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All Journal MEDIA KOMUNIKASI TEKNIK SIPIL Agrikultura Tahkim (Jurnal Peradaban dan Hukum Islam) Indonesian Journal of Educational Studies SUPREMASI: Jurnal Pemikiran, Penelitian Ilmu-Ilmu Sosial, Hukum dan Pengajarannya TOMALEBBI: Jurnal Pemikiran, Penelitian Hukum, Pendidikan Pancasila dan Kewarganegaraan (PPKn) Jurnal Sosialisasi: Jurnal Hasil Pemikiran, Penelitian dan Pengembangan Keilmuan Sosiologi Pendidikan Humano: Research Journal e-Jurnal Arus Elektro Indonesia Harmoni: Jurnal Pendidikan dan Penelitian Seni Budaya Jurnal Teknik Sipil Sari Pediatri Paediatrica Indonesiana Majalah Kesehatan FKUB Jurnal Moral Kemasyarakatan AcTion: Aceh Nutrition Journal Humani (Hukum dan Masyarakat Madani) Edukasi Islami: Jurnal Pendidikan Islam Bawal : Widya Riset Perikanan Tangkap JURNAL EDUCATION AND DEVELOPMENT GUIDENA: Jurnal Ilmu Pendidikan, Psikologi, Bimbingan dan Konseling Etika Demokrasi JURNAL PENDIDIKAN TAMBUSAI Jurnal Kreativitas PKM JAMBURA Journal of Architecture Jurnal Ilmiah Mandala Education (JIME) Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan Pagaruyuang Law Journal Jurnal Respirasi (JR) Pepatudzu : Media Pendidikan dan Sosial Kemasyarakatan Jurnal Review Pendidikan dan Pengajaran (JRPP) Turast: Jurnal Penelitian dan Pengabdian JEMMA | Journal of Economic, Management and Accounting Jurnal Sains dan Teknologi Reaksi Pena Teknik : Jurnal Ilmiah Ilmu-ilmu Teknik Industrial Engineering Journal (IEJ) Majalah Ilmu Pengetahuan dan Pemikiran Keagamaan Tajdid RADIAL: JuRnal PerADaban SaIns RekAyasan dan TeknoLogi AL-ULUM : Jurnal Ilmu Sosial dan Humaniora Jurnal Mekanova : Mekanikal, Inovasi dan Teknologi Agro Bali: Agricultural Journal Al-Qalb : Jurnal Psikologi Islam Jurnal Vokasi Jurnal Teknologi Elekterika Jurnal Prima Medika Sains SOSIOEDUKASI : JURNAL ILMIAH ILMU PENDIDIKAN DAN SOSIAL Bidayah: Studi Ilmu-Ilmu Keislaman Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Pengabdian kepada Masyarakat Nusantara FiTUA : Jurnal Studi Islam Indomera : Jurnal Magister Manajemen JURNAL AL-AQIDAH Jurnal Manajemen dan Organisasi Review (MANOR) International Journal of Engineering, Science and Information Technology JOURNAL LA MEDIHEALTICO Narra J Jurnal Pengabdian Masyarakat (ABDIRA) Lani: Jurnal Kajian Ilmu Sejarah dan Budaya Al-Ihtirafiah Brilliance: Research of Artificial Intelligence Jurnal Pendidikan Ilmu Pengetahuan Alam (JP-IPA) ProBisnis : Jurnal Manajemen Smart: Journal of Sharia, Tradition, and Modernity Jurnal Ilmiah Manajemen dan Bisnis (JIMBI) Jurnal Media Teknologi Jurnal Ilmiah Kesehatan Masyarakat Sisfo: Jurnal Ilmiah Sistem Informasi Seminar Nasional Pengabdian Kepada Masyarakat Journal of General Education and Humanities JUSTER: Jurnal Sains dan Terapan Jurnal Administrasi Bisnis Journal of Government Science Studies Asian Journal of Management Analytics International Journal of Advanced Multidisciplinary Al-Istinbath: Jurnal Hukum Islam QISTINA: Jurnal Multidisiplin Indonesia Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia SKILLS: Jurnal Riset dan Studi Manajemen Pendidikan Islam Postgraduate Management Journal Jurnal Ekonomika Manajemen Dan Bisnis Jurnal Litek : Jurnal Listrik Telekomunikasi Elektronika Teknologi dan Industri Pertanian Indonesia Economos : Jurnal Ekonomi dan Bisnis JAMAS: Jurnal Abdi Masyarakat JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Journal Of Artificial Intelligence And Software Engineering De Cive : Jurnal Penelitian Pendidikan Pancasila dan Kewarganegaraan Jurnal-Teknik Sipil Arsitek Perencanaan Wilayah (J-TSIAP) Alfuad: Jurnal Sosial Keagamaan Jurnal Malikussaleh Mengabdi Syiah Kuala Psychology Journal Jurnal Ilmu Pengetahuan dan Teknologi Bagi Masyarakat Jurnal Social Society Jurnal Ikhtibar Nusantara Jurnal Industri Samudra International Journal of Education, Vocational and Social Science JADMENT: Journal of Administration and Development Jurnal Pendidikan Nusantara Jurnal Cendekia Ilmiah PESHUM Jurnal Penelitian, Pengabdian dan Pemberdayaan Masyarakat Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Elementary Education Research RADIAL: Jurnal Peradaban Sains, Rekayasa dan Teknologi Studia Islamika Academia Open
Bakhtiar Bakhtiar
Program Doktor Jurusan Teknik Sipil, Universitas Diponegoro, Kampus UNDIP Tembalang Jl. Prof. Sudharto, SH Tembalang - Semarang.
