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Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Peran Kegiatan Keagamaan Dalam Meningkatakan Prestasi Akademik Siswa: Studi Kasus SD Negeri 1 Durenan Trenggalek Winarto, Winarto; Suyitno, Suyitno
JUPEIS : Jurnal Pendidikan dan Ilmu Sosial Vol. 4 No. 3 (2025): JUPEIS: Jurnal Pendidikan dan Ilmu Sosial
Publisher : Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jupeis.Vol4.Iss3.1763

Abstract

Sebagai bentuk responsibility terhadap tranformasi dalam dunia pendidikan sekolah harus memiliki kekuatan mewujudkan dan mengembangkan karakter dengan menguatkan peran agama dalam kegiatan pembelajaran yang pada giliranya mendorong siswa untuk memiliki pengetahuan yang menyeluruh pada lulusannya. Kegiatan keagamaan tidak hanya memegang peran penting dalam membentuk karakter siswa namun juga melatih pembiasaan untuk hidup disiplin, bertanggungjawab serta membangun pribadi baik. Dengan disiplin menjadikan belajar akan tertip sehigga menjadi motivasi pencapaian prestasi akademik siswa. Penelitian ini menggunakan metode kualitatif dengan rancangan study kasus, teknik pengumpulan data dengan interview, observasi dan dokumentasi, sedangkan Teknik analisis data menggunakan metode Mailes dan Huberman penyajian data, display data, reduksi data dan ferivikasi data (penarikan simpulan). Peran kegiatan keagamaan di SDN 1 Durenan Trenggalek melalui peran kepala sekolah dalam hal ini berperan sebagai leader of change, pemimpin dan pemberian kebijakan serta koordinator dalam meningkatkan prestasi akademik siswa.  Sebagai agent of change keberedaran implementasi serta evaluator berkegiatan keagamaan dilingkup sekolah diperankan oleh pendidik dan tenaga kependidikan. Siswa, siswa dalam hal ini sebagai objek peningkatan prestasi akademik yang mendapatkan perhatian penuh dari kepala sekolah dan pendidik serta tenaga kependidikan.
The Impact of the Group Investigation (GI) Learning Model on Enhancing Middle School Students’ Science Literacy in Thermal Expansion Topics Listiawan, Listiawan; Winarto, Winarto; Wiyatmo, Yusman
Jurnal Pendidikan MIPA Vol 25, No 3 (2024): Jurnal Pendidikan MIPA
Publisher : FKIP Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Scientific literacy is essential skills that students must master in the 21st century. This study aims to examine the effect of the Group Investigation (GI) learning model on improving science literacy in Middle School students on thermal expansion. The research uses a pre-experimental method with a one-group pretest-posttest design. The sample consisted of one class selected through purposive sampling, namely class VII I at SMP Negeri 5 Yogyakarta. The data collection method involved using a test with a science literacy test in the form of multiple-choice questions. Data analysis was conducted using statistical tests to determine the differences before and after implementing the GI learning model. The study results indicate that the Group Investigation (GI) learning model can improve students' science literacy on thermal expansion. The enhancement in science literacy scores for indicators such as explaining phenomena scientifically, evaluating and designing scientific investigations, and interpreting data and evidence scientifically showed increases of 35.1%, 40.02%, 22.08%, and 39.98%, respectively. The paired sample T-test results indicated that the GI learning model significantly affected science literacy and its indicators. The N-gain test results showed that the GI learning model positively affected science literacy, with the indicators achieving scores of 0.42, 0.64, 0.39, and 0.29, categorized as moderate, moderate, moderate, and low, respectively. The calculated Cohen's d value of 1.457024 falls within the huge category based on Sawilowsky's (2009) criteria. This study concludes that implementing the GI learning model can improve students' science literacy on thermal expansion.      Keywords: group investigation, science literacy, thermal expansion, middle school. DOI: http://dx.doi.org/10.23960/jpmipa/v25i3.pp1549-1558
Problems of Learning Islamic Religious Education at SMK Negeri 3 Palu Winarto, Winarto
Studi Multidisipliner: Jurnal Kajian Keislaman Vol 11, No 2 (2024)
Publisher : Universitas Islam Negeri Syekh Ali Hasan Ahmad Addary Padngsidimpuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24952/multidisipliner.v11i2.13741

