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Nurul Qomariyah
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Journal : Jaringan Laboratorium Medis

 1 
Gambaran Kadar Ureum, Asam Urat, Kreatinin, dan Albumin Pasien TB-MDR yang Mengkonsumsi OAT di RSP Dr. Ario Wirawan Salatiga Qomariyah, Nurul; Hidayah, Nur; Rahmaddina, Selma Aulia
Jaringan Laboratorium Medis Vol 6, No 2 (2024): November 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i2.12348

Abstract

Multi Drug Resistant Tuberculosis (MDR-TB) is a type of tuberculosis that is resistant to two first-line antituberculosis drugs (OAT), namely Isoniazid and Rifampicin. MDR-TB treatment involves a combination of first-line and second-line OAT, which is carried out over a long period of time. The prolonged use of these drugs can cause side effects that affect various organs of the body, especially the kidneys. One indication of impaired kidney function is an increase in blood levels of ureum, uric acid, creatinine and albumin. In addition, side effects of drugs such as Kanamycin, which is nephrotoxic, can cause accumulation in the proximal tubules of the kidneys, reduce the glomerular filtration rate, and impact creatinine levels. Another side effect that can arise during MDR-TB treatment is a decrease in appetite, which leads to decreased nutritional intake, reflected in low albumin levels. This study aims to describe the levels of ureum, uric acid, creatinine, and albumin in patients with MDR-TB undergoing treatment at Ario Wirawan Lung Hospital (RSPAW) Salatiga. This study is descriptive qualitative with a cross-sectional approach. Secondary data were collected from the medical record installation from January to December 2023. This study involved 28 respondents, of which 92.86% had normal ureum levels, 71.43% had normal uric acid levels, 96.43% had normal creatinine levels, and 78.57% had normal albumin levels. A small proportion of respondents had elevated ureum or uric acid levels, with some variation in the combination of abnormal creatinine and albumin levels. The conclusion of this study is that although there were patients with abnormal ureum, uric acid, creatinine, or albumin levels, MDR-TB treatment generally did not significantly affect ureum, uric acid, creatinine, and albumin levels in the majority of patients. However, regular monitoring of renal function and nutritional status is still required to detect and manage adverse effects that may arise during long-term treatment.
Hubungan Kadar Kalium dan Kadar Ureum Terhadap Jenis Obat Baru pada Pasien Tuberkulosis Resistan Obat (TB RO) Anggita, Sasha Marwah; Qomariyah, Nurul; Kahar, Fitriani
Jaringan Laboratorium Medis Vol 6, No 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.11388

Abstract

The use of new types of drugs in RO TB patients will cause disturbances in the body's electrolytes, especially potassium levels, as well as disturbances in urea levels caused by the excretion of urea that is retained in the body. Continuous increases in urea in the body result in the kidneys not being able to work optimally. The aim of this study was to determine the relationship between potassium levels and urea levels on new types of drugs in RO TB patients. The research method used is analytical observational with a cross sectional approach. This research was conducted on 16 February – 16 March 2023 with research subjects being RO TB patients who received treatment with a new type of drug at the Lung Hospital dr. Ario Wirawan Salatiga as many as 21 respondents using a sampling technique that is the total population. Potassium levels were measured using the ISE (Ion Selective Electrode) method and urea levels used the enzymatic UV test method. The data was then processed using the Shapiro-Wilk normality test, then continued with prerequisite tests (crosstab test and homogeneity test) then continued with hypothesis testing, because my data scale was ratio and nominal, the alternative test used was the Chi-Square Test. The equipment test results obtained a homogeneity test with a P value of 0.698 and 0.610 (0.05), meaning the data was homogeneous. The test results for the relationship between potassium and urea levels on new types of drugs for RO TB patients were Chi-Square hypothesis test results with a P value of 0.152 and 0.384 ( 0.05) means there is no relationship between potassium levels and urea levels on new types of drugs in RO TB patients. The results show that the TB drugs bedaquiline and delamanid do not cause kidney function disorders so that RO TB patients can consume these TB drugs regularly.
Derajat Aglutinasi Pemeriksaan Golongan Darah Metode Cell Grouping Berdasarkan Tingkat Konsentrasi Suspensi Sel Khoolidah, Nur Muhjah; Qomariyah, Nurul
Jaringan Laboratorium Medis Vol. 1 No. 1 (2019): May 2019
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v1i1.5181