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Journal : paediatrica indonesiana

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Neutrophil lymphocyte ratio and severity of acute kidney injury in septic children Kowita, Nurul Huda; Sovira, Nora; Safri, Mulya; Ismy, Jufitriani; Haris, Syafruddin; Herdata, Heru Noviat; Bakhtiar, Bakhtiar
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.492-8

Abstract

Background Acute kidney injury (AKI) in sepsis is associated with an inflammatory process in kidney microcirculation and may increase morbidity and mortality in children. The neutrophil lymphocyte ratio (NLR) is an inflammatory biomarker of the inflammatory process in sepsis. Objective To determine the role of NLR in predicting the severity of AKI and to describe the demographic and laboratory characteristics, as they relate to outcomes of pediatric patients with AKI and sepsis. Methods This cross-sectional study was conducted in the PICU at Dr. Zainoel Abidin General Hospital (RSUDZA), Banda Aceh, Aceh. Medical record data were obtained from critically ill children with sepsis and AKI. Chi-square test was used to compare the proportions of each variable. We also calculated odds ratios to evaluate the AKI severity, PELOD-2 score, and patient outcomes. Spearman's analysis was used to look for a possible correlation between NLR and AKI severity in septic children. Results Seventy-one subjects with sepsis and AKI were included. Subject characteristics were as follows: 63.4% males, 63.4% < 1 year of age, 56.3% with respiratory problems as a primary disease, 38% with AKI injury stage, and 54.9% subjects with PELOD-2 score ?10. There was no significant correlation between AKI severity and mortality (OR 3.04; 95%CI 0.990 to 9.378; P=0.052). Subjects with a PELOD-2 score ?10 had a 47.6 times higher chance of mortality in septic children with AKI compared to those with PELOD-2 scores <10. There was no correlation between NLR and AKI severity (r=0.019; P=0.878). Conclusion There is no correlation between NLR and AKI severity. Sepsis accompanied by AKI may increase the risk of mortality in children. Septic children with more severe AKI tends to be less survive.
Risk factors for acute kidney injury in children with critical illness Chalisah, Lilis; Sovira, Nora; Amna, Eka Yunita; Anidar, Anidar; Haris, Syafruddin; Bakhtiar, Bakhtiar
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.398-404

Abstract

Background Acute kidney injury (AKI) is an acute functional kidney disorder that increases morbidity and mortality in children. The mortality rate for critically ill patients accompanied by AKI is quite high and is influenced by the degree of AKI, the severity of the disease, and organ function disorders. Understanding the risk factors of developing AKI in children with critical illness can help prevent AKI. Objective To determine the risk factors for AKI in children with critical illness. Methods This retrospective cohort study included 255 children aged 1 month to 18 years admitted at the pediatric intensive care unit (PICU) of dr. Zainoel Abidin Regional Public Hospital, Banda Aceh, Aceh, from January to December 2022 using medical record data. Bivariate and multivariate analyses were performed. Results Acute kidney injury occurred in 68 (26.7%) patients. Based on pRIFLE criteria, 34 (50%) patients had AKI in the failure stage. Risk factors for AKI in children with critical illness were in descending order of RR: sepsis (RR 14.3; 95%CI 11.68 to 18.66; P=0.000), mechanical ventilation (RR 12.13; 95%CI 8.75 to 15.98; P=0.000), respiratory disorders (RR 2.51; 95%CI 2.06 to 4.02; P=0.003), congenital heart disease (RR 2.08; 95%CI 2.00 to 3.05; P=0.004), CNS disorders (RR 1.24; 95%CI 1.02 to 2.49; P=0.048), nephrotoxic drug use (RR 1.41; 95%CI 1.24 to 3.08; P=0.000), and age 1 month to 5 years (RR 0.072; 95%CI 0.16 to 0.32; P=0.010). Conclusion Sepsis is a risk factor for AKI in children with critical illness, followed by mechanical ventilation use, respiratory disorders, nephrotoxic drug use. Age <5 years is a protective factor.