Abstract

This study discusses the Problems of Islamic Religious Education Learning at SMK Negeri 3 Palu, the main problem in this thesis contains the formulation of the problem of How the Problems of Islamic Religious Education Learning at SMK Negeri 3 Palu, and how the efforts of Islamic Religious Education teachers in solving the Problems of Islamic Religious Education Learning at SMK Negeri 3 Palu, the purpose of the research is to find out the Problems of Islamic Religious Education Learning at SMK Negeri 3 Palu,  and to find out the efforts of Islamic Religious Education teachers in solving Islamic Religious Education Learning Problems at SMK Negeri 3 Palu. To answer these problems, the author uses a qualitative method in this study, which is sourced from field research and data collection techniques through observation, interviews and documentation. To test the validity of the data using Extension of participation, Presistent observation, and Triangulation. The results of the research in the discussion of this thesis are about the Problems of Learning Islamic Religious Education at SMK Negeri 3 Palu various problems found in teaching and learning activities, be it related to the application of methods, mastery of materials, problems with facilities and infrastructure to the media used. The suggestions from this article are, Islamic Religious Education needs to receive attention from various parties. There needs to be cooperation between one party and another.
Pengembangan Instrumen Evaluasi PPDB Model Contetx, Input, Process, Product (CIPP) Winarto, Winarto; Yusufi, Adnan; Khoirurrohman, Taufiq; Kristyaningrum, Dwi Hesty
JURNAL PENDIDIKAN Vol 30 No 2 (2021): July
Publisher : Universitas Veteran Bangun Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32585/jp.v30i2.1395

Abstract

Tujuan dari penelitian ini yaitu untuk mengembangkan instrument evaluasi PPDB sistem zonasi. Jenis penelitian ini adalah penelitian Research and Development (R&D). Model pengembangan yang digunakan adalah 4D dari Thiagarajan (1974). Teknik sampel yang digunakan yaitu purpossive sampling. Teknik pengumpulan data menggunakan wawancara dan angket. Analisis data menggunakan statistik deskriptif. Hasil penelitian diperoleh (1) Instrumen  dikembangkan berdasarkan studi pendahuluan belum ada dan perlu dikembangkan untuk melakukan evaluasi. (2) Instrumen evaluasi model CIPP yang dikembangkan  layak dan valid digunakan berdasarkan hasil validasi ahli evaluasi, ahli pengukuran dan praktisi sekolah dengan kategori  baik Kata-kata kunci : Pengembangan, Instrumen, Evaluasi, PPDB; Zonasi; CIPP              
Interdisciplinary dynamic fluid physics learning in the river environment using the discovery learning model: student environmental literacy study Santiani, Santiani; Rusmulyanti, Ayu Putri; Haryono, Agus; Winarto, Winarto; Reffiane, Fine
Edu Sains: Jurnal Pendidikan Sains & Matematika Vol 13 No 1 (2025): VOLUME 13 NUMBER 1 JUNE 2025
Publisher : IAIN Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23971/bbnt7k39

Abstract

This research aims to determine environmental literacy and the influence of interdisciplinary environmental dynamic fluid physics learning using the Discovery Learning model on students' environmental literacy. This research is quantitative research using a pre-experimental one-group pretest-posttest design method. The technique used in this research is the saturated sample technique, which is a data analysis technique using paired samples t-test. Learning environmentally integrated dynamic fluid physics using the Discovery Learning model can increase students' environmental literacy and have a significant effect on students' knowledge, attitudes and behaviour towards the river environment. Increasing students' ecological literacy is influenced by the implementation of learning, which is quite good, and the students are active. Environmental integration physics learning must continue to be developed so that it becomes an example for teachers to manage classes with environmental literacy outcomes and as an activity to conserve freshwater resources so that the environment is sustainable.
PENGARUH VARIASI BENTUK FLAME HOLDER TERHADAP KARAKTERISTIK NYALA API PADA PEMBAKARAN MESO SCALE COMBUSTOR Mochammad Khoirul Rosidin; Yuliati, Lilis; Winarto, Winarto
Jurnal Rekayasa Mesin Vol. 15 No. 3 (2024)
Publisher : Jurusan Teknik Mesin, Fakultas Teknik, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/jrm.v15i3.1630

