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dan Manajemen Malahayati (JRAMM) Longda Xiaokan : Journal of Mandarin Learning and Teaching JURNAL AKTUAL AKUNTANSI KEUANGAN BISNIS TERAPAN (AKUNBISNIS) Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Fokus Manajemen Bisnis Jupeko (Jurnal Pendidikan Ekonomi) SUPERMAT (JURNAL PENDIDIKAN MATEMATIKA) Nusantara Science and Technology Proceedings Jurnal REKSA: Rekayasa Keuangan, Syariah dan Audit Jurnal Penelitian ADDIN Akrab Juara : Jurnal Ilmu-ilmu Sosial Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Al-Bidayah: Jurnal Pendidikan Dasar Islam Journal of Industrial Engineering & Management Research (JIEMAR) Jurnal Mandala Pengabdian Masyarakat Jurnal Fakultas Ilmu Keislaman UNISA Kuningan Jurnal Dinamika Sosial Ekonomi IJISTECH Awwaliyah Serambi Journal of Agricultural Technology Jurnal Insan Farmasi Indonesia Jurnal Eksis Hydrogen: Jurnal Kependidikan Kimia Devotion: Journal of Research and Community Service Nusantara Hasana Journal INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Jurnal Buana Farma DedikasiMU: Journal of Community Service Abditeknika - Jurnal Pengabdian Kepada Masyarakat Civil Engineering and Technology Journal International Journal of Social Service and Research JUSTIAN - Jurnal Sistem Informasi Akuntansi Journal of Economics and Business Letters Journal of Innovation in Community Empowerment (JICE) Simpatik: Jurnal sistem Informasi dan Informatika JIAPI: Jurnal Ilmu Administrasi dan Pemerintahan Indonesia PESAGI (Jurnal Pendidikan dan Penelitian Sejarah) PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Cermin Dunia Kedokteran Prosiding Konferensi Nasional PKM-CSR Jurnal Interkom : Jurnal Publikasi Ilmiah Bidang Teknologi Informasi dan Komunikasi Jurnal Visi Komunikasi International Journal of Science and Society (IJSOC) JES-MAT (Jurnal Edukasi dan Sains Matematika) CITIZEN: Jurnal Ilmiah Mulitidisiplin Indonesia Nusantara Journal of Behavioral and Social Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International journal of education and learning Chemical Engineering Journal Storage (CEJS) Medical Sains : Jurnal Ilmiah Kefarmasian Labatila: Jurnal Ilmu Ekonomi Islam Jurnal Locus Penelitian dan Pengabdian Jurnal Ilmu Kebidanan (Journal of Midwivery Science) Jurnal Pusat Inovasi Masyarakat Jurnal Litbang Industri Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Jurnal Jarlit Jurnal Riset Akuntansi dan Bisnis Indonesia Jurnal Airaha JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JAMAIKA: Jurnal Abdi Masyarakat Jurnal Bakti Untuk Negeri Lambda: Jurnal Ilmiah Pendidikan MIPA dan Aplikasinya Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Tamkin: Jurnal Pengembangan Masyarakat Islam AMMA : Jurnal Pengabdian Masyarakat APPA : Jurnal Pengabdian Kepada Masyarakat Journal of Public Health and Pharmacy Journal of Food and Pharmaceutical Sciences Jurnal Farmasi Galenika Indonesian Journal of Pharmacology and Therapy
Akrom, Akrom
Universitas Ahmad Dahlan
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EDUCATION WITH BOOKLETS MEDIA ON HIV PATIENTS IN THE HOSPITAL: A QUASI EXPERIMENTAL CLINICAL TRIAL Apriliyani, Fitri; Akrom; Wijaya, Uniarti
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 2 (2022): APRIL
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v1i2.82

Abstract

Regular visits of HIV patients to the hospital are expected to provide a positive therapeutic out-come because during the visit clinical monitoring, laboratory testing, counseling conducted by health workers and VCT themes, as well as taking antiretroviral (ARV) routine drugs every once a month, so that it is expected that the compliance of HIV patients to take ARV drugs will increase. Marking the success of the treatment of antiretroviral therapy come from HIV patients includes the minimum opportunistic infections related to AIDS and malignancy, increased CD4 cell counts, and increased body weight. The purpose of this study was to determine the effect of booklet media education on the level of adherence, perception, clinical out come and the quality of life of HIV patients in RSUD R. Soedjati Soemodiharjo The method used was quasi experimental with the design of two design pretest-posttest groups. Data were analyzed by univariate and bivariate. Statistical tests using a sample independent-sample test. The results obtained from this study are a description of the demographic characteristics of HIV patients in RSUD R. Soedjati Soemodiharjo, namely the highest age at 18-29 years as many as 22 patients (36%), dominated by women 43 people (70,5%), married as many as 49 people (80,3%), elementary school education 35 patients (57,4%), the most work was not working 23 people (37,8%), the highest duration of illness was above 1 year, 29 patients (47,6%), the most comorbid / comorbidities suffered by HIV patients in RSUD R. Soedjati Soemodiharjo were TB as many as 8 patients (36,4%). Perception on perception shows a P value of > 0,05. Intervention on compliance analysis results P > 0,05. Both treatment and control studies have moderate adherence because they have 48 patients (78,6%). Statistical results showed a significant difference for Hb because the SPSS results were P < 0,05 between the treatment with controls and for the leukocyte number P > 0,05, meaning that there was no significant difference between treatment and control. Interventions with quality of life P < 0,05. The conclusion is the influence of quality of life education intervention, Hb on HIV patients in RSUD R Soedjati between the control and treatment groups P <0,05.
The Relationship Between Nutritional Status And Insulin-Like Growth Factor-1 Levels In Stunted Children In Cirebon Regency Siti Pandanwangi; Akrom; Nurkhasanah; Zuniarto, Ahmad Azrul; Hidayati, Titiek; Tsai, Mei Ling
Window of Health : Jurnal Kesehatan Vol 7 No 3 (July 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v7i2.1299

