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All Journal MEDIA KOMUNIKASI TEKNIK SIPIL Agrikultura Tahkim (Jurnal Peradaban dan Hukum Islam) Indonesian Journal of Educational Studies SUPREMASI: Jurnal Pemikiran, Penelitian Ilmu-Ilmu Sosial, Hukum dan Pengajarannya Jurnal Tomalebbi Jurnal Sosialisasi: Jurnal Hasil Pemikiran, Penelitian dan Pengembangan Keilmuan Sosiologi Pendidikan Humano: Research Journal e-Jurnal Arus Elektro Indonesia Jurnal Teknik Sipil Sari Pediatri Paediatrica Indonesiana Majalah Kesehatan FKUB Jurnal Moral Kemasyarakatan AcTion: Aceh Nutrition Journal Humani (Hukum dan Masyarakat Madani) Edukasi Islami: Jurnal Pendidikan Islam Bawal : Widya Riset Perikanan Tangkap JURNAL EDUCATION AND DEVELOPMENT JURNAL PENDIDIKAN TAMBUSAI JAMBURA Journal of Architecture Jurnal Ilmiah Mandala Education (JIME) Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan Pagaruyuang Law Journal Jurnal Respirasi (JR) Pepatudzu : Media Pendidikan dan Sosial Kemasyarakatan Jurnal Review Pendidikan dan Pengajaran (JRPP) Turast: Jurnal Penelitian dan Pengabdian JEMMA | Journal of Economic, Management and Accounting Jurnal Sains dan Teknologi Reaksi Industrial Engineering Journal (IEJ) Majalah Ilmu Pengetahuan dan Pemikiran Keagamaan Tajdid RADIAL: JuRnal PerADaban SaIns RekAyasan dan TeknoLogi AL-ULUM : Jurnal Ilmu Sosial dan Humaniora Agro Bali: Agricultural Journal Al-Qalb : Jurnal Psikologi Islam Jurnal Vokasi Jurnal Teknologi Elekterika Jurnal Prima Medika Sains Bidayah: Studi Ilmu-Ilmu Keislaman Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Pengabdian kepada Masyarakat Nusantara FiTUA : Jurnal Studi Islam Indomera : Jurnal Magister Manajemen JURNAL AL-AQIDAH Jurnal Manajemen dan Organisasi Review (MANOR) International Journal of Engineering, Science and Information Technology Narra J Lani: Jurnal Kajian Ilmu Sejarah dan Budaya Al-Ihtirafiah Brilliance: Research of Artificial Intelligence Jurnal Pendidikan Ilmu Pengetahuan Alam (JP-IPA) ProBisnis : Jurnal Manajemen Journal of Social Research Smart: Journal of Sharia, Tradition, and Modernity Jurnal Ilmiah Manajemen dan Bisnis (JIMBI) Jurnal Ilmiah Kesehatan Masyarakat Sisfo: Jurnal Ilmiah Sistem Informasi Seminar Nasional Pengabdian Kepada Masyarakat JUSTER: Jurnal Sains dan Terapan Jurnal Administrasi Bisnis Ash-Shahabah: Jurnal Pendidikan dan Studi Islam Al-Istinbath: Jurnal Hukum Islam QISTINA: Jurnal Multidisiplin Indonesia Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia SKILLS: Jurnal Riset dan Studi Manajemen Pendidikan Islam Postgraduate Management Journal Jurnal Ekonomika Manajemen Dan Bisnis Jurnal Litek : Jurnal Listrik Telekomunikasi Elektronika Teknologi dan Industri Pertanian Indonesia JAMAS: Jurnal Abdi Masyarakat JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Journal Of Artificial Intelligence And Software Engineering De Cive : Jurnal Penelitian Pendidikan Pancasila dan Kewarganegaraan Jurnal-Teknik Sipil Arsitek Perencanaan Wilayah (J-TSIAP) Journal of Innovative and Creativity Jurnal Malikussaleh Mengabdi Syiah Kuala Psychology Journal Jurnal Ilmu Pengetahuan dan Teknologi Bagi Masyarakat Jurnal Ikhtibar Nusantara International Journal of Education, Vocational and Social Science Jurnal Pendidikan Nusantara PESHUM Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Elementary Education Research RADIAL: Jurnal Peradaban Sains, Rekayasa dan Teknologi Studia Islamika
Bakhtiar Bakhtiar
Program Doktor Jurusan Teknik Sipil, Universitas Diponegoro, Kampus UNDIP Tembalang Jl. Prof. Sudharto, SH Tembalang - Semarang.
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Journal : Paediatrica Indonesiana

