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Journal : Indonesian Journal of Chemistry

Goat Milk Casein Peptides as Potential α-Amylase Inhibitors: A Computational and Experimental Approach Sumlang, Gavriel Hagai Paulus; Handoyo, Rumaisha Lale; Laksitorini, Marlyn Dian; Astuti, Endang; Raharjo, Tri Joko
Indonesian Journal of Chemistry Vol 25, No 3 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100223

Abstract

Goat’s milk proteins can undergo hydrolysis during digestion, producing peptides that may inhibit α-amylase and help treat type 2 diabetes with minimal side effects. Identifying the amino acid composition of these peptides is essential for determining their inhibitory potential. Recent in silico digestion methods have been developed to generate specific peptides. This study aims to identify α-amylase inhibitory peptides from goat’s milk casein hydrolyzate using in silico digestion, followed by peptide synthesis and activity assay. Peptides were derived from goat’s milk casein hydrolyzed using in silico digestion. Molecular docking was employed to predict protein-peptide interactions utilizing the HADDOCK2.4 server, CABS-dock, and PepSite 2 server. Peptides EDVPSER and TNAIPYVR could inhibit α-amylase with IC50 values of 14.16 ± 0.65 and 76.58 ± 2.13 µM, respectively. In vitro evaluation confirmed that EDVPSER from αS1-casein exhibited α-amylase inhibitory potential. This peptide could be developed as a potential therapeutic agent for type 2 diabetes, offering a natural and targeted approach to α-amylase inhibition. Peptide EDVPSER may serve as a basis for further research and development of antidiabetic treatments derived from goat’s milk proteins.
Identification of α-Amylase Inhibitory Peptides from Tryptic Hydrolysate of Caulerpa racemosa Green Algae Protein Husna, Izatul; Habibie, Ahmad; Astuti, Endang; Raharjo, Tri Joko
Indonesian Journal of Chemistry Vol 25, No 4 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.89147

