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ANALISIS POLA DAN AKTOR DALAM SELEKSI KANDIDASI CALON LEGISLATIF : REFLEKSI ATAS PARTAI ADIL SEJAHTERA DI ACEH Bimby Hidayat; Muntasir; Taufik; Mulyadi
Jurnal Ilmu Sosial dan Ilmu Politik Malikussaleh (JSPM) Vol. 5 No. 1 (2024)
Publisher : FISIP Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jspm.v5i1.16691

Abstract

The purpose of this study is to analyze the selection process of candidates for the Aceh Representative Council (DPRA) from the Adil Sejahtera Party (PAS) in the 2024 elections in Aceh Province. This study uses Rahat and Hazan's candidacy theory approach to reveal the dimensions, space, and actors in the selection process. This study uses a descriptive qualitative approach. Data was collected through interviews, literature studies, and supplemented with internal party documents. Data analysis used the Miles and Huberman model through the stages of reduction, presentation, and data verification. The results of the study reveal three patterns of candidate selection for DPRA members from PAS: (1) closed selection pattern; (2) exclusive and centralistic selection pattern. The dynamics of these patterns and actors show that the selection process for DPRA candidates from PAS is not entirely meritocratic but is the result of negotiations among party elites. This study concludes that the selection process for DPRA candidates from PAS is an arena of elitist power contestation. The strong influence of religious leaders in the party means that the selection of candidates is largely determined by party elites.
PHARMACEUTICAL NANOTECHNOLOGY: FORMULATION AND IN VIVO EVALUATION OF CURCUMIN-LOADED NANOSUSPENSIONS FOR ENHANCED ANTI-INFLAMMATORY EFFICACY Issusilaningtyas, Elisa; Williams, Sarah; Muntasir, Muntasir
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 4 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i4.2523

Abstract

Curcumin, a natural polyphenol derived from Curcuma longa, is well-regarded for its potent anti-inflammatory properties. However, its therapeutic application is severely hampered by its extremely low aqueous solubility and poor oral bioavailability, which leads to suboptimal absorption and limited clinical efficacy. Pharmaceutical nanotechnology offers a promising strategy to overcome these biopharmaceutical challenges. This research aimed to formulate a stable curcumin nanosuspension to significantly enhance its dissolution rate and bioavailability, and to subsequently evaluate its improved anti-inflammatory efficacy in an in vivo model. A curcumin nanosuspension was prepared using the high-pressure homogenization technique, stabilized with Poloxamer 188. The formulation was characterized for particle size, polydispersity index (PDI), and zeta potential. An in vivo anti-inflammatory study was conducted using the carrageenan-induced paw edema model in Wistar rats, comparing the efficacy of the nanosuspension against a conventional coarse curcumin suspension. The optimized nanosuspension exhibited a narrow particle size distribution with a mean diameter of 210 nm and a zeta potential of -28.5 mV, indicating good physical stability. The in vivo evaluation demonstrated that the curcumin nanosuspension produced a significantly greater inhibition of paw edema (72.4%) compared to the coarse curcumin suspension (28.1%) at the same dose (p < 0.01). Formulating curcumin into a nanosuspension is a highly effective strategy for overcoming its inherent bioavailability limitations. This nanotechnological approach dramatically enhances curcumin’s anti-inflammatory activity, validating its potential as a powerful therapeutic agent for inflammatory conditions.
