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Masriani .
Program Studi Pendidikan Kimia Universitas Tanjungpura
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Molecular Docking of Anthraquinones from Morinda citrifolia Root as α-Glucosidase Inhibitors Tobing, Aldi; Masriani, Masriani; Arief, Ihsanul
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.17725

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and remains one of the major contributors to global morbidity and mortality. The development of safer and more effective antidiabetic agents from natural products has gained increasing attention due to the limitations of current synthetic drugs. Morinda citrifolia root has been reported to contain various anthraquinone derivatives with potential bioactivity. This study aimed to evaluate the inhibitory potential of 23 anthraquinone derivatives from Morinda citrifolia root against the α-glucosidase enzyme using an in silico molecular docking approach. Molecular docking was conducted using AutoDock Vina against α-glucosidase (PDB ID: 5ZCC) after protein preparation in UCSF Chimera. The docking targeted the catalytic site containing key residues (Arg411, Gln256, and Asp327) that interact with acarbose, and interaction patterns were analyzed using BIOVIA Discovery Studio Visualizer. The results demonstrated that several compounds exhibited stronger binding affinities than the standard inhibitor acarbose (-8.4 kcal/mol), while maintaining similar interaction patterns. In particular, compound 21 (-8.9 kcal/mol, H-bond with Gln256), compound 18 (-8.7 kcal/mol, H-bond with Arg411 and Gln256), and compound 15 (-8.3 kcal/mol, H-bond with Gln256 and Asp327) emerged as the most promising candidates. These findings suggest that anthraquinone derivatives from Morinda citrifolia root may serve as potential α-glucosidase inhibitors and warrant further pharmacokinetic and experimental validation.
Development of Interactive Multimedia on Chemical Bonding Material Iwan; Enawaty, Eny; Masriani
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18039

Abstract

The limited availability of learning media capable of facilitating students’ understanding of abstract concepts in chemical bonding prompted this research. This study aims to determine the validity level of the developed interactive multimedia and to assess teachers’ and students’ responses toward its use. The research employed a Research and Development (R&D) method using a modified ADDIE model, limited to the development stage. The trial subjects consisted of two chemistry teachers and 9 students for the small-scale test, as well as 30 students from grade XI at SMAN 2 Sekadau for the large-scale test.The validation results from experts indicated that the interactive multimedia was highly valid with an average percentage of 94.17%, consisting of 88.33% for the media aspect, 96.25% for the material and language aspects, and 97.92% for the assessment aspect. Student responses reached an average of 90.69% in the small-scale test and 94.53% in the large-scale test, while teacher responses reached 83.07%.The novelty of this research lies in the use of interactive multimedia equipped with a variety of engaging features, such as ice-breaking activities and educational games, which are rarely implemented in chemical bonding learning at the senior high school level. Therefore, the developed interactive multimedia can be used as a learning medium and further tested for its effectiveness.
In Silico Study of Antidiabetic Activity Mikania Cordata as PPAR- γ Agents Oktavianti, Dian; Masriani; Arief, Ihsanul
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18110

