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Video Game Increases Depression in Students Edith Humries; Budi Pratiti; Patricia Wulandari; Rachmat Hidayat
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.035 KB) | DOI: 10.37275/scipsy.v1i1.3

Abstract

Introduction: The effects of exposure to violence in newspaper and electronic media to children and adolescents were being an awareness various parties, namely, researchers, health practitioners and policy makers. Depression is a mental problem that is always found due to exposure to video games. Methods: This study was an observational study with a cross-sectional research design. The subjects of the study were teenagers aged 15-18 years, students of Vocational School Yogyakarta, Indonesia. Data analysis was performed with IBM SPSS 16. Data analysis to assess the relationship between length and video game content with depression levels (Children’s Depression Inventory -2) used Independent student T-test analysis and linear regression analysis. Results: The study subjects consisted of 4.3% men and 95.7% women. There were no significant differences between subjects with male and female sex related to CDI-2 score, p> 0.05. The sexes of men and women have CDI-2 scores of 26.92 ± 5.02 and 26, 42 ± 3.32, respectively. There is a significant relationship between the intensity of playing video games with a CDI-2 score. Research subjects who had the intensity of playing video games for more than 2 hours a day had a higher mean CDI-2 score (28.62 ± 2.62, p <0.05) when compared to research subjects who played video games for less than 2 hours per day (26.13 ± 3.38, p <0.05). There was a significant relationship between video game content and the average CDI-2 score. Research subjects who played violent video games had higher CDI-2 scores (29.91 ± 2.07, p <0.05) when compared to groups who played video games with non-violent game themes (26, 29 ± 3.37 , p <0.05). Based on linear regression analysis, there is a relationship between the intensity of playing video games with the average CDI- 2 score (β = 1.87, SE = 0.72, p = 0.01). Meanwhile, for video game content there is no relationship between video game content containing violence and the average CDI-2 score (β = 1.91, SE = 1.21, p = 0.11). Conclusion: There is a relationship between the intensity of playing video games with the average CDI-2 score.
Profile of Personality and Psychopathology Dimensions of Indonesian Medical Students who Failed in Medical Doctor Competency Exams (UKMPPD) Patricia Wulandari; Rachmat Hidayat; Carla R Marchira
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.7

Abstract

Introduction: Medical doctor competency exams (UKMPPD) in Indonesia is a final test that should be followed by medical student before being declared worthy of a medical doctor’s degree. This exam is certainly intended with good intentions, in order to improve the standards and quality of graduates of Indonesian doctors. However, each policy turns out to have two opposite sides of the situation, on the one hand it is profitable but on the other it often creates new problems. Students’ fear of the competency test often causes new psychological problems for students. No doubt the failure of the competency exam causes students to experience prolonged disappointment and sadness, which in turn will cause depression. This research is the first research that aim to present a description of personality and psychopathology dimension data from UKMPPD participants who failed the test. Method: This study was an exploratory descriptive study by presenting narratives of personality and psychopathology dimensions of unsuccessful UKMPPD participants. This research was conducted at the Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia. Each participant was assessed personality and psychopathology dimensions using MMPI-2 (Minnesota Multiaxial Personality Inventory-2). The results of analysis with MMPI-2 present data in the form of clinical psychic conditions, the work capacity, interpersonal relationships, the work abilities and the ability to change the self potential of the research subjects. Result: The research subjects were UKMPPD participants who did not successfully pass the first exam. From 7research subjects, there were 2 subjects who successfully passed the second exam (28.5%) and there were 3 people who successfully passed after the third exam (43%). Meanwhile, 2 research subjects have not successfully passed the UKMPPD exam until the fifth exam (28.5%). The results are quite surprising that of the 7 participants who failed to pass the UKMPPD exam, all of them felt depression. Conclusion: Medical students who experienced UKMPPD failures have an inability to develop their own potential which result in depression due to failure of the exam
Neuronal Cell Death Induces Depressive Disorder in Rats Depression-Like Behaviors Caused by Chronic Stress Rachmat Hidayat; Mgs Irsan Saleh; Nita Parisa
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.8

