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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Al-'Adalah Irfani Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal ULTIMATICS Jurnal Pengabdian Magister Pendidikan IPA Jurnal Ilmu Hukum The Juris Abditani : Jurnal Pengabdian Masyarakat Jurnal Tabarru': Islamic Banking and Finance Iqtishoduna: Jurnal Ekonomi Islam JKKP (Jurnal Kesejahteraan Keluarga dan Pendidikan) Jurnal Keperawatan dan Fisioterapi (JKF) Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Santhet: (Jurnal Sejarah, Pendidikan Dan Humaniora) Ghancaran: Jurnal Pendidikan Bahasa dan Sastra Indonesia Business, Economics and Entrepreneurship Journal Sport Science Indonesia (JASSI) Jurnal E-Komtek Jurnal Akuntansi Universitas Muhammadiyah Kupang Open Access Indonesia Journal of Social Sciences Jurnal Penelitian Psikologi Health Care : Jurnal Kesehatan Indonesian Psychological Research SELODANG MAYANG Jurnal Agro Indragiri Al-Muaddib : Jurnal Kajian Ilmu Kependidikan Journal of Computer Networks, Architecture and High Performance Computing International Journal of Social Science and Religion (IJSSR) Wedana: Jurnal Kajian Pemerintahan, Politik, dan Birokrasi Jurnal Teknik Informatika (JUTIF) International Journal Of Science, Technology & Management (IJSTM) NUCLEUS: Jurnal Sains dan Teknologi JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) SINTA Journal (Science, Technology, and Agricultural) Jurnal Alwatzikhoebillah : Kajian Islam, Pendidikan, Ekonomi, Humaniora JAMMI Majalah Ilmiah UPI YPTK Iqtishaduna : Jurnal Ilmiah Mahasiswa Hukum Ekonomi Syariah Jurnal Buana Farma Jurnal Akuntansi dan Keuangan Open Access Indonesia Journal of Social Sciences Nursing Care and Health Technology Journal (NCHAT) Jurnal Arastirma Rengganis Jurnal Pengabdian Masyarakat INDONESIAN JOURNAL OF MEDICAL ANTHROPOLOGY Salam (Islamic Economics Journal) STLISTIKA: Jurnal Bahasa, Sastra, dan Pengajarannya Business Perspective Journal PROGRESIF Jurnal Suara Pengabdian 45 DHeJA Jurnal Industri dan Teknologi Samawa (JITSA) International Journal of Health and Pharmaceutical (IJHP) Maternity and Neonatal : Jurnal Kebidanan Jurnal Vokasi Kesehatan Jurnal Pendidikan Transformatif Jurnal Media Pengabdian Kepada Masyarakat (JM-PKM) MEDIOVA: Journal of Islamic Media Studies Jurnal Tazakkur PENDALAS: Jurnal Penelitian Tindakan Kelas dan Pengabdian Masyarakat Al-Istinbath: Jurnal Hukum Islam Kreasi: Jurnal Inovasi dan Pengabdian Kepada Masyaraka Accountia Journal (Accounting, Trusted, Inspiring and Authentic Journal) Journal Agroecotech Indonesia (JAI) PIJAR: Jurnal Pendidikan dan Pengajaran Journal of Child, Family, and Consumer Studies Jurnal Kedokteran Ibnu Nafis Jurnal Teologi Biblika Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Indonesian Journal Economic Review (IJER) Paradoks : Jurnal Ilmu Ekonomi JOURNAL EDUCATIONAL MANAGEMENT REVIEWS AND RESEARCH International Journal of Health Sciences IHSAN : Jurnal Pendidikan Islam Lentera Lansau: Jurnal Ilmu Kefarmasian Jurnal Manajemen, Ekonomi, Hukum, Kewirausahaan, Kesehatan, Pendidikan dan Informatika (MANEKIN) MANKEU (JURNAL MANAJEMEN KEUANGAN) TEKNOBIS : Jurnal Teknologi, Bisnis dan Pendidikan Wahana Islamika: Jurnal Studi Keislaman International Journal of Sustainable Competitiveness on Tourism Prosiding Seminar Nasional dan Call For Paper Kebidanan Universitas Ngudi Waluyo Al-Zayn: Jurnal Ilmu Sosial & Hukum QOSIM: Jurnal Pendidikan, Sosial & Humaniora Jurnal Informatika Polinema (JIP) Vitamedica: Jurnal Rumpun Kesehatan Umum Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Media Akademik (JMA) Jurnal Lingkungan Almuslim Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat JIBEMA: Jurnal Ilmu Bisnis, Ekonomi, Manajemen, dan Akuntansi Jurnal Pharmacia Mandala Waluya Jurnal ABDIMAS MUTIARA Jurnal Pembelajaran Bahasa dan Sastra JOURNAL OF COMMUNITY SERVICE AND APPLICATION SCIENCE (JCSAS) Jurnal Hukum Islam Artinara ARUS JURNAL SAINS DAN TEKNOLOGI JURNAL PENA PAUD IPTEKIN : Jurnal Kebijakan Pembangunan dan Inovasi ENDLESS : International Journal of Future Studies Pharmacon: Jurnal Farmasi Indonesia Jurnal Ilmiah Kesehatan Mandira Cendikia Sevaka: Hasil Kegiatan Layanan Masyarakat Jurnal Praba: Jurnal Rumpun Kesehatan Umum Jurnal Pemikiran dan Pengembangan Pembelajaran BEKTI : Jurnal Pengabdian Kepada Masarakat INOVASI: Jurnal Ekonomi, Keuangan, dan Manajemen Jurnal Riset Keperawatan dan Kesehatan Joong-Ki Jurnal Penelitian Keperawatan JSEF: Journal of Sharia Economics and Finance J+Plus: Jurnal Mahasiswa Pendidikan Luar Sekolah Journal of Ophthalmology KAMBOTI : Jurnal Sosial dan Humaniora Atestasi : Jurnal Ilmiah Akuntansi Galen: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi Pangan As-Sulthan Journal of Education Sinergi : Jurnal Ilmiah Multidisiplin Acman: Accounting and Management Journal Journal Basic Education Skills JPKM Cahaya Negeriku Scripta Economica: Journal of Economics, Management, and Accounting Wahana Islamika; Jurnal Studi Keislaman Jurnal Pelita Pendidikan Journal of Pharmaceutical and Natural Resources Rowter Journal Jurnal Agroindustri Halal
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ANALISIS STRATEGI PENINGKATAN DAYA SAING DAN SKALABILITAS USAHA PRODUK CABAI KERING KWT KP Rama Novera; Suryani; Susanti Sundari; Jevri Buari
Jurnal Media Akademik (JMA) Vol. 3 No. 12 (2025): JURNAL MEDIA AKADEMIK Edisi Desember
Publisher : PT. Media Akademik Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62281/78ctwy56