Abstract

Insulin-like Growth Factor-1 (IGF-1) is a growth hormone mediator that acts as a growth-promoting factor in the growth process and is also an indicator of the adaptive immune system. Children who experience stunting will experience obstacles to growth and cognitive and motor development, affecting their productivity as adults. This research aims to determine IGF-1 levels and their relationship with stunted children's nutritional status. The research method used was observational, with a cross-sectional research design. The population of stunted children in the Tegalwangi locus area, Cirebon Regency, a sample of children aged 24-60 months who met the inclusion criteria of not being disabled and not being sick, was 50 children. The research began with parents filling in informed consent. Continue to fill in data on date of birth, measure height and weight, take @1ml of the child's blood, and analyze IGF-1 using the ELISA method. The research results were that the average IGF-1 level for men was 16,812 ± 5,164 ng/ml and for women 13,810 ± 5,111 ng/ml. Average IGF-1 levels aged 24-36 months were 14,777 ± 4,742 ng/ml, 36–48 months 17,050 ± 4,280 ng/ml, and 48–60 months 15,214 ± 6,248 ng/ml. Data analysis using the Pearson correlation test obtained a value of p=0.871 based on age, p=0.047 based on gender, p=0.643 based on Height for age, and p=0.245 based on Weight for age (95% CI). The conclusion is that there is a relationship between the age of a stunted child and IGF-1 levels, and there is no relationship with nutritional status. All stunted children have IGF-1 values ​​below the standard value for normal children based on the literature, namely ≥ 28.54 ng/ml.
Evaluation of Herbal Honey with Black Cumin and Curcuma xanthorriza as an Antioxidant Supplement for Stunting Prevention Hardia, Lukman; Akrom, Akrom; Hidayati, Titiek; Sulistyani, Nanik
Journal of Public Health and Pharmacy Vol. 5 No. 1 (2025): March 2025
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i1.5549

Abstract

Introduction: Honey has been widely used as a nutritional supplement and medicine. Many herbal honey products are developed as nutritional supplements that are combined with SFM to make them more effective, but there are still many shortcomings due to the unpleasant taste produced, unattractive physical appearance, and high susceptibility to oxidation reactions that cause severe damage to the quality of honey, especially in the content of active substances, viscosity, and pH, which can cause the effectiveness of honey to decrease and result in product failure as nutritional supplements to treat stunting problems. We have developed an herbal honey multi-nutrient supplement that combines honey with black cumin oil and Curcuma xanthorriza extract called HBCX. Adding Curcuma xanthorriza extract and black cumin oil to honey is expected to increase honey's benefits as an antioxidant. This study aims to determine the physicochemical characteristics (pH and viscosity), heavy metal contamination content, polyphenols, and antioxidant activity. Methods: This experimental laboratory research was conducted at the Pharmacy Lab, Faculty of Pharmacy, UAD. The viscosity and pH of HBCX were observed using an Ostwald viscometer and a pH meter. Total phenol determined by Folin-Ciocalteau reagent and gallic acid standard. Determination of antioxidant activity using the DPPH method. The data are presented in a quantitative descriptive manner and matched with the SNI honey standard. Results: The results showed that HBCX herbal honey had a higher viscosity than the sampled honey from the market but was still lower than the SNI requirements. HBCX honey has a lower pH than sample honey products from the market but still complies with national standards. HBCX honey is safe from heavy metal contamination and contains polyphenols. The antioxidant activity of HBCX honey is relatively high, with IC50=54.78 ppm. Conclusion: HBCX has high polyphenol content, is safe from heavy metal contamination, and has sufficient antioxidant activity.
EFEK MINYAK BIJI JINTEN HITAM TERHADAP KADAR TRIGLISERIDA DENGAN NUTRISI PADA PEROKOK AKTIF Rachmayani, Tantri; Akrom; Hidayati, Titiek
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 21 No. 1 (2022): Januari 2022
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.363 KB) | DOI: 10.30743/ibnusina.v21i1.221