Urinary neutrophil gelatinase-associated lipocalin to predict acute kidney injury in children with critical illness Fajri, Rizky; Sovira, Nora; Haris, Syafruddin; Dimiati, Herlina; Bakhtiar, Bakhtiar; Amna, Eka Yunita
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.47-53

Abstract

Background Acute kidney injury (AKI) can increase mortality in children with critical illness. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a biomarker for early prediction of AKI in children. Objective To determine the diagnostic value of uNGAL as a predictor of AKI in children with critical illness. Methods This observational cross-sectional study was conducted in the Emergency Room, Pediatric Intensive Care Unit, and Pediatric Ward of Zainoel Abidin Public Hospital, Banda Aceh, Indonesia, between August and December 2023. Subjects were 40 children aged 1 month to 18 years with critical illness. uNGAL levels were measured on the first day of admission. Blood urea and creatinine levels were measured on the first and third days of admission. We calculated the diagnostic sensitivity and specificity of uNGAL to predict AKI. The optimal uNGAL cut-off point for this purpose was determined using receiver operating characteristic (ROC) curve analysis. Result In the majority of patients (29/40; 72.5%) critical illness occurred at the ages of 5 to 18 years. The most common primary diseases were central nervous system disorders in 14/40 (35%) patients, gastrointestinal infection in 6/40 (15%) patients, and malignancy in 5/40 (12.5) patients. Median uNGAL levels were significantly elevated in subjects with renal impairment [17.37 (range 6.13-29.70) ng/mL] compared to those with normal renal function [4.87 (range 0.32-29.49) ng/mL] (P=0.0001). The optimal uNGAL cut-off point was >9.99 ng/mL, with an AUC of 0.842, 81% sensitivity, and 78.9% specificity to predict AKI. The OR of AKI in children with uNGAL levels >9.99 ng/mL was 10.66 (95%CI 2.30 to 49.30; P=0.003). Conclusion Urinary neutrophil gelatinase-associated lipocalin (uNGAL) can be used as a predictor of acute kidney injury in children with critical illness.
Risk factors for increased transaminase enzymes in children with epilepsy using valproic acid Sari, Ina Julia; Anidar, Anidar; Akbar, Zaki; Yusuf, Sulaiman; Bakhtiar, Bakhtiar; Ismy, Jufitriani
Paediatrica Indonesiana Vol. 66 No. 2 (2026): March 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Valproic acid (VPA) is a commonly used first-line medication for generalized epilepsy. Hepatotoxicity, manifested by elevations in transaminase enzymes, is a serious, life-threatening adverse effect of VPA use. Objective To determine the prevalence and risk factors for elevated transaminase enzymes in children with epilepsy receiving VPA. Methods A cross-sectional study was conducted at Zainoel Abidin General Hospital, Banda Aceh, Indonesia on 50 children with epilepsy aged 1 month to 18 years who received VPA and experienced elevations in serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT). We compared clinical characteristics Results  Of 294 children with epilepsy, 50 children (17%) met the study criteria. Elevated AST was found in 31 (62%) subjects and elevated ALT in 35 (70%) subjects. Bivariate analysis revealed a significant negative association between elevated AST and duration of treatment (OR=0.925; P=0.044) and a positive association between elevated ALT and number of antiepileptic drugs (AEDs) received (OR=7.691; P=0.022). Nutritional status was significantly associated with elevated ALT (OR=0.412; P=0.041). Multivariate analysis showed that the number of AEDs was he only significant risk factor for elevated AST (OR=4.663; P=0.040), and VPA dose was the most significant only significant factor for elevated ALT (OR=1.183; P=0.029). Conclusion In children receiving VPA for the treatment of epilepsy, the number of AEDs received is a risk factor for elevated ALT, while VPA dose is a risk factor for elevated AST.
