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Cytotoxic Activity and Apoptocic Induction of Dicloromethane Fraction Nauclea subdita on WiDr Colon Cancer Cell Hengki Kurniawan; Masriani Masriani; Rini Muharini
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.285-292

Abstract

Colon cancer is one of the most deadly cancers in the world. Conventional treatments such as surgery, radiotherapy and chemotherapy are often limited, especially in metastatic cancer. Therefore, the development of alternative therapies, such as chemoprevention, becomes very important. This study aimed to test the anticancer potential of bengkal (Nauclea subdita) stem bark against WiDr colon cancer cells through cytotoxic, cell cycle, and apoptocic assays. The stem bark of bengkal was extracted using n-hexane and ethanol, then fractionated using dichloromethane (DCM). The results of the cytotoxic test using the MTT method showed that the DCM pH 3 fraction had the highest cytotoxic potential with an IC50 value of 112.81 ± 22.55 µg/mL against WiDr cells. However, the Selectivity Index (IS) value of the DCM pH 3 fraction showed low selectivity (<2). Cell cycle assay using flow cytometry indicated that DCM pH 3 fraction was able to inhibit cell cycle distribution. Furthermore, apoptocic test with Annexin V-FTIC/PI method showed that DCM fraction pH 3 triggered apoptocic mechanism in WiDr cancer cells. This study provides preliminary evidence that DCM fraction pH 3 of bengkal stem bark has anticancer potential against WiDr colon cancer cells, thus DCM fraction pH 3 of bengkal stem bark can be a source of WiDr colon anticancer agent.
Study of Conformational Preferences of Erythro-Carolignan E Assessed By The Coupling Between H7'-H8' in Different NMR Solvents Rudiyansyah Rudiyansyah; Ajuk Sapar; Masriani Masriani
ALCHEMY Jurnal Penelitian Kimia Vol 11, No 1 (2015): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.11.1.99.1-7

Abstract

Erythro-carolignan E (1) has been obtained from the ethanol extract of the wood bark of Durio affinis Becc. This research was conducted in order to prove that conformational preferences of compound 1 were solvent dependent. On the basis of 1H-NMR data, the relative configuration of compound 1 was characterized by a coupling constant (3JHH) value of 3.3 Hz at H-7' in CDCl3. The coupling constant (3JHH) values of H-7' in compound 1 has changed to 4.1 Hz and 5.3 Hz in pyridine-d5 and acetonitrile-d3 respectively. As a result, the conformation of compound 1 at C7'-C8' has changed in different NMR solvents.  In conclusion, structure oferythro-carolignan E that contains a dihydroxy group at C7'-C8' is able to change in different NMR solvent.
Analisis Profil HPLC-PDA Berkombinasi dengan LC-ESI-MS dan Aktivitas Biologi dari Ekstrak Jamur Endofit, Penicillium simplicissimum, yang Diisolasi dari Rimpang Jahe Merah Rini Muharini; Ersando Ersando; Yeni Triana; Maharani Nukila; Rahmad Ulwan; Masriani Masriani; Peter Proksch
ALCHEMY Jurnal Penelitian Kimia Vol 18, No 2 (2022): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.18.2.56860.158-164

Abstract