Abstract

Usaha produk cabai kering olahan yang dikelola oleh Kelompok Wanita Tani (KWT) KP menghadapi tantangan signifikan berupa ketiadaan strategi pengembangan bisnis yang teruji, terukur, dan komprehensif. Kondisi ini menimbulkan ambiguitas terkait optimalitas penetapan harga jual produk serta keberlanjutan margin keuntungan yang sehat. Penelitian ini bertujuan untuk menganalisis strategi pengembangan usaha bubuk cabai kering KWT KP. Inisiatif pengolahan cabai menjadi bubuk kering bertujuan meningkatkan nilai tambah produk, memperpanjang masa simpan, dan menstabilkan fluktuasi harga komoditas bagi UMKM. Analisis strategi dilakukan menggunakan dua pendekatan utama, yaitu Harga Pokok Penjualan (HPP) dan Analisis SWOT. Studi kasus yang dilakukan di Kelurahan Kaliawi, Kota Bandar Lampung, mengidentifikasi temuan finansial penting dimana total biaya produksi tercatat sebesar Rp 595.762 untuk 126 kemasan (30 gram), menetapkan HPP produk pada Rp 4.728 per kemasan. Hasil Analisis SWOT menunjukkan skor agregat IFAS 2,70 dan EFAS 3,10. Nilai ini menempatkan unit usaha KWT KP pada posisi Kuadran I (Strategi Agresif). Berdasarkan temuan tersebut, rekomendasi strategis yang paling tepat adalah Strategi S-O (Strength-Opportunity). Strategi ini menekankan pada penguatan dukungan dan fasilitasi dari pemerintah, optimalisasi pemanfaatan platform digital untuk pemasaran, peningkatan kualitas produk secara berkelanjutan, dan ekspansi jaringan kemitraan strategis untuk mencapai daya saing dan skalabilitas yang lebih tinggi.
Gambaran Deteksi Dini Kesehatan Sebagai Upaya Pencegahan Risiko Penyakit Berbasis Platform Kesehatan Digital Ningsih, Kursiah Warti; Kursiah Warti Ningsih; Rahmi Pramulia Fitri; Dwi Sapta Aryantiningsih; Suryani; Winda Parlin; Roza Asnel; Tengku Hartian; Rahmat Saputra; Mailiza Cahyani; Yoga Saputra
HEALTH CARE: JURNAL KESEHATAN Vol 14 No 2 (2025): Health Care : Jurnal Kesehatan
Publisher : IKES Payung Negeri Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36763/afyt9991

