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SINTESIS DAN UJI BIOAKTIVITAS SENYAWA ANALOG UK-3A 6-HIDROKSI-N-OKTILNIKOTINAMIDA Dadan Ridwanuloh; Herry Cahyana; Muhammad Hanafi
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 1 No 1 (2016): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/farmasi.v1i1.51

Abstract

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Identification and Bioactivity Studies of Flavonoid Compounds from Macaranga hispida (Blume) Mull.Arg Megawati,; Saepudin, Endang; Hanafi, Muhammad; Darmawan, Akhmad; Lotulung, Puspa Dewi N.
Makara Journal of Science Vol. 19, No. 3
Publisher : UI Scholars Hub

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Two flavonoid compounds, 5,7,3’,4’-tetrahydroxy-6-geranylflavonol (1) and kaempferol 7-O-β-glucose (2) have been isolated from the leaves of Macaranga hispida (Blume), Mull.Arg. Isolation and purification were conducted by chromatography methods and chemical structure characterization was carried out by spectroscopic methods. The 5,7,3’,4’-tetrahydrxyi-6-geranyl flavonol (1) and kaempferol 7-O-glucose (2) had moderate cytotoxic activity against murine leukemia P-388 cell lines with IC50 value of 0.22 and 101.5 μg/mL, respectively. The IC50 for antioxidant activities of (1) and (2) were 2.83 and 13.95 μg/mL, respectively. The LC50 of (1) and (2) from BSLT were 350 and >1000 μg/mL, respectively.
Analisis Perhitungan Cost Volume dan Profit Sebagai Dasar Perencanaan Laba Pada PT. Sariguna Primatirta Tbk Muhammad Hanafi; Nurmala Nurmala; Andri Eko Putra
Jurnal Media Akuntansi (Mediasi) Vol. 5 No. 1 (2022): Jurnal Media Akuntansi (MEDIASI), September 2022
Publisher : Universitas PGRI Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31851/jmediasi.v5i1.9366

Abstract

ABSTRACT  This research is a qualitative descriptive study which aims to determine the Analysis of Cost Volume and Profit Calculations as a Basis for Profit Planning at PT. Sariguna Primatirta Tbk period 2017-2020. The data used is secondary data, the population in this study is the data of the Financial Statements of PT. Sariguna Primatirta Tbk which is listed on the Investment Gallery of the Indonesia Stock Exchange. In this study, the authors analyzed the financial report data, namely the calculation of break even points, contribution margins, contribution margin ratios, and calculation of sales targets. Based on the analysis of Cost Volume and Profit shows that at PT. ariguna Primatirta Tbk has been able to manage operational costs that occur to the maximum extent possible, as evidenced by variable costs which tend to remain constant each period. The break even point value has broken even, the profit earned is at the break even point value so that the company is able to make a profit. The contribution margin ratio shows that the company's profit before fixed costs exceeds half of the variable costs that have been incurred. The author suggests taking action to increase revenue or reduce operating costs to reduce the risk of loss and use Cost Volume and Profit analysis to predict the costs to be incurred, the expected income and for further profit planning. Keywords: cost volume profit, profit planning ABSTRAK  Penelitian ini adalah penelitian deskriptif kualitatif yang bertujuan untuk mengetahui Analisis Perhitungan Cost Volume dan Profit Sebagai Dasar Perencanaan Laba pada PT. Sariguna Primatirta Tbk periode tahun 2017-2020. Data yang digunakan adalah data skunder, populasi dalam penelitian ini adalah  data Laporan Keuangan PT. Sariguna Primatirta Tbk yang terdaftar di Galeri Investasi Bursa Efek Indonesia. Dalam penelitian ini penulis menganalisis data laporan keuagan yang dilakukan yaitu perhitungan break even point, contribution margin, rasio contribution margin,dan perhitungan target penjualan. Berdasarkan hail analisis Cost Volume dan Profit menunjukkan bahwa  pada PT. ariguna Primatirta Tbk telah mampu mengelolah biaya oprasional yang terjadi dengan semaksimal mungkin, dibuktikan dengan biaya variabel  yang cenderung tetap setiap periodenya. Nilai break even point   telah melakukan tingkat impas, laba yang diperoleh pada nilai titik impas sehingga perusahaan mampu mendapatkan laba. Rasio  contribution margin menunjukkan bahwa keuntungan perusahaan sebelum biaya tetap yang diperoleh melebihi setengah dari biaya variabel yang telah dikeluarkan. Penulis menyarankan agar mengambil tindakan menaikkan pendapatan atau menurunkan biaya operasional untuk menurunkan risiko terjadinya kerugian dan menggunakan analisis Cost Volume dan Profit untuk memprediksi biaya yang akan dikeluarkan, pendapatan yang diharapkan dan untuk perencanaan laba selanjutnya. Kata Kunci: cost volume profit, perencanaan laba
Bioactivity of Antibacterial Compounds Produced by Endophytic Actinomycetes from Neesia altissima Rina Hidayati Pratiwi; Muhammad Hanafi; Nina Artanti; Rosa Dewi Pratiwi
Journal of Tropical Life Science Vol. 8 No. 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.08.01.07

