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All Journal International Journal of Electrical and Computer Engineering IAES International Journal of Artificial Intelligence (IJ-AI) IJCCS (Indonesian Journal of Computing and Cybernetics Systems) JURNAL PENELITIAN ILMU PENDIDIKAN Sainteks Reaktor TEKNIK Jurnal Forum Nuklir Ganendra: Majalah IPTEK Nuklir Jurnal Sains Materi Indonesia STUDIA ISLAMIKA IPTEK The Journal of Engineering Jurnal Sains dan Teknologi Bulletin of Electrical Engineering and Informatics AdMathEdu : Jurnal Ilmiah Pendidikan Matematika, Ilmu Matematika dan Matematika Terapan Jurnal Kesehatan Masyarakat JEJAK Jurnal Natapraja : Kajian Ilmu Administrasi Negara Analisis: Jurnal Studi Keislaman Ekonomikawan : Jurnal Ilmu Ekonomi dan Studi Pembangunan OPSI Jurnal Pendidikan dan Pemberdayaan Masyarakat Seminar Nasional Teknik Kimia Kejuangan Jurnal Teknologi Informasi dan Ilmu Komputer ROTOR: JURNAL ILMIAH TEKNIK MESIN Majalah Kulit, Karet, dan Plastik Jurnal Ilmiah Teknik Industri JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Ilmiah Manajemen dan Bisnis (JIMB) Indonesian Journal of Science and Technology Walisongo: Jurnal Penelitian Sosial Keagamaan Jurnal Pendidikan Agama Islam Jurnal Humanitas: Katalisator Perubahan dan Inovator Pendidikan AdMathEduSt: Jurnal Ilmiah Mahasiswa Pendidikan Matematika Jurnal Penelitian Pertanian Terapan JURNAL KEPEMIMPINAN DAN PENGURUSAN SEKOLAH Lantanida Journal Jurnal Pengembangan Teknologi Informasi dan Ilmu Komputer ATTARBIYAH: Journal of Islamic Culture and Education QALAMUNA: Jurnal Pendidikan, Sosial, dan Agama EDUCATIO : Journal of Education Caraka : Jurnal Ilmu Kebahasaan, Kesastraan, dan Pembelajarannya Tekinfo | Scientific Journal of Industrial and Information Engineering Jurnal SOLMA Akta Kimia Indonesia Iseedu: Journal of Islamic Educational Thoughts and Practices Martabe : Jurnal Pengabdian Kepada Masyarakat JPP IPTEK (Jurnal Pengabdian dan Penerapan IPTEK) NUSANTARA : Jurnal Ilmu Pengetahuan Sosial EKO-REGIONAL JURNAL PENGEMBANGAN EKONOMI WILAYAH Media Ilmiah Teknik Sipil Indonesian Journal of Chemical Analysis (IJCA) Ekuilibrium : Jurnal Ilmiah Bidang Ilmu Ekonomi Jurnal Rekayasa Lingkungan Jurnal Ilmiah Mandala Education (JIME) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Al-Qalam Performance Jurnal Pendidikan Edutama Borneo Engineering: Jurnal Teknik Sipil JURNAL ILMIAH KESEHATAN SANDI HUSADA Jurnal Review Pendidikan dan Pengajaran (JRPP) The Indonesian Journal of Social Studies Jurnal Kesehatan Masyarakat dan Lingkungan Hidup Infotekmesin Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Klorofil: Jurnal Penelitian Ilmu-Ilmu Pertanian Jurnal Dinamika Manajemen Pendidikan (JDMP) Dinasti International Journal of Management Science JPSI (Journal of Public Sector Innovations) JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Dinasti International Journal of Education Management and Social Science Akta Agrosia Journal of Appropriate Technology for Community Services Jambura Journal of Electrical and Electronics Engineering JATI (Jurnal Mahasiswa Teknik Informatika) SOLUSI Jurnal Ilmiah Profesi Pendidikan Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS AS-SABIQUN: Jurnal Pendidikan Islam Anak Usia Dini Community Development Journal: Jurnal Pengabdian Masyarakat Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Indonesian Journal of Islamic Business and Economics (IJIBE) Sustainable: Jurnal Kajian Mutu Pendidikan Jurnal Inovasi Pendidikan MH Thamrin Journal of Computer Networks, Architecture and High Performance Computing Ulumuna Journal of Applied Data Sciences Amsir Law Jurnal (ALJ) Jurnal Disrupsi Bisnis Jurnal Kewarganegaraan JIAL (Journal of Indonesian Adat Law) Jurnal Aplikasi Ilmu Teknik Industri (JAPTI) Jurnal Sosial dan Teknologi Metafora: Jurnal Pembelajaran Bahasa Dan Sastra Bima Abdi: Jurnal Pengabdian Masyarakat Juwara : Jurnal Wawasan dan Aksara PRIMA : Portal Riset dan Inovasi Pengabdian Masyarakat Journal of Language and Health RUANG KATA: Journal of Language and Literature Studies Journal Of Business, Finance, and Economics (JBFE) International Journal of Management Science and Information Technology (IJMSIT) COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Pelita Teknologi : Jurnal Ilmiah Informatika, Arsitektur dan Lingkungan Jurnal Ilmiah SIGMA: Informatics Engineering Journal of UPB International Journal of Humanities Education and Social Sciences Journal Of Human And Education (JAHE) Husnayain Business Review Perwira Journal of Science and Engineering (PJSE) Balance : Jurnal Akuntansi dan Manajemen Tropical Plantation Journal Journal of Law, Poliitic and Humanities ELOQUENCE: Journal of Foreign Language Asia Pacific Journal of Management and Education Indonesian Journal of Community Diversity and Engagement Prosiding University Research Colloquium Malcom: Indonesian Journal of Machine Learning and Computer Science VIGOR: JURNAL ILMU PERTANIAN TROPIKA DAN SUBTROPIKA Jurnal Keilmuan dan Keislaman IRA Jurnal Teknik Mesin dan Aplikasinya (IRAJTMA) Journal of Business Studies and Management Review Internet of Things and Artificial Intelligence Journal Literasi: Jurnal Pengabdian Masyarakat dan Inovasi INJECTION: Indonesian Journal of Vocational Mechanical Engineering Proceeding Applied Business and Engineering Conference Indonesian Research Journal on Education Innovative: Journal Of Social Science Research Sewagati Jurnal Manajemen dan Penelitian Akuntansi (JUMPA) Journal of Sustainable Community Service Notary Law Journal MAJAPAHIT POLICY Jurnal Riset Rumpun Ilmu Sosial, Politik dan Humaniora (JURRISH) Jurnal AGRISEP: Kajian Masalah Sosial Ekonomi Pertanian dan Agribisnis Journal of Progressive Law and Legal Studies JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Riwayat: Educational Journal of History and Humanities Strata Law Review Journal International Journal of Teaching and Learning (INJOTEL) Jurnal Ilmiah Ekonomi dan Manajemen Jurnal Pengabdian Kepada Masyarakat Bangun Cipta, Rasa, & Karsa (Jurnal PKM BATASA) Jurnal Pelita Pengabdian Jurnal Informatika: Jurnal Pengembangan IT Master Manajemen ADIMA Usadha Journal of Pharmacy Perwira Journal of Community Development (PJCD) Jurnal Intelek Insan Cendikia Jurnal Polimesin IERA, Islamic Education and Research Academy Journal of Sustainable Economic and Business Jurnal Pembelajaran dan Riset Pendidikan Public Sphere: Jurnal Sosial Politik, Pemerintahan dan Hukum International Journal of Sociology and Law Cakrawala: Jurnal Ekonomi, Manajemen dan Bisnis EDUKASI Jurnal Standardisasi ABDIANDAYA : Jurnal Pengabdian dan Pemberdayaan Masyarakat AR-RUMMAN: Journal of Education and Learning Evaluation Jurnal Pemikiran dan Pengembangan Pembelajaran FIKROTUNA: Jurnal Pendidikan dan Manajemen Islam Jurnal ilmiah teknologi informasi Asia Jurnal Ilmiah Kesehatan Sandi Husada Jurnal Legislasi Indonesia Leksis Jurnal Pendidikan Bahasa Dan Sastra Indonesia Jurnal Sosiologi USK (Media Pemikiran & Aplikasi) Jurnal Rekam Medic Jurnal Kesehatan Masyarakat Pawitra Komunika: Jurnal Komunikasi dan Sosial Humaniora Studia Islamika
Suprapto Suprapto
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Optimization of Genetic Algorithm Computation Time with Mutation Probability Variations in Course Scheduling Salman, Rudi; Suprapto, Suprapto; Irfandi, Irfandi; Hutajulu, Olnes Yosefa
Jambura Journal of Electrical and Electronics Engineering Vol 7, No 1 (2025): Januari - Juni 2025
Publisher : Electrical Engineering Department Faculty of Engineering State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjeee.v7i1.28286