 1 
Neutrophil lymphocyte ratio and severity of acute kidney injury in septic children Kowita, Nurul Huda; Sovira, Nora; Safri, Mulya; Ismy, Jufitriani; Haris, Syafruddin; Herdata, Heru Noviat; Bakhtiar, Bakhtiar
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.492-8

Abstract

Background Acute kidney injury (AKI) in sepsis is associated with an inflammatory process in kidney microcirculation and may increase morbidity and mortality in children. The neutrophil lymphocyte ratio (NLR) is an inflammatory biomarker of the inflammatory process in sepsis. Objective To determine the role of NLR in predicting the severity of AKI and to describe the demographic and laboratory characteristics, as they relate to outcomes of pediatric patients with AKI and sepsis. Methods This cross-sectional study was conducted in the PICU at Dr. Zainoel Abidin General Hospital (RSUDZA), Banda Aceh, Aceh. Medical record data were obtained from critically ill children with sepsis and AKI. Chi-square test was used to compare the proportions of each variable. We also calculated odds ratios to evaluate the AKI severity, PELOD-2 score, and patient outcomes. Spearman's analysis was used to look for a possible correlation between NLR and AKI severity in septic children. Results Seventy-one subjects with sepsis and AKI were included. Subject characteristics were as follows: 63.4% males, 63.4% < 1 year of age, 56.3% with respiratory problems as a primary disease, 38% with AKI injury stage, and 54.9% subjects with PELOD-2 score ?10. There was no significant correlation between AKI severity and mortality (OR 3.04; 95%CI 0.990 to 9.378; P=0.052). Subjects with a PELOD-2 score ?10 had a 47.6 times higher chance of mortality in septic children with AKI compared to those with PELOD-2 scores <10. There was no correlation between NLR and AKI severity (r=0.019; P=0.878). Conclusion There is no correlation between NLR and AKI severity. Sepsis accompanied by AKI may increase the risk of mortality in children. Septic children with more severe AKI tends to be less survive.
Risk factors for acute kidney injury in children with critical illness Chalisah, Lilis; Sovira, Nora; Amna, Eka Yunita; Anidar, Anidar; Haris, Syafruddin; Bakhtiar, Bakhtiar
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.398-404

Abstract

Background Acute kidney injury (AKI) is an acute functional kidney disorder that increases morbidity and mortality in children. The mortality rate for critically ill patients accompanied by AKI is quite high and is influenced by the degree of AKI, the severity of the disease, and organ function disorders. Understanding the risk factors of developing AKI in children with critical illness can help prevent AKI. Objective To determine the risk factors for AKI in children with critical illness. Methods This retrospective cohort study included 255 children aged 1 month to 18 years admitted at the pediatric intensive care unit (PICU) of dr. Zainoel Abidin Regional Public Hospital, Banda Aceh, Aceh, from January to December 2022 using medical record data. Bivariate and multivariate analyses were performed. Results Acute kidney injury occurred in 68 (26.7%) patients. Based on pRIFLE criteria, 34 (50%) patients had AKI in the failure stage. Risk factors for AKI in children with critical illness were in descending order of RR: sepsis (RR 14.3; 95%CI 11.68 to 18.66; P=0.000), mechanical ventilation (RR 12.13; 95%CI 8.75 to 15.98; P=0.000), respiratory disorders (RR 2.51; 95%CI 2.06 to 4.02; P=0.003), congenital heart disease (RR 2.08; 95%CI 2.00 to 3.05; P=0.004), CNS disorders (RR 1.24; 95%CI 1.02 to 2.49; P=0.048), nephrotoxic drug use (RR 1.41; 95%CI 1.24 to 3.08; P=0.000), and age 1 month to 5 years (RR 0.072; 95%CI 0.16 to 0.32; P=0.010). Conclusion Sepsis is a risk factor for AKI in children with critical illness, followed by mechanical ventilation use, respiratory disorders, nephrotoxic drug use. Age <5 years is a protective factor.
Urinary neutrophil gelatinase-associated lipocalin to predict acute kidney injury in children with critical illness Fajri, Rizky; Sovira, Nora; Haris, Syafruddin; Dimiati, Herlina; Bakhtiar, Bakhtiar; Amna, Eka Yunita
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.47-53