Co-Authors A. Metta, Yoksan A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Abdul Muhaimin, Abdul Abni, Ahmad Aco Agus, Andi Ade Hermawan Ade Kurniawan Adillah, Zalza Afri, Wedi Agil Al Fatah, Muhammad Ahmad Gaffar Ahmadin Ahmadin Ahsan, Abdillah Aini, Aini Akbar, Muhammad Ramzil Akbar, Zaki Akel, Kaitlyn B. Akhyar Akhyar Akmal, Syarifah Al Karimah, Rusyda Alisa, Nur Almawardi, Almawardi Alya, Nauriel Amar, Muh Amar, Muh. Amin, Nur Syariful Amir, Indra Amna, Eka Yunita Andi Aco Agus, Andi Aco Andi Kasmawati Andrian Kaifan Andriani, Adila Angga Pratama Anggraini, Putri Septia Anidar Anidar, Anidar Ardias, Widia Sri Arief Rahman Aris Baharuddin Arkan, Muhammad Arsaf, Nur Fajar Asmara, Nufadillah Asnawi Abdullah asri, andarini Asriadi, Muh. Asvinia Ananta Zulatuva aswadin, aswadin Aulia, Annisa Rahma Nur Ayubi, Adim Isral Azhar Azhar Aziz, M. Abdul Azizi, Jamalul Azzahra, Fhonna Bagulu, Ahmad Baharman Supri, Baharman Bait, Muhaimin Bangngalino, Desi bangalino Basir, Basir Basri, Nur Ahmad Bidang, Afrida Budiarti Putri Uleng Burhanuddin Burhanuddin Chalisah, Lilis Cut Ita Erliana Dafrina , Armelia Dafrina, Armelia Dahri, Irsyasd Darnifayanti, Darnifayanti Dedy Syahrizal Demak, Nini A. Kiay Dewi Fitriana Djafar, Ahmad Dora Darussalam, Dora Edward, Eka D. Edward, Eka Destianti Edy, Khairunnisa Eka Safira, Nurul Elawati, Elawati Elfia Elfia elyusra ulfah Emi Maulani Era, Era Erni Erni Ervina, Yuni Erwina Erwina Ezwarsyah Ezwarsyah Fadhil, M. Fadhli Syamsudin Fadliani, Fadliani Fahriani, Marhami Fahruddin Fahruddin Fajri, Rizky Fatih, Muhammad Agung Al Fatih fatimah Fatimah Fauzi Fauzi Fazriani, Liana Febrianti, Maisarah Kasim Femmy, Femmy Firawati, Satria Firdaus, Muhammad Aryan FIRMAN UMAR, FIRMAN Fitriani Fitriani Fitrianti Fitrianti, Fitrianti Fuadi, Wahyu Gani, Fauzi A. Gani, Subhan A Gani, Subhan A. Garaika Gelyo, Alvin Johon Julian H, St Hasmawati Hajar, Andi Baso Hajar, Nurfahmi Hanifuddin Jamin, Hanifuddin Harapan Harapan Hartati Hartati Haryati, Wiwin Haslinur, Sari HASNAWI HARIS, HASNAWI Hasruddin Haypheng, Te Herdata, Heru N. HERI, RIRIN NURFAATHIRANY Herlina Dimiati, Herlina Herman Herman Hermawan*, Ade Heru Noviat Herdata, Heru Noviat Hidayanti, Nurul Hidayatun Nisa, Hidayatun Hilmi, Ulfa Idris, Muh Irfan Ima Maria Imam Suyitno Indah Andika Octavia Iqbal, Lailul Irma, Halimah Tri Irsyad Dhahri Samad Irwansyah , Defi Irwansyah, Defi Islam, Fausia Ismail, Ashari Ismy, Jufitriani Iwan K. Hadihardaja Jazila, Ulfa Jebaru, Yakub Joetata Hadihardaja Jufriadi Jufriadi, Jufriadi K, Fitriani. Kamue, Yurni Khalida, Azhariah Khiyarudami, Khala Iva Kowita, Nurul Huda Kurniati Kurniati Labonsa, Umar Lestari, Anastasya Lilingan, Bernadet Lubis, Ahmad Husin Lubis, Fandi Lubis, Putri Fatma Nagara M Tahir M Yusuf M. Rasyid