Abstract

Identification of alternate bioactive compounds isolated from microbial endophytes from plants may lead to better solution against antibiotic resistance. Main objective of this research is to determine the bioactivity of antibacterial compounds produced by endophytic actinomycetes, which was isolated from stem bark of Neesia altissima Bl. at Halimun Salak Mount. Detection of bioactive compounds was assayed using Thin Layer Chromatography (TLC) by employing bioautography. Bioactivity was assayed using crude extract against five microorganisms using agar diffusion methods. Tetracycline was used as a positive control. The result of antibacterial activity from endophytic actinomycetes isolate revealed that the bioactive compounds were effective in inhibiting the growth of bacteria Bacillus cereus (1.25 mm), Salmonella typhimurium (5.75 mm), and Shigella flexneri (4.37 mm). Bioactivity of ethyl acetate extract from bioactive compounds of endophytic actinomycetes has an antibacterial activity against bacteria Bacillus cereus (13.00 mm) and Staphylococcus aureus (15.90 mm), at a concentration of 250,000 ppm. Each of TLC fraction was able to inhibit growth of B. cereus at a minimum concentration of 10,000 ppm. In conclusion, the bioactive compounds produced by endophytic actinomycetes can have inhibitory effect towards B. cereus. The category of that compounds are narrow spectrum. The bioactive compound isolated from endophytic actinomycetes may have other implications such as anticancer, antifungal, and antioxidant.
PREPARATION OF 2-AMINOETHYLSULFONIC ACID Widiyarti, Galuh; Hanafi, Muhammad; Isnijah, Siti; Kardono, Broto Sugeng; Ermawan, Ermawan; Ngadiman, Ngadiman; Sundowo, Andini
Makara Journal of Science Vol. 13, No. 1
Publisher : UI Scholars Hub

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Preparation process of 2-aminoethylsulfonic acid (taurine) from ethanolamine, sulfuric acid and sodium sulfite has been studied. The process involves two steps of reactions, the first was esterification of ethanolamine (H2N-CH2-CH2-OH) with sulfuric acid to produce the intermediate product of 2-aminoethyl ester (H2N-CH2-CH2-OSO3H) which then was extended to the second step by sulfonation with sodium sulfite to produce 2-aminoethylsulfonic acid (H2N-CH2-CH2- SO3H). These two process conditions were observed by varying mole ratio of reactants, temperature and time period of reactions. Taurine product was qualitatively analyzed using 1 H-NMR and LC-MS. Physical-chemical analysis were done by observing its melting point and determining its water, chloride and sulfate contents. Its melting point, water content, and sulfate content were 290o C, 0.303%, and 3 ppm, respectively, while its chloride content was undetected. After purification, the yield of process was 25.57%.
THE FREE RADICAL SCAVENGING AND ANTI-HYPERGLYCEMIC ACTIVITIES OF VARIOUS GAMBIERS AVAILABLE IN INDONESIAN MARKET Widiyarti, Galuh; Sundowo, Andini; Hanafi, Muhammad
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

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Batasan Wewenang Peradilan Agama DiIndonesia Dalam Penyelesaian Sengketa Ekonomi Syariah Abdul Mughni; Muhammad Hanafi
Jurnal Hukum Ekonomi Syariah Vol. 2 No. 2 (2019): Jurnal Hukum Ekonomi Syariah AT-TAHKIM
Publisher : INSTITUT AGAMA ISLAM TAZKIA