Abstract

Introduction: Depression is believed to be a disorder in which an increase in serotonin activity in the brain. This has implications for the development of various antidepressant drugs that work to increase serotonin levels, by inhibiting serotonin reuptake. However, management with antidepressants is still believed to be not optimal, there are still various problems that have not been able to be solved only by increasing serotonin levels in the brain. Therefore, it is necessary to do further exploration to find out other possible pathophysiology of depressive disorders. This study intended to explore the role of apoptosis of neuronal cells in the prefrontal cortex to answer the hypothesis that depression was not only caused by increased serotonin levels but also there was a role of dead neuronal cells in the prefrontal cortex which will trigger the body's homeostatic efforts to compensate by increasing serotonin levels. Methods: A total of 30 male Wistar rats (200 ± 20 g) were obtained from Eureka Research Laboratory (Palembang, Indonesia). Experimental animals were placed in cages under controlled conditions (12 hours of light / dark cycles with temperatures of 22 ± 1˚C and humidity of 40-60%), fed and drank ad libitum. Experimental animals with depression model were induced using Chronic Mild Stress (CMS). CMS procedures were performed with mild stressors such as repeated cold stress (4 ° C), space reduction in the homecage, changed cages and social interaction with other animals of the CMS group. To assess wether animal were being depression or not, the animal were tested using Forced Swimming Test (FST). After induction, rats were randomly divided into two groups which each contained 15 animals: the normal control group (not induced CMS) and the CMS group (negative control). Furthermore, the animal model was performed perfusion to maintain organ when evacuation was done, cell damage did not occur. To evaluate cell organ, immunohistochemistry examination and ELISA examination was performed. All data are presented as mean ± standard deviation and all statistical analyzes are performed with the SPSS 25 (IBM) program. Result: This research showed that CMS animal model has a greater duration of immobility than the normal group and serotonin level in CMS animal models decreased almost threefold compared to the normal group. In addition, there were increased expression of caspase-3 indicates that more neuronal cells suffered from apoptosis. So, in this research, it was clearly stated that in depressive disorder, there were elevation of neuronal cell apoptosis in the prefrontal cortex. Conclusion: Neuronal cell apoptosis in the prefrontal cortex plays a role in the pathophysiology of depression through activation of negative feedback on serotonin production.
Are Young Women More Potential to Commit Suicide? Patricia Wulandari; Rachmat Hidayat
Scientia Psychiatrica Vol. 1 No. 3 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i3.16

Abstract

Introduction: Convenience in various aspects of life in fact does not guarantee people live happier. Every year around the world around one million people die from suicide. One of the most consistent findings in suicide research is that women make more suicide attempts (tentament suicide) than men. This research is the first research conducted as an effort to increase the awareness of all medical potentials of young women to commit suicide. Methods: This research was qualitative research with an in-depth interview approach to respondents. The subjects of this study were patients with a diagnosis of tentamen suicide who consulted the Cattleya Consultation Center, Palembang, Indonesia. Results: All subjects with a tendency to commit suicide were female (100%) with a young age, ie the youngest age was 16 years and the oldest was 28 years. Women at this age are classified as young and productive age. It was found that most of the patients had avoidant personality traits (43%). In addition, the factors that triggered the emergence of tentamen suicide in some respondents were social and environmental factors (44%), namely in the form of friendship factors (peer groups), and the experience of bullying. Conclusion: Young women have the potential to do tentamen suicide.
Brain Development of Attachment Experience: How Does It Affects Our Brain? Rachmat Hidayat; Patricia Wulandari
Scientia Psychiatrica Vol. 2 No. 3 (2021): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v2i3.39

Abstract

Our infant experiences involve our emotions, behavior, perceptions, and our mental models of the world of others and ourselves. Implicit memories encode the early forms of our learning about the world. Implicit memories directly shape our experiences here and now with no clue as to their origins from past events. Attachment research, combined with independent findings from our modern studies of genetics and developmental neurobiology, suggests that certain types of communication in emotionally connected relationships offer an essential experience that a child's mind can develop. This literature review describes how our experience in childhood affects brain development.
Effect of Andrographis paniculata on Blood Sugar Levels Through Regulation of Alpha-Glucosidase Enzyme Expression: An In Vivo Study Rachmat Hidayat; Patricia Wulandari
Eureka Herba Indonesia Vol. 3 No. 1 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i1.56