Abstract

Genetic Algorithm (GA) often requires a long computation time due to the complexity of its processes. Therefore, efforts are needed to optimize GA computation time, particularly in scheduling lectures at the Electrical Engineering Study Program of Universitas Negeri Medan, which is the focus of this research. One possible approach is determining the appropriate mutation probability (Pm) value. This study employs the Mutation Probability Variation Method, where Pm is constrained between 0 and 1 and varied from a minimum value of 0.01 (1%) to a maximum value of 0.1 (10%). Simulations were conducted using Matlab R2012b, with constant parameters including a population size of 100 and a crossover probability (Pc) of 0.85. Iterations were performed to evaluate the effect of Pm on computation time and solution performance. The results show that at Pm = 0.06, the Genetic Algorithm achieved the fastest computation time, averaging 0.382 seconds. This study also identifies that GA computation time is significantly influenced by algorithm parameters and the complexity of the problem. By selecting an appropriate Pm, a balance between exploration and exploitation can be achieved, reducing computation time without sacrificing solution quality. This research contributes significantly to the development of more efficient algorithms for optimization applications, particularly in lecture scheduling.Waktu komputasi dalam Algoritma Genetika (AG) sering kali memerlukan waktu yang lama akibat kompleksitas komputasi yang dikerjakan. Oleh karena itu, perlu dilakukan upaya untuk mengoptimalkan waktu komputasi AG, khususnya dalam perencanaan jadwal kuliah di Program Studi Teknik Elektro Universitas Negeri Medan, yang menjadi objek penelitian. Salah satu upaya yang dapat dilakukan adalah dengan menentukan nilai probabilitas mutasi (Pm) yang tepat. Penelitian ini menggunakan Metode Variasi Probabilitas Mutasi, di mana nilai Pm dibatasi antara 0 hingga 1 dan divariasikan dari nilai minimum 0,01 (1%) hingga nilai maksimum 0,1 (10%). Simulasi dilakukan menggunakan perangkat lunak Matlab R2012b, dengan parameter konstan yaitu ukuran populasi 100 dan probabilitas crossover (Pc) 0,85. Proses iterasi dilakukan untuk mengevaluasi pengaruh Pm terhadap waktu komputasi dan performa solusi. Hasil simulasi menunjukkan bahwa pada Pm = 0,06, Algoritma Genetika mencapai waktu komputasi tercepat, yaitu 0,382 detik. Penelitian ini juga mengidentifikasi bahwa waktu komputasi AG sangat dipengaruhi oleh parameter algoritma dan kompleksitas masalah yang dihadapi. Dengan pemilihan Pm yang tepat, keseimbangan antara eksplorasi dan eksploitasi dapat dicapai, sehingga waktu komputasi berkurang tanpa mengorbankan kualitas solusi. Penelitian ini memberikan kontribusi signifikan dalam pengembangan algoritma yang lebih efisien untuk aplikasi optimasi penjadwalan kuliah. 
Experimental study fluidized bed reactor using number hole 8 to see distribution gas fluid pressure Eswanto, Eswanto; Pinem, Riza Refaya; Suprapto, Suprapto
Jurnal Polimesin Vol 21, No 5 (2023): October
Publisher : Politeknik Negeri Lhokseumawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30811/jpl.v21i5.4101