Abstract

Early health detection is an important strategy in preventing disease risks in the community. Through routine health checks, disease risk factors can be identified early so that preventive interventions can be carried out appropriately. However, the utilization of early health detection services at the community level, especially in rural areas, is still not optimal. This study aims to describe early health detection as an effort to prevent disease risks in the community of Hamlet 1, Baru Village, Kampar Regency. This study is a descriptive study with a survey approach. The subjects were 312 heads of families domiciled in Hamlet 1, Baru Village, Kampar Regency. Data were collected through family data collection using a health platform that includes routine health check behavior for non-communicable diseases, early detection of cervical cancer, smoking behavior in the home, and infant immunization coverage by age group. Most families have not undergone routine health checks at least every 6 months, specifically abdominal circumference examinations (80.45%), early detection of cervical cancer (92.63%), blood sugar (59.62%), and cholesterol (58.97%). In addition, 43.27% of family members smoke in the home. Infant immunization coverage shows disparities across almost all age groups, particularly for follow-up immunizations such as PCV, Rotavirus, Influenza, MR, JE, Varicella, and Hepatitis A. The persistently low early detection of NCDs and suboptimal infant immunization coverage highlight the need to strengthen health education, increase access to services, and strengthen the role of families and health workers at the community level.
Adagrad Optimizer with Compact Parameter Design for Endoscopy Image Classification Pariyasto, Sofyan; Suryani; Arfeni Warongan, Vicky; Vika Sari, Arini; Wijaya Widiyanto, Wahyu
ULTIMATICS Vol 17 No 2 (2025): Ultimatics : Jurnal Teknik Informatika
Publisher : Faculty of Engineering and Informatics, Universitas Multimedia Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31937/ti.v17i2.4225

Abstract

Research on CNN Model and Adagrad Optimizer is expected to help identify diseases in the medical world. Especially in the field of image classification in Gastrointestinal endoscopic procedures . The research is specifically for the process of classifying medical images of Diverticulosis, Neoplasm, Peritonitis and Ureters . Previously, there have been quite a lot of studies on CNN and its various optimizers. However, those who have studied the Adagrad optimizer are not too many, especially those discussing the use of minimum parameters. The use of minimum parameters is expected to be one of the contributions of researchers in the fields of computing and medicine. The research was conducted to determine the use of the best parameters and obtain the highest level of accuracy. The research was conducted using minimum epochs starting from epoch 1, epoch 5, and epoch 10. Then the combination process between epoch and the number of convolution layers between 1 and 5 was carried out, resulting in 15 combinations. The test was carried out using 4000 images with 1000 images in each class. From the results of the test, the highest accuracy value was obtained, namely 82.875%. Then the highest average accuracy value was 81.625%.
Comparing The Hematological Effects of BPaL/BPaLM Regimens to Those of Standard Regimens in the Treatment of Drug-Resistant Tuberculosis: A Narrative Review Apgar, Satrias; Suryani
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.12071