Abstract

Background Acute kidney injury (AKI) can increase mortality in children with critical illness. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a biomarker for early prediction of AKI in children. Objective To determine the diagnostic value of uNGAL as a predictor of AKI in children with critical illness. Methods This observational cross-sectional study was conducted in the Emergency Room, Pediatric Intensive Care Unit, and Pediatric Ward of Zainoel Abidin Public Hospital, Banda Aceh, Indonesia, between August and December 2023. Subjects were 40 children aged 1 month to 18 years with critical illness. uNGAL levels were measured on the first day of admission. Blood urea and creatinine levels were measured on the first and third days of admission. We calculated the diagnostic sensitivity and specificity of uNGAL to predict AKI. The optimal uNGAL cut-off point for this purpose was determined using receiver operating characteristic (ROC) curve analysis. Result In the majority of patients (29/40; 72.5%) critical illness occurred at the ages of 5 to 18 years. The most common primary diseases were central nervous system disorders in 14/40 (35%) patients, gastrointestinal infection in 6/40 (15%) patients, and malignancy in 5/40 (12.5) patients. Median uNGAL levels were significantly elevated in subjects with renal impairment [17.37 (range 6.13-29.70) ng/mL] compared to those with normal renal function [4.87 (range 0.32-29.49) ng/mL] (P=0.0001). The optimal uNGAL cut-off point was >9.99 ng/mL, with an AUC of 0.842, 81% sensitivity, and 78.9% specificity to predict AKI. The OR of AKI in children with uNGAL levels >9.99 ng/mL was 10.66 (95%CI 2.30 to 49.30; P=0.003). Conclusion Urinary neutrophil gelatinase-associated lipocalin (uNGAL) can be used as a predictor of acute kidney injury in children with critical illness.
Co-Authors A. Metta, Yoksan A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Abdul Muhaimin, Abdul Abni, Ahmad Aco Agus, Andi Ade Hermawan Ade Kurniawan Adillah, Zalza Afri, Wedi Agil Al Fatah, Muhammad Ahmad Gaffar Ahmadin Ahmadin Aini, Aini Akbar, Muhammad Ramzil Akel, Kaitlyn B. Akhyar Akhyar Akmal, Syarifah Alisa, Nur Alya, Nauriel Amin, Nur Syariful Amir, Indra Amna, Eka Yunita Andi Aco Agus, Andi Aco Andi Kasmawati Andriani, Adila Angga Pratama Anggraini, Putri Septia Anidar Anidar, Anidar Ardias, Widia Sri Arief Rahman Aris Baharuddin Arsaf, Nur Fajar Asmara, Nufadillah Asnawi Abdullah asri, andarini Asvinia Ananta Zulatuva aswadin, aswadin Ayubi, Adim Isral Azhar Azhar Aziz, M. Abdul Azizi, Jamalul Azzahra, Fhonna Bagulu, Ahmad Bait, Muhaimin Bangngalino, Desi bangalino Basri, Nur Ahmad Budiarti Putri Uleng Burhanuddin Burhanuddin Chalisah, Lilis Cut Ita Erliana Dafrina , Armelia Dafrina, Armelia Dahri, Irsyasd Darnifayanti, Darnifayanti Dedy Syahrizal Demak, Nini A. Kiay Dewi Fitriana Djafar, Ahmad Dora Darussalam, Dora Eddy Prianto Edward, Eka D. Edy, Khairunnisa Eka Safira, Nurul Elawati, Elawati Elfia Elfia elyusra ulfah Emi Maulani Era, Era Ervina, Yuni Erwina Erwina Ezwarsyah Ezwarsyah Fadhil, M. Fadliani, Fadliani Fahriani, Marhami Fahruddin Fahruddin Fajri, Rizky Fatih, Muhammad