Abstract

This study used an experimental method by directly observing the object under study. The independent variables in this study include the geometry of the flame holder on the meso-scale combustor, airflow, and fuel discharge. The research data were analyzed and displayed in graphical form as well as flame visualization. This research concludes that combustion using a flame holder circle has a more stable and even flame compared to a flame holder concentric ring and backward facing step. The shape of the Flame holder circle also produces a higher flame temperature. The results of this study contribute to the development of MPG based on micro combustion with a better understanding of the interaction between flame holders, reactant velocities and equivalent ratios in achieving stable and efficient combustion in meso-scale combustors. This research can provide important input for the development of high-efficiency micro-combustion-based power generation technology in the future.  
OPTIMIZATION OF SHELL AND TUBE HEAT EXCHANGER DESIGN WITH INCLINED BAFFLES Rahman, Aulia; Winarto, Winarto; Siswanto, Eko
International Journal of Mechanical Engineering Technologies and Applications Vol. 5 No. 1 (2024)
Publisher : Mechanical Engineering Department, Engineering Faculty, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/MECHTA.2024.005.01.7

Abstract

Shell and tube heat exchanger (STHeX) design development continues to be carried out to increase the effectiveness of a system. One way is to investigate the optimal baffle design. The new structure of STHeX with Inclined-Segmental Baffles is further investigated. The experiment was carried out using the numerical method Computing Fluid Dynamics (CFD) software with three-dimensional modeling. The results show that the heat change coefficient value is lower than conventional STHeX, However, the pressure drop value is reduced quite significantly. Therefore, it is necessary to know the overall heat transfer coefficient value per pressure loss (U/DeltaP). Hence, we get U/DeltaP values of 0.9 and 0.68 for STHeX with Inclined-Segmental Baffle and conventional STHeX, respectively. Thus, there is a significant increase ranging from 37-34%. It is concluded that STHeX with Inclined-Segmental baffles increases the U/DeltaP value significantly compared to conventional STHeX.
Pengaruh Waktu Aplikasi Paecilomyces spp. terhadap Penekanan Nematoda Bengkak Akar (Meloidogyne spp.) pada Tanaman Tomat (Lycopersicum esculentum Mill.) Winarto, Winarto; Reflinaldon, Reflinaldon
Jurnal Proteksi Tanaman (Journal of Plant Protection) Vol. 1 No. 2 (2017): Desember 2017
Publisher : Plant Protection Department, Faculty of Agriculture, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jpt.1.2.88-94.2017

Abstract

The application time of Paecilomyces spp. was assumed affecting its ability to suppress the root knot nematode (Meloidogyne spp.). This study aimed to get the effective application time to suppress Meloidogyne spp. The study was carried out at greenhouse and Biological Control Laboratory of Faculty of Agriculture, University of Andalas from March to June 2015. The research method used was compeletely random design (CRD) with 5 treatments and 4 replications. The application times consisted of 14 days before planting, 7 days before planting, at planting time, 7 days after planting, 14 days after planting and control. Application time of Paecilomyces spp. on 7 days before planting was the best time to reduce the number of root knot, the group of nematode eggs, nematode eggs and nematode larvae in the soil.
Efektifitas Serbuk Daun Tagetes erecta Linnaeus untuk Mengendalikan Nematoda Bengkak Akar (Meloidogyne spp.) pada Tanaman Tomat (Lycopersicum esculentum Mill.): english Trismal, Okiel; Busniah, Munzir; Winarto, Winarto
Jurnal Proteksi Tanaman (Journal of Plant Protection) Vol. 2 No. 2 (2018): December 2018
Publisher : Plant Protection Department, Faculty of Agriculture, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jpt.2.2.65-71.2018