Abstract

Blood transfusions must go through of strict procedures to prevent transfusion reactions that can appeared. One  procedure that must be do is the examination of ABO and Rhesus blood group. Ratio of antigens and antibodies play a role in the formation of agglutination. The more bonded antigens-antibodies, the larger, clearer, and stronger the agglutination will be. Analyzing the different of degree of agglutination of blood examination cell grouping method based on cell suspension concentration level. The type of research used is experimental research. The subjects of the study were 18 college students were grouped by blood group A, B and AB. Each cell specimen was treated to make cell suspension concentration of 5%, 10%, 15% and 20%. All examination result show degree of agglutination 4+. The cell suspension concentration of 5%, 10%, 15% and 20% in blood type A and B examination show the same data that’s degree of agglutination 4+ with clear background. The cell suspension concentration of 5 in blood type AB examination show degree of agglutination 4+ with clear background of 70%.
Prevalensi Hasil Pemeriksaan HBsAg dan Anti HBs pada PSK (Pekerja Seks Komersial) Priyatno, Djoko; Qomariyah, Nurul
Jaringan Laboratorium Medis Vol. 1 No. 2 (2019): November 2019
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v1i2.5453

Abstract

Commercial sex workers are a high risk group of STD infection (HIV-AIDS, syphilis, gonorrhea and Hepatitis-B). Transmission of HBV 100x faster than the HIV. Diagnosis HBsAg and Anti-HBs is a marker of HBV infection can be detected at least 2 weeks before clinical symptoms appear. The incidence of STIs Semarang (in 2012) is the highest in the resocialization Argorejo as much as 1,623 cases. Monitoring of Hepatitis B in resocialization has not become a routine examination. The formulation of the research problem is "How prevalence of HBsAg and Anti-HBs on resocialization PSK Argorejo Semarang?". This study is observational analytic cross-sectional design. Specimens research is venous blood PSK Argorejo resocialization who check monitoring of HIV-AIDS in August-September 2015.  Sampling a total of sampling for examination imunoserologis HBsAg and Anti-HBs in the strip method. Analysis of the relationship between host factors with HBsAg and anti-HBs using Spearman's test. Negative values on the results of HBsAg while the percentage of anti-HBs PSK resocialization some 29%. There is no relationship between age, education and knowledge with Anti-HBs. There is a relationship between sexual behavior with Anti-HBs. Upregulation required screening and immunization of Hepatitis-B infection in the community resocialization Argorejo Semarang.
Validasi Pemeriksaan Kolesterol Total Metode CHOD- PAP pada Sampel yang Disimpan Selama 1 Minggu dalam Suhu 4-8°C Nabilla, Jihan; Ulya, Nabila Intifa; Ardianty, Rieke Rofikoh; Agiska, Sabrina Dela; Nadifah, Fatkhatin; Qomariyah, Nurul
Jaringan Laboratorium Medis Vol. 5 No. 1 (2023): May 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i1.8690

Abstract

High total cholesterol levels cause various diseases, especially those related to the heart  and blood vessels. Total cholesterol test uses serum as a sample and must be analyzed within one hour after sampling.However, in the field sometimes there are inspection delays.Some studies have proven that serum stored for one week at a temperature of 4-8°C has different results in total cholesterol examination. For this reason, this study aims to determine the validity of total cholesterol examination using the CHOD-PAP method of serum samples stored for one week at a temperature of 4o-8oC. Validation test based on eight parameters, there are precision, accuracy, linearity, reportable range,limit detection, quantitation limit,  recovery, and interference. Only the recovery test was not accepted from eight parameters. Based on the Kruskal Wallis test, the sig value is 0.172 <0.05, it can be stated that there is no difference in serum storage time for one week at a temperature of 4-8℃ on total cholesterol levels using CHOD-PAP method.
Gambaran Nilai Index Trombosit pada Pasien Tuberulosis Paru yang Mengonsumsi Obat Anti Tuberkulosis Widiyanto, S.Y. Didik; Qomariyah, Nurul; Sofyanita, Eko Naning
Jaringan Laboratorium Medis Vol. 5 No. 2 (2023): November 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i2.9646