Abstract

Hiperlipdemia merupakan salah satu kasus terbesar yang dapat menyebabkan kematian di seluruh dunia dan tidak lepas dari pola konsumsi makanan (nutrisi). Karbohidrat dan lemak adalah bagian dari nutrisi yang dapat mempengaruhi kadar trigliserida. Tujuan utama penelitian ini adalah untuk mengetahui efektivitas Minyak Biji Jinten Hitam (MBJH) terhadap persentase trigliserida yang dipengaruhi oleh pola konsumsi karbohidrat dan lemak yang diberikan kepada perokok selama 30 hari. Penelitian ini menggunakan metode Randomized Controlled Trial, dengan total 39 subjek dibagi menjadi empat kelompok. Grup 1 menerima plasebo 3x1 kapsul / hari, kelompok masing-masing 2,3 dan 4 menerima MBJH 3x1 kapsul / hari, MBJH 3x2 kapsul / hari dan MBJH 3x3 kapsul / hari, kemudian pada hari ke-31 darah diambil untuk di analisis. Analisis data menggunakan One Way ANOVA untuk melihat persentase rata-rata trigliserida di antara kelompok perlakuan yang dipengaruhi oleh konsumsi karbohidrat dan lemak. Hasilnya dikatakan signifikan jika nilai-p <0,05 sedangkan dalam penelitian ini diperoleh nilai-p 0,860. Berdasarkan hasil ini dapat disimpulkan bahwa tidak ada perbedaan yang berarti terhadap persentase trigliserida setelah pemberian Minyak Biji Jinten Hitam yang dipengaruhi oleh konsumsi karbohidrat dan lemak.
Analisis Polifarmasi Terhadap Interaksi Obat Di Rumah Sakit Umum Kota Pekalongan Permadi, Yulian Wahyu; Akrom; Imam Riadi; St Rahmatullah
Lamda: Jurnal Ilmiah Pendidikan MIPA dan Aplikasinya Vol. 5 No. 1 (2025): April
Publisher : Lembaga Bale Literasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58218/lambda.v5i1.1200

Abstract

The use of drugo in large quantities is called polypharmacy. The number of drug interactions depends on the number of drugs consumed, the possibility of drug interactions increases as more drugs are used in the prescription. This study aims to analyze the incidence of polypharmacy and drug interactions in outpatient prescriptions at Pekalongan City General Hospital. This study is a retrospective descriptive study conducted by analyzing outpatient prescription data for the period March–May 2023 at the hospital pharmacy depot. Prescription sheets containing two or more drugs (R/) were identified through reliable literature sources, namely www.drugs.com and www.medscape.com. Data were grouped and analyzed using SPSS spearman test. The results showed that of the total incidence of drug interactions of 877 patients, the gender of the patients was mostly female (68%), the age of the most was 26-45 years (58%), the number of drugs in the prescription was the largest two drugs with potential interactions 44%, the level of polypharmacy was moderate (48%), minor (21%), major (13%) and no interaction (18%). The largest number of diagnoses in the prescription was two diagnoses at 44%. The highest drug interaction mechanisms are pharmacodynamics (57.3%), pharmacokinetics (13%), unknown (29.7%). The most interacting drug combinations are rifampicin isoniazid 6.9%, furosemide cefixime 4.5% and sertraline gabapentin 4.5%. The correlation between the number of drug use and diagnosis according to the results of this study is a significant, strong and unidirectional correlation. Based on the results of this study, it is recommended that polypharmacy in prescriptions can be minimized and drug interaction monitoring be tightened to reduce the risk of dangerous side effects.
Sekolah Lansia “SEGAR” Berbasis Pemanfaatan Toga dalam Pencegahan Penyakit Degeneratif Supadmi, Woro; Dania, Haafizah; Akrom, Akrom; Saputri, Ginanjar Zukhruf; Mufidah, Syarifatul; Sari, Prita Anggraini Kartika
Jurnal Peduli Masyarakat Vol 7 No 3 (2025): Jurnal Peduli Masyarakat: Mei 2025
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v7i3.6595

Abstract

Lansia merupakan kelompok usia yang rentan terhadap penyakit degeneratif, seperti hipertensi, diabetes melitus, dan hiperkolesterolemia, yang memerlukan pengelolaan jangka panjang. Di Kelurahan Wirobrajan, Yogyakarta, prevalensi penyakit ini cukup tinggi, sementara pemahaman dan keterampilan lansia dalam pengelolaan kesehatan secara mandiri masih rendah. Program pengabdian ini bertujuan meningkatkan pengetahuan dan keterampilan lansia dalam pemanfaatan Tanaman Obat Keluarga (TOGA) secara tepat guna sebagai langkah preventif dan pengendalian penyakit degeneratif. Kegiatan dilaksanakan melalui program Sekolah Lansia Segar (Sehat dan Bugar) dalam tiga sesi edukatif yang bersifat partisipatif, diikuti oleh 63 lansia anggota Majelis Tabligh Aisyiyah Ketanggungan. Hasil evaluasi menunjukkan pengetahuan peserta mengenai penyakit degeneratif, penggunaan obat dan pemanfaatan TOGA. Seluruh peserta memahami bahwa TOGA memiliki khasiat sebagai obat, namun konsistensi dalam penggunaannya masih perlu ditingkatkan. Kegiatan ini terbukti efektif dalam memberdayakan lansia untuk mengelola kesehatannya secara mandiri.
Comparative analysis of macronutrient, vitamin, and mineral intake between stunted and non-stunted children in cirebon Pandanwangi, Siti; Akrom, Akrom; Nurkhasanah, Nurkhasanah; Zuniarto, Ahmad Azrul
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 2 (2025): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.2.162-169