Abstract

Drug-resistant tuberculosis (DR-TB) is a problem for health around the world, and standard treatments don't work very well. The new treatment plan that includes bedaquiline, pretomanid, and linezolid (BPaL) and its variant with moxifloxacin (BPaLM) has a shorter treatment time and higher success rates, but there is still a chance of hematological side effects. Based on recent studies, this article looks at the hematological effects of BPaL/BPaLM regimens compared to standard regimens in DR-TB therapy in great detail. The study found that BPaL/BPaLM has a different effect on blood cells than standard regimens. It increases the risk of anemia (31.9% vs. 25.4%) and thrombocytopenia (47.8% vs. 23.1%), but it lowers the risk of leukopenia (2.2% vs. 14.6%). The main way that BPaL/BPaLM causes hematological toxicity by linezolid is affecting mitochondrial dysfunction, activating inflammatory pathways, and throwing off iron homeostasis. BPaL/BPaLM is a better choice because it has a shorter treatment time (24–26 weeks vs. 78–96 weeks) and fewer pills (923–924 vs. 5,460–7,296). However, it does require close monitoring of blood levels. A thorough understanding of the hematological effects of the BPaL/BPaLM regimen makes it easier to handle side effects and makes DR-TB treatment more likely to work.
Pelatihan Phsycological First Aid (PFA) untuk Meningkatkan Skill Konseling Mahasiswa Bimbingan Konseling Islam Sari, Melly Novita; Haq, Baiq Aida Islahul; Amelia, Yessi Arba; Septarinjani, Hernindya; Suryani; Fahrurrozi; Sukirno, Agus; Furqonuddin, Asep; Itang; Humaemah, Ratu; Marfu’ah, Siti; Jamaluddin; Azim, Muhamad Fadli; Setiadi, Rezky Mehta
PROGRESIF: Jurnal Pengabdian Komunitas Pendidikan Vol. 6 No. 1 (2026)
Publisher : Sekolah Tinggi Ilmu Ekonomi Indonesia Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36406/progresif.v6i1.45

Abstract

The campus environment often exposes students to academic, social, andpersonal pressures that can af ect their mental health. As a result, peer counseling becomes anessential approach to support students facing psychological dif iculties. One key skill in peer counselingis Psychological First Aid (PFA), which provides initial emotional support to individuals experiencing psychological distress. This PFA training was conducted for third-semester BKI students to enhance their ability to provide psychological support based on Islamic principles. The method used in this activity combines a literature-based socialization approach with practical exercises through seminars, discussions, and counseling simulations. The results show that while participants understood PFA theory well, some still faced dificulties in applying the techniques, especially in formulating the right questions as counselors. In conclusion, furthertraining is needed to strengthen the application of these counseling skills.
Inovasi Pakan Fermentasi Berbasis Limbah Pertanian untuk Meningkatkan Produktivitas Sapi Potong Suryani; Hidayat, Taufiq
SINTA Journal (Science, Technology, and Agricultural) Vol. 6 No. 2 (2025)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/sinta.6.2.343-354

Abstract

Penelitian bertujuan untuk mengidentifikasi jenis limbah pertanian yang optimal untuk difermentasi sebagai pakan sapi potong. Mengembangkan formulasi pakan fermentasi dengan kombinasi mikroba probiotik yang meningkatkan daya cerna dan ketersediaan nutrisi. Percobaan dilakukan menggunakan Rancangan Acak Kelompok (RAK) dengan 4 perlakuan dan 4 ulangan. Perlakuan tersebut antara lain: Perlakuan A adalah jerami padi amoniasi fermentasi 40% + konsentrat 60%; Perlakuan B jerami padi amoniasi fermentasi 40% + Konsentrat 50 % + rumput lapangan 10 %; Perlakuan C adalah jerami padi amoniasi fermentasi 40% + Konsentrat 40% + rumput lapangan 20%; Perlakuan D adalah jerami padi amoniasi fermentasi 40% + Konsentrat 30 % + rumput lapangan 30 %. Parameter yang diukur adalah konsumsi bahan kering, konsumsi bahan organik dan efesiensi ransum dan pertambahan bobot badan. Data dianalisa dengan metode analisis sidik ragam dan perbedaan pada masing-masing rataan diuji lanjut dengan Duncan Multiple Range Test (DMRT). Hasil analisis keragaman menunjukkan inovasi pakan fermentasi berbasis limbah pertanian untuk meningkatkan produktivitas sapi potong berpengaruh tidak nyata (P>0,05) berkisar 4,65 kg/ekor/hari sampai 4,74 kg/ekor/hari, bahan organik berkisar 3,85 kg/ekor/hari sampai 4,16 kg/ekor/hari, pertambahan bobot badan harian berkisar 0,76 kg/ekor/hari sampai 0,82 kg/ekor/hari dan berpengaruh sangat nyata (P<0,01) terhadap efisiensi ransum berkisar 10,86% sampai 17,86%. Berdasarkan hasil penelitian perlakuan terbaik adalah perlakuan C (jerami padi amoniasi fermentasi 40% + konsentrat 40% + rumput lapangan 20 %) dan D (jerami padi amoniasi fermentasi 40% + konsentrat 30% + rumput lapangan 30%) mampu meningkatkan konsumsi bahan kering, bahan organik dan efesiensi ransum dan pertambahan bobot badan harian.
Suplementasi Ransum Sapi Aceh dengan Leguminosa dan Functional Feed untuk Meningkatkan Produktivitas Hidayat, Taufiq; Suryani
SINTA Journal (Science, Technology, and Agricultural) Vol. 6 No. 2 (2025)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/sinta.6.2.327-342