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Abstract

At 2006, a government has issued constitution No.3/2006 aboutreligious court.Which is an amandement of constitutions No.7/1989. Whereinconstitution No.3/2006, an authority of religious court has been expanded. Andinserting a dispute retolution of Islamic economic as a part of absolut authority ofreligious court, as described in clause No.49 constitution No.3/2006. The research hasapplied normatively, which using positive law principles in sync. Then compare it toknow the practice of that law in a reality. And the data was collected from literature(case) study, and reinforced by an interview. The findings is, the constitution cannotimplemented effectively in religious court. Because of an unstability of theregulations of Islamic economic in religious court.
MEMBANGUN PROFESIONALISME GURU DALAM BINGKAI PENDIDIKAN KARAKTER hanafi, Muhammad
JURNAL ILMU BUDAYA Vol. 5 No. 1 Juni (2017): Jurnal Ilmu Budaya
Publisher : Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34050/jib.v5i1 Juni.2356

Abstract

Teachers are professional educators with the primary task of educating, teaching, guiding, directing, training, assessing, and evaluating learners in early childhood education, primary education, and secondary education. Professional is a work or activity undertaken by a person and becomes a source of income of his life that requires expertise, skill or skill that meets certain quality or norm standards and requires professional education. As a profession, thecompetence that must be possessed by a teacher, namely personality competence, pedagogic competence, professional competence, and social competence. Teachers have a strategic role in the field of education, even other adequate educational resources are often meaningless if not accompanied by adequate teacher quality. Likewise, the opposite happen, if the quality teacher is poorly supported by other supporting resources are adequate, can also cause less optimal performance. In other words, teachers are at theforefront of improving the quality of education services and outcomes. In many cases, the quality of the education system as a whole is related to the quality of teachers. To that end, improving the quality of education should be done through efforts to improve the quality of teachers character. The professionalism of a teacher must be framed in character education, because to educate the character of the learner can only be done by a teacher of character. So,educating characters must be character, because the most effective way of educating is to set an example.Key words: Professionalism, character education, teachers, pedagogic systems, learners
KESANTUNAN BERBAHASA DALAM PERSPEKTIF SOSIOLINGUISTIK Hanafi, Muhammad
JURNAL ILMU BUDAYA Vol. 2 No. 2 (2014): Jurnal Ilmu Budaya
Publisher : Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34050/jib.v2i0.2386

Abstract

Speech community concept can be seen/shown through three approaches; Firstly, on the basis oftheir common language forms, secondly by rules that regulate those common language forms,and thirdly from the perspective of the common cultural concepts. Speech community is possiblycreated if certain group of individuals, for the reason of common territory, professions, hobbieshave exactly the same language and possess the common judgement on any linguistic norms. Thesame case can also be projected to any speech communities in certain social, household,governmental, or religious domains to mention a few possibilitites.Keywords: linguis politnes, sociolinguistic, speech commuity.
Morelloflavone and Molecular Docking from Stembark of Chisocheton lasiocarpus and Its Cytotoxic Activity Against Breast Cancer Mcf-7 Cell Lines Nurlelasari, Nurlelasari; Harneti, Desi; Maharani, Rani; Darwati, Darwati; Mayanti, Tri; Farabi, Kindi; Hanafi, Muhammad; Supratman, Unang
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.6845