Abstract

Diabetes mellitus remains a significant global health problem, requiring safer and more effective therapeutic agents. Peroxisome Proliferator-Activated Receptor gamma (PPAR-γ) plays a crucial role in regulating glucose metabolism by enhancing insulin sensitivity, making it a key target in the development of antidiabetic drugs. Pioglitazone, a PPAR-γ agonist from the thiazolidinedione class, has long been used as a conventional therapy; however, its long-term use is associated with side effects such as fluid retention, weight gain, and an increased risk of heart failure. The World Health Organization recommends the development of natural-based drugs with minimal adverse effects. One promising plant candidate is Mikania cordata, which has been reported to possess antidiabetic activity and contains various bioactive compounds, including terpenoids, flavonoids, sterols, and sesquiterpenoids. This study aimed to evaluate the bioactive compounds of Mikania cordata as potential natural PPAR-γ agonists using a molecular docking approach. A total of 36 ligands from M. cordata were docked to the PPAR-γ protein (PDB ID: 2PRG), with Pioglitazone serving as the positive control. Docking was performed using PyRx with the AutoDock Vina system after ligand and protein preparation with UCSF Chimera 1.16. The docking results were analyzed using BIOVIA Discovery Studio Visualizer to identify the interactions between the ligand–protein complexes. The results showed that Cordatolide exhibited the lowest binding affinity (–9.1 kcal/mol), followed by Stigmasterol (–8.9 kcal/mol), both of which were better than Pioglitazone (–8.8 kcal/mol). Interaction analysis revealed that Cordatolide formed two hydrogen bonds with key residues ARG288 and GLY284, accompanied by stable hydrophobic interactions without any unfavorable contacts. Meanwhile, Stigmasterol also showed competitive affinity, although its stability relied solely on hydrophobic interactions without hydrogen bonding. Therefore, Cordatolide demonstrates strong potential as a natural PPAR-γ agonist with fewer side effects compared to conventional therapies. This study provides a novel finding on the potential of M. cordata as a natural PPAR-γ agonist; however, further in vitro and in vivo evaluations are required to confirm its pharmacological activity.
Tinjauan Hukum Ekonomi Islam Terhadap Pelacakan Status Industri Produk Halal Masriani, Yulies Tiena; Mungawanah, Novia; Pakina, Ridho; Wahyuni, Husnia Hilmi
JURNAL ILMIAH HUKUM DAN DINAMIKA MASYARAKAT Vol 23, No 2 (2025): HUKUM DAN DINAMIKA MASYARAKAT
Publisher : Fakultas Hukum Universitas 17 Agustus (UNTAG) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56444/hdm.v23i2.6664

Abstract

The halal industry has grown rapidly, with approximately 1.8 billion global consumers and an annual transaction value reaching USD 650 million. Demand for halal products is increasing, making halal certification, halal standards, and halal traceability systems key factors in ensuring the halal status of food products. Indonesia, with an 87.2% Muslim population, has a large halal market and the potential to become a global halal economic hub. In this context, a halal traceability system is a crucial element in ensuring the integrity of halal products throughout the supply chain, from raw materials to consumers. Accurate information technology and documentation are key enablers in implementing this system. This study aims to examine the dynamics of the implementation of a halal traceability system and evaluate its role in halal product assurance in Indonesia, taking into account the contribution of Islamic economic law. The study also explores the challenges in implementing this system and how it can support the growth of the halal industry. Using a normative and analytical legal approach, this study hopes to provide policy recommendations to strengthen the halal assurance system, in accordance with Sharia principles, and support Indonesia as a major player in the global halal industry.
Komunikasi Verbal Dan NonVerbal Fotografer Dalam Foto Runing Di Samarinda Masriani, Masriani; Sary, Kezia Arum; Alfando, Johantan; Dwivayani, Kadek Dristiana
Jurnal Media Informatika Vol. 6 No. 6 (2025): Edisi Nopember - Desember 2025
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jumin.v6i6.7451