Abstract

Penelitian bertujuan untuk mengevaluasi penambahan leguminosa Indigofera zollingeriana dan fuctional feed (kulit kopi) dalam ransum sapi Aceh untuk meningkatkan konsumsi bahan kering, konsumsi bahan organik, kecernaan bahan kering, kecernaan bahan organik, kecernaan protein, pertambahan bobot badan harian dan efesiensi ransum pada sapi Aceh.. Percobaan dilakukan menggunakan Rancangan Acak Kelompok (RAK) dengan 4 perlakuan dan 4 ulangan. Perlakuan tersebut antara lain: Perlakuan A adalah Rumput Pakchong 40% + Konsentrat 60%; Perlakuan B Rumput Pakchong 40% + Konsentrat 40 % + Indigofera (I.zollingeriana) 20 %; Perlakuan C adalah Rumput Pakchong 40% + Konsentrat 35% + Indigofera (I.zollingeriana) 25%; Perlakuan D adalah Pakchong 40% + Konsentrat 30 % + Indigofera (I.zollingeriana) 30 % + Kulit Kopi 1 %. Parameter yang diukur adalah konsumsi bahan kering, konsumsi bahan organik, kecernaan bahan kering, kecernaan bahan organik, kecernaan protein, pertambahan bobot badan harian dan efesiensi ransum. Data dianalisa dengan metode analisis sidik ragam dan perbedaan pada masing-masing rataan diuji lanjut dengan Duncan Multiple Range Test (DMRT). Hasil analisis keragaman menunjukkan suplementasi ransum sapi Aceh dengan leguminosa dan functional feed untuk meningkatkan Produktivitas berpengaruh tidak nyata (P>0,05) terhadap konsumsi bahan kering berkisar 4,55 kg/ekor/hari – 4,78 kg/ekor/hari, bahan organik berkisar 3,85 kg/ekor/hari – 4,18 kg/ekor/hari, kecernaan bahan kering berkisar 61,84% - 65,20%, kecernaan bahan organik berkisar 62,28% - 67,04%, kecernaan protein 64,36% - 68,27%, pertambahan bobot badan harian 0,64 kg/ekor/hari – 0,68 kg/ekor/hari dan berpengaruh sangat nyata (P<0,01) terhadap efesiensi ransum berkisar 10,86% - 14,66% . Berdasarkan hasil penelitian perlakuan terbaik adalah perlakuan C dan D dengan penggunaan Indigofera (I.zollingeriana) 20 % dan 25 % mampu meningkatkan konsumsi bahan kering, bahan organik, kecernaan bahan kering, bahan organik, protein, pertambahan bobot badan harian dan efesiensi ransum.
Optimalisasi Kesehatan Dan Kebugaran Melalui Integrasi Olahraga Dan Edukasi Kesehatan Di Pondok Pesantren Daarul Faqih Sartika, Ika; La Ode Isa; Basman; Reski Ana Abadi; Suryani; Bilal Ahmad Anugrah; Akbar Firansa
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 2: Februari 2026
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v5i2.13165