Abstract

Innovations related to fluidization systems using fluidized bed reactor are still needed to be developed in order to improve the fluidization process services for particle in order to produce the right fluid pressure in certain fluidized bed spaces that are currently operating. In this research, the pressurized fluid in question is air sourced from a compressor which has been arranged in such a way. The aim of the research is to obtain information regarding the characteristics of bubble resulting from the air pressure process pressing fluidized system particle. The research method was carried out by experimenting with testing fluidized bed reactor as test model in the form 8 hole, providing air pressure from compressor then observing the characteristics visually. The results of this visually documented research have been carried out and obtained. By using the number of hole 8 with height silica sand inserted to height of 25 cm, which is measured from the beginning of the hole plate before pressure is applied. After being given high pressure the bed increased to 27.6 cm, the highest bubble diameter was obtained at the input air pressure of 8 bar, which was 3.9 cm, with bed silica sand produced 26.1 cm, where the babble condition began to appear after the 9th second. Other characteristics also obtained reactor temperature of 25.45 °C where this condition is the smallest when compared to other pressure input results, this is because the small input pressure causes the temperature to be low, while the large pressure input temperature becomes higher due to many factor, including friction between silica sand, silica sand collisions, and faster movement of particle material.
Influence of Indium Tin Oxide (ITO) poling temperature in vacuum on surface roughness of Polyvinylidene Fluoride(PVDF) film Suprapto, Suprapto; Lisyanto, Lisyanto; Eswanto, Eswanto; Riadi, Selamat; Gunawan, Safri; Iskandar, Henry; Jubaidah, Jubaidah; Muhtadin, Muhtadin
Jurnal Polimesin Vol 21, No 6 (2023): December
Publisher : Politeknik Negeri Lhokseumawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30811/jpl.v21i6.4454

Abstract

The surface roughness is a significant parameter of the performance of PVDF thin film sensors. In this work, we have investigated the effect of ITO poling in vacuum at various temperature on the surface roughness of uniaxially stretched PVDF film. The influence of poling temperature on the surface roughness of PVDF film was examined using atomic force microscopy (AFM). In this work, the AFM data are obtained through the database, and topography is analyzed using Gwydion Software (GS). GS has characterized surface roughness in terms of Average Roughness (Ra), Root Mean Square (Rrms), and Arithmetic average height (Rz). The results show that the GS can detect and measure profile thickness and roughness on a nanoscale with reliable accuracy. The results confirm that the increased poling temperature can reduce the roughness of the surface.
Traffic Safety Management Index (TSMI) Fikri, Muyazzinul; Aqil Ghifari, Khalif; Adhi P, Baskara; Suprapto, Suprapto; Hanif, Ahmad; Fauzan M, Rizqi
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 8 (2024): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v4i8.2788

