reduction, data presentation and drawing conclusions. The research results show that K3 policy strategy planning is implemented in accordance with government regulations contained in PP No. 20 of 2012. Supervision is carried out with company references in the form of Law no. 1 of 1970 and ISO 45001:2015 where the number of K3 supervision is 2 Safety Officers or according to the needs of the project. Meanwhile, reporting is carried out internally, containing incident reports to the Project Manager and Branch Manager which are carried out via telephone or verbally by the safety officer on duty
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAGING BUAH MAHKOTA DEWA (PHALERIA MACROCARPA) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS DAN STAPHYLOCOCCUS EPIDERMIDIS Nasution, Ali Napiah; Girsang, Ermi; Cenggono, Melise; Br Pelawi, Riri Sri Hagana
Jambura Journal of Health Sciences and Research Vol 6, No 4 (2024): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i4.27415

Abstract

Mahkota Dewa (Phaleria macrocarpa) adalah tanaman obat populer di Indonesia yang berasal dari Papua dan tumbuh subur di iklim tropis. Buah tanaman ini kaya akan senyawa antibakteri, termasuk alkaloid, polifenol, flavonoid, saponin, dan tanin, yang tergolong dalam metabolit sekunder. Penelitian ini menyediakan kontribusi baru dalam bidang farmakologi dengan mengeksplorasi efektivitas ekstrak etanol dari daging buah Mahkota Dewa (Phaleria macrocarpa) terhadap Staphylococcus aureus dan Staphylococcus epidermidis pada berbagai konsentrasi. Tujuan penelitian untuk menilai aktivitas antibakteri ekstrak etanol dari daging buah Mahkota Dewa. Metode yang digunakan adalah desain Post Test Only Control Group dengan pengujian in vitro. Ekstrak etanol disiapkan pada konsentrasi 20%, 40%, dan 60% melalui proses maserasi. Uji fitokimia menunjukkan keberadaan flavonoid, alkaloid, saponin, terpenoid, tanin, dan fenol. Aktivitas antibakteri diuji dengan metode difusi cakram, dan zona hambat diukur setelah inkubasi selama 24 jam pada suhu 37°C. Hasil penelitian menunjukkan bahwa ekstrak etanol Mahkota Dewa memiliki aktivitas antibakteri yang signifikan terhadap Staphylococcus aureus dan Staphylococcus epidermidis. Konsentrasi 60% menghasilkan zona hambat yang paling besar, yaitu 1,48 mm untuk Staphylococcus aureus dan 4,08 mm untuk Staphylococcus epidermidis, sedangkan konsentrasi 20% dan 40% menunjukkan efek antibakteri yang lebih rendah. Analisis statistik menggunakan uji Kruskal-Wallis dan Mann-Whitney menunjukkan adanya perbedaan yang signifikan antara konsentrasi ekstrak dan kontrol. Kesimpulan bahwa ekstrak etanol dari daging buah Mahkota Dewa (Phaleria macrocarpa) menunjukkan sifat antibakteri yang signifikan terhadap S. aureus dan S. epidermidis, terutama pada konsentrasi 60%. Namun, efektivitasnya masih lebih rendah dibandingkan dengan kloramfenikol.