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kesadaran dan pemahaman santri terhadap pentingnya menjaga kesehatan dan kebugaran melalui integrasi olahraga dan edukasi kesehatan di Pondok Pesantren Daarul Faqih. Program ini dilatarbelakangi oleh empat permasalahan utama, yaitu keterbatasan aktivitas fisik pada santri, kurangnya edukasi kesehatan, fasilitas olahraga yang belum memadai, serta keterbatasan akses informasi kesehatan. Metode yang digunakan dalam kegiatan ini adalah metode partisipatif dan pendekatan edukatif, dengan pengukuran efektivitas dilakukan melalui pre-test dan post-test. Hasil kegiatan menunjukkan adanya peningkatan signifikan pada pemahaman santri setelah mengikuti program. Rata-rata nilai pre-test berada pada kisaran 31,25% hingga 43,25%, sedangkan nilai post-test meningkat menjadi 71,5% hingga 81%. Santri menjadi lebih aktif dalam kegiatan fisik, memahami pentingnya pola hidup sehat, serta mampu memanfaatkan fasilitas olahraga dan sumber informasi kesehatan secara lebih baik.
Analysis Of Factors Affecting The Performance Paramedic At Hospital Royal Prima Medan Suryani; Ermi Girsang; Sri Lestari Ramadhani; Sri Wahyuni Nasution
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.604 KB) | DOI: 10.51601/ijhp.v2i1.22

Abstract

Paramedics as human resources run health services in hospitals. Paramedic performance is closely related to the quality of hospital services. The purpose of this study is to analyze the factors that affect the performance of paramedics at RSU Royal Prima Medan. This type of research is quantitative research with a cross-sectional design. The location of this research was conducted at RSU Royal Prima Medan. The research sample is all paramedics at RSU Royal Prima Medan as many as 112 people. The survey data were analyzed using the chi-square test and logistic regression. The results showed that there was an influence of motivation on the performance of paramedics (p= 0.000 <0.05), there was an effect of ability on the performance of paramedics (p = 0.000 <0.05), there was an effect of knowledge on the performance of paramedics (p = 0.000 < 0.05). ), there is an effect of the work environment on the performance of paramedics (p= 0.000 < 0.05), there is the effect of incentives on the performance of paramedics (p = 0.000 < 0.05), there is an effect of promotion on the performance of paramedics at the Royal Prima Hospital Medan in 2021 (p= 0.000 < 0.05). The variable that most dominantly influences the performance of paramedics at RSU Royal Prima Medan in 2021 is the motivation variable with a p-value of 0.016, OR = 4.182 (95% CI = 1.300-13,448). So the suggestions in this study are expected that hospitals can minimize these factors by redesigning work to reduce role ambiguity and paramedic boredom at work. there is the effect of incentives on the performance of paramedics (p = 0.000 < 0.05), there is an effect of promotion on the performance of paramedics at the Royal Prima Hospital Medan in 2021 ( p = 0.000 < 0.05.
MOLECULAR DOCKING ANALYSIS OF SELECTED CURCUMA XANTHORRHIZA CONSTITUENTS AS POTENTIAL ANTICANCER DRUG Endang Zainal Hasan, Akhmad; Artika, I Made; Suryani; Luthfi Ramadhani, Dhani
BIOTROPIA Vol. 30 No. 1 (2023): BIOTROPIA Vol. 30 No. 1 April 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.1.1386