Abstract

Selama tahun 2023-2024, Peristiwa kejadian berbahaya dan kecelakaan di area pertambangan banyak terjadi di jalan. Hal ini yang perlu diwaspadai, karena telah menyebabkan kerugian materi maupun non-materi. Adapun kejadian tersebut menimbulkan berbagai macam kerugian, seperti kerusakan alat, penghentian kegiatan operasional, pencemaran lingkungan akibat tumpahan oli, penurunan citra perusahaan, hingga kematian. Pada umumnya, kejadian berbahaya dan kecelakaan pada area Jalan merupakan salah satu penyebab langsung yang diakibatkan oleh adanya kondisi tidak aman yang secara berangsur-angsur tidak ditindak lanjuti. Padahal, jalan merupakan salah satu penunjang utama dalam kegiatan penambangan dan termasuk ke dalam aspek Sarana, Prasarana, Instalasi, Pertambangan (SPIP) yang perlu dirawat dan diperhitungkan dalam kajian teknis yang ada, sesuai dengan peraturan yang berlaku. Oleh karena itu, perlu adanya suatu program yang dapat dijadikan suatu metode untuk penilaian kondisi tidak aman dan rencana tindak lanjut sebagai upaya peningkatan keselamatan operasional. Program Traffic Safety Management Index (TSMI) merupakan program yang bersifat accountable atau terhitung untuk menilai kestandaran suatu kondisi tidak aman di jalan dan pengelolaan jalan tambang baik itu dalam kondisi jalan, pengendalian lalu lintas, dan tingkah laku karyawan sesuai dengan peraturan yang berlaku pada KepMen ESDM 1827 Tahun 2018 tentang Pedoman Pelaksanaan Kaidah Teknik Pertambangan yang Baik dan Kepdirjen 185 Tahun 2019 tentang Petunjuk Teknis Keselamatan Pertambangan dan Pelaksanaan, Penilaian, dan Pelaporan SMKP Minerba. Traffic Safety Management Index (TSMI) nantinya akan memunculkan sistem dashboard dengan pemetaan suatu nilai yang dapat mempresentasikan kondisi tidak aman di jalan dan langkah upaya prioritas dalam tindakan perbaikan
Reconstruction of the Muhammadiyah Educational System in Social Change Suprapto, Suprapto; Hadi, M Faziurrahman; Jayadi, Mahsun
Jurnal Pendidikan Edutama Vol 11 No 2 (2024): July 2024
Publisher : IKIP PGRI Bojonegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30734/jpe.v11i2.4344

Abstract

This research aims to reveal the role of Muhammadiyah education in social transformation that influences people’s lives. The approach used is literature study. Capitalism in the educational context is often associated with the exploitation of business opportunities, whic often leads to unethical practices, such as the use of educational funds for personal gain or institutional interests. The aim of this research is to find a solution to overcome the problem of capitalization in education, which has had an impact on the high dropout rate among students. economic empowwerment efforts are important in this context, where education funding is often subsidized to overcome the challenge of high costs in providing education. 
Adab Education Management in Islamic Boarding School: A Case Study Shafwan, Muhammad Hambal; Suprapto, Suprapto
Jurnal Pendidikan Edutama Vol 12 No 1 (2025): January 2025
Publisher : IKIP PGRI Bojonegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30734/jpe.v12i1.4862

Abstract

This research aims to discuss how to manage adab education at the TQH al-Hasyimi Tenggulun Solokuro Lamongan Islamic Boarding School. is qualitative research with a case study approach, which means this research is carried out in a natural context to understand the phenomena that occur. The methods used include various techniques to carry out in-depth interpretation of the phenomenon. The results of this research explain that adab education at the TQH al-Hasyimi Islamic boarding school uses the book "at-Tibyan fi adab Hamalah al-Qur'an" as a guide. The implementation of learning the book "al-Tibyân fî Âdâb Hamalah al-Qur'ân" at the TQH al-Hasyimi Islamic Boarding School, with a management process that includes planning, organizing, actualling and controlling, requires time is not instant and a continuous process. In practice, students are expected to be able to apply the etiquette taught in the book, such as: (1) Cleaning the Heart: Protecting the heart from despicable qualities and always trying to gain the approval of Allah SWT; (2) Polite Appearance: Ensure a neat and polite appearance when participating in learning activities; (3) Consistency of deposit times: Prioritize deposit times in the morning to repeat memorization with discipline; (4) Getting used to night Qira'ah: Performing tadarus and night prayers regularly to increase spirituality and understanding of the Qur’an.
Analysis of workload and fatigue Batik Cap workers in Sukoharjo Lestari, Mathilda Sri; Komariah, Ainur; Suprapto, Suprapto; Sari, Maria Puspita
OPSI Vol 17 No 2 (2024): ISSN 1693-2102
Publisher : Jurusan Teknik Industri, Fakultas Teknologi Industri UPN "Veteran" Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31315/opsi.v17i2.10947

Abstract

Batik is an ancestral heritage of the Indonesian people that has been preserved to this day, particularly on the island of Java. In Java, the centers of the batik industry are located in Pekalongan, Yogyakarta, Surakarta, and Sukoharjo. In Sukoharjo, there are several home industries producing batik cloth, especially in the Krendetan Sukoharjo area, which specializes in both written and stamped batik. The batik-making process in these home industries is performed manually using simple tools. A preliminary survey revealed that the batik-making process involves repetitive tasks and imposes a high workload, particularly in the batik stamping process. This study aims to determine energy expenditure during work, energy expenditure during rest, and energy consumption needs for workers in the batik industry. The research was conducted in the stamping section and the boiling process to remove wax from the fabric. The results showed that energy expenditure during the batik stamping process was 382 kcal/hour, while in the boiling process it was 402 kcal/hour. Energy expenditure during rest was 354 kcal/hour in the stamping process and 367 kcal/hour in the boiling process. Energy consumption during the stamping process was 29 kcal/hour, and in the boiling process, it was 36 kcal/hour. The required rest time for the stamping process was 7.43 minutes per 15 minutes of work, while for the boiling process it was 5 minutes per 30 minutes of work.
Modifikasi Pati Secara Asetilasi dan Aplikasinya Sebagai Bahan Dasar Filamen Jaring Ikan Ramah Lingkungan Triastuti, Warlinda Eka; Suprapto, Suprapto; Muyassaroh, Tisnuliah; Bawafi, Suardhana; Sampurno, Ade Citra Oktaviana Elok; Meghotsah, Muhammad Akha; Aditama, Fitra Diannico; Ardhana, Krisna Setya
Prosiding Seminar Nasional Teknik Kimia "Kejuangan" 2023: PROSIDING SNTKK 2023
Publisher : Seminar Nasional Teknik Kimia "Kejuangan"