Abstract

Background: The food consumed by children greatly affects how they will live in the future. The amount of nutrition that enters a child's body affects their health and intelligence. Macronutrients, vitamins and minerals are vital components in the body for the processes of growth and development, endurance, and other important functions. Low nutritional intake in children will cause them to experience growth failure, resulting in stunting.Objectives: This study was to compare the intake of macronutrients (protein, fat, and carbohydrate), vitamins (A, E, B1, B2, B6, C, folate), and minerals (sodium, potassium, magnesium, calcium, phosphorus, iron, and zinc) between stunted and non-stunted childrenMaterials and Methods: This study used a cross-sectional design. The population of the study was toddlers living in the Tegalwangi area, a sample of 100 children, ages 2 to 5, who were willing to sign a consent form as research subjects was split into 50 stunting and 50 non-stunting children. The time for the study began in January-May 2023. Data was collected using the 3x24 hour nutritional recall questionnaire method, followed by converting nutritional intake through the Nutrisurvey softwareResults: Nutritional intake for stunted children, shows that there are 12 intake criteria below the nutritional adequacy rate, while 5 intake criteria meet the standard. While for children who are not stunted, 12 criteria meet and 5 criteria do not meet the nutritional adequacy standard.Conclusion: Analysis of differences in the intake of the two groups found that there were no significant differences in the intake of macronutrients (carbohydrates), vitamins (E, B2) and minerals (sodium, potassium, calcium and phosphorum) with p>0.05, and significant differences in the intake of macronutrients (protein, fat). vitamins (A, B1, B6, C, folate), and minerals (magnesium, iron, zinc) with p<0.05. 
Nanotechnology-Based Nanopolymeric Polyherbal Formulation for Enhanced Antioxidant and Anti-Glycation Activity Astuti, Febriana; Mustofa; Arif Budi Setianto; Akrom
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.972-981

Abstract

Elevated oxidative stress and glycation give to the enhancement of degenerative condition such as diabetes and heart disease. Herbal extracts such as Apium graveolens, Centella asiatica, and Orthosiphon stamineus possess well-documented antioxidant and anti-glycation properties. However, their therapeutic effectiveness is measured by poor bioavailability, highlighting the need for innovative formulations. Nanotechnology presents a indicative of success approach by improving the solubility and distribution of active compounds. This study developed a nanopolymeric formulation by combining extracts of Apium graveolens, Centella asiatica, and Orthosiphon stamineus utilizing the ionic gelation method by chitosan, NaTPP, and Tween 80. The nanoparticles were characterized based on particle size, PDI, zeta capability, TEM, and FTIR. In vitro assays utilizing peripheral blood mononuclear cells (PBMCs) were conducted to analyze antioxidant activity through Nrf2 and GST expression, and anti-glycation capability by measuring AGEs. The nanopolyherbal particles had an average size of 186 ± 46.81 nm, by a PDI of 0.434 ± 0.04 and a zeta capability of -29.69 ± 1.54 mV. Both 1% and 3% nanopolyherbal treatments increased Nrf2 stages (66.77 ± 7.65 and 63.13 ± 2.75, respectively) and GST stages (87.97 ± 49.48 and 73.57 ± 4.61) compared to the control group (Nrf2: 54.1 ± 1.0; GST: 68.93 ± 2.28). The nanopolyherbal formulation also significantly decreased AGE itemion (1%: 1075.67 ± 107.51; 3%: 813.33 ± 117.05) compared to the control (1497.33 ± 161.58). These outcomes reveal that the nanopolyherbal formulation enhances antioxidant activity and inhibits glycation in PBMCs, suggesting its capability for managing oxidative stress-related condition.
Antioxidant Effects of Temulawak and Black Cumin Honey in Stunted Children: A Study in Cirebon Siti Pandawangi TW; Akrom, Akrom; Nurkhasanah, Nurkhasanah; Ahmad Azrul Zuniarto
Journal of Public Health and Pharmacy Vol. 5 No. 2 (2025): July 2025
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i2.5950

Abstract

Introduction: The imbalance between the production of free radicals and the antioxidant defense system in the body will cause the body to experience oxidative stress. This can be caused by chronic malnutrition. In children, this condition causes growth and development failure called stunting. Honey, temulawak and black cumin are herbs with high antioxidant content, formulated in one preparation to test its effectiveness. The purpose of the study was to determine specific descriptions experienced by stunted children and to test the antioxidant effectiveness of preparation temulawak-black cumin honey. Methods: The research method used was quasi-experimental, pre-post design, the research time starts from January-May 2023. The population of Stunting children in the Tegalwangi locus area, Cirebon Regency, the selected samples or subjects are children aged 24-60 months who meet the inclusion criteria. The subjects were divided into 2 groups, namely the treatment group that received the test preparation for 4 months and the control group without the provision of the test preparation. Blood sampling was carried out simultaneously or simultaneously at the village hall with the help of trained analysts. The antioxidant parameters superoxide dismutase, catalase, glutathione peroxidase and free radical parameters Nitric oxide and malondialdehyde. The data obtained will be analysed using an independent t-test. Results: The results of the study on 50 stunted children showed low levels of Superoxide Dismutase, Catalase, Glutathione peroxidase, and free radical parameters Nitric oxide and Malondialdehyde were obtained high. This means that stunted children experience oxidative stress. There was significant antioxidant effectiveness with increased levels of SOD and Catalase in the treatment group (P<0.05), a decrease in NO and MDA in the treatment group (P<0.05) compared to the control group. Conclusion: Temulawak-black cumin honey preparation has activity to reduce oxidative stress in stunted children in Cirebon.
PREDIKSI TOKSISITAS, ANALISIS ADME DAN DOCKING MOLEKULER ASIATICOSIDE TERHADAP PENGHAMBATAN ANGIOTENSIN CONVERTING ENZYME: TOXICITY PREDICTION, ADME ANALYSIS AND MOLECULAR DOCKING OF ASIATICOSIDE AGAINST ANGIOTENSIN CONVERTING ENZYME INHIBITION Capritasari, Rafiastiana; Akrom, Akrom; Setianto, Arif Budi; Putri, Meilisa; Hasna, Elly Rosita; Astuti, Febriana
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2411