Abstract

Stress conditions will trigger the histone hyperacetylation process due to histone acetyltransferase p300/CBP (HAT PCAF) constantly transfers acetyl groups from acetyl-CoA to conserved lysine residues on histone proteins to form ε-N-acetyllysine. This can be a cause of cancer. The purpose of this study was to investigate the potential mechanisms and inhibition of PCAF HAT by chemical components of C. xanthorrhiza namely, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and xanthorrizhol using in silico, the molecular docking method.  Results showed that the components of C. xanthorrhiza as ligands have the capability to inhibit the binding of acetyl-CoA to histone. These results can be used to predict the inhibitory mechanisms exhibited by C. xanthorrhiza components, as competitive and noncompetitive substances. We hypothesize that C. xanthorrhiza components resemble a substrate, leading to prevention of the natural substrate (histone) to bind to the enzyme, and hence block the product formation. The smallest free Gibs energy was exhibited by curcumin on chain B and by bismethoxycurcumin on chain A, with values of -8.8 and -8.4 Kcal/mol, respectively.
Co-Authors Abda Abda Abdul Aziz, Faqih Abdul Rasyid Ariadi Abu Yazid, Abu Abubakar, Salim Achmad Dandi Firmansyah Ade Lokma Adelina Fitri Tanjung Adlia Suprianinsi Afrida Sriyani Harahap Agung Hartoyo Agung Setiabudi Agus Sofyan Agus Sulastio Agusten Agusten, Agusten Ahyuna Aidah Raihana Akbar Firansa Akbar Yusuf Akhirul Kahfi Syam Akhmad Endang Zainal Hasan Akhyar, Miftahul Al Munawar, M. Itoillah Alesia Lorenzza Sinaga Alfian Reymon Makaruku Ali Murtopo Amalita Puji Anggitasari Amelia, Yessi Arba Aminah Toaha Andari, Soetji Andrew Ridow Johanis M Andri, Gus Anggi Fatmadiwi Anggun Wida Prawira Anik Wahyunita Anisy Nurul Janah Anitya Novi Widyaastuti Antarissubhi Apgar, Satrias Aprianti, Rina Apriantri, Rina Apriliani Aprinaldi, Mohd. Arfeni Warongan, Vicky Arham Arifin Arifin, Suci Ramadhani Arika Maulidia Arini Vika Sari Ariska Arniati Rasyid Arwansyah Aryantiningsih, Dwi Sapta Asmariani Asnel, Roza Asnel, Roza Aspadiah, Vica Astrid Indalifiany Atania Rosbina Br Bangun Aulia, Shindi Avisena Nusantari, Farida Ayu Azim, Muhamad Fadli Azim, Muhammad Fadli Azmi, Zul Basman Bertafioni Tyas Putri Bilal Ahmad Anugrah Budhi Mulyadi Butsainah Jauharah Taqiyyah Candra, Hadi Carolina, Thabita Dedes Wirdana Deny Rahmat Dessy Elva Listianti Dessy Naomy Andhiny Hutagalung Desti Puswati Desy Mariani Devita Madiuw Dewi, Desy Eka Citra DHIYAN NANY WIGATI Dian Rahmaniar, Dian Diana Yunita Dewi Didik Himmawan Dina Septika Dewi Khofifa Dini Maulinda Dini Syavani Dirhan Djoko Susanto Dodi, Syafria Dodoh Khodijah Dr.H.Mukhamad Anieg,Lc,Ma Dwi Nopriyanti Dwi Putri Sulistya Ningsih Dwi Sapta Aryantisningsih Dyandra, Zarach Ade Edward, Yusuf Ronny Edwin Fathur Deriyanto Eka Ristin Tarigan Elih Minarti Elsa Widia Entaresmen, Raden Ajeng Erlina Erlina Ermi Girsang Erni Marlina, Erni Eva Latifatul Uzza Fadli Alwi, Ahmad Fadli Alwi Fahrauk Faramayuda, Fahrauk Fahrurrozi Faizal Faizal Hermanto Farhan Muhammad Naji Farida A Nusantari Fasya, Hasna'Sabila Fausia. 