Abstract

Diabetes mellitus (DM) is a disease characterized by an increase in blood glucose levels caused by insulin deficiency, either absolute or relative. The α-glucosidase enzyme functions to accelerate the absorption of glucose by the small intestine by catalyzing the hydrolytic cleavage of oligosaccharides into monosaccharides. This study aims to explore the potential of AP extract in regulating blood sugar levels through inhibition of α-glucosidase activity in the intestine. This study is an in vivo experimental study. A total of 30 \ rats were divided into a control group and treated with Andrographis paniculata. Examination of blood sugar levels was carried out by spectrophotometry and examination of alpha-glucosidase enzymes by ELISA. Data analysis was performed using SPSS software with univariate and bivariate analysis. Andrographis paniculata extract was able to reduce blood sugar levels and was able to decrease the activity of the alpha-glucosidase enzyme as the dose increased. Andrographis paniculata extract is able to reduce blood sugar levels by inhibiting the activity of the alpha-glucosidase enzyme in the intestine.
Pengaruh Iskemia-Reperfusi terhadap Gambaran Seluler Tubulointerstisial Renalis, Kadar Cystatin C dan Glomerular Filtration Rate (GFR) Tikus Wistar Ahadi Aulia Rahman; Rachmat Hidayat; Sri Nita
Sriwijaya Journal of Medicine Vol. 2 No. 3 (2019): Vol 2, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v2i3.54

Abstract

Acute Kidney Injury (AKI) merupakan penurunan fungsi ginjal secara cepat. Penyebab AKI terbesar adalah iskemia/reperfusi yang memicu respon inflamasi dan menyebabkan kerusakan ginjal. Inflamasi merupakan respon proteksi dan perbaikan jaringan, namun dapat menyebabkan fibrosis yaitu jaringan normal digantikan oleh matriks ektraseluler seperti kolagen. Kerusakan yang terjadi pada bagian tubulointerstisial berpengaruh besar terhadap fungsi ginjal yang dapat diukur dengan GFR menggunakan cystatin C. Tujuan penelitian ini adalah untuk mengetahui pengaruh durasi iskemia-reperfusi terhadap gambaran seluler tubulointerstisial, kadar cystatin C dan GFR pada tikus Wistar sertakorelasi antara gambaran seluler tubulointerstisial, kadar cystatin C dan GFR. Penelitian ini adalah penelitian eksperimental dengan desain posttest only with control group. Penelitian menggunakan 30 ekor tikus Wistar yang dilakukan di animal house dan laboratorium biomolekuler Fakultas Kedokteran Universitas Sriwijaya. Gambaran seluler tubulointerstisial, kadar cystatin C dan GFR dinilai dengan persentase fraksi area kolagen, ELISA dan rumus Larsson.Iskemia 30 menit dan reperfusi 14 hari 99,1% berpengaruh terhadap persentase fraksi area kolagen, iskemia 120 menit dan reperfusi 14 hari 98,8% berpengaruh terhadap kadar cystatin C serta 99,5% berpengaruh terhadap GFR. Terdapat korelasi yang signifikan antara persentase fraksi area kolagen dan kadar cystatin C (p=0,0001, r=0,901), serta GFR (p=0,0001, r=-0,834), lalu antara kadar cystatin C dan GFR (p=0,0001, r=-915). Durasi iskemia-reperfusi berpengaruhterhadap gambaran seluler tubulointerstisial, kadar cystatin C dan GFR serta terdapat korelasi antara gambaran seluler tubulointerstisial, kadar cystatin C dan GFR pada tikus Wistar.
Regulation of Cell Cycle Rachmat Hidayat; Lusia Hayati
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.236

Abstract

The cell cycle is a vital process in the life of every organism. Normally, the cell cycle results in cell division. Cell division consists of 2 main processes, namely DNA replication and chromosome division that has been duplicated into 2 daughter cells. Cyclin is expressed periodically so that the cyclin concentration varies at each phase of the cell cycle. Cdks are threonine or serine protein kinases which must bind to cyclin for its activation. The concentration of Cdks is relatively constant during the cell cycle. Cyclin-dependent kinase inhibitor (CKI) is a protein that can inhibit Cdk activity by binding to Cdk or the cyclin-Cdk complex
Molahidatidosa from Pathophysiology to Clinical: Literature Review Rachmat Hidayat; Irawan Sastradinata
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.260