Abstract

Chisocheton is a plant of the Meliaceae family which has been known as a source of limonoids, triterpenoids, steroids, alkaloids and phenolics. This plant is the second largest in the Meliaceae, with 53 species widely distributed in tropical and subtropical regions including Indonesia. From this genus, compounds that have interesting activities have been found, including anti-inflammatory, antimalarial, cytotoxic, antitumor and anticancer. One of the species that has the potential to find new compounds is Chisocheton lasiocarpus because there are still few phytochemical studies. This study aims to inform the structural elucidation of one of the compounds from the stem bark of C. lasiocarpus, namely morelloflavone and its cytotoxic potential against breast cancer cells using the in silico method against ER-α receptors (PDB code: 3ERD), ER-β (PDB code: 1QKM). ) and HER-2 (GDP code: 3PP0).
Co-Authors . Hariyanti Abd Kahar Abdul Gani Abdul Mughni Ade Chandra Iwansyah Adipratiwi, Nadia Adnan, Andi Astina Afriza Media Ahmad Ramadani, Ahmad Ahmad Shohibul Wafa Akhmad Darmawan Alaiddin Koto, Alaiddin Ali Karmani Almasri Amalia Amalia Ameliah, Nurul Andi Karman, Andi Andi Sadapotto Andini Sundowo Andri Eko Putra Anggraini, Febi Ansumarwaty, Febiyanti Apriandini, Lisya Apriani, Ari Aprilia, Jesika Wanda Ardiansyah, Febry Aries Sukariawan Aris Doyan Arisanto, Ahmad Budi Ariyani, Titin Armanda Putra, Mochammad Ravi asma, Rasma Asmawati, Talitha Raissa Asrifan, Andi Aswadi Aswadi Aswadi Atiek Soemiati Atiek Sumiati Atmawinata, Maya R Aulia, Meilita Auliya, Isnie Azahra, Silena Azhari, M. Rozi Azim, Nur Santriani Utari Azizah, Arsyiah Salma B. Suwandl Bagaskara, Bagaskara Berna Elya Buhari Buhari Chatarina Umbul Wahyuni D Efrina Dadan Ridwanuloh Darwati Darwati Demastita, Ni Putu Fanty Desi Harneti Putri Huspa Desi Ramayanti Djamil, Ratna Dwi Astuti Ecca, Suleha Elidayani, Evi Ellyzena Wulandari Elviandri, Elviandri Endang Saepudin, Endang Erma Ermawan Ermawan ERWAHYUNI ENDANG PRABANDARI Erwin, Muh Evawani Elysa Lubis Fadlina Chany Saputri Farabi, Kindi Fatimah Azzahrah Fatimatushshalichah, Syayidati Fatmawati Fatmawati Fatmawaty Fatmawaty Fatonah, Astri Amaliah Fauzi Febrianto Fauzi, Kevin Azhar Fauziah Nur Ariza Fenny Bintarawati Firma Hafmi Fitri Rahayu Fitrianingtyas, Rizki Galuh Widiyarti Gatot Yudoko Ghapur, Muhammad Abdul Ghazali, Fikri Ghofardhan, Muhammad Ghozali, Arinaa Sabilah Gulo, Jelistin Gunawan Gunawan Hajijah, Humairah Hakiki, Dina Hany, Iga Permata Harsie, Sutag Hasan Hasan Hasan Hasan Hasanuddin Hasanuddin Hasibuan, Wildan Ansori Hasnaliah, Hasnaliah Hattu, Muhammad Ikhsan Hayu Dwimawanti, Ida Hendig Winarno Hendra Saputra Herry Cahyana Hidayat, Tegar Samudra Hizyam, Muhammad Huzaena, Mifta Idayanti Idayanti Idharul Haq Iis Irawatty Dewi Ika Mustika Ilhamuddin Ilhamuddin Ilhamuddin Ilhamuddin, Ilhamuddin Imam Fauji, Imam Intan Nurjaya Iranda Nadya Febianty Irmawadi, Zaibun Irwan Yon Hadi Islami, Tessa Jala, Jusrianto Jamaluddin Ahmad Jamilah Abbas Jemi, Renhart Jumatriadi Jumatriadi, Jumatriadi Jumiati Jumiati Jumiati Junedi, M Irfan Jusrianto K, Nuraini K, Rahmana Emran Kahar, Kurnia Putri Kamal, Kamal Kardono, Broto Sugeng Kasau, M Nurzin Kasman, Nuraini Kasmiati Khairunnisa, Shofiyah Khalik, Suhartini Khalik, Suhartini Kindy S, Mhd Al Kurnia Sofyan Kurniati Kurniati Kusmardi Kusmardi L, Syahrir Lababa Lababa