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Samadan Ginting, Rian Fedriko Gressy Novita Gunawan Santoso Gusmulyani Hadi Sumitro, Wiwid Haeru Tullisa Minnah hana lestari Haq, Baiq Aida Islahul Harahap, Aynil Paydah Harahap, Azija Sari Hardiansyah Hardianti Haris, Vera Suzana Dewi Hartanto HARTATI Hartono, Rudi Hasanah, Tita Hastiah Hasyrif SY Hendrawati Hendryadi Hendryadi Hennie Tuhuteru Hentihu, Emma Khumairah Hera Dwi Triani Herman Heriadi Hermanto, Koko Herwawan, Joan Herly Hestiana Putri Hibrati Hidayatul Fitri Hikmawaty, Lisna Hudaningsih, Nurul I MADE ARTIKA Ibnudin Ida Ayu Gede Wahyu Wedanthi Ika Sartika Iksan Adiasa ILHAM Imam Wahyudi Indrawan, Imam Wahyudi Indahyani, Rezki Indra Gunawan Indrawan, Irjus Irasari Kusuma , Yuna irham Irjus Indrawan Irni Cahyani Isfaizah Ismail, Hartiwiyanti Ismayanti, Silvia Isramuddin Itang Izakiah Jahuddin, Rahmat Jamaluddin Jayanti Dwi Puspita Jevri Buari Jihadul Ullia Joko Siswanto Julian Muhammad Hasan Julietta Hutabarat Kamas Kumala Dewi, Intan Kumalasari , Nurya Kuntjorowati, Elly La Ode Isa La Sumange Lestari, Rinda Linda Listiyaningrum Loly Subhiaty Idrus Lubis Irsan Lubis, Silvi Puspa Widya Lutfiyah Luthfi Ismayeni Luthfi Ramadhani, Dhani M. 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Lucky Rafnelly Rafky Rahim, Farida Rahman, Said muhammad aulia rahman Rahmania RAHMAT MULIADI RAHMAT MULIADI, RAHMAT Rahmat Saputra Rahmawati Rahmi Pramulia FS Rama Novera Ramadani, Rizkia Fitri Rangkuti, Juni Andriani Ranti Melasari RATU HUMAEMAH, RATU Ratumanan, Tanwey Gerson Renny Maisyarah Resi Ria Lestari Reski Ana Abadi Riadlussalehah Riani Safitri Ricard Janottama Ricardo Freedom Nanuru Riche Fermayani Rina Rina Aprianti Rini Puspitasari, Rini Riniasih , Wahyu Riniasih, Wahyu Risa Nurmala Dewi Risha, Ar Riska Indrayati Riska Rita Rismahara Lubis Risti Linta Chumaira Riyadi Subur, Riyadi Rizki Sahara Rochmah, Nur Syifa Rosandra Firdi Silvian Rosliana rozaqiy, robby Rudi Sanjaya Rumagia, Faizal Rusniati, Rizky Safira Kusnaini Safriana Safura, Siti Sahara, Hairin Salma Samputri Santoso Ujang Effendi Saraswati, Henny Sari, Melly Novita Sarmita Sartono Selvia Rindang Ompusunggu Septarinjani, Hernindya Setiadi, Rezky Mehta Setyaningsih Shafira Indriani Sia'tang , Weni Silaban, Sry Wulan Silvi Nur Hakiki Siregar, Ina Namora Putri Siti Darmi Amir Siti Fatimah Siti Maesaroh Siti Marfuah, Siti Siti Nurul Istiqomah Siti Samsiah Sitti Zubaidah Sitti Zubaidah sitti zubaidah - Siwi Nugraheni Sofyan Pariyasto Sotya Partiwi Ediwidjojo Sri Harijati, Sri Sri Indrayati Sri Lestari Ramadhani sri sudiarti Sri Temu Sri Untari Suci Destry Ananda Suhartina Sukirno, Agus Sumarlin Mus SUNARTO Sundarsih, Dedeh Sunusi Dauda Suratini Suri Salmiyati, Suri Suriansah Suryani Suryani Susanti Sundari Susanti, Azizah Amelia Eka Susbandiah Susi Susanti Susilo Wulan Sustianingsih, Ira Miyarni Sutiyono Syahra Eliza Yanti Syaiful Hadi Syam, Asrul Syamsuwirman Syarifudin , Efi Syartiwidya Tasijawa, Fandro Armando Taufiq Hidayat Teguh Kusumo Nugroho Temu, Sri Tengku Hartian Tessa Tetty Tiurma Uli Sipahutar Teuku Salfiyadi Tiara Suci Lestari Tiara Surena Br Sitepu Tika Dwi Ningrum Titin Ringgiani Kumala Dewi Toto Rusmanto Triyono, Gandung Umbu Andira Ummi Zakiyah, Ummi Utami, Yulia Uun Sunarsih Valensya Yeslin Tomasoa Vanny Leutualy Veronika vicky arfeni warongan Vitriani Wa Ode Nova Noviyanti Wa Ode Sitti Zubaydah Wahidah Nur Khasana Wahidah Nur Khasanah Wahyu Dewi Hapsari WAHYUNI Wahyunita, Vina Dwi Widhiyanto, Michael Widiono ahmad fajri Widiyanto, Wahyu Wijaya Winda Parlin Windayani Windi Permana Wullandary, Sekar Ayu Yadri Irwansyah YASYIFA DIAN URFINA Yayuk Kurnia Risna Yodha, Agung Wibawa Mahatva Yoga Saputra Yonce Melianus Killa Yugi Febia Yuli Asmanto Yulianto Yulizar Yusnina Maisyaroh Yusriwarti Yusrizal Zahera Mega Utama, Zahera Mega Zaidala, Uzia Zain, Zaki Faddad Syarif Zubaida Rohmawati Zuliana Zurifah