Abstract

Hydatidiform is a gestational trophoblast disease which is histopathologically characterized by the proliferation of avascular trophoblast cells and corial villi and undergoing hydrophic degeneration. The proliferation of trophoblast cells in hydatidiform moles can be in the form of cytotrophoblast, syncytiotrophoblast or intermediate trophoblast proliferation.
Sarcopenia from Pathophysiology to Clinical : Literature Review Rachmat Hidayat; Nur Riviati
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.261

Abstract

The causes of sarcopenia are thought to be multifactorial including: environmental factors, illness, activation of inflammatory pathways, mitochondrial dysfunction, loss of neuromuscular junctions, reduced number of satellite cells and changes in the quality of hormonal function. The mechanism of sarcopenia occurs because the aging process coupled with reduced physical activity can cause the formation of cytokines to increase so that inflammation is easy, insulin resistant, anabolic resistance and neuromuscular impairments.
Co-Authors Aan Hardiyansah Abdul Mahatir Najar Abdulwahab Hakimi Abu Bakar Abu Bakar Abudarda, Andi Risda Fitrianti Achmar Mallawa Adnindya, Msy Rulan Agus Indra Jaya Agus Junaidi Agus Junaidi Agustian, Kresnawidiansyah Ahadi Aulia Rahman Ahmad Ahmad Ahmad Fatoni Ahmad Salim, Ahmad ahmad yani Ahmad Zain Sarnoto Ahmad, Arfandi Aji, Muhammad Pramono Alhan, Khusni Alvian, M. Andri Anang Tribowo Andayani, Nurfitri Andi Alfa Reza Andiani, Lia Andres Andres Andriana, Nadila Andronias Siregar Annisa Wimaulia Azlin Anuar, Arman Bin Aprilyanti, Cindy Apriwandi . Arifin, Nurdin Arindi Maretzka Aryanto, Hermawan Noval Ayeshah A Rosdah Azakhia, Yolanda Citra Baharuddin Baharuddin Bainamus, Putri Milanda Bella Stevanny Bemba, Tonia Buchari Buchari Budi Pratiti Burhan, Ahmad Syarif Carla R Marchira Catherine Christine, Debbie Cinthya Callathea Dahlan, Dadang - Dariyanto, Erwin David Usman Debby Handayanti Harahap Dessa, Rima Djoko Widodo Edith Humries edy susanto Ella Amalia, Ella Ellya Verawati Elsa Iskandar Erizka Rivani Erlina Erlina Erma Agusliani Ester G Pansserga Fahcreza Faisal Syahputra, Faisal Fajarwati, Lia Fathonah, Andina Nur Fatmawati Fatmawati Fatmawati Fildzah Hashifah Taufiq Fiona Widyasari Firdaus Muhammad Firjatullah, Andhika Fauziana Griselda Griselda Hadi, Dudi Abdul hadi, marwan Hammy, Hammy Hamzah, Fajri Handayani, Lisa Hani Subakti Haryanto Haryanto Herman Paninggiran Hermansyah Hermansyah Hermansyah Herry Hasnawi Herwansyah HUSNUL KHOTIMAH Ichsan, Amirul Ika Kartika Ikrima Ikrima Ilahi, Rahmat Imam Pribadi Inggarsih, Rara Irawan Sastradinata Irawan Sastradinata Irham Irham Irsan Saleh Ismar Hamid Iwan Setiawan Jamalullail Jayawarsa, A.A. Ketut Joko Marwoto Joko Marwoto Julian Sigap Rosadi Suwarso Junoretta Haviva Ernanto Kahar, Irsan Kahar, Irsan Kahar Kashardi, Kashardi Kemas Abdul Mutholib Luthfi Kemas Ya'kub Rahadiyanto Krishna, Hidan Bayu Krisna Murti Kumba Digdowiseiso, Kumba KURNIA KURNIA, KURNIA Lestari Barus, Irene Sukma Linda Purnama Listianingsih, Lona Lusia Hayati Lusia Hayati Lusia Hayati Lusia Hayati Lusia