Implementasi Program Pencegahan dan Penanganan Stunting di Kota Tebing Tinggi Widyastari, Elisa; Ginting, Chrismis Novalinda; Nasution, Ali Napiah
MAHESA : Malahayati Health Student Journal Vol 4, No 12 (2024): Volume 4 Nomor 12 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i12.16250

Abstract

ABSTRACT Stunting, a result of chronic malnutrition characterized by relatively short stature for the age of the child, remains one of the most common nutritional problems found in poor and developing countries and is closely related to the incidence of recurrent infections and inadequate psychosocial stimulation. As the prevalence of stunting reaches 31% in 2022, the Government of Indonesia targets to reduce the prevalence of stunting in Indonesia to 14% by 2024 through various programs involving various elements of government. This study aims to assess the implementation of stunting prevention and management programs in Tebing Tinggi. This qualitative study with a cross-sectional approach was conducted in Tebing Tinggi City in December 2023. The informants in this study consisted of three key informants, namely the Head of the Public Health Division of the Tebing Tinggi Health Office, the Primary Nutritionist of Puskesmas Satria, and the Nutrition Executive Officer of Puskesmas Teluk Karang, and six regular informants, namely parents with stunted children. The data was collected through in-depth interviews with informants with the help of in-depth interview guidelines. The implementation of the stunting prevention and management program in Tebing Tinggi has routine communication between implementation actors and program targets, has adequate human resources, funds, facilities, and infrastructure, positive disposition of implementation actors even without incentives, and has standard operational procedures and clear distribution of responsibilities. The implementation of the stunting prevention and handling program in Tebing Tinggi was good; however, it should be noted that there are still shortcomings in the aspect of communication with program targets. Keywords: Stunting, Implementation, Policy, Program  ABSTRAK Stunting, yaitu kondisi malnutrisi kronis yang ditandai dengan badan yang relatif pendek berdasarkan usia anak, masih menjadi salah satu permasalahan gizi yang paling sering ditemukan di negara-negara miskin dan negara berkembang dan berkaitan erat dengan kejadian infeksi berulang serta stimulasi psikososial yang tidak adekuat. Dengan prevalensi stunting yang mencapai 31% di tahun 2022, Pemerintah Indonesia menargetkan mampu menekan prevalensi stunting di Indonesia menjadi 14% pada tahun 2024 melalui berbagai program yang melibatkan berbagai elemen pemerintahan. Penelitian ini bertujuan untuk menilai bagaimana implementasi program pencegahan dan penanganan stunting di Kota Tebing Tinggi. Penelitian ini merupakan penelitian kualitatif dengan pendekatan potong-lintang yang dilakukan di Kota Tebing Tinggi pada Desember 2023. Informan pada penelitian ini terdiri dari tiga informan kunci yaitu Kepala Bidang Kesehatan Masyarakat Dinas Kesehatan Kota Tebing Tinggi, Nutrisionis Ahli Pratama Puskesmas Satria, dan Petugas Pelaksana Gizi Puskesmas Teluk Karang dan enam informan biasa, yaitu orang tua dengan anak stunting. Data penelitian ini dikumpulkan dengan wawancara mendalam dengan informan dengan bantuan pedoman wawancara mendalam. Penelitian ini menemukan bahwa implementasi program pencegahan dan penanganan stunting di Kota Tebing Tinggi memiliki komunikasi rutin antar aktor implementasi dan terhadap sasaran program, memiliki sumber daya manusia, dana, serta sarana dan prasarana yang adekuat, disposisi aktor implementasi yang positif walaupun tanpa insentif, dan memiliki standard operational procedure dan distribusi tanggung jawab yang jelas. Dapat disimpulkan bahwa implementasi program pencegahan dan penanganan stunting di Kota Tebing Tinggi berjalan dengan baik; namun perlu diingat bahwa masih terdapat kekurangan dalam aspek komunikasi dengan sasaran program. Kata Kunci: Stunting, Implementasi, Kebijakan, Program
