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Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAcĀ 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAcĀ 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Co-Authors , Wilchan Robain A. Tenriawaruwaty Ade Reza Adrian Adriansyah, Ahmad Ardi Afindah, Nur Agesti, Suci Ahfandi Ahmad Ahmad Randy Ahmad Rizani, Ahmad Ahmad Yusuf Ahmad, Haslinah Ahsyar, Tengku Khairil Aisya, Sitti Akhmad Darmawan Akil Musi, Muhammad Aldhyansah, Steven Alfiah A Ali Harris, Ali Ali, Nur Fitriana Muhammad Aliya, Rahma Alwi, Salma Amelia, Agnes Aminuddin Syam Amrullah, Fauzan Ananta, Dian Ananta, Nur Via Andi Ardiansyah Arifin Andi Muhammad Akram Mukhlis Andi Satriana Andrean, Fizal Okta Angraini Ani Anjarwati Annisa Noor Alfisyahr Ansyari, Muhammad Fadli Anto J. Hadi Anugrah Ashafil Apdoludin Apdoludin, Apdoludin Ari Widyaningsih Ariani, Novita Arief Maulana Arif Marsal Arisma, Baiq Haemi Aryani, Ine Kusuma Asniar Khumas Asrul Sani Astrilia Damayanti Asyiah Simanjorang Aulia Nurul Hikmah Aulia Rahmah Aulia Wulandari Azizah Azizah Bahlawan, Zuhriyan Ash Shiddieqy Bayu Triwibowo Carla Wulandari Sabandar Dadan Wildan, Dadan Daiyah, Isrowiyatun Danil Risaldi Dedek Helida Pitra Dewi Diniaty Dewi Mulfiyanti Dewi, Fitria Ratna Dhini Mufti Dhiva, IGN Aditya Dinar, Muhammad Dorkas Dyah Retnoningrum Dyandra Malika Fajri Eka Putra, Randi Eki Saputra Eki Saputra Emelinda Erwinsyah Ery setiawan Eva Amalia Alvionita Fadhilah Afifah Fadillah, Muhammad Rezky Falhamilat Wikron Fathin, Afif Fauzan Khalid, Muhammad Febi Nur Salisah Feri Yoga Saputra Fiorenza An Nafisah Fitria Jannatul Laili Fitriani, Arifah Devi Fizhara Syaharani Giopani Simbolon Giyatno Gusmita, Emilya Hafiez Zahran Hajar Hajar Halmar, Halbina Famung Handro, Fedro Ali Hapisah Haratua, Chandra Sagul Harefa, Afnan Hariadi Harni Sartika Kamaruddin Haroky, Faruq Hartatiana Haryanti, Enny Hasmiati Hegar Harini Helmiah Heni Pujiastuti Herlina Herlina Herlina Yusuf Heru Suparman Hidayat, Irwin I Gede Dharman Gunawan I Gusti Ayu Ng. Susanti I Ketut Subagiasta Idria Maita Ihsan, Muhsinul Ika Agustina Novitasari Imansyah, M. Aditiya Indra Wahyu, Indra Indrawati Inggih Permana Iri Hamzah Irma Irvan, M Irwan ISKANDAR Ismarini, Novi Ismu Kusumanto Isni Hijriana Isrowiyatun Daiyah Iswani, Fahrona Izzawati Arlis Jamali, Raihan Hafidz Jamaluddin P Januarsih Jaya Negara, I D G Jinani Firdausiah Jones, Clive Kadir, Muhammad Kadir Karlina Sari KARTINI Kasim Yahiji Kunti Ayu Vedanti Lestari Handayani Lubis, Ayuni Fachrunisa luciana, Lisma M. Solikhul Huda Magdalena Mahdi, Taufiq Mahendra, Alwi Azis Maifrizal Mala, Hairul Malikhul Askar, Bayu MANUNTUN ROTUA Mariah Marleni Marpaung, Muhammad Nazaruddin Martani, Ahmad Mashatim Yaku Maulida, Dara