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Discovery : Jurnal Ilmu Pengetahuan Jurnal Ilmiah Ar-Risalah: Media Ke-Islaman, Pendidikan, dan Hukum Islam Al-Syakhshiyyah : Jurnal Hukum Keluarga Islam dan Kemanusiaan JES (Jurnal Ekonomi Syariah El-Qist : Journal of Islamic Economics and Business (JIEB) Indonesia Berdaya Akrab Juara : Jurnal Ilmu-ilmu Sosial STUDI PELAKSANAAN SELFMEDICATION PADA PENDERITA DIARE BERDASARKAN TINGKAT PENGETAHUAN MASYARAKAT PESISIR KECAMATAN SOROPIA KABUPATEN KONAWE Community Empowerment Jurnal Teknologi Pertanian Gorontalo Management of Zakat and Waqf Journal (MAZAWA)) Al-Sharf: Jurnal Ekonomi Islam INTAJUNA: Jurnal Pendidikan, Pengajaran, Bahasa, dan Sastra Arab Jurnal Ilmiah Wahana Pendidikan Kalbiscientia Jurnal Sains dan Teknologi Devotion: Journal of Research and Community Service Jurnal Simki Pedagogia VARIA HUKUM: Jurnal Forum Studi Hukum dan Kemasyarakatan JPUA: Jurnal Perpustakaan Universitas Airlangga: Media Informasi dan Komunikasi Kepustakawanan Jurnal Abdi Masyarakat Indonesia Al-Idaroh: 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for the Partnership Agreement Parties Jurnal El-Thawalib Media Didaktika Jurnal Bisnis Manajemen dan Akuntansi Jurnal Pengabdian Masyarakat Bhinneka PKM Linggau: Jurnal Pengabdian dan Pemberdayaan Masyarakat Al-Idarah : Jurnal Manajemen dan Bisnis Islam International Journal of Educational Research Excellence (IJERE) Pedagogika: Jurnal Ilmu-Ilmu Kependidikan Indonesian Research Journal on Education Al-Hukmi : Jurnal Hukum Ekonomi Syariah dan Keluarga Islam Innovative: Journal Of Social Science Research Nanggroe: Journal Of Scholarly Service Jurnal Manajemen dan Penelitian Akuntansi (JUMPA) SABAJAYA Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Bangsa HIKMATUNA: Journal for Integrative Islamic Studies Medical and Health Journal Global Education Journal Wahana Pedagogika: Jurnal Ilmiah Pendidikan dan Pembelajaran ISLAMICA : Jurnal Ilmu-Ilmu Agama Islam Nanggroe: Journal of Scholarly Service APPA : Jurnal Pengabdian Kepada Masyarakat ABDIMASY: Jurnal Pengabdian Kepada Masyarakat Journal of Community Service and Society Empowerment Mazinda: Jurnal Akuntansi, Keuangan, dan Bisnis Welfare State Jurnal Hukum Hikmatuna JEBD Journal of Financial, Business and Economics Jurnal Bakti Masyarakat Manajemen Jurnal Media Akademik (JMA) AB-JOIEC: Al-Bahjah Journal of Islamic Economics Al-Kharaj: Jurnal Ekonomi, Keuangan & Bisnis Syariah Da'watuna: Journal of Communication and Islamic Broadcasting Jurnal Pengabdian Masyarakat Journal of International Multidisciplinary Research jabdimasunipem Iltizam : Jurnal Ekonomi dan Keuangan Islam Ta'dibiya: Jurnal Agama dan Pendidikan Islam Journal of Islamic Law (EJIL) Ar Rehla: Journal of Islamic Tourism, Halal Food, Islamic Traveling, and Creative Economy The International Journal of Medical Science and Health Research International Journal of Mechanics, Energy Engineering and Applied Science (IJMEAS) Al-Idaroh Tadibiya; Jurnal Agama dan Pendidikan Islam Lempuk: Jurnal Ilmu Kelautan dan Perikanan Linggamas: Jurnal Pengabdian Masyarakat IKRAM: Jurnal Ilmu Komputer Al Muslim Indonesian Journal of Pharmacology and Therapy Journal of Industrial and Syariah Economics Jurnal Cendekia Ilmiah Madania: Jurnal Kajian Keislaman Parewa Saraq: Journal of Islamic Law and Fatwa Review Jurnal El-Thawalib Sultra Journal of Mechanical Engineering Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Journal of Management Al-Infaq : Jurnal Ekonomi Islam Journal of Community Development Diversity IZZI: Jurnal Ekonomi Islam Qiyas : Jurnal Hukum Islam dan Peradilan An-Nisa’ Journal of Gender Studies
Mustofa Mustofa
Departement of Pharmacology, Faculty of Medicine, University Gadjah Mada, Yogyakarta
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Fertigasi Otomatis Nirdaya Berbentuk Jaring Laba-laba (Lingko) Abas, Rizan; Mustofa, Mustofa; Hariadi, Hariadi; Akuba, Syamsu
JTPG (Jurnal Teknologi Pertanian Gorontalo) Vol 10 No 2 (2025): Jurnal JTPG (November)
Publisher : PROGRAM STUDI MESIN DAN PERALATAN PERTANIAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30869/jtpg.v10i2.1539