Hayati, Lusia Luthfi, Kemas Abdul Mutholib Mahmuddin Mahmuddin Mail, Abdul Maisya, Irin Makbruri Amin Malik, Aulia Januar Maria Margareth Wilson Marlinda, Dwi Martino Dwi Nugroho MARYANTI, LILIS Maslukin, Maslukin Mauladan, Ravy Maulana Saputra Maximillian Wilson Meilinda, Salsa Rizkia Mgs Irsan Saleh Mgs Irsan Saleh Mirna Dianita Muallin, Muallin Mubarok, E. Saefuddin Muhammad Anzarach Pratama Muhammad Bima Muhammad Damar Udin Muhammad Irsan Saleh Muhammad Reagan Muhammad Reagen Muhammad Ridwan Muhammad Rifani, Muhammad Muhammad Rizky Hidayatullah Muhlis Muhlis Mukti Zainuddin Murlena, Murlena Muslina Muslina Muthia, Putri Muthia, Putri Nadia Khoirina Najla Khairunnisa Nandang Iriadi Nani Solihati Nasriandi Nasriandi Ninuk Riesmiyantiningtias Nita Parisa Noorzaman, Sandi Noviyan, Rizky Dwi Nur Ainun Nur Riviati, Nur Nur Saqinah Galugu Nur, Rahmat Nur, Suaib Nurdina, Mutia Nurhasanah Nurhayati, M Sinta nurliah, nurliah Nurpahni, Siti Salma Nurrahmah, Andi Nurwijayanti Oktaviyani, Hikmatul Olivia Azalia Putri Pajarianto, Hadi Pamungkas, K J paosan, ahmad Patricia Wulandari Patry, Him Petty Purwanita Poku, Ham pongtiku, ita Prakarsa, Bambang Pramono, Yacob Agung Prayudhi, Risa Prihatina Anjela Purnamasari, Septi Puspa Sari, Puspa Puspa Zulaika Puspita, Sabrina Diah Puspitasari, Andini Putra, Suadi Sapta Putri Muthia Rachman, Andry Arifian Rachmat Hidayat Raden Ayu Adelia Safitri Raden Sunita Radiyati Umi Partan Radjikan Rahayu, Rosi Rahman, Ahadi Aulia Rahman, Ahadi Aulia Rahman, Alfi Rahmat Rais Rahmat Saleh Raihan Aqiilah N.L. , Andi Ahmad Ramadana, Radiyah Ramadhan, Hamzah Ramadhani, Anjas Ramli, Musdalifah Rara Inggarsih Rara Inggarsih Rashidah Unaib Al Zayid Rasyidah Jalil Reisha Notonegoro Resva Meinisasti Rety, Alghazali Riani Erna Rijaluddin, Khalid Rima Rachmawati Riri Juliantika Risnanosanti Risnanosanti Riswanto, A Heri Riswanto, A. Heri Riswanto, Andi Heri Riswanto, Heri Rosiyadi, Didi Safi'i, Imam Sahidan Sahidan Sahidan Sahidan Sahni Putri, Andi Rani Saksitha, Deassy Arestya Salni Salni Saman, Saman Samsuri, Fhadil Hidayat Sapinah, Pipin Sarah Sari , Windy Dian Sari H. S., Maharani Puspita Sari, Anggi Psutpita Sari, Windy Dian Sarmila, Sarmila Sarnato, Ahmad Zain Satriansyah , Arief Sekarini, Ratih Ayu Sepang, Rosa Marten Septi Purnamasari Septi Purnamasari SEPTIAN, DIAN Seruni, Seruni Shalita Dastamuar Shina Abdulkadir Sony Sanjaya Sonya Syarifah Sri Nita Sri Nita Sri Nita Sri Nita, Sri Sri Tuti Rahmawati Sri Vandayuli Riorini Sry Agustina St. Aisjah Farhum, St. Aisjah Sudaramanto, Bagus Sujud, Atsari Surya Ade Saputera Surya Darma Surya Darma Syarif Burhan, Ahmad Tanjung, Enha Syahrul Taufiq Indera Jayadi Tiara Fatrin Triwani Triwani Triwani Tungki Pratama Umar Tungki Pratama Umar Tunru, Andi Alif Udi Rusadi Uswatun Hasanah Veithzal Rivai Zainal Wahyudin Wahyudin Wardani, M. Fikri Wardiansyah Wiganepdo, Suryatno Wijaya, Maya Septa Winda Ramadianti, Winda Wirna, Risalah Sabila Yeni Agustin Yuliansyah, Chandra Yundari, Yundari Yuni sahruni, Ade Yusnaini Yusnaini Yusnia Budiarti Yusril Yusril Zaidan, Naufal Muhamad Zakaria, Khairunnisa Zen, Agustian Ziske Maritska