Abstract

The presence of risk factors related to the severity of cardiovascular disease is a key consideration in adjunct therapy as an immunostimulant.One of the plants with potential as a cardioprotective immunostimulant is pegagan.Asiaticoside in pegagan leaves can inhibit AT1R and reduce NF-κβ activity.This study aims to predict the interaction of ligands with the receptor of cardioprotective immunostimulant agents.This study uses Molecular Docking simulations with molecular docking using Autodock Tools 1.5.6 and visualization using BIOVIA Discovery Studio Visualizer 24.1.The target macromolecule used is AT1R (PDB 4ZUD) which was downloaded from the PDB.The molecular docking parameters were analyzed based on binding energy.Pharmacokinetic characteristics were evaluated using the SwissADME tool.The binding result of the test ligand molecule to AT1R is -4.50 ±0.595 kcal/mol. The reference ligand has an AT1R binding value of -7.74±0.036 kcal/mol. Validation of the molecular docking method has an RMSD value of 1.857±0.356 Å. The toxicity prediction of the compound Asiatikoside at LD50 4000mg/kg and pharmacokinetic analysis were conducted using the boiled-egg method, which indicates that  Asiatikoside is predicted cannot cross the blood-brain barrier. The ADME prediction results show that the Asiatikoside has 3 parameters that do not meet the bioavailability parameters, namely a molecular weight of 959.12g/mol, TPSA polarity of 315.21A, and flexibility of 10. Conclusion Asiaticosides is predicted to have limitations in terms of oral bioavailability, so special formulations such as nanoencapsulation techniques are needed to help improve its bioavailability Keywords:  Asiaticosides; ACE Inhibition; Molecular Docking
Co-Authors - Sagiran Aa Setiawan Abas, Siti Nur Rahmatiya Abdelghani Echchabi Abdul Aziz Abdul Fat-Han Ismail Abdul Hamid Abdullah Ayedh abdurrahman rahman Ade Permatasari Adeliyanti Adeliyanti Adhy Kurnia Triatmaja Aditya Peramana Maheztra Adnan Adnan, Adnan Adrianison Adrianison Ae Suaesih Afif Alwanuddin Afifah Naziihah Afrizal Afrizal Agamasi, Amalia Agariadne Dwinggo Samala Agesti Hasna Ekawati Agita, Adinda Puspa Agnes Jatiningrum Agung Wibowo Agus Khobir Permana Agus Wibowo Agustina Susilowati Agustina Susilowati Agustyana, Andini Ahmad Bahruddin Ahmad Hafidzul Kahfi Ahmad Suryadi, Ahmad Ahmad Turmudzi Ahmad Turmudzi, Ahmad Ainun Muthoharoh Ainun Rahma Firdausy Ajeng Dianing Kartika Aji, Dicky Qulyubi Akhmad Baihaqi Akmal Hakim Ali Akbar Ali Imron Alif Darmawan Alifah Fidela Allen Pranata Putra Alvenus Willim, Herick Amalia, Farah Amalia, Nur Rizky Amaliyah Tazkiyah Amandha Boy Timor Aminuyati Amir M. Suruwaky Amiruddin Saleh Anak Agung Ayu Sisthayoni Anak Agung Ngurah Yusa Darmadi Ananda, Dhea Andang Adi Fitria Hananto Andi Baso Thabrani Andi Ifriani Harun Andi Ifriani Harun* Andi Pancanugraha Andi Widjaya Andrew John Macnab Andriana Wihartantri Kusumaningrum Andrijono Andrijono Andriyanto Andriyanto Anestia Retno Kusumastuti Anggun Pulihana Wilujeng Anggy Rima Putri Aniq Astofa Anisa Nurfitriana Anita Dwi Putri Galla Annisa Eka Fitrianti Antonius, Rosanio Anwar, Muslih Aprilia Divi Yustita Apriliana Vivy Candra Ardhia Fefrine Indarta Ardianik Ardianik Ardiyanto, Restu Arhandy Arfah Ari Nurweni Ari Pramitha Suandi Ari Simbara Ari Simbara, Ari Arief Rahman Ariestya Indah Permata Sari Arif Budi Setianto Arif Hidayat Arif Santoso Arifan Q. Raharjo Arihni Arihatal Jannah Aris Purwanto