Abstract

Pertanian Indonesia menghadapi tantangan berupa keterbatasan air, perubahan iklim, dan tuntutan peningkatan efisiensi produksi. Teknologi fertigasi menjadi salah satu solusi yang mampu meningkatkan pemanfaatan air dan nutrisi secara presisi. Penelitian ini bertujuan merancang dan mengevaluasi kinerja sistem fertigasi otomatis nirdaya berbasis desain lingko yang memanfaatkan gaya gravitasi tanpa kebutuhan energi listrik. Sistem dirancang menggunakan drum penampung berkapasitas 80 L, pipa PVC berbagai ukuran, serta mekanisme pengontrol ketinggian air otomatis. Tanaman uji adalah kangkung darat (Ipomoea reptans), dengan parameter pertumbuhan meliputi tinggi tanaman, panjang batang, panjang helai daun, dan jumlah daun selama periode 32 hari. Hasil penelitian menunjukkan bahwa desain fertigasi nirdaya berbentuk lingko mampu mendistribusikan air dan nutrisi secara relatif merata ke seluruh ring. Rata-rata tinggi tanaman berada pada kisaran 17,9-18,1 cm, panjang batang 12,5-12,8 cm, panjang helai daun 6,5-6,8 cm, serta jumlah daun 9-11 helai. Ring 1 menunjukkan keunggulan pada pembentukan daun, Ring 2 pada pemanjangan batang, sementara Ring 3 memberikan pertumbuhan yang stabil. Variasi antar ring dipengaruhi oleh jarak distribusi, perbedaan tekanan aliran, serta faktor lingkungan seperti intensitas cahaya dan kondisi media tanam. Temuan ini membuktikan bahwa sistem fertigasi otomatis nirdaya berbasis desain lingko efektif, hemat energi, dan berpotensi menjadi teknologi tepat guna untuk pertanian berkelanjutan, khususnya pada daerah dengan keterbatasan akses energi listrik. Pengembangan skala lebih luas dan pengujian pada komoditas lain direkomendasikan untuk meningkatkan potensi penerapannya dalam sistem budidaya modern.
PEMBERDAYAAN PENGURUS BUMDES MELALUI PELATIHAN KETERAMPILAN MANAJERIAL UNTUK MENINGKATKAN EFEKTIVITAS PENGELOLAAN DESA Wahyuni, Daru; Mustofa, Mustofa; Ngadiyono, Ngadiyono; Wardani, Nita Kusuma; Puspitaningrum, Yuliastuti
Jurnal Pengabdian Masyarakat AbdiMas Vol 12, No 2 (2025): Jurnal Pengabdian Masyarakat Abdimas
Publisher : Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/abd.v12i2.10219