Maulidiyah Mawaddah, Zuriatul Mayasari, Dyta Silvia Mayurni Firdayana Malik Medi Hendra, Medi Melati, Anggi Mhd. Idris Lubis Mipa, Jepi Okta Mona Fronita, Mona Monifa Putri Mu'ah Muhammad Muhammad Dassir Muhammad Hasan Muhammad Nurdin Muhammad Salahudin, Muhammad Muhammad Yusri Bachtiar Muhiddin Muhiddin Mukminah Mukti, Raihan Muliasari, Handa Munawir H. Usman Munawwarah Malik Musofa Rusli Mutia, Risma Nadha, Diana Nadya Alessya Nankervis, Leo Nasution, Nur Shabrina Natasha Weisdhania Weisdhania Naufal Kurniawan Nelfianti Lisa Nisa', Sayyidatun Nisrina Muslihin Norlaila Sofia Novarita, Herni Novianti, Elpi Nuning Dwi Merina Nur Alawiyah Hasibuan Nur Kholifah Chandra Mulyani Nur Rohmah Prihatanti Nuranisa, Rizky Nurdin, Fadilah Nurfadillah Nurfadillah Nurhasanah Nurhidayah Nurjannah Nurlaela Oktavianita, Lisa Opi Andriani Owildan Wisudawan B Prasojo, Dwi Pratama, M. Hengky Prihatanti, Nur Rohmah Prihatin, Kukuh Primahana, Gian Priyambodo, Bayu Purwati, Nining Putra Astaman Putri, Oktaviani Putro, Raden Mas Wahyu Eko Qadrianti, Laeli Qinayah, Mirnatul Rafidah Rahmad Fauzi Rahmadina Rahman, Hafiz Aulia Rahmat Makmur Rahmi Raisa, Daeva Raisa, Daeva Mubarika Rajib Saddam Rakhmawati, Hidayatur Razi, T. Khairol Refka Revina Melyata Ekwanda Refril Dani Reni Guswita Restu Nur Hasanah Haris Rezky Dwi Fitriani Ria Pusvita, Mega Ribut Prastiwi Sriwijayanti Ridha Alamsyah Rifkawati Rina Ratianingsih Riska Rissa, Mutiara Zahira Rizaldy, MHD. Agung Rodiah Romlah Rosmini Siahaan Rozanda, Nesdi Evrilyan Rozanda, Nesdi Evrylian Rusdiyah Sudirman Made Ali Rusman, Irma Saalino, Valentina Salam, Diah Astari Samrudin Samsul Arifin Sandi, Kelvin Mei Santoso, Natasya Sarifudin, Muhamad Nur Sarina Sepiani Septian, Adi Serlis Rusandi Shobirin Shulhan Abdul Gofar Sinurat, Sinar Siska Prasinta Kesum Siti Alifhya Nurhaliza Siti Musarofah Sitti Nadirah Sitti Nurhalisa Soep Sri Anjani Sriwahyudin Moonti Sudibyo, Anung Sukirman SUKIRNO Sulfasyah sultan SUMARNI Suparno Suparno, Tejo Suprapti, Eka Syahbuddin Syahputra, Fadli Syahputra, Rafiki Syaifullah Syamsu Nur, Syamsu Syamsuardi Syamsuardi Syamsuddin, Agustan Tedi Yunanto Tengku Khairil Ahsyar Terminanto, Ade Ananto Thamrin Tahir Tri Eka Suroja Trini Hariyanti Tshamaroh, Muthia Ulfa, Kurnia Ummul Fausiah Usman Usman Viariska, Ferdita Yurike vonny khresna dewi Wa Ode Masrida Wahidanur Wahyuni, A. Panca Wahyuningsih Wardani, Ambarsari Kusuma widia zalvi Wilni Wahda Ulwiyati Winanda, Salsa Winardi, Arif Rahman Windayani, Sri Windy Florence Vionita Wiwik Handayani Wulandari, Anggy Julia Yantoro Yeni Susilawati Yesa, Aditya Nugraha Yulidar Yulisara, Ekatri Yunariyah Yuniarti Yunita Engriani Yusnita Zacky, M. Zaenal Arifin Zahruddin Zakiah Zarnelly Zarry, Cindy Kirana Zidny Nuris Yuhbaba