Aristia, Bella Fevi Ariyani, Herda Arman Syah Putra Arman Syah Putra Armansyah T Arri Handayani Arsi Arsi Arsip Perangin angin Arum, Dinar Famora Ary Norsaputra Arya Adiningrat Aryadillah, Entus Aryan Sugara Asti Reswari Dewi Astofa, Aniq Aulia Farah Diba Aulia Uswatun Khasanah Auliya Salsabilla Azali, Aulia Syafadilla Baehaqi Bagus Haryadi Bambang Nolo Kresno Barnabas Bonardo Hana Christina Baso Mukramin Bastian Addy Sanjaya Bhisma Murti Billy Nugraha Bimo Eka Yudha Saputra Bisyri, Hanifah Bisyri, Hanifah Bowo Hery Prasetyo, Bowo Hery Brian Rinaldy Irsyad Budi Al Amin Budiyono Budiyono Budiyono Budiyono Burhannudin Ichsan Caesar Bagus Reyaldi Candra Agustina Canggih Puspo Wibowo Capritasari, Rafiastiana Chaerul Umam Wardani Chairul Amni, Chairul Christa A. M. Suares Christa Edo N Cindy Fransisca Citra Ariani Edityaningrum, Citra Clyde, Vierina Cut Kamilah Al Farhany Cut Morina Zubainur D, Harjanti P Daffa Satya W Danang Prasetyaning Amukti Danang Triagus Setiawan Darmawan, Endang David Yoga Pradana Dazrullisa Dazrullisa Dearmi Artis Dede Prasetyo Denda Sabrina Emily Dessy Lina Oktaviani Suendra Devi Nur Faddhila Silitonga Devina Ravelia Tiffany Subroto Dewa Ayu Putu Mega Puriani Dewa Bagus Sanjaya Dewantara, Putu Mas Dewantoro, Vandrias Dewi Apriani DEWI SHANTY Dewi Wulan Sari Dewi, Rissa Maharani Dian Yuliani Diantika, Sri Diari Indriati Didik Susetiyanto Atmojo Difa Maulina Syahidah Dimas Eko C Dimas Satrio Wibowo Dimas Sondang Dimas Sulistio Dini Mardhiyani Dini Novi Endah Sari Dini Nurlaela Dirgantara Fathurrizkie H Doni Marisi Sinaga Donny Nauphar Dr. Edy Sujana,SE,Msi,AK . Dr. Susilawati Susilawati Dwi Andayaningsih Dwi Haryoto Dwi Karti Handayani Dwi Marintan Marintan Dwi Prasetiyawati D.H. Dwi Utami Dwina Gustia Diary Dwining Handayani Dyah Anantalia Widyastari Dyah Aryani Perwitasari Dyah Respati Dyah Respati Suryo Sumunar Edisah Putra Nainggolan Edy Marsudi Edy Widayat Efi Astuti Eka Asih Putrina Taim Eka Nur Rahayu Eka Perwitasari Fauzi Elisabeth Patricia Febriani Jonison Elsa Nurdyah Puspitarini Elsye Gunawan Endang - Gunaisah Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Darmawan Endang Indrawati Endang S. R Enny Kusumawati Eny Enawaty Erlina Erna Listyaningsih Ernik Yuliana Erviana Erviana Ervizal A.M. Zuhud Erwan Arist yanto Ery Al Ridho Euis Meinawati Evy Aristawati Fadia Yuda M Fahira Fahmi Fahmy Abdul Haq Faisal Nur Arib Fajar Okta Widarta Fakhry Khotibul Umam Fandi Muhammad Nugroho Farhurohman, Oman Farida Fadlliatul Husna Farida Umamah FATIMAH FATIMAH fatimah Fatimah Fatmasari Sukesti Fatwa Hasbi Fauzia Liesly Anindya Fazrina Andriani Sakinah Lubis Feangi, Yanti Fitriani Febrian Hendra Kurniawan Febriana Astuti Fengky Satria Yoresta Fera Ibrahim Feri Anggita Hastanto Feri Anggita Hastanto Fery , Lasiyano A Fery Hardiana Fifia Chandra Fingki Marwati Firman Pribadi Fitri Apriliyani Fitri Nur Mahmudah Franklyn Hoek Fuad mas&#039;ud Galih Albarra Shidiq Galih Prakoso Galuh Tunjung Gde Made Swardhana Gede Adi Yuniarta, SE.AK . Gede Rhama Sukmayoga Wiweka Ghifary, Muhammad Irza Ginabila Ginabila Ginandjar Zukhruf Saputri Ginanjar Z. Saputri Ginanjar Zuhruf Saputri Golda Law S Grhanesia Denashurya, Tiara Gusti Arilaksono, Dwisetyo Gusti Fikrifauzi Alimmahiransyah H, Setijanen Djoko Haafizah Dania Habibis Saleh Hadimi Hadimi Hadiningrat, Ayunda Putri Hafiza Hafiza Hafizh Muhammad Noor Hamka Hakim Handayani - Hanif Rahman Adi Hansel Deltino Bandaso haq, Nasrul Hari Wisodo, Hari