Abstract

AbstractThis Community Service (PkM) activity aims to improve the managerial capacity of the Bergas Village-Owned Enterprise (BUMDes) management in Klaten Regency, enabling them to manage the organization professionally, effectively, and sustainably. This program was motivated by the problems of low managerial skills, suboptimal financial management, and minimal use of digital technology in BUMDes operational activities. The implementation method included an initial survey, problem formulation with partners, three days of intensive training, and six months of follow-up mentoring. The training materials focused on three main aspects: preparing digital financial reports, developing human resource soft skills, and digital marketing strategies. The results of the activity showed a significant increase in the participants' ability to prepare application-based financial reports, communicate effectively within the organization, and utilize social media to promote village products. The activity evaluation also showed that 83% of participants understood the material very well, and 75% stated that the training materials were very useful. This program succeeded in improving the professionalism of BUMDes management, strengthening accountability and transparency in financial management, and expanding the digital-based marketing network. Thus, this activity significantly contributes to supporting the achievement of the Sustainable Development Goals (SDGs), particularly in reducing inequality and improving the welfare of rural communities through local economic empowerment. Kata kunci: Community empowerment, Village-Owned Enterprises (BUMDes), managerial skills. AbstrakKegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk meningkatkan kapasitas manajerial pengurus Badan Usaha Milik Desa (BUMDes) Bergas, Kabupaten Klaten, agar mampu mengelola organisasi secara profesional, efektif, dan berkelanjutan. Program ini dilatarbelakangi oleh permasalahan rendahnya kemampuan manajerial, kurang optimalnya pengelolaan keuangan, dan minimnya pemanfaatan teknologi digital dalam kegiatan operasional BUMDes. Metode pelaksanaan meliputi survei awal, perumusan masalah bersama mitra, pelatihan intensif selama tiga hari, serta pendampingan lanjutan selama enam bulan. Materi pelatihan difokuskan pada tiga aspek utama, yaitu penyusunan laporan keuangan digital, pengembangan soft skill sumber daya manusia, dan strategi pemasaran digital. Hasil kegiatan menunjukkan peningkatan signifikan dalam kemampuan peserta menyusun laporan keuangan berbasis aplikasi, berkomunikasi secara efektif dalam organisasi, serta memanfaatkan media sosial untuk promosi produk desa. Evaluasi kegiatan juga menunjukkan bahwa 83% peserta memahami materi dengan sangat baik, dan 75% menyatakan bahwa materi pelatihan sangat bermanfaat. Program ini berhasil meningkatkan profesionalisme pengurus BUMDes, memperkuat akuntabilitas dan transparansi pengelolaan keuangan, serta memperluas jaringan pemasaran berbasis digital. Dengan demikian, kegiatan ini berkontribusi nyata dalam mendukung pencapaian tujuan pembangunan berkelanjutan (SDGs), khususnya pada aspek pengurangan kesenjangan dan peningkatan kesejahteraan masyarakat desa melalui pemberdayaan ekonomi lokal. Kata kunci: Pemberdayaan masyarakat, BUMDes, keterampilan manajerial.
KIPRAH KIAI DALAM MEMBENTUK KARAKTER AKHLAKUL KARIMAH DI PONDOK PESANTREN Mustofa; Siti Aimah
Jurnal Media Akademik (JMA) Vol. 4 No. 1 (2026): JURNAL MEDIA AKADEMIK Edisi Januari
Publisher : PT. Media Akademik Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62281/61ddnn28