Abstract

Penelitian ini mengkaji peran komunikasi verbal dan non-verbal yang digunakan fotografer dalam praktik foto-running di Kota Samarinda. Metode yang digunakan adalah kualitatif deskriptif dengan teknik purposive sampling. Data dikumpulkan melalui wawancara mendalam, observasi partisipatif, serta dokumentasi visual berupa unggahan media sosial dan materi distribusi foto. Sampel penelitian terdiri dari fotografer lapangan dan pelari sebagai penerima pesan. Analisis data dilakukan menggunakan analisis tematik dari Braun & Clarke untuk menemukan pola komunikasi serta konteks kemunculannya. Hasil penelitian menunjukkan bahwa komunikasi non-verbal seperti gerakan tubuh, contoh pose, kontak mata, dan penggunaan papan atau properti menjadi saluran utama yang paling efektif dalam situasi ramai dan bising. Meskipun demikian, instruksi verbal tetap memiliki peran penting, terutama untuk menyelaraskan momen pemotretan melalui hitungan seperti “satu-dua-tiga.” Teknologi seperti Instagram, Google Drive, dan FotoYu tidak hanya berfungsi sebagai media distribusi, tetapi juga turut membentuk ulang cara kerja fotografer serta menimbulkan pertimbangan etis dalam publikasi foto. Hambatan komunikasi yang kerap terjadi meliputi jarak, kerumunan, kebisingan, kondisi cuaca, dan masalah privasi peserta. Untuk mengatasinya, fotografer memadukan strategi verbal dan non-verbal dengan prosedur koordinasi sebelum acara dimulai. Secara teoretis, penelitian ini memperkaya kajian interaksi simbolik pada komunikasi visual olahraga dan memberikan rekomendasi praktis berupa SOP pra-event, lexicon gestur, dan standar repositori digital untuk meningkatkan efektivitas serta etika praktik fotorunning di era digital.
Co-Authors A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Abd Hakim Laenggeng, Abd Hakim Abd. Hakim Laenggeng, Abd. Hakim Abdul Hafiz, Iqbal Abdul Hakim Laenggeng Abdullah Abdullah Abdurrohman Wahab Achmad Ramadhan Ade Mirza Afandi Afandi Afif Noor Agnes Maria Janni Widyawati Agnes Maria Janni Widyawati Agung Hartoyo Agusta, Muhammad Farras Leonasa Agustinus Ridwan Ahmad Yani T Aini Zahra Aisyah Nur Pratiwi Aisyah Saleh, Nur Ajuk Sapar Ajuk Sapar Ajuk Sapar4 Akrom, Akrom Al Mu’min, Muhammad Ridhwan Aladawiyah, Aladawiyah Albertus, Amos Aldri Frinaldi Aloysius Mering Amalia Buntu Amalia, Diza Nurul Amat, Amat Amiruddin Kasim Amran Rede Amsal Alhayat Anah Setiawati Anastasia Ilin Andi Asrafiani Arafah Andi Hairil Alimuddin Andi I. Harun Andi Ifriany Andi Ihwan Andriyani, Putri Anggi Fatmadiwi Aninda, Dea Aninindya, Istamarra Aditya Anisa Fitri Annisa Utami Antonius Antonius Aprianus Aril Aprilya, Dinda Apriyani Apriyani Arafah, Andi Asrafiani Arit Arit Arsitas, Dian Ashari, Abdul Asifah, Nur Asma Asma Asriah Nurdini M. Astriani Natalia Br Ginting Azwa Fadilla Wafiq Bakri Hasanuddin Bella Agustina Bilqis, Adilla Bustamin Bustamin Cahyani, Indah Regita Cahyani, Melur Regista Chairul Chairul Chorina, Malisa Claudina Marditha Damayanti, Alfina Darsah, Mohammad Datubaringan, Jein Dea Aninda Defiana Aliyatur Rosidah Delima, Nur Depasthika, Sistha Citra Devianti, Rika Dewi Tureni Dewi, Melyana Dian Oktavianti, Dian Dian Ria Puspita, Dian Ria Diana Pujiningsih