p-Index From 2021 - 2026
14.282
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Teknik Sipil dan Arsitektur JAM : Jurnal Aplikasi Manajemen Journal of Degraded and Mining Lands Management JURNAL ILMIAH MATEMATIKA DAN TERAPAN Pendas : Jurnah Ilmiah Pendidikan Dasar Journal of Islamic Nursing Jurnal Sistem Cerdas Dirasah : Jurnal Studi Ilmu dan Manajemen Pendidikan Islam Zonasi: Jurnal Sistem Informasi Jurnal Sekolah Dasar (JSD) Diagnosis: Jurnal Ilmiah Kesehatan Widya Aksara: Jurnal Agmaa Hindu Jurnal Kajian Anak (J-Sanak) Jurnal Teknik Sipil dan Arsitektur Health Care : Jurnal Kesehatan Jurnal Health Sains Jurnal Teknik Informatika (JUTIF) Indian Journal of Forensic Medicine & Toxicology Jurnal Kesehatan Tambusai HOAQ (High Education of Organization Archive Quality) : Jurnal Teknologi Informasi An-Nahdlah: Jurnal Pendidikan Islam Indo-MathEdu Intellectuals Journal Proceedings Series on Social Sciences & Humanities Indonesian Journal of Innovation Studies Jurnal Ilmu Kebidanan dan Kesehatan Jurnal Ilmiah Kesehatan Promotif Journal of Community Service International Journal of Public Health Excellence (IJPHE) Ahmad Dahlan Legal Perspective Sevanam: Jurnal Pengabdian Masyarakat JURNAL MUARA PENDIDIKAN JURNAL TUNAS PENDIDIKAN Jurnal Manajemen Pendidikan Islam Darussalam (JMPID) Jurnal Abdi Dharma Masyarakat Journal of Industrial Community Empowerment JURNAL KESEHATAN IBU DAN ANAK (KIA) Jurnal Pusat Akses Kajian Pangan dan Gizi Jurnal Adijaya Multidisiplin Melati: Jurnal Media Komunikasi Ilmu Ekonomi Sosiologia : Jurnal Agama dan Masyarakat Jurnal Inovasi Pendidikan dan Teknologi Informasi (JIPTI) Journal of Informatics and Computing Qawwam Jurnal Rakat Sehat : Pengabdian Kepada Masyarakat JURNAL SMART ANKes Agridev Journal : Agribusiness Digitalization & Community Development Jurnal Pendidikan Profesi Guru Jurnal Rekayasa Sistem Informasi dan Teknologi PORTAL ABDIMAS Financial Management Studies Prosiding Seminar Nasional dan Call For Paper Kebidanan Universitas Ngudi Waluyo Journal Information & Computer (JICOM) JPS (Jurnal Pharma Saintika) Jurnal Pendidikan Guru Sekolah Dasar Jurnal Karya Generasi Sehat Jurnal Kebidanan Media Farmasi Jurnal KALANDRA Jurnal Medicare Jurnal Kesehatan dr. Soebandi RESLAJ: Religion Education Social Laa Roiba Journal Gudang Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Universitas Anak Bangsa Health Care : Journal of Community Service Beujroh : Jurnal Pemberdayaan dan Pengabdian pada Masyarakat Jurnal Penelitian Sains dan Kesehatan Avicenna Journal Of Chemical Process Engineering Journal of Fisheries & Marine Jurnal Pendidikan Dasar dan Keguruan EKOBIS ABDIMAS : Jurnal Pengabdian Masyarakat The Indonesian Journal of Computer Science La Parole : Journal of Language Teaching and Pedagogy Riau Jurnal Teknik Informatika International Journal of Community Services GABBAH : Jurnal Pertanian Dan Perternakan Jurnal Sains dan Kesehatan Jurnal Multidisiplin Pengabdian Masyarakat (JMPM) International Journal of Management, Economic and Accounting