Anti-Bacterial Activity Test of Carrot Tuber Ethanol Extract Hydrogel Preparation (Daucus Carota L.) in Inhibiting the Growth of Bacteria and Their Ability in the Healing Process of Grade II Burns on Wistar Rat (Rattus Norvegicus) Welly Ria Utami Lubis; Ali Napiah Nasution; Hanjaya; Alvin Abrar Harahap; Muhammad Nawal Hasya; Jeri Yuliansyah; Ermi Girsang
Jurnal Multidisiplin Madani Vol. 3 No. 6 (2023): June, 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v3i6.3529

Abstract

Carrots are root vegetables that are very common in Indonesia. Carrot plant (Daucus carita L.)  is a root vegetable plant that has a high content of beta carotene, rich in dietary fiber, natural antioxidants and high vitamin A which is 12,000 IU. The reddish-yellow color of carrots is due to the high content of carotene pigment. The sample used in this study was fresh carrot tubers. The tubers are separated from other impurities and then washed thoroughly and then drained and weighed. Next, the tubers are dried at a temperature of 30-40oC until the tubers are dry (marked when broken brittle). Simplisia that has dried (brittle) is powdered with a blender and stored in a tightly closed container and stored at room temperature. The preparation of the extract is carried out by maceration using 70% ethanol solvent. According to the Indonesian Herbal Pharmacopoeia (2008), as much as 1 part of simplisia dry powder is put into the maserator, added 10 parts of solvent. Soak for the first 6 hours while stirring occasionally, then let stand for 18 hours. Separate the maserat by filtering. Repeat the extraction process at least twice with the same type and amount of solvent. Furthermore, all the mafiber is collected, then evaporated with a  rotary evaporator at a temperature of ±50oC until a thick extract is obtained. The results showed that ethanol extract of carrot tubers with a simplisia weight of 500 grams produced a yield of 3.78% with an extract weight of 68.9 grams. The results below show that carrot tuber ethanol extract shows phytochemical screening results that contain flavonoids, alkaloids, glycosides, tannins and steroids. The results of the measurement of the diameter of the inhibitory zone above showed that ethanol extract of carrot tubers (Daucus carota L.) can inhibit the growth of  Pseudomonas aeruginosa and Staphylococcus aureus  bacteria at concentrations of 10-400 mg / mL. The measurement results obtained the diameter of the inhibitory zone with a strong inhibitory zone response category at all concentration variations. It was found that high concentrations had activity that did not differ significantly from low concentrations. Carrot tuber ethanol extract has a significant difference (p < 0.05) when compared to the positive and negative groups while the results of the measurement of bacterial killing power above show that carrot tuber ethanol extract (Daucus carota L.) can inhibit the growth of Pseudomonas aeruginosa and Staphylococcus aureus bacteria  at concentrations of 10 – 100 mg / mLl
Test the Effectiveness of Carrot Tuber Ethanol Extract Cream Preparation Formulation in Preventing Increased Melanin in Male Wistar Rats Exposed to UVB Light Wulan Dhari; Ali Napiah Nasution; Djohan; Widyaningsih Oentari; Widya Pasca Amir; Anita Merry Cisca; Ermi Girsang
Jurnal Multidisiplin Madani Vol. 3 No. 6 (2023): June, 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v3i6.3535

Abstract