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Fishing nets are generally made of synthetic polyamides such as nylon. The use of nylon nets has negative impacts, such as habitat destruction. So it is necessary to consider the use of biodegradable nets. One of the potential natural materials that can be used as eco-friendly fishing net filaments is starch. The research aims to modify cassava and corn starch by acetylation method to improve their characteristics. Starch modification was carried out by adding acetic acid with variable concentrations of 10%, 15%, 20%, 25%, and 30% into the starch. Modified starch was analysis for water content, swelling power, solubility, and FTIR. In the manufacture of filaments using modified corn 15% with a test result of 0.04; 0.13; 0.05. The results of the FTIR analysis showed a combined functional group between HDPE and starch at wave numbers 2922.2cm-1 and 1371.7cm-1. Starch content has an effect on reducing the weight of filament degradation. SEM analysis showed that the compatibility of the filament with the addition of MA increased but the internal structure of the filament gradually expanded with increasing starch content. The results of the analysis of tensile strength and elongation at break of the filament are 1.81 kgf and 119.77%
MODIFIKASI DAN KARAKTERISASI PATI JAGUNG (Zea mays, [L]) DAN XANTHAN GUM DENGAN CROSSLINKING AGENT ASAM SITRAT Pratama, Septian Rizki; Suprapto, Suprapto
Usadha Journal of Pharmacy Vol. 1 No. 2 (2022): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v1i2.103

Abstract

Pati jagung adalah eksipien yang telah banyak digunakan dalam pembuatan sediaan tablet sebagai filler, binder dan disintegrant. Pati memiliki dua komponen yaitu amilosa dan amilopektin. Kedua molekul tersebut berperan terhadap sifat fisik dan kimia pada pati yang berpengaruh pada tingkat pembengkakan granula pati. Pati alami mengandung banyak amilosa sehingga bersifat kering, kurangnya daya lekat, dan cenderung menyerap banyak air. Oleh karena itu, perlu dilakukan modifikasi pati dan xanthan gum (XG) dengan crosslinking agent asam sitrat untuk memperbaiki kekurangan pada sifat fungsional pati agar aplikasinya lebih luas. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian XG terhadap pembentukan kopolimer crosslinking dan karakterisasinya. Penelitian ini menggunakan XG dengan variasi konsentrasi 5%, 10%, dan 20% dengan asam sitrat, dan kontrol positif (XG 5% tanpa asam sitrat). Kopolimer crosslinking hasil modifikasi dikarakterisasi meliputi uji FTIR, daya mengembang (swelling), kecepatan alir dan sudut diam. Hasil modifikasi pati jagung menunjukan adanya pembentukan crosslink pada formula 1, 2, dan 3 ditandai dengan terbentuknya gugus C=O (ester) dengan uji FTIR pada peak 1713,94 cm-1, 1714,38 cm-1, dan 1714,63 cm-1. Hasil analisis menunjukan nilai swelling power yang semakin besar, kecepatan alir yang semakin meningkat yaitu 6,52 g/detik, 9,90 g/detik dan 11,62 g/detik dan sudut diam yang semakin tinggi 23,934°, 24,564°, dan 26,543°.
OPTIMASI TABLET LEPAS LAMBAT KAPTOPRIL MENGGUNAKAN PVP SEBAGAI BAHAN PENGIKAT DAN TALK-MAGNESIUM STEARAT SEBAGAI BAHAN PELICIN DENGAN METODE SIMPLEX LATTICE DESIGN Alita, Gesvi Sari; Suprapto, Suprapto
Usadha Journal of Pharmacy Vol. 2 No. 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v2i1.121