Abstract

Tagetes erecta Linnaeus is classified as a nematisidal plant so that it can control root-knot nematodes (Meloidogyne spp.). The purpose of this study was to determine the dose of T. erecta leaf powder, which was effective in controlling root-knot nematodes (Meloidogyne spp.) on tomato. This study used a Completely Randomized Design (CRD) with six treatments and four replications, namely the effectiveness of several doses of T. erecta leaf powder (control/ no treatment, 5 g, 10 g, 15 g, 20 g, 20 g, 25 g each 5 kg of soil). The results showed that the application of T. erecta leaf powder reduced the amount of root-knot, number of eggs and groups of eggs and the number of nematodes in the soil. The most effective dose was 20 g/ 5 kg of soil.
Co-Authors . Reflinaldon A. G, Moh. Excel AA Sudharmawan, AA abdurrouf Abdurrouf Aditama, Hanna Shafira Adumiranti, Yuninda Afiana Rohmani Agus Haryono Aji Pamungkas Al Banin, Qori Alfi, Zuhana Realita Alfirdaus, Rasya' Alfriyani, Dhelfi Alva Alghazali, Alghazali Amru Sofian Ananda, Farhan Anggit Grahito Wicaksono Anindito Purnowidodo Annaas Budi Setyawan Antari, Arlita Leniseptaria Aprina, Fenty Ardiyansyah, Aqib Arfianti Arfianti Ario Sunar Baskoro Aristotika, Addin Aritonang, Isabella Landini Arsyad, Muhammad Muqtadho Artanto, Ardi Aryadi Suwono asmara, iman Nugraha Asmawi Asri Widowati Aswidyaningrat, A. Masrurah Aulia Rahman Azizah Azizah Badri, Putri Rizki Amalia Baehaqi Barus, Nia Karmelia Boediningsih, Widyawati Br Lumban Gaol, Anjani Br. Saragih, Rintan Butar-Butar, Hotlan Ceacilia Srimindarti Christina Indrajati Cristian, Lianawati D. J. Djoko Herry Santjojo Daito, Apollo Dapa Pirdos, Gilang Darmawi . Darmawi Darmawi Darnetty, Darnetty Dedi Supriadi Defi Pramesti Devika, BelaVista Dian Dewin Purnama Dika Vivi Widyanti Dinayah, Saffana Zahro Dita Puji Rahayu Eddy S Siradj Eddy Widiyono Ediati Sasmito Eko Siswanto Eksa Rusdiyana, Eksa Elda Nazriati Elperida J. Sinurat Elperida Sinurat, Elperida Endang Sri Lestari Endang Sri Lestari Endang Susilaningsih Fahrezy, M. Fajar Akbar FARADILLA, FARADILLA Fauzan Hasbi Aqil Fernando, Edith Fine Reffiane Firdaus Firdaus Firdaus Fitriansyah, Erwin Fitriyana, Nazwa Aulia Ginting, Elby Randa Br Guntur Setiawan, Guntur Habibillah, Nanda Kholifatu Nur Haliatur Rahma, Haliatur Hamdhan Djainudin Hamidy, Muhammad Y. Haryanto, Andra Yudistira Haryanto, Kanto Hasmiandy Hamid Hendri Budi Santoso Hermawan, Muhammad Vendy Hindami, Fahrizan Imam Holili, Holili Huriatul Masdar Hutabarat, Jansen Iban, Carlos Imam Khoirul Rohmat ING Wardana Insih Wilujeng Irham, Lalu M. Irmade, Oka Ismadi, Sabandi Isnaini Nurkhayanti Ivana Tanoko Jati Nugroho JHELANG ANNOVASHO Jon Henri Purba, Jon Henri Junika Napitupulu Juremi, Nabila Sukma Kamid, Abdul Khatimah, Khusnul Kis Djamitun Kisdjamiatun Kisdjamiatun Kojin, Kojin Kristanty Natalia Marina Nadapdap, Kristanty Natalia Marina Kristyaningrum, Dwi Hesti Kristyaningrum, Dwi Hesty kusrini, Desi Kusumastuti , Rizky Laifa Rahmawati, Laifa Lalu Muhammad Irham Lathif, Yuniar Fahmi Layyinatus