Abstract

Artikel ini menganalisis kiprah strategis kiai sebagai figur sentral dalam pembentukan karakter akhlakul karimah santri di pondok pesantren. Penelitian ini menggunakan pendekatan kualitatif-deskriptif melalui studi literatur yang diperkaya dengan kerangka teoritis pendidikan pesantren dan kepemimpinan Islam. Hasil kajian menunjukkan bahwa transformasi karakter santri berlangsung melalui tiga pilar utama, yaitu keteladanan (uswatun hasanah), internalisasi prinsip adab sebelum ilmu, serta sistem pengabdian (khidmah) yang terintegrasi dalam kehidupan sehari-hari pesantren. Kiai berperan sebagai living curriculum yang memadukan otoritas keilmuan, spiritualitas, dan kepemimpinan karismatik dalam membentuk integritas moral santri. Di era disrupsi digital, kiai juga menjalankan fungsi strategis sebagai kurator kebenaran dengan menanamkan budaya tabayyun, literasi digital berbasis akhlak, serta penguatan riyadhah untuk merespons tantangan dekadensi moral, hoaks, dan hedonisme digital. Sinergi antara tradisi spiritual pesantren, kewibawaan kiai, dan kemampuan adaptasi terhadap modernitas menghasilkan santri berkarakter moderat, berintegritas, dan berdaya tahan tinggi sebagai modal sosial penting bagi pembangunan karakter bangsa.
ANALYSIS OF THE COMPLIANCE OF SELABINTANA TOURIST PARK MANAGEMENT WITH THE DSN-MUI FATWA ON SHARIA TOURISM Rahayu, Sri; Mustofa, Mustofa; Nasrudin, Nasrudin; Jaenuddin, Jaenuddin; Hidayat, Agi Attaubah
Ar Rehla: Journal of Islamic Tourism Halal Food Islamic Traveling and Creative Economy Vol. 5 No. 2 (2025)
Publisher : Faculty of Islamic Economic and Business - Universitas Islam Negeri Sayyid Ali Rahmatullah Tulungagung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21274/ar-rehla.v5i2.11611

Abstract

Abstract: Selabintana Tourism Park has the potential to become a sharia-complient tourism destination as per DSN-MUI fatwa No.108/2016. Although it does not have binding legal force, this fatwa remains the main reference in the development of halal tourism in Indonesia. This study aims to analyze the implementation of the sharia tourism fatwa at Selabintana Tourism Park, Sukabumi Regency. The study uses a qualitative method with an empirical juridical approach. Data collection techniques were carried out through observation and interviews with tourism managers. The study reveals that Selabintana Tourism Park has implemented saveral principles of sharia tourism, including the provision of worship facilities, halal culinary products, environmental cleanliness, separate of sanitation facilities for men and women, and efforts to avoid activities that conflict with sharia. However, implementation has not been fully optimized due to the limited understanding of managers and the community regarding the concept of halal tourism, the absence of regional policies supporting halal tourism certification, and the lack of integration of sharia values into the destination management system. Collaboration with the Halal Product Guarantee Agency (BPJPH) is necessary to strengthen education, collaboration, and branding strategies in realizing sharia tourism. Keywords: fatwa of the indonesian ulema council (mui), sharia tourism, selabintana tourist park Abstrak: Taman Wisata Selabintana berpotensi menjadi pariwisata syariah yang berpedoman pada fatwa DSN-MUI No.108/2016, meskipun tidak memiliki kekuatan hukum yang mengikat, fatwa ini tetap menjadi referensi utama dalam pengembangan wisata halal di Indonesia. Penelitian ini bertujuan untuk menganalisis implementasi fatwa pariwisata syariah di Taman Wisata Selabintana, Kabupaten Sukabumi. Penelitian menggunakan metode kualitatif dengan pendekatan yuridis empiris. Teknik pengumpulan data dilakukan dengan observasi dan wawancara terhadap pengelola wisata. Penelitian menunjukkan bahwa Taman Wisata Selabintana telah menerapkan sebagian prinsip pariwisata syariah, antara lain penyediaan fasilitas ibadah, kehalalan produk kuliner, kebersihan lingkungan, pemisahan fasilitas sanitasi antara laki-laki dan perempuan, serta upaya menghindari aktivitas yang bertentangan dengan syariah. Namun, implementasi belum sepenuhnya optimal karena keterbatasan pemahaman pengelola dan masyarakat mengenai konsep wisata halal, belum adanya kebijakan daerah yang mendukung sertifikasi wisata halal, serta belum terintegrasinya nilai-nilai syariah ke dalam sistem manajemen destinasi. Kolaborasi dengan Badan Peneyelenggara Jaminan Produk Halal(BPJPH) diperlukan untuk penguatan edukasi, kolaborasi serta strategi branding untuk mewujudkan pariwisata syariah. Kata Kunci: fatwa dsn-mui, pariwisata syariah, taman wisata selabintana
PENGARUH KUALITAS TIDUR TERHADAP TINGKAT PRODUKTIVITAS MAHASANTRI DI LINGKUNGAN LEMBAGA TINGGI PESANTREN LUHUR MALANG Natasyah Asviana; Mustofa; Yasri Rahmawati; Tsaabitah Jihaan Sabrina; Ayesa Zahwa Amelia; Aditia Dhani Mustofa
Jurnal Studi Pesantren Vol. 6 No. 1 (2026): Jurnal Studi Pesantren
Publisher : Pascasarjana Universitas Al-Qolam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35897/studipesantren.v6i1.1847