Abstract

Peptides have been reported as a potential alternative for antidiabetic therapy by inhibiting α-amylase, one of the key enzymes involved in carbohydrate metabolism. This study aimed to identify α-amylase inhibitory peptides derived from trypsin hydrolysate of Caulerpa racemosa protein. The protein was extracted using trichloroacetic acid (TCA)/acetone. The resulting peptides were fractionated using a strong cationic exchanger-solid phase extraction (SCX-SPE) column. The peptide fractions were tested for α-amylase inhibitory activity, and the peptides in the most active fraction were identified using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Seven fractions were obtained from SCX-SPE elution at pH 3 to 9. The fraction eluted at pH 5 exhibited the highest α-amylase inhibitory activity, with an IC50 value of 43.70 µg/mL. Four peptides with the sequences VQKEKR, MNFYCISSK, DLCDYIHNK, and ISICYEK were identified from this fraction. Molecular docking studies revealed that the peptides with sequences MNFYCISSK and VQKEKR had the strongest interactions with α-amylase. The peptide binding affinity energies of MNFYCISSK and VQKEKR were −10.3 and −9.4 kcal/mol, respectively, with RMSD values of 0.3 ± 0.0 and 0.3 ± 0.2 Å. It can be concluded that the peptides with sequences MNFYCISSK and VQKEKR could be proposed as potential antidiabetic peptides with an α-amylase inhibition mechanism.
Co-Authors - Hardjono - Kustiono - Siskandar A. Tri Widodo, A. Tri A.A. Ketut Agung Cahyawan W Aan Nurhasanah Abdul Aman Achmad Hidayat Sutawidjaya Achmad Rifa’i, Achmad ACHMAD RIFAI Achmad Rifai RC Achmad Rifai RC, Achmad Achmad Sutawijaya Adi Nur Cahyono Adi Prehanto Agnes Nanda Saputri Agus Hermanto Agus Nuryatin Agus Yuwono Agus Yuwono Ahmad Badawi Saluy Ahmad Busyairi, Ahmad Ahmad Habibie, Ahmad Akhilia, Tudrika Akhlilia, Tudrika Akhmad Syaikhoni Alam, M. Nurul Ali Formen Almira Jovankova Yunan Amin Yusuf Ana Mufidatus Saadah Andi Mursidi Andreanna Kusuma Wardhani Andreanna Kusuma Wardhani Andri Yulianto Andriana, Zehan Anggraini, Shomalla Fadilah Anggraini, Yeni Anggraini, Yeni Ani Rusilowati Anik Aslikhah Antonius Tri Widodo Arief Yulianto Arika Palapa Aris Dwiyanto Ariyantho, Ariyantho Arzyana, Aan Dwi Ashri, Haningtiyas Nur Shalati Ashri, Haningtiyas Nur Shalati Asmawi, Chairunnisa AT. Widodo, AT. Atik Yuliyani Azizah, Markhamah Watianur Bagus Kisworo, Bagus Bambang Subali Bambang Subali Bambang Subali Belita Yoan Intania Beni Habibi Budi Dyah Lestari Bunyamin Bunyamin Bunyamin Bunyamin Cahyo Budi Utomo Caridah, Caridah Chandra, Klara Kharisma Bunga Cinta Salim, Clarrisa Vicky Fidela Damayanti, Laila Damayanti, Lilis Decky Avrilianda Desi Wulandari, Desi Dewi Seswita Zilda Dewi, Kiky Rosita Diah Haryani, Diah Dian Fajarwati, Dian Dienti, Lulu Sania Djoko Widodo Durroh, Lum’Atud Dwi Kurniawati Handayani Dwi Setyowati Dwi Wahyu Nugraeni Dwiyanto, Aris DYP. Sugiharto, DYP. Edi Waluyo Eka Titi Andaryani Eko Handoyo Eko Handoyo Eko Pujiastuti, Eko Ellianawati, Ellianawati Elsa Monica, Elsa Emmy Budiartati Endah Wulansari Endang Astuti Ernawati, Pepti Ernawati, Turini Ernawati, Turini Erni Suharini Esa Rizqy Oktavianingtyas Esty Setyo Utaminingsih Eti Nurwening Sholikhah Etty Soesilowati Faizal Amir, Faizal Fakhruddin Fakhruddin Fakhruddin Fakhruddin Fakhruddin Fakhruddin Fakhruddin Fakhruddin Fakhruddin Farida, Linda Zaenati Nur Fathur Rokhman Fatwa, Ayomi Fitriasari , Diah Nur Fransiskus Janu Hamu Galih Cahya Pratama Gayatri, Diah Gayatri, Diah Gentur Ciptaningtyas Ginanjar, Bagus Gofita Destiviani Pratama Guntur Abdul Yunus, Guntur Abdul Hakim, Khaled Maulana Ihya Arief Rakhman Hamzah Pagarra, Hamzah Handoyo, Rumaisha Lale Hardo Sujatmiko Harianingsih harianingsih - Harianingsih, Harianingsih Harianingsih, Harianingsih Hariyastuti, Anik Haryono Haryono Haryono Haryono Havidz Aima Hendrajaya Hendrajaya, Hendrajaya Heri yanto Heri Yanto Heri, Lalu Hery Yanto Heryanti, Yudina Tri Hidayat, Dharma Try Kusuma Hidayati, Wiwik Husna, Izatul I Made Sudana Ika Ratnaningrum Ike Kurniawati Ilyas Ilyas Imam Shofwan Imam, Atfalul Imaniar Djara, Jean Indarwati Indarwati Indra Sakti Pangestu Indrawati, Elly Indriyani, Isti Indriyani, Isti Irma Shinta Dewi Isdaryanti, Barokah Jeffri Ardiyanto Jeffri Ardiyanto Joko Sutarto