Harjanti P D Hartati, Meity Hasna, Elly Rosita Hasriati Hasriati Hatip, Ahmad Hegar Nurjannah Hendajany, Nenny Henny Nuraini Heny Kristanto Herizka Ayuk Arviani Herlin Widasiwi Setianingrum Herman Dwi Surjono Herman Lusa Heru Kuswanto Hery Murnawan, Hery Hestiningtyas Yuli Pratiwi Hikmatul Mustagfiroh Hikmatul Mustaghfiroh Hilda Rachmi hilmi, hilmi herawati Hipmi, Ahmad Fahrian Hiya Nalatissifa Husna Amalya Melati I Gede Dion Raharja I Gede Made Krisna Dwi Putra I Gusti Agung Komang Diafari Djuni Hartawan I Gusti Bagus Eka Pramana Putra I Gusti Ketut Ariawan I Gusti Ngurah Agastya I Gusti Ngurah Edi Putra I Gusti Ngurah Parwata I Gusti Putu Bagus Sasrawan Mananda I Kadek Satrya Budhi Prabawa I Ketut Mertha I Ketut Rai Setiabudhi I Komang Oka Wijaya Kusuma I Made Gardita Sardana I Made Haribawa Setiawan I Made Tjatrayasa I Nyoman Sudiarta I Putu Diland Agustya Sandika Putra I Putu Pande Eka Krisna Yoga I Wayan Agus Slamet I Wayan Kartika Setiawan Ibrahim Ibrahim Ice Wirevenska Ichwan Ridwan Rais Ida Bagus Made Widyasmara Ida Bagus Surya Dharma Jaya Ignatius Soni Kurniawan Ihsany Arafiasetyanto Prihadi Ika Amalia Kartika Ika Mardiatul Ulfa Ika Parma Dewi Ikhsan Ikhsan Illah Sailah Imam Nawawi Imam Riadi Imam Syahrobani In'am Ilmiawan, Muhammad Indah Nirwana Akay Indang Julita Indita Dwi Ariani Indra Bayu Mulyadi Indrayanti, Indrayanti Indrayanti, Indrayanti Indri Nurasa Ipung Ardiansyah Ira Lestari Irawan Sukma Irawan Sukma, Irawan Irma Erviana Irma, Risdiana Irmanwidjasmara, Dzikri Irna Faradila Isabella Meliawati Sikumbang Ismi M.Idris Istri Bartini Ivan Andalenta Ivana Aprilia Pratiwi Iwandikasyah Putra Izze Afkarina Jajuk Herawati Janti Sudiono Jantje B. Mangare Jatiningrum, Agnes Jenny Buckworth Joko Dwi Santoso Joko Sudibyo Joko Sudibyo Juhji, Juhji Julita, Julita Kahar, Muhammad Syahrul Kamid, Kamid Karjiyem Karjiyem Karmeliya Firdaus, Mila Karmilasari Keshia Kristin Ketut Adi Riantara Khairul Asri Khairul Saleh Khairul Yadi Khairuni Ismu Khusnul Dwi Istnaini Kinanti, Putri Kintoko Kintoko Koesoemo Ratih Krisna Dewi Kuriasari Pratiwi Kurniawan, Nurcholid Umam Kusdiyanto Kusdiyanto Kusumawardani, Nurul Kyswantoro, Yunita Firdha La Ifa Laela Hayu Nurani Laila Nuranna Laili Apriani Lalu Muhammad Irham Lathifah, Sofiani Leni Susanti Lestari Yusuf Lia Nurmalia Lia Riani Liana Mangifera Liesma Yuhelvia Lilis Suryani Lin Suciani Astuti Lina Karlinasari Linda Lestari Loisa Ratna Yuvita Olla Luh Gede Leli Kusuma Dewi Luh Putu Ratna Sundari Lukman Hardia Luky Septiansyah Anjastika M Amar M Arvin Nugroho M. Ikhsan Made Antara Made Dian Shanti Kusuma MADE KUSUMA NEGARA Made Oka Ari kamayani, Made Oka Ari Mahendrawan Nugraha Aji Pratama Malya Veda Rosenna Maman Suryaman Mamluatun Ni’mah Maretalinia MARIA BINTANG Mariana Mariana Marina Ayu Viniriani Markus Suryoutomo Marstyawan Marstyawan Marstyawan Marstyawan Marstyawan, Marstyawan Marwati, Fingki Mary Ismowati Mas'ud, Fuad Mashadi Mashadi Masriani . Mayta Novaliza Isda Ma’rifah Ma’ruf Ma’ruf Megawati Megawati Mei Haryono Meilan Meilan Meilan Meilan, Meilan Meilan, Meilan Meiliawati, Fithri meirisa sahanata Meisi Nur Seratih Meiva Eka Sri Sulistyawati Melania Regina Ao Melisa Rizki Mentari Eka Wahyuni Meri Meri Mgs Afriyan Firdaus Misbachul Munir Misbah Sururi Mochammad Abdul Azis Mochammad Imron Awalludin Mohammad Anshori Mohammad Syamsul Azis Monita Destiwi Mubarika Mubarika Mubarika Mubarika Mubarika, Mubarika Muchamad Arif Budiyanto Mudinillah, Adam