Abstract

Sleep is a primary need that plays an important role in maintaining body functions to continue to run properly. The density of daily activities and rhythms in the Islamic boarding school environment often requires good time management. However, in reality, rest patterns and sleep quality are less noticed, such as sleeping late at night because of college assignments, organizational activities or committee activities that become routine. This study aims to analyze the relationship between sleep quality and the productivity of collage students at the Luhur Malang Islamic Boarding School. This study uses a quantitative observational analytical research type with a cross-sectional approach that was carried out in May 2025 at the Luhur Malang Islamic Boarding School. The number of samples successfully collected in this study was 90 collage students. The data obtained were then processed by calculating the average value of each variable (sleep quality and productivity) and then a correlation was carried out between the two. The average value is then divided into three levels, namely: low (1.00-2.99), medium (3.00-3.99), and high (4.00-5.00). Then the Pearson correlation test was carried out using statistical software, namely SPPS. The results obtained for the low sleep quality category were 61 people (67.8%), and 29 people (32.2%) with a correlation coefficient of the two variables of r = 0.988 with a significance value of p = 0.001. This means that there is a positive relationship between sleep quality and productivity levels. This has a direct impact on sleepiness in the morning. As a result, poor sleep quality is one of the causes of decreased collage student productivity.
STRATEGI INFLUENCER MARKETING SEBAGAI UPAYA OPTIMALISASI BRAND AWARENESS DAN MINAT BELI KONSUMEN WARDAH Salsabila Imarotul Maftuhah; Mustofa
Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Vol. 1 No. 6 (2025): Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah (Bulan Desember 2025)
Publisher : PT. Saha Kreasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64788/ar-rasyid.v1i6.253

Abstract

This study explains whether influencer marketing can be used as the most effective brand awareness strategy in increasing consumer interest in Wardah products. This research uses a qualitative method with a library research approach taken from scientific articles and scientific journals about Halal cosmetics and skincare in Indonesia. The results of the study show that influencer marketing can increase brand awareness through several mechanisms, namely influencer credibility, authenticity of content, visual appeal, and influencer informative that attracts consumer buying interest. This study found that Wardah brands in their Wardah products need to choose credible influencers, provide educational content in marketing Wardah products.
Digital post-harvest transformation: Implementing IoT-based grain drying to enhance farmer welfare in Ngarum Village Mar’atullatifah, Yulaikha; Iswavigra, Dwi Utari; Wicaksono, Nicky Gilang; Prasetyo, Deny; Suyahman, Suyahman; Wicaksono, Ardy; Mursalim, Mursalim; Mahmudah, Himmatunnisak; Mustofa, Mustofa; Faruq, Muhamad; Puspasari, Novela Putri
Community Empowerment Vol 10 No 11 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ngarum Village has a significant grain production potential of 43,459 tons per year, yet farmers face challenges with traditional drying processes that are vulnerable to sudden weather changes. This condition often leads to degraded grain quality and lower market prices. This community service program aims to increase productivity and economic value through the implementation of an Internet of Things (IoT)-based rain detection system. The methods include technical training, appropriate technology implementation, and continuous mentoring. Results indicate that IoT technology successfully maintains grain moisture at an optimal level of 14%, reduces post-harvest losses by 10%, and achieves an 80% adoption rate among farmers. Furthermore, the digitalization of farm management has increased the grain's selling price by 10%. The application of this technology has proven effective in improving post-harvest efficiency, enhancing harvest data accountability, and supporting sustainable farmer welfare.
Flavonoid synergy in antioxidant optimization: a study of Apium graveolens and Orthosipon stamineus Astuti, Febriana; Akrom; Setianto, Arif Budi; Hidayati, Titiek; Mustofa; Anwar, Muslih; Sun, Suny
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30599