Ridha M. Yunasri Ridhoh Madjowa, Nona Fitriana Magfirah Perkasa Maiyulanda, Betria Mardatilla, Andi Mahdiana Mato, Rahmit Aditya Mega Fatimah Rosana Meutia, Rizka Inda Meutia, Sri Miswar, Khairul MMSI Irfan ,S. Kom Mohamad Januar Fuad MS, Abdul Rasyid Muchlis Muchlis Mudatsir Mudatsir Muhammad Fajar Muhammad Haekal Yunus Muhammad Iqbal Muhammad Irwansyah, Muhammad Muhammad Jamili Muhammad Muhammad Muhammad Nasir Muhammad Zakaria Muis, Nurhasni Multazam, T Mulya Safri, Mulya Munawarah, Zahira Munawir Munawir Musa, Lutfi Alfia S. Mustaring Mustaring Mutammimul Ula Muthmainnah, Anggun Naim, Abdul Najamuddin Najamuddin, Najamuddin Najli, Emilia nasir, muh Nasti, Nilawati Nebras, Aqeel Nikman Azmin Nita Sari, Nita Nora Sovira, Nora Novayanti Sopia Rukmana, Novayanti Sopia Nur Adli Nur Annisa Nur rohman Nurfadila Nurfadila, Nurfadila Nurnaningsih, Andi Nurul Qalbi, Nurul Padli, Sul Paisal, M. Patahuddin Patahuuddin Poltak, Hendra Priono, Singgih Priyani, Putu Devi Putra, Remmy Lazuardi Putri, Muspira Riana R. Rusli Rachman, Ari Putra Raden Mohamad Herdian Bhakti Rahmawati, Rahmawati Rahmi, Nurul Maulina Rahmia, Rahmia Randiawan, Randiawan Ratnasari, Dini Saptika Rifdan . Rivai, Andi Muhammad Rizal S, Muh. Rokayah, Yayah Ronaldi, Ronaldi Rosninda, Rosninda RR. Ella Evrita Hestiandari Rusdi Andid, Rusdi Rusyanti, Siti S, Muh. Rizal Safana, Garsia Sahabuddin, Rohmansyah Sahputra, Ilham Sakka, Abdul Rahman A Sakman Salahuddin Salahuddin Salma Salma Samsul Anwar Sani, Nur Sanjaya, Mhd Sajid Saptari, Mochamad Ari Saputra, Irwan Saputra, Muh. Adam Saputra, Raihan Saputri, Juwa Sari, Dian Ekawati Sari, Idha Sari, Ina Julia Sayed Munazzar Siswahyudianto Siti Hadijah Sobhan, Sobhan Sofyan, Diana Khairani Solly Aryza Sonata, Ilham Sovira, Sovira SRI RAHAYU Sri Rezeki Sri Wulandari Srikandi, Mira sriwahyuni Sriwahyuni Suandi SUDIRMAN, MUH. sufriani, sufriani Suhendri, Ilham Asyraf Sukatin, Sukatin Sulaiman Yusuf Sulianingsih, Ladiva Eka Supardin, Muhammad Fauzan Supriadi Supriadi Surbakti, Ernawati Br. Surwati, Surwati Suyitno, Iman Syafiuddin, Achmad Syafruddin Haris, Syafruddin Syafruddin Syafruddin Syahyadi, Rizal Syaifullah Syaifullah Syam, A Fitria Syam, A. Fitria Syarief, Syarifuddin Syarif, Nurul Hidayanti Syawaloedin HP, Andi Try Haldyaqhza Syibral Malasyi, Syibral Syukriah Syukriah, Syukriah Tadjuddin Tadjuddin Tespani, Jessy Teuku Multazam Teuku Zulfadli Tilawah, Nining Tita Menawati Liansyah Trisna Trisna, Trisna Ummarah, Latifa Usman, Said Wagner, Abram L. Wahyuni, Neni Sri Wamnebo, Muhammad Ikhsan Widdha Mellyssa Widia, Widia Wira Winardi, Wira Wiwik Handayani Yanti, Budi Yorinda Rahmah, Nurfa Yufika, Amanda Yusman, Yusman Yusuf, Iswandi Zahratul Fitri, Zahratul Zakaria, Iskandar Zamzami Zuhaira, Zuhaira Zulfia , Anni