Agung Al Fatih Fauzi Fauzi Febrianti, Maisarah Kasim Femmy, Femmy Firawati, Satria FIRMAN UMAR, FIRMAN Fitriani Fitriani Fitrianti Fitrianti, Fitrianti Fuadi, Wahyu Gani, Subhan A Gani, Subhan A. Garaika Gelyo, Alvin Johon Julian H, St Hasmawati Haerunnisa Haerunnisa, Haerunnisa Hajar, Andi Baso Hajar, Nurfahmi Hanifuddin Jamin, Hanifuddin Harahap, Julienda Br Harapan Harapan Hartati Hartati Haryati, Wiwin Haslinur, Sari Haypheng, Te Herdata, Heru N. HERI, RIRIN NURFAATHIRANY Herlina Dimiati, Herlina Herman Herman Hermawan*, Ade Heru Noviat Herdata, Heru Noviat Hidayatun Nisa, Hidayatun Hilmi, Ulfa Idris, Muh Irfan Ima Maria Imam Suyitno Indah Andika Octavia Iqbal, Lailul Irma, Halimah Tri Irsyad Dhahri Samad Irwansyah, Defi Islam, Fausia Ismy, Jufitriani Iwan K. Hadihardaja Jazila, Ulfa Jebaru, Yakub Joetata Hadihardaja Kamue, Yurni Khalida, Azhariah Khiyarudami, Khala Iva Kowita, Nurul Huda Labonsa, Umar Lilingan, Bernadet Lubis, Ahmad Husin Lubis, Fandi Lubis, Putri Fatma Nagara M. Yunasri Ridhoh M. Yusuf Madjowa, Nona Fitriana Magfirah Perkasa Maiyulanda, Betria Mardatilla, Andi Mahdiana Mato, Rahmit Aditya Meutia, Rizka Inda Meutia, Sri MMSI Irfan ,S. Kom Mohamad Januar Fuad MS, Abd Rasyid MS, Abdul Rasyid Muchlis Muchlis Mudatsir Mudatsir Muhammad Iqbal Muhammad Irwansyah, Muhammad Muhammad Jamili Muhammad Muhammad Muhammad Nasir Muhammad Tahir Muhammad Zakaria Muis, Nurhasni Multazam, T Mulya Safri, Mulya Munawarah, Zahira Munawir Munawir Musa, Lutfi Alfia S. Mutammimul Ula Najamuddin Najamuddin, Najamuddin Najli, Emilia nasir, muh Nasti, Nilawati Nazaruddinsyah, Faaris Nikman Azmin Nilawati Nilawati Nita Sari, Nita Nora Sovira, Nora Novayanti Sopia Rukmana, Novayanti Sopia Nur Annisa Nur rohman Nurfadila Nurfadila, Nurfadila Nurjannah Nurjannah Nurnaningsih, Andi Padli, Sul Paisal, M. Poltak, Hendra Priono, Singgih Priyani, Putu Devi Putra, Remmy Lazuardi Putri, Muspira Riana R. Rusli Rachman, Ari Putra Rahmawati, Rahmawati Rahmi, Nurul Maulina Rahmia, Rahmia Randiawan, Randiawan Rifdan . Rivai, Andi Muhammad Rizal S, Muh. Ronaldi, Ronaldi Rosninda, Rosninda RR. Ella Evrita Hestiandari Rusdi Andid, Rusdi S, Muh. Rizal Safana, Garsia Sahputra, Ilham Sakman, Sakman Salahuddin Salahuddin Salma Salma Samsul Anwar Sanjaya, Mhd Sajid Saptari, Mochamad Ari Saputra, Irwan Saputra, Muh. Adam Sari, Dian Ekawati Sari, Idha Sayed Munazzar Siti Hadijah Sobhan, Sobhan Sofyan, Diana Khairani Solly Aryza Sovira, Sovira Sri Rezeki Srikandi, Mira sriwahyuni Sriwahyuni Suandi sufriani, sufriani Suhendri, Ilham Asyraf Sulaiman Yusuf Supardin, Muhammad Fauzan Surbakti, Ernawati Br. Surwati, Surwati Syafiuddin, Achmad Syafruddin Haris, Syafruddin Syafruddin Syafruddin Syaifullah Syaifullah Syam, A Fitria Syam, A. Fitria Syarief, Syarifuddin Syibral Malasyi, Syibral Syukriah Syukriah, Syukriah Tadjuddin Tadjuddin Tespani, Jessy Teuku Multazam Tita Menawati Liansyah Trisna Trisna, Trisna Usman, Said Wagner, Abram L. Wahyuni, Neni Sri Wamnebo, Muhammad Ikhsan Widdha Mellyssa Windarta, Jaka Wira Winardi, Wira Wiwik Handayani Yanti, Budi Yufika, Amanda Yusman, Yusman Yusuf, Iswandi Zahratul Fitri, Zahratul Zakaria, Iskandar Zulfia, Anni