Mufidah Mufidah Mufidah, Syarifatul Muh Muhlis, Muh Muh Suryono MUHAMMAD AGUS SUPRAYUDI Muhammad F Aziz Muhammad Fahmi Johan Syah Muhammad Faittullah Akbar Muhammad Fikri Muhammad Irza Ghifary Muhammad Izzul Fikri Noor Muhammad Japar Muhammad Kadafi Muhammad Miftah Muhammad Muhlis Muhammad Nuh Muhammad Ridza Muhammad Sabilal Muhajirin Muhammad Wahyu Firmansyah Muhammad Wahyu Romadhon Muhammad Yani Muhammad Yusron Maulana El-Yunusi Muhammad Zainuri Mujib Mujib Munandar Munandar Munawar Khalil Munawar Muchlish Mundilarto Mundilarto Muniroh Munawar Murtini Murtini Mushlihudin Mushlihudin Mustasim, Mustasim Mustofa Mustofa Mustofa Mustofa Mustofa, Mustofa N. Widodo N., Yusro Edy Nadhira Handayani Nadiya Assyfa Nadiya N Afifah Nadya Amalia Nadya Laurencya Nafiah, Mufidatun Najelita, Athiyah Nanik Sulistyani Naresworo Nugroho Nawan Primasoni Nazariah Nazariah Neni Probosiwi Ni Kadek Ayu Marini Sarasdiyanthi Ni Luh Putu Eva Yanti Ni Wayan Kesari Dharmapatni Nice Maylani Asril Nining Lestari Ninuk Sri Sunarsi Noer Fauziah Rahman Norma Tiku Kambuno Nugraha, Asep Erik Nungky Angginia Ningrum Nunuk Irawati Nunuk Suryani Nur Arib, Faisal Nur Azizah Syahrana Nur Fadilah Bakri Nur P, Kanindya Nur Prasetyawan Nur Rizky Amalia Nurani Siagian Nurcholid Umam Nurcholid Umam Kurniawan Nurdin, Kuntum Ekawati Nurfadilah Nurfadilah Nurhasanah Nurhasanah Nurhidayati Nurhidayati Nuril Maulida Nurkhasanah Nurkhasanah Nurkhasanah Nurlaelatul Maulidah Nurlaelatul Maulidah Nursafiah, Nursafiah Nursamsiar Nursamsiar Nurul Aisyah Nurul Hidayah Nurul huda Nurul Huda Nurul Liana Herianti Nyemas Hidayati Nyoman Sridana Okta Amelia Okta Muthia S Okta Muthia Sari Okta Mutia Sari Olly S. Hutabarat Olyvia Wulan Kencana Ony Hardoko P Priatno Pacu Putra Palupi, Endah Pamuko Aditya Rahman Permana, Muki Satya Permatasari, Ade Pertiwi , Deasy Vanda Pichpisith Pierre Vejvisithsakul Pingkan A. K. Pratasis Po-Hao Chang Prasasti Bintarum Prasetyawan, Nur Prayogi Pakpahan, Simon Prihadi Prihadi Prita Anggraini Kartika Sari Priyadi, Andi Puput Kusumawardani Moehas Purbayu Budi Santosa Purnomo . Purwaningrum, Prapti Wigati Purwoko, Agus Puspa A Pitayati Puspitasari, Alvina Arum Puspitosari D Putri Prica Salsabila Putri Sekar Sari Putri, Meilisa Qoriati Mushafanah R.R Moekarni Raafqi Ranasasmita Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Rachmat Sahputra Rachmayani, Tantri Raden Mohamad Herdian Bhakti Rafiastiana Capritasari Rahmah Johar Rahmat Rasmawan Rahmayati Rahmayati Rahmi Nurhaini, Rahmi Rajab, Muhammad Andy Rana Dhiya Fadhilah Rani Dewi Pratiwi Ratna Wahyu Pusari . . Reny Diah Lestari Resi Febriyanti Resi Yudhaningsih Resti Yuliarni Restu Dwi Nugraeni Retnaningdyastuti . Revis Asra Reynaldi Nurikhsan Gustiana Putra Rezika Meliza Riadini Wahyu Utami Riana Dyah Wijayanti Ricky Alexander Samosir Rida Kurnia Hijriani Ridho, Ery Al Riduwan Riduwan Rifqi Abdul Fattah Riki Supriyadi Rinah Rinah Rini Andriyani Rini Muharini Rintis Rizkia Pangestika Rio Tirta Sudarma Rio Wirawan Ririn Apriani Ririn Ariesty Ririn Safitri Risa Wati - AMIK BSI Tasikmalaya Risa Wati - AMIK BSI Tasikmalaya Risdiandri Iskandar Riska Novitasari Rismawati Rasyid Rissa Maharani Dewi Riyanto Riyanto Riza Adrianti Supono Riza Alfian Rizka Agustine Rizka Novia Atmadani Rizky Budi Santoso Rizma Nurfadjrin Rochim Suratman Rody Putra Sartika Rohidin Rohidin Rosenna, Malya Veda Rosikhul Islah I Rosy Hutami Rosye H.R. 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