Abstract

Kaptopril merupakan obat yang digunakan dalam pengobatan hipertensi dan gagal jantung dengan frekuensi penggunaan obat dalam sehari harus diberikan berulang kali. Tablet lepas lambat memiliki efek terapeutik lebih panjang dibandingkan dengan tablet biasa karena melepaskan obat ke dalam tubuh secara bertahap sehingga dapat mengurangi frekuensi penggunaan obat. Tujuan dari penelitian ini untuk mengetahui pengaruh kombinasi bahan pengikat PVP dan bahan pelicin talk-magnesium stearat terhadap sifat fisik granul dan sifat fisika-kimia tablet lepas lambat kaptopril, serta untuk mengetahui konsentrasi bahan pengikat PVP dan bahan pelicin talk-magnesium stearat yang dibutuhkan agar tercapai formula yang optimum pada sediaan tablet lepas lambat kaptopril. Penelitian ini dibuat dengan perbandingan PVP dan talk-magnesium stearat formula I (9:9) mg; formula II (15:3) mg; formula III (3:15) mg; formula IV (3:15) mg; formula V (6:12) mg; formula VI (12:6) mg; formula VII (15:3) mg. Evaluasi yang dilakukan terhadap granul yaitu kecepatan alir, sudut diam, dan rasio Hausner, sedangkan evaluasi yang dilakukan terhadap tablet yaitu keragaman bobot, kekerasan, kerapuhan, dan laju disolusi tablet. Data hasil percobaan diolah dengan program design expert versi 13.0 menggunakan metode simplex lattice design. Hasil penelitian menunjukkan bahwa kombinasi PVP dan talk-magnesium stearat meningkatkan kecepatan alir granul, memperkecil sudut diam granul, meningkatkan rasio Hausner, menurunkan keragaman bobot, meningkatkan kekerasan tablet, mengurangi kerapuhan tablet, dan menurunkan laju disolusi tablet. Formula optimum tablet lepas lambat kapropril 300 mg didapatkan 2 solusi dengan nilai desirability 0,702 dengan kombinasi PVP (8,42 mg) dan talk-magnesium (9,57 mg).
Co-Authors Abadi Sanosra Abdul Aziz Ahmad Abdul Basith, Mohammad Resi Abdul Karim Abdul Qodir Abdul Quddus Abdul Wahab Abei, Fikri Achmad Dwitama Karisma Achmad Faisal Achmad Ridwan, Achmad Adhi P, Baskara Adi Soeprijanto Aditama, Fitra Diannico Afiahayati Afiahayati, Afiahayati Agus Arifin, Agus Agus Mulyawan, Agus Agus, Junaidi Agustiani, Elly Agustin Suraswati Agustin Suraswati, Agustin Ahmad Dwi Arga Ahmad Firdaus, Ahmad Ahmad Hanif Ahmad Syaufi Ahmadi Hasan Ahmadi, Haerul Aigah Ameilia Manullang Ainur Komariah Aisyah Endah Palupi Ajeng Wijayanti, Lumastari Al Amruzi, HM Fahmi al farobi, afif Al Ikhlas, Al Ikhlas Albubaroq, Hikmat Zakky ALEXCANDRA, HISAR Alfiana Alfiana Ali Altway Alifah Hernanda, Rasikha Alita, Gesvi Sari Aminuyati Amiria, Hana Dhia Amri, Novita Amrulloh, Muhammad Chasan Anafih, Erwinda Sam Andi Akbar Subari Andik Adi Suryanto Andika, Sophian Andrean Rahady Juanizar Anggraini, Ike Anik Herminingsih Anwar, Seful APHA, Journal Manager Apriliawati, Tonika Aqil Ghifari, Khalif Ardhana, Krisna Setya Ardiansyah, Dimas Lutfiana Ardiyanti, Annisa Arintoko Arintoko, Arintoko Aris Setiawan Arlinwibowo, Janu Arwadi Sinuraya Aryanta Sembiring, Robi Asih, Dewi Supri Asrudin, Muhammad Aswan Supriyadi Sunge Awaliyah, Nabilah Hasna’ Ayu Safira, Amellia Ayu Sitanini Azizi, Muhammad B.A. Tjipto Sujitno Bambang S, TH.Teddy Bambang Sumardjoko Bangsawan, Achmad Baqiyah, Alvi Khoirul Barima, Hima Bariot Hafif Baskoro, Ari Yudha Basuki , BASUKI BASUKI Batumahadi, Batumahadi Bawafi, Suardhana Bayu Mahendra Bayu Wiyantoko Binsar Panjaitan, Binsar BUDI WIBOWO Bunyamin Arsyad Cakranegara, Pandu Adi Chandra S Cutiana Windri Astuti, Cutiana Windri Daito, Appolo Damanik, Marini Danar Agus Susanto Danawati Hari Prajitno Darmaputra, I Gde Darsini . . Daud, Fadly Dedi Saputra Dewangga, Sakti Dewi Nurhanifah, Dewi Dewi Riniarti Dewi Supri Asih Dewi, Meilinia Shinta Kusuma Dewi, Ratna Fitriana Diah Setyorini Gunawan Dian Ardifah Iswari Dian Wijaya Diansyah, Diansyah Didik Prasetyoko Didit Kurniadi Dijan Rahajuni Djaja , Djuniawan Karna