Jurnal Cendekia Ilmiah INOVTEK Polbeng - Seri Informatika Journal of Health Literacy and Qualitative Research Mathematics Education Journal Jurnal Ilmiah Manajemen Agribisnis Jurnal Inovasi Pembelajaran Sinergi : Jurnal Ilmiah Multidisiplin Jurnal Informatics Nivedita Prosiding Seminar Nasional Keguruan dan Pendidikan (SNKP) Jurnal Pendidikan dan Pembelajaran Sekolah Dasar Jurnal Aplikasi Sains dan Teknologi : Agrisevika Master of Civic Innovation and Education Technology. JPSB
Claim Missing Document
Check
Articles

Found 2 Documents
Search

Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAcĀ 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAcĀ 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Co-Authors , Wilchan Robain . Zakiah A. Tenriawaruwaty Abdillah, Muhamad Aznar Adrian Adriansyah, Ahmad Ardi Afindah, Nur Agesti, Suci Ahfandi Ahmad Ahmad Randy Ahmad Rizani, Ahmad Ahmad Yusuf Aisya, Sitti Akhmad Darmawan Alfiah A Ali Harris Ali Idrus Ali, Nur Fitriana Muhammad Aliya, Rahma Alwi, Salma Amelia, Agnes Amrullah, Fauzan Ananta, Dian Ananta, Nur Via Andi Ardiansyah Arifin Andi Bintang Andi Muhammad Akram Mukhlis Andi Satriana Andrean, Fizal Okta Angraini Ani Anjarwati Annisa Noor Alfisyahr Ansyari, Muhammad Fadli Anugrah Ashafil Apdoludin Apdoludin, Apdoludin Ari Widyaningsih Ariani, Novita Arief Maulana Arif Marsal Arisma, Baiq Haemi Aryani, Ine Kusuma Asniar Khumas Asrul Sani Astrilia Damayanti Asya Nawar Karimah Asyiah Simanjorang Aulia Nurul Hikmah Aulia Rahmah Aulia Wulandari Bahlawan, Zuhriyan Ash Shiddieqy Bayu Triwibowo Carla Wulandari Sabandar Dadan Wildan, Dadan Daiyah, Isrowiyatun Damayanti, Ivanda Eka Danil Risaldi Dedek Helida Pitra Dewi Diniaty Dewi Mulfiyanti Dewi, Fitria Ratna Dhani Sutanti Dhini Mufti Dhiva, IGN Aditya Dorkas Yufice Ariyanti Kale Dufi Roma Dini Dwiba Elisa Dyah Retnoningrum Efi Kristiana Eka Putra, Randi Eki Saputra Eki Saputra Elisa Junita Emelinda Eni Kusumawati Erni Yuliastuti Erni Yuliastuti Ery setiawan Esi Safitri Eva Amalia Alvionita Fadhilah Afifah Fadillah, Muhammad Rezky Falhamilat Wikron Fathin, Afif Fauzan Khalid, Muhammad Febi Nur Salisah Fitria Jannatul Laili Fitriani, Arifah Devi Fizhara Syaharani Giyatno Gusmita, Emilya Hafiez Zahran Hajar Hajar Halmar, Halbina Famung Handro, Fedro Ali Hapisah Harefa, Afnan Hariadi Harianah Akib Harni Sartika Kamaruddin Hartatiana Haryadi, Yogi Haryanti, Enny Hasmiati Hegar Harini Helmiah Heni Pujiastuti Herlina Yusuf Hidayat, Irwin Hj. Zakiah I Gede Dharman Gunawan I Ketut Subagiasta Idria Maita Ihsan, Muhsinul Ika Agustina Novitasari Imansyah, M. Aditiya Indra Wahyu, Indra Indrawati Inggih Permana Irawan, Dodi Irfan Madamang Iri Hamzah Irma Irvan, M Irwan ISKANDAR Islamiah, Raudah Ismarini, Novi Ismu Kusumanto Isni Hijriana Isrowiyatun Daiyah Iswani, Fahrona Izzawati Arlis Jamali, Raihan Hafidz Jamaluddin P Januarsih Jaya Negara, I D G Jones, Clive Kadir, Muhammad Kadir KARTINI Kasim Yahiji Khofiatun kristiningrum, dian Kunti Ayu Vedanti Kurniawan, Kia Lestari Handayani Linda