Abstract

Oxidative stress, which arises by an imbalance among the formation of free radicals and the body's antioxidant defenses, is a pivotal factor in the pathogenesis of numerous degenerative abnormalities, comprising cardiovascular abnormality. Flavonoids, that are natural chemicals by antioxidant capabilities, have been identified as potential agents for protection against the adverse impacts of oxidative stress. The objective of this study was to ascertain the flavonoid substance of Apium graveolens and Orthosipon stamineus extracts and their antioxidant activity. The technique comprising qualitative and quantitative phytochemical tests to decide the flavonoid substance of the extracts. In addition, bioactive compounds were screened utilizing LC-HRMS, and antioxidant activity was evaluated utilizing the DPPH technique. The outcomes of this study drawn the presence of flavonoid compounds, alkaloids, tannins, and saponins in the Apium graveolens and Orthosipon stamineus extracts. The Orthosipon stamineus extract was found to contain steroid compounds. The screening of flavonoids compounds utilizing LC-HRMS has drawn the presence of the greatest diversity of flavonoid compounds in the Apium graveolens extract. The antioxidant activity assay employed quercetin as the standard, possessing an IC₅₀ value of 3.95 μg/mL. Apium graveolens extract exhibited an IC₅₀ value of 58.86±0.44μg/mL, Orthosiphon stamineus extract drawn an IC₅₀ value of 61.69±0.21 μg/mL, whereas the combined extract yielded an IC₅₀ value of 46.32±0.34 μg/mL. The outcomes indicate that the extract combination shows superior free radical scavenging ability compared to the individual extracts, suggesting its potential to enhance the antioxidant efficacy of bioactive compounds derived by herbal plants.
Implementasi Kuliah Kerja Nyata (KKN) Berbasis Pemberdayaan Partisipatif Untuk Pengembangan Berkelanjutan Masyarakat Desa Kloposepuluh Sukodono Sidoarjo Pranidya, Cici Dwi; Kholik, Muhammad Nurkholis; Yumna, Isna Aulia; Safitri, Anggi; Maslachah, Cholilatul; Sofiana, Elda; Aliyah, Faridatul; Isma, Khilyatul; Fajar, Muhammad; Mustofa, Mustofa; Sakinah, Nur; Aditama, Wahyu
ABDIMASY: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2025): Desember
Publisher : LPPM Institut Agama Islam Bani Fattah Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52431/abdimasy.v4i2.4253

Abstract

Pengabdian kepada masyarakat melalui Kuliah Kerja Nyata (KKN) merupakan wujud implementasi Tri Dharma Perguruan Tinggi yang mengintegrasikan teori akademis dengan kebutuhan riil masyarakat. Studi ini dilaksanakan di Desa Kloposepuluh, RW 02, Kecamatan Sukodono, Kabupaten Sidoarjo dengan tujuan meningkatkan kualitas pendidikan keagamaan, kesadaran lingkungan, dan pemberdayaan ekonomi melalui peran aktif mahasiswa. Metode yang digunakan melibatkan wawancara terstruktur, observasi, serta pendampingan langsung pada masyarakat dan pelaku UMKM. Hasil kegiatan menunjukkan peningkatan kemampuan membaca Al-Qur’an di Taman Pendidikan Al-Quran, penerapan teknik ecoprint dan edukasi literasi finansial di sekolah dasar, serta pendampingan penggunaan teknologi digital pembayaran QRIS dan pembuatan Nomor Induk Berusaha (NIB) bagi UMKM. Program KKN juga mempererat solidaritas sosial melalui kegiatan bersih-bersih masjid dan partisipasi aktif masyarakat dalam kegiatan rutin komunitas. Hasil pengabdian ini memberi dampak positif yang signifikan dalam berbagai aspek kehidupan masyarakat, memperkuat kapasitas lokal, dan mengembangkan peran mahasiswa sebagai agen perubahan yang berkontribusi pada pembangunan berkelanjutan desa.
Formulation Optimization and In Vitro Antioxidant Evaluation of a Polyherbal Nanosuspension Incorporating Apium graveolens, Centella asiatica, and Orthosiphon stamineus Astuti, Febriana; Akrom; Mustofa; Setianto, Arif Budi; Hidayati, Titiek
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.65-83