Dianni Dina Liana Dinda Kartika Wijayanti Dita Nurlina Dona Fitriawan Dwivayani, Kadek Dristiana Dzul Fadly Effendy, Mutiara Eka Kartina Ekowati Handharyani Elisa Futri Elsye Apriliantika Engga, Mardinus Eni Mayasari Eny Enawati Eny Enawati Eny Enawati Eny Enawaty ERDAWATI, SRI Erlina ERLINA Erlina Erlina Erlina Erlina Erma Susanti Ersando Ersando Ersando Ersando Ersando, Ersando Erwina Oktavianty Eti Nurwening Sholikhah Fadhilah, Raudhatul Fadila, Rismayana Fadli Fadli Fadly Yashari Soumena Fadly, Dzul Faisal Afda’u Fajar Suwarno, Fajar Falah, Syauqi Muhammad Shobibul Farida Mayar Farida Setiawati FATIMA, SITI Fatma Dhafir Fatmadiwi, Anggi Fatmah Dhafir Febriani, Vita Indri Fia Tiaraseta Firman Shantya Budi Firra Meliana Pratiwiningrum Fita Kurniasari Fithri Anggraini Fitri, Rosiana Gerina, Febrilia Gibran, Muhammad Hafiz, Muhammad Iqbal Abdul Hairida Hairida Hamdani Hamdani Hamsa, Hamsa Hanif, Faizira Nur Hanifa, Elsa Hardiyanti, Masitoh Hariyani, Cici Hariyanti, Weni Hasibuan, Nikmah Hasmini F17111019, Hasmini Hazarianti, Putri Helsa Ulfa Destari Henny Herawaty Herniawati Herniawati Herniawati, Herniawati Hidayat, Niko Hj. Musdalifah Nurdin Hotimah Husna Amalya Melati Husna Amalya Melati Husna Amalya Melati Husna Amalya Melati Husnia Hilmi Wahyuni I Made Budiarsa I Nengah Kundera Idris Idris Ifriani, Andi Ifriany, A. Ifriany, Andi Ifriany, Andy Ihsanul Arief Iis Puspa Subekti Ika Kania Fatdo Wardani Indah Dwiprigitaningtias Indri Astuti Ino Talino Iqbal Abdul Hafiz Ira Lestari Ira Lestari Ira Lestari Ira Lestari, Ira Lestari Irene Yudea Listra Irfan Maftuh Iskandar, Ratnasari Isnaini F17111035, Isnaini Isninar, Isnainar Istamarra Aditya Aninindya Istikomah Istikomah Istikomah, Istikomah Istikomah istiqomah istiqomah Istiqomah Istiqomah Iwan Jaya, Andi Eka Putra Juli Ana Jumarang, Ishak Kalijunjung Hasibuan Karmila karmila karmila Khofifah Aditha Parawansa Khofifah Aditha Parawansa Khofifah Aditha Parawansa Krestian, Hery Kristiando Siburian Kundera, I Negah Kusudaryani, Praditya Adi Laenggen, Abd. Hakim Laili Fitri Yeni Lestari M.P Alibasyah Liana, Dina Lilies Lilies Lilies N Tangge Lisa Lisa, Lisa Listiani, Etma Listra, Irene Yudea Luh Beti Karmia Lukman Hadi Lukman Hadi Lukman Hadi Lukman Hadi, Lukman Lukman Hakim Maftuh, Irfan Maharani Nukila Manap Trianto marbela, lilis Mardasela, Tery Mardin, Mardin Margareta Lita Widiansari Maria Ulfa Maria Ulfah Maria Ulfah Maria Ulfah, Maria Ulfah Marisa Marisa Markus Suryo Utomo Markus Suryoutomo Maruf Maruf, Maruf Maryani Maryani Maryani Maryani Maryati, Riski Neli Maskus Suryoutomo Masri, Esther Maulina Diah Maulina Diah Maya Sari Meikasari, Anisa Putri Meisi Nur Seratih MELANIA, PURNAMA Melur Regista Cahyani Meri Meri Mieke Anggraeni Dewi Miftahul Kautsari Mirnawati, Nurul Aini Mohamad Jamhari Mohammad Jamhari Monica, Icha Monica, Qois Monica, Sarah Muh. Ishak Jumarang Muhammad Anggung Manumanoso Prasetyo Muhammad Arifin Muhammad Farras Leonasa Agusta Muhammad Gibran Muhammad Iqbal Abdul Hafiz Muhammad Ridhwan Al Mu’min Muhammad Sodikin Muhammad Syahrizal Mukhtar, Raine Ramdhanya Munawaroh, Faridatul Mungawanah, Novia Mustamiroh, Mustamiroh Mustofa Mustofa Mustofa Muttalib, Yuges Saputri Nadila, Andi