Joko Widodo Juriyah Juriyah, Juriyah Kamsidjo Budi Utomo Kamsidjo Budi Utomo Khumaedi - Khumaedi Khumaedi Krido Bangun Nugroho, Dwi Kodrat Kurniasih, Enggar Kurniawan, Dedi Muhammad Kurniawan, Dedi Muhammad Kurniawati, Ike Kusumaningrum, Indah Kusumaningrum, Vina Eka Kusumawardhany, Intan L. Hendrowibowo Laila Cahya Pratiwi Lantip Diat Prasojo lestari, winda Lintang Markhamah Watianur Azizah Listiyanto, Listiyanto Lusi Rachmiazasi Masduki, Lusi M Jazuli M. Khafid Mahalul Azam Maharani Lulu Chairunnisa Mahdi Majid, Nur Kholis Maman Rachman Maman Rahman, Maman Mamun, Yohanes Mamun, Yohanes Manggaranti Maria Amelia Marifah, Maulina Zaidatul Marisa, Lilin Marlyn Dian Laksitorini, Marlyn Dian Mashudi Mashudi Masrukhi ., Masrukhi Masrukhi Masrukhi Masrukhi Masrukhi Masruri, Muh Bukhari Masturi Masturi Mintarsih Arbarini Moch. Fatkhuronji, Moch. Moh Yasir Alimi Mohamad Miftah Muarifuddin Muarifuddin, Muarifuddin Mudasir Mudasir Muh. Khafid Muhammad Khafid Muhammad Khammas Ainun Ni'am Muhammad Saefudin Muhammad Shobirin, Muhammad Mujiati Mujiati Mukhayanah Mukhayanah Munajiyah, Siti Murwati Murwati Murwatiningsih Murwatiningsih, Murwatiningsih Musino, Musino Musino, Musino Muslichah Tri Suprapti Muslikhin Mustikaningrum, Galih Muthmainnah, Fadkhuli Muttaqin, Muhammad Fauzan Mu’arifuddin, Mu’arifuddin Nadia Saputri Nafi’ah, Hidayati Nas Haryati Setyaningsih Ngabiyanto Ngabiyanto - Ningrum, Alya Putri Maradika Ningsih, Anisya Pratama Noor Hudallah Noor Sulistiyono Nuni Widiarti Nuniek Herdyastuti Nur Cahyani Nur Cholis Nur Faridatus Solehah Nur Hasanah Nur Hidayati Nurdiana, Fitri Nurilla, Asma Azizah Nurul Hidayah Oktaviani, Intan Oktia Woro Kasmini Handayani Pamungkas, Meylinda Ambar Panca Dewi Purwati Panca Dewi Purwati, Panca Pangestuti, Rahayu Pendriana, Yuli Peni Lestari Philip X. Fuchs Pramiasih, Endah Primahana, Gian Pulung, Maria Ludya Purwadi Suhandini Puspitasari, Wendy Putri, Diana Kusuma Putri, Tira Cintia Qarasyi, Achmad Qhuzairy Qodriyati, Tri Ulya Qodriyati, Tri Ulya R. Soelistijanto R.C., Rifai R.C., Rifai Rahardian Adi Nugroho Rahmah, Rismanadya Rahmi Anekasari Rasdi Ekosiswoyo Respati Tri Swasono Resya Waryani Retnoasih, Putri Rianafik, Ifti Riduwan Riduwan, Riduwan Rifa’i, Achmad Rifai RC., Achmad Rinda, Rinda Herdiyani Risaad, Rismayani Rizky Sania Ros Mawar Hutagaol, Kristina RR Sri Endang Pujiastuti Ruchman Basori Rudin, Raka Bachtian Rukono, Rukono Rumalowak, Nurul Febrianti Rusdarti - Sabirin Matsjeh Samsudi -, Samsudi Samsudi . Sandy Arif Saputri, Agnes Nanda Sari, Amalia Devita Sarwi Sarwi Mahmud Sarwi Mahmud Setiadi, Rizki Setyaningsih , Natalia Erna Shelly Yulia Shelly Yulia Sholikhah, Farkhatun Siswoyo, Rasdi Eko Siswoyo, Rasdi Eko Siti Handayani Siti Rahmawati Siti Rahmawati Sri Kartini Sri Maryati Deliana, Sri Maryati Sri Sulistyaningsih Sri Sumartiningsih SRI WARDANI Stalis Norma Ethica Subronto, Subronto Sucihatiningsih Dian Wisika Prajanti Sudarmin Sugiyo Sugiyo Sugiyo Sugiyo, Sugiyo Sujarwo Sujarwo Sukamto Sukamto Sukartono Sukartono Sukestiyarno Sukestiyarno Sukestiyarno Sukestiyarno Sukestiyarno Sukestiyarno Sukma, Ely Sarantika Sumbali, Bambang Sumlang, Gavriel Hagai Paulus Sunarto Sunarto Sungkowo Edy Mulyono Supriyadi Supriyadi Susi Susanti Susilo, Sigit sutarmi sutarmi Suwito Eko Pramono Taadi, Darpia Taadi, Darpia Tarto -, Tarto Teguh Supriyanto Titi Prihatin Titi Prihatin Titi Prihatin Titi Prihatin Tri Rini Nuringtyas Tri Suminar Triana, Vivit Triyantono, Kis Tunggul, Yudhana Wisnu Tunggul, Yudhana Wisnu Tutik Dwi Wahyuningsih Tyasmiarni Citrawati Udan Kusmawan Udi Utomo Udi Utomo Ujiarto, Toto Ujiarto, Toto Umi Latifah Urrofik, Safira Arbella Aurell Ury, Ury Utomo, Bagus Ginanjar Utsman Utsman, Utsman Vannesa, Leni Vinky Tri Oktariani Wadiyo Wadiyo Wadiyo Wadiyo Wadiyo Wagiran Wagiran Wahyu Hardyanto Wahyu Lestari Wahyu Trisnawati Wasino Wasino Wasino Widada, Tri Widiasih Widiatmaka, F. Pambudi Widiyanti, Erna Widiyanti, Erna Widiyanto Widiyanto Widodo Widodo Wirawan Sumbodo Wisacita, Miranti Wulandari, Istri Yani Istadi Yanto, Wakhid Nur Yogaswara, Radite Yudi Siswanto Yudi Siswanto Yuli Kurniawati Sugiyo Pranoto Yuli Pendriana Yuli Sudargini Yuli Utanto Yulia Sri Utami Yulianti , Ian Yulistyawan, Nanang Eko Yuliyanti, Novi Yustina Sapan Zakiyatul Jamilah, Zakiyatul