Phytochemical Study and Antioxidant Activity of Anti-Aging Cream from Three Rote Plants Muntasir, Muntasir; Purnasari, Cahyani; Upa, Nurul Fatmawati Pua
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study examines the antioxidant potential of three plants used by the people of Rote Ndao in skin care, namely Puteh Wood (Alstonia scholaris), Kesambi (Schleichera oleosa), and Moringa (Moringa oleifera). The background of the study was based on skin aging triggered by oxidative stress due to free radicals. The research objectives were to identify active phytochemical compounds, formulate the three extracts into creams, and analyze their potential synergism and antioxidant activity in a descriptive-exploratory manner. Extraction using 70% ethanol was carried out by maceration method, while phytochemical identification was applied by color reaction and precipitation tests for alkaloids, flavonoids, tannins, saponins, terpenoids, and steroids. Vanishing cream-based cream formulation was successfully made with good physical characteristics, namely homogeneous, pH 6.8, and spreadability of 5.7 cm. Qualitative antioxidant activity test using DPPH method showed a rapid change of DPPH purple color to pale yellow in mixed extracts and creams, indicating stronger antioxidant activity than single extracts. The results indicate the presence of potential antioxidant compounds in all three plants and an indication of synergistic effects between extracts that may come from the interaction of different classes of phytochemical compounds. These findings provide an important basis for more in-depth quantitative studies in the development of natural ingredient-based antioxidant products. Keywords: Anti-aging, Phytochemical, Cream, Polyherbal, Synergism, Qualitative, Rote Ndao, DPHH
Co-Authors - Indrawan Azis, - - Sri Prilmayanti Awaluddin, - Aan Suriadi Abdullah Abdullah Abdus Salam, Abdus Abu Bakar, Muhammad Bin Adu, Apris A. Afri, Lasarus Agus Setyobudi Agustin Mardiana, Nur Ai Nurhayati Akbar Awaluddin Aldi Benggu Ali Warsito Alves, Livia Ambarwati, Rini Amelya Betsalonia Sir Amiruddin, Teungku Anastasia Sofia L. Keraf Andari, Soetji Andarmoyo, Sulistyo Anderias Umbu Roga Andi Ummul Khair Andreastra, Agustinus Putu Asirah, Asirah Astuti, Aldiana Azmy, Khairul A’la, Putri Nurul Baharuddin Baharuddin Baharuddin Baharuddin Bahruni . Berek, Norce Ch. Bimby Hidayat Bimby Hidayat Buka, Sisilia Prima Yanuaria Christin Rony Nayoan Christina Rony Nayoan Conrad L. H. Folamauk Dadang Muhammad Hasyim David B.W. Pandie Deddy Satria M Dewi Sri Handayani Diana Catharina Yohanes Diki Prayugo Wibowo Dionesia Octaviani Laput Dito Anurogo, Dito Djati, Hyronymus Djawa, Agostin Nofembriyani Edon, Caro David Hadel Edwinandro V Salju Elisa Issusilaningtyas Emily Nur Saidy Ernita Dewi Erny Erawati Pua Upa Ervina Indriyani Eufrasia Prinata Padeng Fadhlur Rahman Faradina, Anggia Farida Arinie Soelistianto Fauzi Fauzi Fauzi Fauzi Fawzy, Nabiyl Ahmad Fhahri Mubarak Folamauk, Conrad Liab Hendricson Fransiska Nova Nanur Gracewati Rambu Ladu Day Haijal, Ahmad Halena Meldy Asa Halimatussakdiah Halimatussakdiah Harahap, Elly Warnisyah Hari Rarindo Hasnawati Husen Hendra Nusa Putra Hetgen Palabuan Hlaing, Nandar Htwe, Thandar Idawati Trisno Ika Febianti Buntoro Imran, Un Dini Indah Raya Indra Mawardi Indriati