Abstract

Tuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis which mostly attacks the lungs. Based on several studies, it is stated that tuberculosis sufferers who take OAT for healing experience side effects in the form of lowering the platelet index due to reactions from drugs that lyse platelets. This research is a descriptive study with a cross sectional design. Research was conducted on 30 respondents who consumed OAT. The results of this study obtained results of more than 50% on one of the platelet indices, namely the PWD value, which was obtained with low results with a total of 19 patients (63.3%), while for other indices such as platelet counts there were 21 patients (70%) , MPV in 28 patients (93%) and PCT in 23 patients (77%) had normal results. The conclusion of this study is that platelet index examinations in TB patients tend to be low in MPV and PDW, while they show high results in PLT and PCT examinations.
Hubungan Kadar Kalium dan Kadar Ureum Terhadap Jenis Obat Baru pada Pasien Tuberkulosis Resistan Obat (TB RO) Anggita, Sasha Marwah; Qomariyah, Nurul; Kahar, Fitriani
Jaringan Laboratorium Medis Vol. 6 No. 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.11388

Abstract

The use of new types of drugs in RO TB patients will cause disturbances in the body's electrolytes, especially potassium levels, as well as disturbances in urea levels caused by the excretion of urea that is retained in the body. Continuous increases in urea in the body result in the kidneys not being able to work optimally. The aim of this study was to determine the relationship between potassium levels and urea levels on new types of drugs in RO TB patients. The research method used is analytical observational with a cross sectional approach. This research was conducted on 16 February – 16 March 2023 with research subjects being RO TB patients who received treatment with a new type of drug at the Lung Hospital dr. Ario Wirawan Salatiga as many as 21 respondents using a sampling technique that is the total population. Potassium levels were measured using the ISE (Ion Selective Electrode) method and urea levels used the enzymatic UV test method. The data was then processed using the Shapiro-Wilk normality test, then continued with prerequisite tests (crosstab test and homogeneity test) then continued with hypothesis testing, because my data scale was ratio and nominal, the alternative test used was the Chi-Square Test. The equipment test results obtained a homogeneity test with a P value of 0.698 and 0.610 (>0.05), meaning the data was homogeneous. The test results for the relationship between potassium and urea levels on new types of drugs for RO TB patients were Chi-Square hypothesis test results with a P value of 0.152 and 0.384 (> 0.05) means there is no relationship between potassium levels and urea levels on new types of drugs in RO TB patients. The results show that the TB drugs bedaquiline and delamanid do not cause kidney function disorders so that RO TB patients can consume these TB drugs regularly.
Gambaran Kadar Ureum, Asam Urat, Kreatinin, dan Albumin Pasien TB-MDR yang Mengkonsumsi OAT di RSP Dr. Ario Wirawan Salatiga Qomariyah, Nurul; Hidayah, Nur; Rahmaddina, Selma Aulia
Jaringan Laboratorium Medis Vol. 6 No. 2 (2024): November 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i2.12348