This study was conducted with the aim of proving carrot tuber extract (Daucus carota L.) formulated in cream form can prevent an increase in the amount of melanin in the skin tissue of male wistar rats (Rattus norvegicus) exposed to UVB light and see histopathological changes due to carrot tuber extract given as a prevention of increasing the amount of melanin. This study is experimental with a post-test only control group research design. The test method used was testing the amount of melanin modified using a 13 watt Exoterra UVB 200 lamp. The animals tested were rats (Rattus norvegicus) male wistar strain aged 2-3 months, weighing ± 200 grams. Male rats were randomly divided into 6 groups. Each group consists of 5 male rats. The test area on the back of the back is 2x2 cm2. Group I male rats without cream administration as a negative control group, Group II male rats for Parasol Face Sunscreen Cream as a positive group. Group III is the group with the provision of basic ingredient cream and group IV-VI is the group with the administration of 25% carrot tuber extract cream; 50 %; 75 %. topically for 4 weeks.. The evaluation was performed by observing the amount of melanin at week 4 of histopathology analyzing in the test area. The results will be processed with IBM SPSS 21.0 and analyzed with the steps of Descriptive Analysis, Normality Analysis with data using Shapiro-Wilk test and Homogeneity using Levene's test, Comparative Analysis using one way Anova test, followed by Post-hoc test with LSD test. If the data is abnormal, use non-parametric analysis of the Kruskal-Wallis test followed by the Mann-Whitney test. The results showed that extra ethanol of carrot tubers can prevent the increase in the amount of melanin. This was shown by its ability to reduce melanin and histopathological changes in a group of male rats applied carrot tuber ethanol extract cream within 4 weeks
Co-Authors ', Bustami ', Zulkarnain - Suratno A, Fitriana Ratih A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Abd. Rasyid Syamsuri Abdi Putra, Simeon Abdillah S., Abdillah S. Achmad Hidayatno Adam, Hikmah Adwin Ade Irma Lumbantobing Adek Amansyah Adelia Adelia, Adelia Aditya Azri Rizki Aditya Rochman, Aditya Adrian Adrian Adwindea, Ardana Afriani, Miskah Aghus Sofwan Agus Budi Wahyudi Agus Hariyanto Ahmad Baihaqi Ahmad Ismail Alapi, Rahmat Aldi Tambunan Aldo Hermawan Suryana Aldy Valentino Alexander Angkasa Alfian Putra Alhumaira Oryza Sativa Alvin Abrar Harahap Amalia, Viki Aminuyati Amrullah Amrullah Ananda Safitri Andin Eka Safitri Anggraini, Tri Lidya Anita Merry Cisca Anita Zahra Anton Timur Jailani Harahap Anugrah Santoso, Hardi Anzib, Nuraini Arbi, Faisal Arfianti, Tri Arie - Vonikartika Arif, Julio Arigusman, Revalgi Ilham Aris Triwiyatno Aris, Anita Ariyansyah, Refy Arna Fransisca Mp Arravi, Rajulian Nurkholis Arviandi, Rizki Aryanie, Irne ashegaf, farhan taufiqurrahman Asnani Asnani Asri Widiya Sitompul Asyrun Alkhairi Lubis Atiqa Sabardila Atyanta Nika Rumaksari Awang Harsa Kridalaksana Awang Roni Effendi, Awang Roni Azhar Azhar Bagus Setiadi Baharuddin Baharuddin Bashar Awaluddin Nafsah Batara Sanjaya Harahap Baum, Gunilla Benny Rusli, Benny Binarwan Halim Br Ginting, Anissa Destryana Br Ginting, Liani Br Pelawi, Riri Sri Hagana Budy, Agung Cahya Buulolo, Netralman T.N Carles, Carles Carolina Carolina Ce, Win Cendy Juliana Cenggono, Melise Chandra Wilim Chiuman, Linda Chrismis Novalinda Ginting Cindy Stefanie Sinaga Clarissa Lister Corvis L. Rantererung Cut Elvira D. T. Chandra, D. T. Dadan Moh. Hamdani Dadang Redantan, Dadang Daniel Prem Raj Pandid Darjat Darjat Dede Falahudin Dedek Saripah Dedy Cahyadi, Dedy Delken Kuswanto Devi Damayanti Devi Yunita Devi Yunita Dewi Taurusyanti Dewi, Nindia Salsabila Mia Dhiwa Gemilang Pramadhani Diana Indrasanti Dio Damara Handoyo Djohan Djohan Duha, Kristin Berlianta Duha, Sonya Marsela Pieta Dung, Le Quang Dung, Le Quang Dwi Andika Putra Dwi Hindarti, Dwi Dwi Rohma Nuraini Dyna Marisa Khairina Dzil Fikri Edy Setioko, Edy Efratiwi Marpaung Ekiyantini W, Ekiyantini