Rimpang jahe merah digunakan sebagai tumbuhan obat tradisional dan diketahui mengandung senyawa-senyawa berkhasiat. Dekade ini eksplorasi mikroorganisme yang bersimbiosis dengan tumbuhan obat mendapat perhatian besar guna mencari alternatif sumber senyawa berkhasiat obat. Penelitian ini bertujuan memperoleh informasi profil kimia ekstrak Penicillium simplicissimum, jamur endofit yang diisolasi dari rhizoma jahe merah, menentukan daya hambatnya terhadap bakteri Staphyloccocus aureus dan Escherichia coli, dan mengevaluasi aktivitas sitotoksiknya terhadap sel limfoma tikus L-5178Y, sel kanker payudara (T47D dan 4T1) dan sel kanker usus (WiDr). Skrining fitokimia melalui teknik KLT dan pereaksi spesifik memperlihatkan adanya golongan senyawa alkaloid, triterpenoid, dan sterol pada ekstrak. Analisa data high-performance liquid chromatography dengan detektor photodiode array (HPLC-PDA) yang dikombinasikan dengan data LC-ESI-MS serta perbandingan data literatur memberikan dugaan bahwa salah satu komponen senyawa utama adalah citreonigrin F, yang diisolasi sebelumnya dari P. citreonigrin. Evaluasi aktivitas antibakteri menunjukkan bahwa ekstrak P. simplicissimum tidak memiliki daya hambat terhadap pertumbuhan kedua bakteri uji. Akan tetapi, ekstrak P. simplicissimum memberikan penghambatan yang lemah terhadap sel limfoma tikus L-5178Y pada konsentrasi 10 μg/mL dan aktivitas sitotoksik yang moderat terhadap sel kanker payudara dan sel kanker usus dengan IC50 >100 μg/mL. Temuan ini menunjukkan bahwa jamur endofit P. simplicissimum yang diisolasi dari jahe merah ini memiliki potensi untuk dieksplorasi lebih lanjut guna memperoleh senyawa berkhasiat obat.  Profiling Analysis of HPLC-PDA Combined with LC-ESI-MS and Biological Activity of an Endophytic Fungi P. Simplicissimum Extract Isolated from Red Ginger Rhizome. Red ginger rhizome has been used traditionally as a medicinal plant, and its active principal constituents have been known. In the recent decade, the exploration of endophytes in medicinal plants received huge interest in finding new bioactive compound sources. This research aims to obtain the chemical profile of an endophytic fungi P. simplicissimum extract isolated from Red ginger rhizome. This study also further evaluates its antibacterial activity against Staphyloccocus aureus and Escherichia coli and its cytotoxicity against L-5178, 4T1, T47D, and WiDr cell lines. The phytochemical screening of the extract using the TLC technique and specific reagents shows the existence of alkaloids, triterpenoids, and sterol. The further analysis using high-performance liquid chromatography with photodiode array detector (HPLC-PDA) and LC-MS/MS data, as well as literature comparison, indicated that one of the major compounds was citreonigrin F, which isolated previously from P. citreonigrin. The evaluation of antibacterial activity showed that P. simplicissimum extract did not inhibit the growth of both bacteria tested. However, P. simplicissimum extract showed a weak inhibition against L-5178Y rat lymphoma cells at a concentration of 10 μg/mL and a moderate cytotoxic activity against breast cancer cells and colon cancer cells with IC50 >100 μg/mL. Nevertheless, this study showed that P. simplicissimum isolated from red ginger could be further explored for its bioactive compounds.
Co-Authors A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Abd Hakim Laenggeng, Abd Hakim Abd. Hakim Laenggeng, Abd. Hakim Abdul Hakim Laenggeng Abdullah Abdullah Abdurrohman Wahab Achmad Ramadhan Achmad Ramadhan Ade Mirza Afandi Afandi Afif Noor Agnes Maria Janni Widyawati Agnes Maria Janni Widyawati Agung Hartoyo Agusta, Muhammad Farras Leonasa Agustinus Ridwan Ahmad Yani T Aini Zahra Aisyah Nur Pratiwi Aisyah Saleh, Nur Ajuk Sapar Ajuk Sapar Ajuk Sapar4 Akbar Al Mu’min, Muhammad Ridhwan Aladawiyah, Aladawiyah Albertus, Amos Aldri Frinaldi Allfira, Elisse Nur Aloysius Mering Amalia Buntu Amalia, Diza Nurul Amat, Amat Amiruddin Kasim Amran Rede Amsal Alhayat Anah Setiawati Anastasia Ilin Andi Asrafiani Arafah Andi Hairil Alimuddin Andi I. Harun Andi Ifriany Andi Ihwan Andriyani, Putri Anggi Fatmadiwi Aninda, Dea Aninindya, Istamarra