Abstract

Multi Drug Resistant Tuberculosis (MDR-TB) is a type of tuberculosis that is resistant to two first-line antituberculosis drugs (OAT), namely Isoniazid and Rifampicin. MDR-TB treatment involves a combination of first-line and second-line OAT, which is carried out over a long period of time. The prolonged use of these drugs can cause side effects that affect various organs of the body, especially the kidneys. One indication of impaired kidney function is an increase in blood levels of ureum, uric acid, creatinine and albumin. In addition, side effects of drugs such as Kanamycin, which is nephrotoxic, can cause accumulation in the proximal tubules of the kidneys, reduce the glomerular filtration rate, and impact creatinine levels. Another side effect that can arise during MDR-TB treatment is a decrease in appetite, which leads to decreased nutritional intake, reflected in low albumin levels. This study aims to describe the levels of ureum, uric acid, creatinine, and albumin in patients with MDR-TB undergoing treatment at Ario Wirawan Lung Hospital (RSPAW) Salatiga. This study is descriptive qualitative with a cross-sectional approach. Secondary data were collected from the medical record installation from January to December 2023. This study involved 28 respondents, of which 92.86% had normal ureum levels, 71.43% had normal uric acid levels, 96.43% had normal creatinine levels, and 78.57% had normal albumin levels. A small proportion of respondents had elevated ureum or uric acid levels, with some variation in the combination of abnormal creatinine and albumin levels. The conclusion of this study is that although there were patients with abnormal ureum, uric acid, creatinine, or albumin levels, MDR-TB treatment generally did not significantly affect ureum, uric acid, creatinine, and albumin levels in the majority of patients. However, regular monitoring of renal function and nutritional status is still required to detect and manage adverse effects that may arise during long-term treatment.
Co-Authors AA Sudharmawan, AA Abd Haris, Abd Abrori, Muroqidil Achmad Reza Mu’afa Adang Suhendra Afmi Fuad Agiska, Sabrina Dela Agustin, Dewi Ahmad Asryl Adhim, Rifqi Ahmad Zaki Mubarak, Ahmad Zaki Aini, Laily Nur Ainur Rofiq Sofa Al Fuad, Muhammad Rizqi Al Hadi, Kasnawi Al-laitsi, Mu'awiyatu Alaa, Siti Alfan Maulana Unis Aliyah, Hikmatul Amelia Sari Aminudin Afandhi Andayani, Astutik Andiarti, Rika Andriyani, Ririn Anggita, Sasha Marwah Anung Sugihantono Apriyansah, Noval Dias Ardianty, Rieke Rofikoh Ari Kristina, Susi Ariani, Tami Oktavia ARIFA, LULUK LUSIANA Ariska Wulandari, Yeni Art-In, Sitthipon Aseptin Murdini, Lia Ashbara, Kevin Arielga Biyan Asrowardi, Imam Auliya, Qurrotu A’yuni Awalloedin, Niki Ayu Sri Hartanti, Dyah Azahra, Sresta Aziz, Su'udin Azizah, Kamilatin Bagus Syahril Argowilda Benardy, Dhika Chelvian Satya Cahya Putri, Ardana Chusnah, Miftachul De Leon, Jardene Marie Gensaya Destiana Rachmawati Dewi Fuadatul Latifah Dinda Khumairoh, Salsabila Dinda Putri Alfarorino Distinarista, Hernandia Djoko Priyatno, Djoko Dona Eka Putri Duri, Iin Desmiany Eka Putri Amelia Surya Eko Purwanto Elly Puspitarini Ermis Suryana Evi Winingsih, Evi Fadhiah, Masyitha Sari Fahmi, Ach. Syafiq Fathimah Khansha Aswitama Fathiyaturrahmah Fathorrozy, Fathorrozy Fatiah, Keisyah Baitul Fatimah, Rahmatul Fausi, Suhud Al Fauzi Fauzi Firda Nur Zanah Fitri, Mellyana Frida I. Darusman Gata, Windu Gustinanda, Rizky Haiyudi, Haiyudi Halidah, Noor Halimatus Sakdiyah Halmahera, Amelia Dhamara Sofyati Hamdan Syakuro, Muhamad Hariani, Lilik Sri Harissman Hasan, Miftahul Hasani, Mohammad Rohib HENDRATNO