Djuharyanto, Teguh Djuita, Warni Dominikus Rato Dwi Ari Purwanto Dwi Priantoro Dwi Purwoko Dwi Wahyuni Ganefianti, Dwi Wahyuni Dyah Aruming Tyas Edora, Edora Edy Riyanto Eka Daryanto Eka Daryanto, Eka Eko Wahyono, Eko Emy Handayani Endang Sri Gunawati Endi Hari Purwanto Ennanto, Ennanto Eny Rahmawati Erlina Erlina Ersan Ersan Eswanto, Eswanto F. Dirun, Wikarya Faddillah, Fahmi Fadly Azhar Faishal, Achmad Faizah Faizah Fajar Dwi Prasetyo Fakhri Izzul Haq, Muhammad Fakhrina Fahma Fathurrahman Muhtar Fatima, Gupita Nadindra Fatkur Mu'in Fauzan M, Rizqi Fauzi, Habibillah Achmad Putra Febrian Kwarto Fikri, Muyazzinul FIRMAN UMAR, FIRMAN Firmansyah Nasution, Taufik Forita Dyah Arianti, Forita Dyah Ghiffari, Muhammad Giantama Adhy Prima Ginting, Delon Ananda Giovan Panjaitan, Asido Giyoto Gunawan, Muhammad Tigo Gunawan, Safri Gusti Muzainah Hadi Musthofa Hadi Musthofa, Hadi Hadi, Hairul Hadi, M Faziurrahman Hairil Anwar Hanggara, Buce Trias Harmami Harmami Hartono, Bambang Dwi Hazim, Muhammad Fadhlurrahman Hendrawan, Henky HENRY ISKANDAR Hermaningsih, Anik Herzanti, Amelia Hetrianto, Roman Hidayatin, Dwi Hidayattulloh, Hidayattulloh Hikmah Muhaimin Historiawati Historiawati Hosan, Elfawa Hutajulu, Olnes Yosefa I Gde Ichsan Anwary, Ichsan Idrus, Muhamad Ignatius Sriyana Ilmy, Muhammad Azianoor Inayatullah, Putri Asti Indrawatiningsih, Nonik Indura, Alif Chandra Irawan, Kelvin Irfan Miftahul Fauzi Irfandi Irfandi, Irfandi Irma Azalia, Inez Islah Islah, Islah Ismadi Raharjo, Ismadi Ismail Thoib Isnaini, Silviana Dwi Iswandi Iswandi Iswar, Nabila Salsabila Ita Lusiyana Ita Ulfin Iwan Harsono Jauhari, Sodik Jaya, Jamie Armadi Jenny Yudha Utama Jhodi Pratama Joko Purnomo Joko Sutrisno Jubaidah, Jubaidah Juli Hadiyanto Juli Handayani Juliana Waromi, Juliana Kabul, Abdul Hamid Kamaruddin, Muh Ihsan Karim, Syaban Abdul Kesi, Reval Bani Kevin Abdillah, Mohammad Khaerul Anam Komariah, Ainur Krisdayanto, Tiyan Reky Kukuh Ageng Pribowo Kurnia, Mega Kurniawati, Puji Kurniawati, Puji Kuswadi, Didik Lailatul Qomariyah, Lailatul Lailiyah, Yayang Komaroh Lailun Ni’mah, Yatim Lathifah Lanonci Latif, Asriyadi Latif, Sarifudin Andi Lely Susita Lestari, Gagas Puji Lestari, Mathilda Sri Leuhery, Ferdy Liana Mangifera Lilis Siti Badriah Lilis Suryani Lily Pudjiastuti, Lily Listiyanto, Listiyanto Lisyanto . Lubis, Aulia Madjid Luluk Ayu Widyantika M Tahir Mafizatun Nurhayati Mahsun Jayadi, Mahsun Maigoda, Tony Cortis Malau, Raymond Regol Maria Puspita Sari, Maria Puspita Marlina, yuli Marsyaf, Marsyaf Marthin, Marthin Mathilda Sri Lestari Maulana, Ahmad Rizki Mawadah, Saadah Luthfiah Mayasari Mayasari, Mayasari Meghotsah, Muhammad Akha Meidiansyah, Fadli Meifida Ilyas Meilinda Ayundyahrini Melvi, Lisa Miftahul Huda Miharja, Muhammad Najamuddin Dwi Millenio, Gifford Adji Akbar Minanari, Minanari Muchlis Hamdi Muhaimim, Hikmah Muhammad Ashari Muhammad Asir Muhammad Hambal Shafwan Muhammad Idrus Muhammad Ilham Muhammad Iqbal Muhammad Iqbal Firdaus, Muhammad Iqbal Muhammad Najib Muhammad Nepo Fauzan Muhsi, Muhsi Muhsin Aseri, Muhsin Muhtadin Muhtadin Mukhlis Mukhlis Mulat, Trimaya Cahya Mulyani Zulaeha Muniroh, Mu’awanatul Murti Astiningrum Musaddad, Anwar Mustika, Cindyva Thalia Muteringbumi, Haidir Ali Muyassaroh, Tisnuliah Nabella Rizka Tianlie Nadiah Nadiah nasir, muh Nasrodin Nasrodin, Nasrodin Nasution Nasution Nawangwulan, Apriliya Ni'mah, Yatim Lailun Ningsih, Tri Widyastuti Niniek Fajar Puspita, Niniek Fajar Nonsi Tentua, Meilany Noviani, faizah Nur Aida, Nur Nur Azizah Nur Syamsi Norma Lalla Nurfaizin, Irham Nurhadji Nugraha Nurhasanah Nurhasanah Nurlaili Humaidah, Nurlaili Nurliah Nurdin Nurul Lailatul Khusniyah Nurwahidah Jamal Nurwantara, Ma’ruf Pambudi Nurwijayanti Nyoman Bayu Mahendra Oktafiana , Anisa Omiyani*, Selva Omiyani, Selva Pakpahan, Binsar Panunggul, Victor Bintang Pasaribu, Firentus Agustone