A. Tedju Hinga Iskandar Zulkarnaen Iskandar Zulkarnaen Ismail, Eddy H. Ismed Ismed Jacob Matheos Ratu Joko Sangaji Judijanto, Loso Junia Jessy Sarupy Junias, Marylin S. Kamaluddin, La Ode Amijaya Kamaruddin, Ilham Karolus Tokan, Yohanes Kenjam, Yoseph Khrisna Agung Cendekiawan Kiat, Ton Kikhau, Adriana M. O. Koamesah, Sangguana Marthen Jacobus Kolobani, Mathias Nathaniel Kolobani, Matias Nataniel Kuswara, Ketut Mahendra Lady Napedi Aome Laela Lek, Siri Lenggu, Chatrin Jansye Lerik, M. Dinah Charlota Lewi Jutomo Listyawati Nurina Litik, Serlie Loda, Yohana Jawe Lubis, Suriati Luh Putu Rulianti M Rizwan M. Rizwan M. Sjahrul M. Sjahrul M.Akmal Maidelwita, Yani Manafe, Ovlian Afri Manalu, Teacher Mandala, Damelia Manongga, SP. Manongga, Stefanus P Manurung, Imelda Februati Ester Margareta Elisabeth Kartona Aru Maria Ermelinda Menge Bay Maria Faustina Arvidiani Mariana D.C. Lerik Mariana Paulina Putri Billa Marianus Ketmoen Marisa Sinlae Masrida Sinaga Masrida Sinaga Masrida Sinaga MAURITZ PANDAPOTAN MARPAUNG Mayners, Marline Miksusanti Miksusanti Muhajirin Dean Muhammad Aminullah, Muhammad Muhammad Bin Abu Bakar Muhammad Zakir Muhammad Zakir MULYADI Mustakin Sahdan Muzaffarsyah, Teuku Myint, Aung Nabuasa, Bernadeta Stien Julian Nadra Aga Iryani Nadra Aga Iryani Nadra Aga Iryani Nahak, Dominggus Florianus Naibaho, Netty Maria Naidi Faisal, Naidi Najla Rihadatul Aisy Napitupulu, Melissa Putri M. Natalia Lisma Br Sembiring Neti Sulami Nicholas Edwin Handoyo Nizar Saputra Nofriana Inna Manulangga Noor Diah Erlinawati Nur Hasanah Nur, Marselinus Laga Nurak, Maria Antonia Nurani Ai Erlinawati Nurani Nurani Nurani Nurani Nurani Nurani Nurhikma Awaluddin Nurina, Rr. Listyawati Nurkhalika, Rachmi Nurlaela Nurul Huda Nurviani, Rahima Oematan, Videl Apsi Panie, Chatrina H. Perceka, Andhika Lungguh Priyo Sasmito Purnasari, Cahyani Purnawan, Sigit Putri, Hera Nur Radja Riwu, Yuliana Rahman, Dahlan A Rasdi , Rasdi Razak, Faisal Refli, Refli Regaletha, Tadeus A. L. Regaletha, Tadeus Andrea Lada Rina Waty Sirait Riski Arisando Bahan Riski Dwi Prameswari Riski Dwi Prameswari Riwu, Magdarita Rizwan, Muhammad Roga, Andrias Umbu Rulianti, Luh Putu Rustam Rustam Rustan DM Rustan, Rustan Sabina Gero Safitri , Rizka Sahdan, Mustakim Saidy, Emily Nur Salesman, Frans Salju, Edwinandro V Sani, Hafaf Lutfiani Saputra, Ronni Sarci M,Toy Sariyusda, Sariyusda SATRIYAS ILYAS Savitri, Dita Nurul Senci Marselin Beti Serlie K.A. Littik Setianto, Rony Seubelan, Linda Siregar, Try Mahendra Siti Horidah Soelistianto, Farida Arinie Soleman Landi Soleman Landi Sonya Amelia Souza, Felipe SP Manongga Sri Hartanti Masneno Sukiman Sukiman Sumarauw, Jeane L.I. Sumayyah Jamal H. M. Arifin Sutomo, Deni Anggreani Syahdan, Mustakim Syarif, Isymiarni Syarkawi, Syarkawi Syauqi, Anis Tadeus A. L. Regaletha Tadeus Andreas Lada Regaletha Tadeus Andreas Lada Regaletha Tan, Ethan Taufik Teo, Ryan Thadeus A.L Regaletha Thai, Aom Thalib, M Kurniawan Tibuludji, Paula Titu Eki , Ayub Toy, Sarci M. Tulandi, Selvana Stien Un Dini Imran Upa, Fatmawati Pua Upa, Nurul Fatmawati Pua Weraman, Pius Wijaya, R. Pasifikus Christa Wilanda, Alifah Williams, Sarah Wong, Lucas Wuryandari, Tutik Wutun, Nikosius Dae Sory Yermia Djefri Manafe Yoseph Kenjam Zani, Benny Novico Zulham Zulhilmi Zulhilmi Zulkarnaen Zulkarnaen Zulkifli Halid