Hendri Hermawan Adinugraha Heni Listiana Henny Regina Salve Herani, Zahra Hery Widijanto Hidayatingsih, Nur HILMAN, LUTHVAN Humaidah, Humaidah Hunain, Ishaq Hutomo, Muhammad Agita I Wayan Ari Makmur Iful Rahmawati Mega, Iful Rahmawati Ilmi Usrotin Choiriyah Indah Mulyani INDARTI, TITIK Inge Andriani Inge Andriani Intaglia Harsanti Intan Kartika Sari Islami, Riska Dwi Iwan Triyuwono Kahar, Fitriani Karimah, Karimah Karoma, Karoma Kasinyo Harto Kasiyati, Menik Kenes Pranandari Khirdany, Elvin Nury Khoiriyah Isni Khoiru Nisa, Afifah Khoirunnisa Virgiana Khan Khoolidah, Nur Muhjah Kuncara, Rachmad Bayu Larasmoyo Nugroho Lestari, Sri Isfantin Puji Lugiana, Namira Aisyah LUTHFATUN NISA M., Lina M.M. Nilam Widyarini Maghfiroh, Muliatul Mahyudin, Amnan Alfasya Ibnu Manshur, Ahmad Margaretta Sisterindah Martini, Ni Nyoman Putu Marzuki Marzuki Matrissya Hermita Maya, Maya Melinda, Lily Mochammad Akbar Marwan Mohammad Dhiya’ul Muhibbin Muarrifah, Sholehatul Mubarok, Muhammad Umam Mufarihah, Zahrotul Muharifin, Eko Munir Munir, Munir Muqorrobin, M Rizqil Hasan Mustaqimah, Diana mutiara mutiara Muttaqien, Moh Hasan Firghol Nabilla, Jihan Nadifah, Fatkhatin Nadiyah Nadiyah Nadya Rizkiyanti Rahmanillah Naguib Ahmed Osman, Ahmed Mohamed Yehia Nikmah, Ajeng Nafilatun Nikmah, Luluk Ainun Nisa, Khairan Norjannah, Norjannah Nugroho, Irfan Arif Nur Hasmalawati, Nur Nur Hidayah Nur Qomariyah, Siti Nurdin, Amila Nurfatona, Winda Yulia Nurwijayanti Nuzulan, Moh. Aji Zulfan Nyoman Putu Martini, Ni Oktaf Rina Oktomi Wijaya Parawansah, Siti Hanifah Perdana Putri, Rachma Greta Permana, Lalu Teguh Prajudy, Sugeng Prastiwi, Lusiana Pratanti, Anisa Dwi Prayoga, Bagus Dwi Pulungan, Dewi Ayu Pratiwi Putra Ayuni, Aditya Putra, Septafiansyah Dwi Putramulyo, Satriogi Putri Amalia Sari Putri I’malia Putri, Risma Nur Ariyana Quroyzhin Kartika Rini Rachmah, Qonita Rahmaddina, Selma Aulia Rahman, Fadali Rahmawati, Priska Ardya Ramadhan, Akhmad Viqri Rasyadi, Ach. Faidi Reginald, Muhammad Alvin Retno Dyah Puspitarini Reza, Anggit Ridwansyah, Eksa Rinarto Subroto Rini Akmeliawati Rini Indryawati Ririh Jatmi Wikandari Riris Diana Rachmayanti Rizandi, Dien Nabila Rizky Maulana, Nafta Rohmania, Dyah Ratna Romadhon, Muhammad Qomari Rosichin Mansur Rosidah, Umi Rush Aviciena, Iqbal S. Wahyuni Sahal, Ahmad Nur Samoh, Tasneem Santri, Ichtiarini Nurullita Sasangka, Parisade Galih Sastra Kusuma Wijaya Sa’adah, Nurus Septi Ambar Indraningtia Sukma Septian Emma Dwi Jatmika, Septian Emma Dwi Setyaningrum, Eva Shoffi, Robius Silvianasari, Firly Nur Sisterindah, Margaretta Siti Azizah Siti Cahyati Siti Masrohatin Siti Rahmawati Sofyanita, Eko Naning Sri Wahyuni St. Rodliyah, St. Rodliyah Subawe, Imam Subyantoro, Eko Sudirman Sudirman Sugiono Sugiono Suhada', Haris Suhatril, Ruddy J. Suhayat Minardi Sukandarman, Sukandarman Sulistyawati Sulistyawati Sumartono Sumartono Supriati, Anita Supriyatna, Agiska Ria Susana Prapunoto Sutanto, Rohadi Eko suudin aziz Syaifullah Syaifullah Syamsuddin Syamsuddin Taipabu, Rahmadani Tauriana, S Teguh Ardianto, Teguh Triatmono, Agus Ula, Zava Nuruzzuhrotil Ulfa, MH Muflihatul Uly, Rizkiyah Dewi Ulya, Dwi Ulya, Nabila Intifa Umi Hanifah, Elsa Veithzal Rivai Zainal Vina Kumala Wahyu Rahardjo Wahyu Rahardjo Wahyu Rahardjo Wahyu Rahardjo Wahyu Rahardjo Wardani, Aulia Fatma Wardatul Jannah, Wardatul Widiyanto, S.Y. Didik Widuri, Trisnia Widyawati, Dewi Kania Wirawan, Rahadi Wiwit Sulistyasmi Woro Supadmi Wulandari, Indri Eka Wulandary, Dian Anisa Yuli Ifana Sari, Yuli Ifana Yunina, Qurratu A Zahra, Shafiyya Zahroh, Intan Zahruna, Ulfi Zani, Novanna Rahma Zukhruf Saputri, Ginanjar Zulul Lailatul Masruroh Zuriati