Elang Pramana Putra Elianta, Peter Elis Anggeria Elizabeth, Riana Elvira, Cut Erida Nurahmi Ermi Girsang Ermi Girsang Ermi Girsang Ermi Girsang Ermi Girsang ERMI GIRSANG Ermi Girsang Ermi Girsang Ermi Girsang Ermi Girsang ETRINA MELINDA Eva Kristina Pelawi Evelyn Angie Fabian, Audric Faderina Komisia Fadillah, Adil Ridlo Fahlevy, Ridho Fahrul Agus Faizun, Nurul Fariz Septiawan Fauziyyah, Afifah Febri, Ririn Febyami Neimsegel Simatupang Feraera, Andrialius Fieterson, Kriahan Joel Fioni, Fioni Firman Pratama Firmansyah Nur Budiman, Firmansyah Nur Fiska Maya Wardhani Fitrayani, Fitrayani Fitri Yanti Fitriansyah, Rizko Prasada Florenly Florenly Frederick Frederick Galuh Ambar Sasi Gidion Franklin Simorangkir Ginting, Chrismis Novalinda Ginting, Liani Br Giovani, Cut Maneka Girsang, Ermi Glorio ias Natanael Gunawan, Bambang Panji Gusnawati, Gusnawati H. Firman Halik, Moh. Nur Halima, Piyanto Handayani, Rr. Novita Wahyu Handoko, Erwin Hanjaya Hanna Sari Widya Kusuma, Hanna Sari Widya Hantarum, Hantarum Hapsari, Yolanda Aulia Harahap, Milna Chairunnisa Hariadi, Dadang Budi Harino, Hiroya Harino, Hiroya Hariyanto Halim Hariyento Halim Hartina Harun Joko Prayitno Hasan, Riyani Susan BT Hayatun Nufus Iriyanti Heliza Rahmania Hatta, Heliza Rahmania Herjayanto, Muh. Heru Joko Budirianto Hidayat, Alfa Manarul Hikmatul Mustaghfiroh, Hikmatul Hikmawati, Nita Hilal, Zaimah Hilyana, Siti Himawan, Noni Holan Dianju Melva Meinaria Sitanggang Hutagalung, Mangatas HP Hutomo, Rizky Aditya I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister Icuk Prayogi Ihsan Hanif Febriliayan Iin Purnamasari IKHTIARI, REFI Ilham Surya Fallo Inneke F. M Rumengan Inoue, Koji Inoue, Koji Iqbal Maulana Akbar Ira Puspita Dewi, Ira Puspita Irawan, Desika Indra Irpan Kusyadi Irwan, Mulia Islahuddin, Islahuddin Islamiah, Nurul Istiqomah, Widya Jaka Sutresna Jaka Sutresna Jannah, Rusidatul Jauhari, Isynu Lutfhi Jeri Yuliansyah Jerry Fidelio Susanto Joko Daryatmo Jonizar, Jonizar jonizar, Jonizar Juan Alphanto Bemindra Julio Arif Kartika, Sri Kasmiati Kateni, Darul Kesuma, Farah Shyfa Kharisma Radhityas, Nuryasinta Kholil, A. Yusuf Kinoshita, Masato Kinoshita, Masato Koesmawati, Tiny Agustini Kopong, Agustina Kunzmann, Andreas Kunzmann, Andreas Kurniawan, Dedy Hendra Kusmadi L. Ledoh, Dominggus Laksmi Irianti Larasati ., Larasati Lensari, Delfy Lestari Sukarniati Lestari, - Lestari, Rachmatika Liawati - Liawati Liawati Lie, Maylia Lie, Sukirman Lister, Clarissa Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich livana ph Lizuardi, Amiril Lubis, Windy Claudia Lumbantobing, Christina JRE Lydia Yusuf M. Shabri M. Syafi’i, M. Syafi’i Makhfud Syawaludin Malaka, Muhammad Hajrul Malau, Reghita Claudia Maman Somantri Mangatas Silaen Mangesti, Yovita Arie Mansyur, Fakhruddin Manullang, Corry Yanti Manurung, Rachel Gita Berlian Mardiana Putri br. Tambunan Marhadi Saputro Maribeth, Annisa Lidra Maricella, Adrianie Martina Martina Masdar Helmi Masdul, Muh Rizal Maturbongs, Agatha Cecilia Maya Sari Mutia Miarsa, Fajar Rachmad Dwi Mira Setiawati Miranda Sortalina Baringbing Mohandas Indradji Mohd. Nur Syechalad, Mohd. Nur Mokhamad Yusron Rafi Moriza Lesmana Muhamad Abduh, Muhamad Muhamad Agung Prasetyo Muhamad Ardy Kurniawan Muhamad Irvan Vadilah Muhamad Ridwan Wijaya Muhammad Agus Muljanto Muhammad Dimas Nugroho Muhammad Djafar Muhammad Ilyas Yusuf Muhammad Imaduddin Muhammad Irfannurroja Muhammad Nawal Hasya Muhammad Ridwan Muhammad Rivai Muhammad Syahdan Muhammad Yunus MUHAMMAD ZAINAL Muhammad Zainudin Mulia Saputra Mulya Munawar Agus Riyadi Munawaroh, Sitie Mustamin, Siti Walida Mutia, Maya Sari Muzzaki, Arisla Choirudin Nabilah Khairunnisa Nadia Artha Dewi Nadia Zenni Andari Nadiyah Santika Nafilah, Azimah Nurin Naimul Faizah, Naimul Naipospos, Bonaventura Nanda Parariski Purba Nandar Cundara, Nandar Nanik Setyawati Natali, Oliviti Nindia