Nadila, Nadila Nahria, Syarifatun Nani Zurahmah Nanik Yuningsih Natasya, Qois Neisya Benhadj Neli Maryati, Riski Nelly Dayanti Neni Haryani Ningsih, Kurnia Ningsih, Sri Rahayu Noprianti, Dini Nova Citra Novi, Winda Cinthia Novirianti, Novirianti Nugroho, Very Sapto Nur Ainun Nur Atika Nur Haliza Nur Zaqiyyah Nurhalimah, Risna Nurhamijah Nuria, Rika Nurlinda, Andika Nurmala Nurmala Nurpaisah, Nurpaisah Nurul Salima Oktariani, Desy Oktavia, Rini Pakina, Ridho Parawansa, Khofifah Aditha Pasaribu, Revi Lestari Peter Proksch Pingkan Ramadhan Sailendra Pingkan Ramadhan Sailendra Pinta Rini Harpiyani Pitri, Rosiana Pranata, Rio Pratami, Hutianas Muhar Pratiwi, Bella Pratiwi, Divya Indah Pricylia Chintya Dewi Buntuang Purnama Melanie Purwandi, Oktavianus Eduardo Purwanto, Sandi Purwasih, Lidya Sri Putra, Rody Putri Yuli Utami Putri, Regina Triana Putriyani Putriyani Qhatimah, Saripa Husnul Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Radhiana, Ainun RAFIQA RAFIQA, RAFIQA Ragil, Ragil Rahayu, Irma Septi Rahma, Saparina Rahmad Ulwan RAHMAN, ARIVAIE Rahmat Rahmat Rahmat Rasmawan Rahmatul Amin, Dewita Rakhmaji, Iqbal Ramadhan Sailendra, Pingkan Ramadhanti, Yana Razoki, Razoki Renaningtyas, Agneviana Pratikta Ditya Reski, . Rico Hediyansah Ridho Pakina Ridho Pakina Rika Silviani, Rika Rini Muharini Risya Sasri Risya Sasri Risya Sasri Riyanti, Ririt Riyanto, Izory Roman Robiatul Adawiyah Rody Putra Sarti Rody Putra Sartika Rosita F02111011, Rosita RR. Ella Evrita Hestiandari Rudi Heryanto Rudiyansyah Rudiyansyah Rudiyansyah Rudiyansyah, Ruqiah Ganda Putri Panjaitan Sabdaningtyas, Katherina Sahputra, Rachmad Sahputra, Rahmat Sailendra, Pingkan Ramadhan Sakur, Muhammad Samekto Wibowo Samekto Wibowo Sandi Yoga Pradana Sary, Kezia Arum Saryana Sasri, Risya Sastria, Andi Seilendra, Pingkan Ramadhan Selina, Selina Sembiring, Rinawati Shamdas, Gamar B.N. Shantya Budi, Firman Siahaan, Gorga Josua Chrisvandoli Sigit Irianto Silpia Vilda Saputri Simamora, Andronikus Wp Siska Putri Damayanti Sitti Aminah Sri Lestari Sri Rahayuningsih Sri Wahyuni Sri Wahyuni Sriwahyuni, Eko Stephanus Sahala Sucipta, Johantan Alfando Wikandana sukriadi sukriadi Sultra Tari Suryoutomo , Markus Susanto, Ary Susi Iravati Susi Iravati Susi Susanti Sutrisnawati Mardin Syamsul Bahri Syamswisna , Syarifudin Syarifudin Syarifudin Syech Zainal Tari, Sultra TATI NURHAYATI Tatu Maesaroh TETI SUSANTI Therisia, Stefany Tiara Tiara Tiara, Tiara Tobing, Aldi Toyib Bikoir Tresna Kurniawati Trisanty, Yulia Trisnawati, Resty Tulus Djunanto Tulus Gover Sirigo Ringo Tulus Junanto Tulus Junanto Tumale, Serli Ulandari, Uci Umi Maftuhah Sandra Utami, Putri Yuli Utin Thiya Novasari, Utin Thiya Verya Adithya Violeta, Cornelia Virahmi, Virahmi Vita Oktavianty Waginah, Nur Wahdah Aliyah Wahyuni, Resti Putri Wardatullatifah, Ince Siti Warohmah, Mawaddatul Warsidah Warsidah Warsidah Warsidah Warsidah, Warsidah Wasmen Manalu Widian Sari, Margareta Lita Widyasari, Ida Ayu Made Tania Wikke Prawitaningtyas WILDA, WILDA Windarsih, Yulia WOLLY CANDRAMILA Yeni Triana Yuges Saputri Muttalib Yulianti Yulianti Yunianto, Andi Eka Yunita Puspasari Zakia, Zakia Zasmita, Eka Zulfa Zakiah Zulfan Z Zulfan Z, Zulfan