Shifa, Layyinatus Liani, Ica April Lilis Yuliati Listiawan, Listiawan Liswarni, Yenny Liza Rusdiyana Lobes Herdiman Lubis, Frisda Yanti M. Yunus Malik, Ricat Hinaywan Maludin Panjaitan Mangasa Panjaitan, Mangasa Marbun, Sondang N. B. Martinus Adi Anggoro, Martinus Adi Matlawi, Adika Arifin Matsuani, Matsuani Mayasari, Ni Made Elva Melianna, Saur Miranita Khusniati Mislan Sihite, Mislan Moch. Agus Choiron Moch. Munir, Layyin Mahfiana I Nyoman Nurjaya Mochammad Khoirul Rosidin Moeis, Edya moelia Mohamad Sofyan Harahap Mohammad Sodiq, Mohammad Mubarok, Muhammad Nanang Muhamad Syafiq Muhammad Anis, Muhammad Muhammad Yulis Hamidy Mujahidah Mujahidah Munzir Busniah Murniyati, Murniyati Mustofa , Zaenal Nadapdap, Kristanty M. N. Nadrah, Yatim Md Nahar, Achmad Wildan Khoerun Nanik Marfuati Nathania, Auren Nik Haryanti Nofrijon Sofyan, Nofrijon Norma D. Handojo Nugroho, Trilaksana Nugroho, Vincentius Tangguh Atyanto Nurohman , Sabar Oemolos, Sefni Oktavia, Elisa Panggabean, Toman Priyambodo, Panggih Purnomo Hadi Putra Ananda Setiawan, Davis Putra, Jogi Aprihan PUTRI WULANDARI Putri, Wahyuni Eka Putut Marwoto Rahmi, Fifin L Rajagukguk, Roy Jhons Suyanto Rakhmasari Y.A Ramadhan, Ardi Randi Adzin Murdiantoro Rangkuti, Ina F. Rasmulia Sembiring Rasydianah, Rasydianah Ratna Wulan Febriyanti Razali, Renardy Reza Rebriarina Hapsari Retnoningsih, Diyah Ayu Reza Satrio Rihadatul Aisy, Nada Riki Sukiandra Rina Rahayu, Rina Risdiansyah Risdiansyah Risdiantoro, Rindra Riski Prihatningtias, Riski Risya Pramana Situmorang Riva Ismawati, Riva Rivai Wardhani Robinhot Gultom, Robinhot Rr. Poppy Puspitasari Rupajati, Pathya Rusdi Rusli, Rusdi Rusdiana, Yayang Rusmulyanti, Ayu Putri S, Donel Sa'diyah, Dewi Fitrotus Sabar Nurohman Salsabila Zahra, Salsabila Santiani Santiani Santoso, Rio Pudjidarma Sarafuddin, Sarafuddin Sari, Maya Novita Sarjadi Sarjadi Sarjadi Sarjadi Sarwi - Selamat Budijitno Selamat Siregar Shuhada, Ahmad Sianturi, Jeudi A. T. P. Sianturi, Jeudi A.T.P. Sifa, Layyinatus Silalahi, Sahat P. Remus Simamora, Kiki Fajrina Sinurat, Siti Normi Siti Normi, Siti Siti Nurlatifah, Siti Siti Sundari Siti Sundari Slamet Wahyudi Soelistiyowati, Endang Sonny, Sonny Soraya Soraya Sri Inakawati Sri Jumini Suci Widiantoro, Panca Suhandri, Wiwin Sukarni Sukarni Sulyanti, Eri Supriyono Supriyono Susbiyanto, Susbiyanto Suyitno Suyitno Syachrofi, Muhammad Syahputra, Muhammad Ghaza Tandian, Nathanael P Tarigan, Krisan Aprilla Br Tarigan, Sri Hulina Taufiq Khoirurrohman Taufiq, Thiyas Tono Tiur Rajagukguk, Tiur Tri Nur Kristina Trismal, Okiel Trisnawarman, Trisnawarman Trizelia . Udadi Sadhana, Udadi Ulhak, Romi Dhia Umar, Erfiana Uripno Budiono V. Rizke Ciptaningtyas Wati, Rita Fajar Wawaysadhya Agastya Wirawan Adikusuma Wiwit Ade Fidiawati Yaherwandi Yan Wisnu Prajoko Yordan, Adam Yudhistira, Yusuf Yudiantoro, Ismanu Yudistira, Yusuf Yuhandri, Toni Yulianti , Lilis Yulmira Yanti Yunisman, Yunisman Yusman Wiyatmo Yusufi, Adnan Zahra, Leina Putri Zahria, Linta Zahro, Umi Chabibatus Zaidah Nur Rosidah Zainul Ikwan, Muh. Zulfa Atabaki, Zulfa