Pawana, Sekhar Chandra Perando Sitanggang Pibisono, Arif Pinem, Riza Refaya Prakoso, Lukman Yudho Pramditiyan, Fauzan Rizaki Prasetyo, Sutrisno Aji Pratama, Septian Rizki Prayitno Prayitno Prayitno Prayitno Puji Kurniawati Purnama, Yulian Purnma, Aldi Purwanda, Nur Widia Purwoko, Agus Putra*, Eka Kurniawan Putra, Devangga Putra Adhitya Putra, Irawan Haji Putranto, Afif Hendri Putri, Sherly Octaviana Putty Anggraeni R. Nurfazriah, Latifah Rachmad Hidayat Rachman Sidharta Arisandi, Rachman Sidharta Rahmadian, Reza Rahmaniar Rahmaniar, Rahmaniar Rahmatul Ahya Rahmatul Ahya Rahmawati, Apriliana Nadia Ramli, Verawati Ranam, Sanudin Rasyid, Muh Fadli Faisal Ravendianto Ravendianto Reza Amarta Prayoga Reza Perdanakusuma, Andi Rian Prasetyo Riana Puspita, Riana Richad Hasan, Jhems Rill lsaris Rini Fidiyani Ristyana, Rida Rivai , VeithZainalzal Riyanto Suprawihadi Riyanto, Ari Budi Rizal Abdullah, Rizal Rizky Abdul Aziz Rochman, Apriatur Rochman, Arif Roman Hetrianto Romanto, Kristian Rosmiah Rosmiah, Rosmiah Rosnidar Sembiring Rossy, Riza Fachrul Rr. Ernawati Rubiyah Rubiyah Rudi Salman Rumanintya Lisaria Putri, Rumanintya Lisaria S. Suripin Saadah, Nurus Sabarudin Akhmad Sahputra, Nazar Sahrir, Salman Salsabila, Maulidia Sampurno, Ade Citra Oktaviana Elok Santosa Pradana Putra Setya Negara Santosa Santosa Santosa Santosa Saprudin Saprudin Saprudin Saprudin, Saprudin Saputra, Andy Eka Saputra, Firza Asep Saputri, Hafiar Sardi, Sopian Andika Sari, Ike Mayta Sari, Marta Hayu Raras Sita Rukmika Sasongko, Ananto Tri Satriawan, Devi Sayono Sayono Selamat Riadi Setyo Atmodjo Setyorini, Adelya Hesty Shailendra, Oktovan Agung Sheryl Niken Sekar Maulidya Shophan Tornado, Anang Silakhuddin Silakhudin Simanjuntak, Ardi Simetris Harahap, Handala Siminto Siminto, Siminto Sinurat, Marja Siti Nurul Yaqinah, Siti Nurul Siti Rofingatun Situmeang, Chandra Solly Aryza Soma Setiawan Ponco Nugroho Sophie Hapsari Sri Kaidah Sri L, Mathilda Sri Mulati Sri Mulati, Sri Sri Nadilah Sri Nadilah, Sri Sri Nugroho sri Nugroho Sri Warjiyati Sudarmiani Sudarmiani, Sudarmiani Sudjatmoko Sudjatmoko SUGENG HARIANTO Sugeng Santoso Sugiono, Didik Sukamta Sukamta Sukaryono Sukaryono Sukidi Sukidi Sulaeman, Asep Arwan Sulaeman, Maryam Sulaeman, Maryam Sumarlam Sumarni Sumarni Sumarno . sunardi sunardi Sunita Dasman Supardi Supardi Suparji Suparji Supnawadi, Supnawadi Suprapto Suprapto Supratman, Eman Suprio Pratomo, Muhammad Supriyanto Supriyanto Surya Dharma Suryanti, Rensi Susbiyani, Arik Susilowati Rahayu Sutrisno Sutrisno Sutrisno, Joko Sutrisno Sutrisno, Sutrisno Suwarni Suwarni Suwarno Imam Samsul Suyatno, Sugeng Suzanne , Nina Syaefullah, Nur Kholid Syafiq Maricar, Muhmmad Syahra, Assyfa Syaiful Anwar, Agus Setiadi, Suwali, Syaikhul Falah Syamsudin Rois, Syamsudin Taime, Habel Tamtama, Noviadry Nur Tasrim, Tasrim Tatar Bonar Taufik Taufik Taufik, Opik Abdurrahman Tentua, Meilany Nonsi Thoib , Ismail Thomas Tukirin Thomas Tukirin, Thomas Titik Purwati Widowati Titik Purwati Widowati, Titik Purwati Tjipto Sujitno Tornado, Anang Shophan Tri Esti Purbaningtias Trimaya Cahya Mulat Tukiran Tukiran Ubaidillah, Rizal Utama, Wahyu Velthuzend, Andre Wahdi, Hilmy Wahidah Wahidah Wahono . Wahono Wahono Wahyono, Eko Wahyono Wahyu Dwi Mulyono Wahyu, Syamsul Wahyudi Sutopo Warlinda Eka Triastuti Waston Wibakti, Aji Restu Wibowo, Ardianto Bayu Wijaya, Nahrul Wiwien Andriyanti Wiwien Andriyanti Wiyanto, Tri Ngudi Wiyantoko, Bayu Wiyantoko, Bayu Yaqin, Akbar Haqul Yatim Lailun Ni'mah Yenni Kurnia Gusti Yopan Rahmad Aldori Yudhi Herliansyah Yulia Pujiharti Yulianto, M.Farrel Shyva Pradana Yuniar, Dewi Yunus, Muh Yurizka Melia Sari Yusi Tyroni Mursityo Yuyu Wahyudin Zakaria Zakaria Zakky Almubaroq, Hikmat Zaman, Komarun Zeti Nofita Sari Ziyad, Ziyad Zubir, Moondra Zuchrillah, Daril Ridho Zulkarnain Zulkarnain Zulkarnain Zulkarnain