Dwi Saputri Lisa Trina Arlym Lubis, Ayuni Fachrunisa luciana, Lisma M. Solikhul Huda Magdalena Mahdi, Taufiq Mahendra, Alwi Azis Maifrizal Mala, Hairul Malikhul Askar, Bayu MANUNTUN ROTUA Mareta Kemala Sari Mariah Marleni Marpaung, Muhammad Nazaruddin Maulida, Dara Maulidiyah Mawaddah, Zuriatul Mayasari, Dyta Silvia Mayurni Firdayana Malik Medi Hendra Media, Dirga Melati, Anggi Mipa, Jepi Okta Mona Fronita, Mona Monifa Putri Mu'ah Muhammad Muhammad Dassir Muhammad Nurdin Muhammad Salahudin, Muhammad Muhammad Yusri Bachtiar Muhiddin Muhiddin Mukminah Mukti, Raihan Muliasari, Handa Munawwarah Malik Musofa Rusli Mutia, Risma Nabila Husna Nabilah Nadha, Diana Nadya Alessya Nankervis, Leo Nasution, Nur Shabrina Natasha Weisdhania Weisdhania Naufal Kurniawan Neneng Santi Purnawati Nining Purwati Nisa', Sayyidatun Nisrina Muslihin Norlaila Sofia Novarita, Herni Novianti, Elpi Nuning Dwi Merina Nur Alawiyah Hasibuan Nur Kholifah Chandra Mulyani Nur Rohmah Prihatanti nur samsiah Nurahayu, Siti Nuranisa, Rizky Nurdin, Fadilah Nurfadillah Nurfadillah Nurhasanah Nurhidayah Nurjannah Nurlaela Nurrohmatul Amaliyah Oktavianita, Lisa Opi Andriani Perawati Natalia Sinaga Prasojo, Dwi Pratama, M. Hengky Prihatanti, Nur Rohmah Prihatin, Kukuh Primahana, Gian Priyambodo, Bayu purnawati, neneng santi Putra Astaman Putra, Yogi Irdes Putri Hayatul Fatimah Putri, Oktaviani Putro, Raden Mas Wahyu Eko Qadrianti, Laeli Qinayah, Mirnatul Rafidah Rahmad Fauzi Rahmadina Rahman, Hafiz Aulia Rahmat Makmur Rahmi Raisa, Daeva Raisa, Daeva Mubarika Rakhmawati, Hidayatur Razi, T. Khairol Refka Revina Melyata Ekwanda Refril Dani Reni Guswita Restu Nur Hasanah Haris Rezky Dwi Fitriani Ria Pusvita, Mega Ribut Prastiwi Sriwijayanti Ridha Alamsyah Rina Ratianingsih Riska Rissa, Mutiara Zahira Rizaldy, MHD. Agung Rodiah Romlah Rozanda, Nesdi Evrilyan Rozanda, Nesdi Evrylian Rusman, Irma Ryanda, Nayla Husna Saalino, Valentina Salam, Diah Astari Samsul Arifin Sandi, Kelvin Mei Santoso, Natasya Sarifudin, Muhamad Nur Sarina Sepiani Serlis Rusandi Shulhan Abdul Gofar Sinurat, Sinar Siska Prasinta Kesum Siti Alifhya Nurhaliza Siti Musarofah Sitti Nadirah Sitti Nurhalisa Soep Sri Anjani Sriwahyudin Moonti Subhanadri Sudibyo, Anung Sugiharti, Novi SUKIRNO Sulfasyah sultan SUMARNI Suparno Suprapti, Eka Syahbuddin Syahputra, Fadli Syahputra, Rafiki Syaifullah Syamsu Nur, Syamsu Syamsuddin, Agustan Tedi Yunanto Tengku Khairil Ahsyar Terminanto, Ade Ananto Titin Suprihatin Tri Eka Suroja Trini Hariyanti Tshamaroh, Muthia Ulfa, Kurnia Ummul Fausiah Usman Usman Viariska, Ferdita Yurike Vivi Silawati Vonny Khresna Agung Suhadi Mohammad Hakimi Dewi Wa Ode Masrida Wahidanur Wahyudin Wahyuni, A. Panca Wahyuningsih Wardani, Ambarsari Kusuma Waridah widia zalvi Winanda, Salsa Winardi, Arif Rahman Windayani, Sri Wiwik Handayani Wulandari, Anggy Julia Yantoro Yeni Susilawati Yesa, Aditya Nugraha Yulidar Yulisara, Ekatri Yuniarti Yunita Engriani Yusnita Zacky, M. Zaenal Arifin Zahruddin Zarnelly Zarry, Cindy Kirana Zidny Nuris Yuhbaba