Salsabila Mia Dewi Nita Anggraini, Nita Normawati Normawati, Normawati Novi Indrayati Nur Fitriyani Nurahmi, Nurahmi Nurfitri Ekantari Nurhaliza Arfadilla Nuriana, Wahidin Nursalam Nursalam Nurwijayanti Nury, Ahmad Sulthan Nyoman Wendri Oke Hariansyah Oktaviani, Emma Paftalika, Reiza Bani Perani Rosyani Pertiwi, Dora Hatika Poko, Feny Rizkia Prasetyo Adi Pratiastuti, Wike Prima Daniyati Kusuma Priyono Priyono Purbo Putra Sastaman B Putranto Manalu Putri Khaerunnisa Putri, Mutiara Kristiani Putri, Riri Virzan Rachma Puspitasari Raden Muharam Natadisastra Rahimi, Armon Rahmadini, Rizki Rahmah Yulianti Rahman, Ibadur Rahmasari, Herisa Rahmat Padyawan, Andhy Raihan Ramadhani Rakhmanda, Andhika Ramada, Raynaldi Surya Ramadhan Efendi Ramadhani, Natalia Putri Ramjaun, Shaheen Bibi Rasidin Rasidin Rasul Ratna Dewi Ratna Widyawati Razki, Cut Danisha Reffanda Kurniawan, Reffanda Reh Malem br Karo Renaldi Revisdah Revisdah, Revisdah Ria Hartaty Rido Gunawan Ridwan, Ridwan Riko Mardani Saputra Riky Suherman Simanjuntak Rina Rizkia Rini Elvira Hutabarat Rio Antono Robbani, Hamdan Rochyatun, Endang Roizza Dema Nurikhwan Romadhon, Ahmad Heru Roni Sefia Rosianty, Yuli Rovi Pahliwandari, Rovi Rubiyatno Rubiyatno Rulli Rosandi Rustam HN, Muhammad S. Redjeki Sababuli, Jeklin M. Safwan Safwan, Safwan Sahidin . Sahna Ferdinand Ginting Said Musnadi Saipul Sihotang Salfa Nindya, Faradhina Salman, Abrar Mujahidin Salovetian, Marcelino Salwa Juani Adrasah Samliok Ndobe Sari, Dina Meilita Sari, Laura Kartika Satria, Brama Yoga Satrio Haryo Benowo Wibowo Savitri Sembiring, Mahral Effendi Sembiring, Rinawati Septya Maharani, Septya Setiawati, Suzzanna Shahdevi Nandar Kurniawan, Shahdevi Nandar Shelvi Eka Tassia Sihaloho, Hendra F. Silaen, Mangatas Simatupang, Veronica Triwindari Sinaga, Reza Audina Siregar, Oscar Solideo Siregar, Reza Arfan Siti Rahma Sitin Nurul Khasanah, Sitin Nurul Son Suwasono, Son Sri Lestari Ramadhani Sri Lestari Ramadhani Nasution Sri Lestari Ramadhani Nasution Sri Mulyati Sri Rezeki Sriatun Sriatun Sriminarti, Nurul Stephanie Raibalaki Suadi Suadi Suandy, Suandy Suci Erawati SUCI FERDIANA Sucy Hasfya Sugeng Riyanto Suherlina - Suherlina Suherlina, Suherlina - Sukamto, Ika Sumiyarsi Sulistijanto, Eddy Sulistyoningrum, Harum Sumardi . Sumiati Sumiati Supardi Djasmani, Supardjo SUPRAPTO Supriati, Yulia Supriyanto Supriyanto Suriani Suriani Suryadinata Suryatama, Yahya Rizkiandra Susanna Halim Susi Susanti Suwandy Suwandy Suyono, Tan Suyono, Tan Syura, Asy T. Arie Setiawan Prasida Tambunan, Gempita Cahaya Aulia Tampubolon, Elisabet Tan Suyono Tanjaya, Angela Taufan Hidayat Tcanty Indrianti Thomas Stefanus Kaihatu Tiara Nabila Nabati Tjiawi, Midoro Tobing, Madeline Angeline Tri Atmoko Tri Putra, Kurniawan Triwarti, Hairul Triyoni Purbonegoro, Triyoni Ulina Karokaro Umar Ibrahim Valencia Yuwono Veranyca Chiuman Vijay Dhillon Vonikartika, Arie - WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wahyuni Nasution wandi Wardana, Rico Ariesta Wattayakorn, Gullaya Wattayakorn, Gullaya Welly Ria Utami Lubis Werfete, Rivaldy Alfrets Whalsen Duli Agus Lauh Wibawa, Iskandar Wibowo, Satrio Haryo Benowo Widya Pasca Amir Widya Pratiwi Widya Puspita Cahyani Widya Yanti Sihotang Widyaningsih Oentari Widyaningsih Oentari Widyastari, Elisa Wiedya Kristianti Angeline Wijaya, Joshua Andre Wildianti, Delia Winda Winarti Windraskinasih, Mutiara Wiranto Wiranto Wulan Dhari Yaasmiin nuhaa asa Putri Yakub Nasucha Yamamoto, Yu Yamamoto, Yu Yatsuzuka, Emi Yatsuzuka, Emi Yogi Rizky Pangestu Yogie Chandra Yolen Perdana Sari Yoridha Aulia Sinuraya Yosmina Tapilatu Yossi Diantimala Yuli Christyono Yuliana Yuliana Yulidar Yulidar Yulindasari Sutejo, Yulindasari Yundari, Yundari Yunike Yessica Ulina Yusof, Shahrizad Yusof, Shahrizad Yusuf, Lydia Zendrato, Arisman Zerry All Vindo Tarigan Zidan, Muh. Zuhdi, Muhammad Fikri Zumhari