Aditya Anisa Fitri Annisa Utami Antonius Antonius Aprianus Aril Aprilya, Dinda Apriyani Apriyani Arafah, Andi Asrafiani Arit Arit Arsitas, Dian Ashari, Abdul Asifah, Nur Aslam Aslam, Aslam Asma Asma Asriah Nurdini M. Astriani Natalia Br Ginting Asyraf, Asyraf Azwa Fadilla Wafiq Baehaqi Bakri Hasanuddin Bella Agustina Bilqis, Adilla Bustamin Bustamin Cahyani, Indah Regita Cahyani, Melur Regista Chairul Chairul Chorina, Malisa Claudina Marditha Damayanti, Alfina Darsah, Mohammad Datubaringan, Jein Dea Aninda Defiana Aliyatur Rosidah Delima, Nur Depasthika, Sistha Citra Devianti, Rika Dewi Tureni Dewi, Melyana Dian Oktavianti, Dian Dian Ria Puspita, Dian Ria Diana Pujiningsih Dianni Dina Liana Dinda Kartika Wijayanti Dita Nurlina Dona Fitriawan Dwi Mulya Iswaningsih Dwivayani, Kadek Dristiana Dzul Fadly Effendy, Mutiara Eka Kartina Eka Kusuma Wardani Ekowati Handharyani Elisa Futri Elsye Apriliantika Engga, Mardinus Eni Mayasari Eny Enawati Eny Enawati Eny Enawati Eny Enawaty ERDAWATI, SRI Erlina ERLINA Erlina Erlina Erlina Erlina Ersando Ersando Ersando Ersando Ersando, Ersando Erwina Oktavianty Eti Nurwening Sholikhah Fadhilah, Raudhatul Fadila, Rismayana Fadli Fadli Fadly Yashari Soumena Fadly, Dzul Faisal Afda’u Fajar Suwarno, Fajar Falah, Syauqi Muhammad Shobibul Farida Mayar Farida Setiawati FATIMA, SITI Fatir, Fatir Fatma Dhafir Fatmah Dhafir Fia Tiaraseta Firman Shantya Budi Firman Shantya Budi Firman Shantya Budi, Firman Shantya Firra Meliana Pratiwiningrum Fita Kurniasari Fithri Anggraini Fitri, Rosiana Gerina, Febrilia Gibran, Muhammad Hafiz, Muhammad Iqbal Abdul Hairida Hairida Hamdani Hamdani Hamsa, Hamsa Hanggara Yoga Adhitama Hanif, Faizira Nur Hanifa, Elsa Hardiyanti, Masitoh Hari Mardika, Isnan Hariyani, Cici Hariyanti, Weni Hasibuan, Nikmah Hasmini F17111019, Hasmini Hazarianti, Putri Helsa Ulfa Destari Hengki Kurniawan Hengki Kurniawan, Hengki Henny Herawaty Herniawati Herniawati Herniawati, Herniawati Hidayat, Niko Hj. Musdalifah Nurdin Hotimah Husna Amalya Melati Husna Amalya Melati Husna Amalya Melati Husna Amalya Melati Husnia Hilmi Wahyuni I Made Budiarsa I Nengah Kundera Idris Idris Ifriani, Andi Ifriany, A. Ifriany, Andi Ifriany, Andy Ihsanul Arief Iis Puspa Subekti Iis Puspa Subekti Ika Kania Fatdo Wardani Indah Dwiprigitaningtias Indri Astuti Ino Talino Iqbal Abdul Hafiz Ira Lestari Ira Lestari Ira Lestari Ira Lestari, Ira Lestari Irene Yudea Listra Irfan Maftuh Iskandar, Ratnasari Isnaini F17111035, Isnaini Isninar, Isnainar Istamarra Aditya Aninindya Istikomah Istikomah Istikomah, Istikomah Istikomah istiqomah istiqomah Istiqomah Istiqomah Iwan Jaya, Andi Eka Putra Juli Ana Jumarang, Ishak Junaidi Junaidi Justiarani, Justiarani Kalijunjung Hasibuan Karmila karmila karmila Khofifah Aditha Parawansa Khofifah Aditha Parawansa Khofifah Aditha Parawansa Krestian, Hery Kristiando Siburian Kusudaryani, Praditya Adi Laenggen, Abd. Hakim Laili Fitri Yeni Lestari M.P Alibasyah Liana, Dina Lilies Lilies Lilies N Tangge Lisa Lisa, Lisa Listiani, Etma Listra, Irene Yudea Luh Beti Karmia Lukman Hadi Lukman Hadi Lukman Hadi Lukman Hadi, Lukman Lukman Hakim Maftuh, Irfan Maharani Nukila Manap Trianto marbela, lilis Mardasela, Tery Mardin, Mardin Margareta Lita Widiansari Maria Ulfa Maria Ulfah Maria Ulfah Maria Ulfah, Maria Ulfah Marisa Marisa Markus Suryo Utomo Markus Suryoutomo Maruf Maruf, Maruf Maryani Maryani Maryati, Riski Neli Maskus Suryoutomo Masri, Esther Maulina Diah Maulina Diah Maya Sari Meikasari, Anisa Putri Meisi Nur Seratih MELANIA, PURNAMA Melur Regista Cahyani Melviani Meri Meri Mieke Anggraeni Dewi Miftahul Kautsari Mirnawati, Nurul Aini