Ladeska, Vera Lalu Aldi Lalu Muh. Fahri LALU RUDYAT TELLY SAVALAS Landong, Ahmad Lanta, Jumiati Lilik Kustiyah Linayanti Linda Maryani Lotulung, Puspa Dewi N. Lutpiyah Lutpiyah M Nurzin K M, Usman M. Idris M. Nurzin R. Kasau Mahise Okten Ramadhani Mahmud, Nurlaelah Mailawati Mamoru Kanzaki Manda, Ibrahim maria ulpah Marshalina, Afifah Marzuki Marzuki Masnawati Mau’ud, Mohamad Megawati, Meliantari, Dian Mhd.Furqan Mierza, Vriezka Minarti Minarti Moch. Chasani Mohammad, Amrija Mudzakir Nur Hidayatussani Muh. Zahirul Haq Usman Muh.Herianto Muhamad Rizal Martua Damanik Muhamad Zaril Gapari Muhammad Ihsan Muhammad Iksan, Muhammad Muhammad Nawir Muhammad Ridwan Muhammad Rizki Muhammad Zul Fahmi Muhammad, Firdaus Yusri Muhlis Mujib Ridwan Muliani Mulyana Mulyana Mulyani, Ridha Munir Anshory Muntari Muntari Murdani, Elisa Musdalifa Basri Nada Saniyah Nadirah, Nadirah Naf’an Tarihoran Nahdah, Khalilah Nurun Narrij Lotulung, Puspa Dewi Nasrullah Nasrullah Nasrullah Ngadiman Ngadiman Ngadiman Ngadiman Ni Luh Putu Pebri Artayani . Nia Aprilia Nina Artanti Nina Artanti Nindiyana, Baiq Nurmaulida NL, Puspa Dewi Nofrianto, Noke Norcahyono Norcahyono Nova Yohana Nur Asmah NUR FADILAH Nur Luthfi Hanif Al-Baihaqi Nur, Andi Herlina Nuraini K Nuraini Kasma Nurlaelah Mahmud Nurlelasari Nurlelasari Nurlia Arsyad Nurmala Nurmala Nurmala Nurmala Nurul Fadhilah Suardi Nurwahida Nurwahida, Nurwahida Nurwulan, Zulhilda Pandapotan Simbolon Pandiangan, Martina Pohan, Selamat Pramono, Sekardini Cahyaning Pramudito, Adrian Prastiwi, Mentari Dwi Puji Budi Setia Asih, Puji Budi Puspa D.N Lotulung Rahayu, Karmila Dwi Rahmat Mulyana Dali Rahmayani, Mentari Tri Indah Rahutomo, Suroso Raja Joko Musridho Ramadhan, Dany Ramdhani, Eka Putri Cahya Rani Maharani Rasyid, Rustam Efendy Razali, Mariany Renhart Jemi Rifa’i Rika Oktavia Damayanti Rina Hidayati Pratiwi Riska Handayani Rita K Sari Rita Kartika Sari Rohmat, Siti Saudah Rony, Zahara Tussoleha Rosa Dewi Pratiwi Rosmalena Rosmalena Rosmini Kasman Rusmaliati, Rusmaliati Rusny Edy Rustam Efendi Ruswati, Ruswati Ryandi Safitri, Noraya Safni Marwa Safrina, Suci Safutra, Ricky Indrawan Saifullah Saifullah Saifullah Sailal Arimi Sainab Sakiah Sakiah Salahuddin Salahuddin Saleh, Firman Salsabila Fitriyani Sam Hermansyah Samsul Hadi Sanati, Sanati Santy Rahmawati Saprizal Hadisaputra Sari, Riski Monno Sarifuddin Sarifuddin Sedijani , Prapti Senny Widyaningsih Septiasa, Alfia Muawanah Serli Sanggang Sarasta Shibata Kozo Silvia Fadila Siti Annisa Wahdiniawati, Siti Annisa Siti Isnijah Siti Sunariyati Siti Zulfa Sofa Fajriah Soleh Kosela Sri Karyati Sri Mursiti Suardi Zain, Suardi Subaidi, Mohammad Subhan Nooriansyah Sukranudin Suleha Suleha Ecca Suleha, Suleha Sulistiyowati, Arrin Suminar A Achmadi Suminar S Achmadi Suminar S Achmadi Sutag Harsie Syafrudin, Din Syahrir L Syahrul Aiman Syamsu T Syamsul Arifin Syamsul Bahri Syamsur Rizal Syufina, Arina Shofia T, Syamsu Tati Herlina Teni Ernawati Thowimma, One Tri Mayanti Tri Yuniningsih Ulpah, Kamaria Unang Supratman Undri Rastuti Uniawati Usman M Usniati, Ita Vinella Winata Vivitri Dewi Prasasty Wahyu Khalik Efendi wahyuni wahyuni Waluyo, Danang Wasrin Syafii Yanotama T Laksana Yanti Fitria Yasir ", Yasir Yayuk Andayani Yesi Desmiaty, Yesi Yoselina, Prima Yulianingrum, Aullia Vivi Yunni, Yunni Yusmah Yusmah Yusmah Yusmah, Yusmah Yusuf Amrozi Zozy Aneloi Noli Zulfahmi Zulfahmi