Mohamad Jamhari Mohammad Jamhari Monica, Icha Monica, Qois Monica, Sarah Muh. Ishak Jumarang Muhammad Anggung Manumanoso Prasetyo Muhammad Arifin Muhammad Farras Leonasa Agusta Muhammad Gibran Muhammad Iqbal Abdul Hafiz Muhammad Ridhwan Al Mu’min Muhammad Sodikin Muhammad Syahrizal Mukhtar, Raine Ramdhanya Munawaroh, Faridatul Mungawanah, Novia Musrika, Musrika Mustamiroh, Mustamiroh Mustofa Mustofa Mustofa Muttalib, Yuges Saputri Nabila, Chesya Nadila, Andi Nadila, Nadila Nahria, Syarifatun Nani Zurahmah Nanik Yuningsih Neisya Benhadj Neli Maryati, Riski Nelly Dayanti Neni Haryani Ningsih, Kurnia Ningsih, Sri Rahayu Noprianti, Dini Nova Citra Novi, Winda Cinthia Novirianti Novirianti Nugroho, Very Sapto Nur Ainun Nur Atika Nur Haliza Nur Zaqiyyah Nurhalimah, Risna Nurhamijah Nuria, Rika Nurlinda, Andika Nurmala Nurmala Nurpaisah, Nurpaisah Nursaeni Nurul Salima Oktariani, Desy Pakina, Ridho Parawansa, Khofifah Aditha Pasaribu, Revi Lestari Peter Proksch Pingkan Ramadhan Sailendra Pingkan Ramadhan Sailendra Pinta Rini Harpiyani Pitri, Rosiana Pranata, Rio Pratami, Hutianas Muhar Pratiwi, Bella Pratiwi, Divya Indah Pricylia Chintya Dewi Buntuang Purnama Melanie Purwandi, Oktavianus Eduardo Purwanto, Sandi Purwasih, Lidya Sri Putri Yuli Utami Putri, Regina Triana Putriyani Putriyani Qhatimah, Saripa Husnul Qois Natasya Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Radhiana, Ainun Rafif, Muhammad RAFIQA RAFIQA, RAFIQA Ragil, Ragil Rahayu, Irma Septi Rahma, Saparina Rahmad Ulwan RAHMAN, ARIVAIE Rahmat Rahmat Rahmat Rasmawan Rahmatul Amin, Dewita Rakhmaji, Iqbal Ramadhanti, Yana Razoki, Razoki Renaningtyas, Agneviana Pratikta Ditya Reski, . Rico Hediyansah Ridho Pakina Ridho Pakina Rika Silviani, Rika Rini Muharini Risya Sasri Risya Sasri Risya Sasri Riyadi Riyadi Riyanti, Ririt Riyanto, Izory Roman Robiatul Adawiyah Rody Putra Sartika Rosita F02111011, Rosita RR. Ella Evrita Hestiandari Rudi Heryanto Rudiyansyah Rudiyansyah Rudiyansyah Rudiyansyah, Ruqiah Ganda Putri Panjaitan Sabdaningtyas, Katherina Sahputra, Rachmad Sahputra, Rahmat Sailendra, Pingkan Ramadhan Sakur, Muhammad Salmianti, Salmianti Samekto Wibowo Samekto Wibowo Sandi Sandi Sandi Yoga Pradana Sary, Kezia Arum Saryana Sasri, Risya Sastria, Andi Seilendra, Pingkan Ramadhan Selina Selina Sembiring, Rinawati Shamdas, Gamar B.N. Shantya Budi, Firman Siahaan, Gorga Josua Chrisvandoli Sigit Irianto Silpia Vilda Saputri Simamora, Andronikus Wp Siska Putri Damayanti Sri Rahayuningsih Sri Wahyuni Sri Wahyuni Sriwahyuni, Eko Stephanus Sahala Sucipta, Johantan Alfando Wikandana Sukatin, Sukatin sukriadi sukriadi Sultra Tari Suryoutomo , Markus Susanto, Ary Susi Iravati Susi Iravati Susi Susanti Sutrisnawati Mardin Syamsul Bahri Syamswisna , Syarifudin Syarifudin Syarifudin Syech Zainal Tari, Sultra TATI NURHAYATI Tatu Maesaroh TETI SUSANTI Therisia, Stefany Tiara Tiara Tiara, Tiara Tobing, Aldi Toyib Bikoir Tresna Kurniawati Trisanty, Yulia Trisnawati, Resty Tulus Djunanto Tulus Gover Sirigo Ringo Tulus Junanto Tulus Junanto Tumale, Serli Ulandari, Uci Umi Maftuhah Sandra Utin Thiya Novasari, Utin Thiya Verya Adithya Violeta, Cornelia Virahmi, Virahmi Vita Indri Febriani Vita Oktavianty Waginah, Nur Wahdah Aliyah Wahyuni, Resti Putri Wardatullatifah, Ince Siti Warohmah, Mawaddatul Warsidah Warsidah Warsidah Warsidah Warsidah, Warsidah Wasmen Manalu Widian Sari, Margareta Lita Widyasari, Ida Ayu Made Tania Wikke Prawitaningtyas WILDA, WILDA Windarsih, Yulia WOLLY CANDRAMILA Yeni Triana Yuges Saputri Muttalib Yulianti Yulianti Yunianto, Andi Eka Yunita Puspasari Zakia, Zakia Zasmita, Eka Zulfa Zakiah Zulfan Z Zulfan Z, Zulfan