Abstract

Antioxidants play a crucial role in protecting cells from damage caused by free radicals, particularly reactive oxygen species (ROS). Herbal plants contain various bioactive compounds, such as phenolics, flavonoids, terpenoids, and alkaloids, which exhibit strong antioxidant properties to neutralize these harmful molecules. However, the bioavailability of these compounds is often limited due to their poor water solubility. Nanotechnology offers a promising solution, specifically through the development of nanosuspensions. This approach enhances the solubility of these compounds by reducing their particle size to the nanometer scale, thus improving absorption in the body. In this study, nanosuspensions were formulated using extracts from Apium graveolens, Centella asiatica, and Orthosiphon stamineus through a two-factor optimization approach with Design-Expert® version 13 software. The optimal formulation contained 25 mL of chitosan, 6 g of Tween 80, and 10 mL of sodium tripolyphosphate (Na-TPP), resulting in nanosuspensions with an average particle size of 220.00(1157) nm, a polydispersity index (PDI) of 0.59±0.06, and a zeta potential of −28.27±0.37mV. The antioxidant activity was evaluated using DPPH and ABTS assays. In the DPPH assay, the nanopolyherbal formulation showed an IC50 of 41.780(3064) μgmL−1, while the combined extract had an IC50 of 44.930(2989) μgmL−1. The ABTS assay revealed an IC50 of 28.21 μgmL−1 for the nanosuspension, significantly lower than the combined extract’s 54.22 μgmL−1. These results highlight the superior antioxidant activity of the nanosuspension, emphasizing the potential of nanotechnology to enhance the efficacy of bioactive compounds from herbal plants.
Co-Authors -, Nasiri A Halim A. Fitriani Abas, Rizan Abdilah, Ulil Absor Faiq Abdul Gofir Abdul Hakim, Al Hasan Abdul Kholik Abdul Manaf Ali, Abdul Manaf Abdul Rahim Abdul Rokhim Abdullah, Rizky Achmad Dinoto Achmad Sehan Ade Nur Rohim Ade Setiawan Adi Putranto, Hanafi Adika Suwarman Adisty Ridha Damasuri Aditama, Wahyu Aditia Dhani Mustofa Afib Rulyansah Agus Faisal Asyha Agus Luthfi Agus Pahrudin agus prasetyo aji Agus Sugiarto Agus Supriadi Agussalim Agussalim, Agussalim Agustin HP, Agustin Agustina, Feny Rizki Eka Ahmad Asrof Fitri Ahmad Hamim Sadewa Ahmad Khoirul Fata Ahmad Nouvel - AMIK BSI Purwokerto Ahmad Nouvel - AMIK BSI Purwokerto Ahmad Syaifuddin Romli Aini, Saqofa Nabilah Akhmad Akbar Susamto Akhwani Akhwani Akhwani, Akhwani Akrom, Akrom Akuba, Syamsu Al Hakim, Mahathir Muhammad Alatas, Haidar Alexis Valentin, Alexis Alfi Yasmina Alfinatus Zayyinah Alfiyah, Viny Alfiyantani Nugroho Ali Djamhuri Ali Ghufron Mukti Ali Muhson alimin alimin aliyah, faridatul Almurni, Muhammad Furqon Amri, Aini Nurul Andayani, Tri M. Andi Hairil Alimuddin Andi Namirah Muh. Syuaib AS, Andi Andini Hardiningrum Andrian Saputra Ange Desire Yapi, Ange Desire Angger Styo Yuniarti Anggraeni, Andi Sri Dewi Ani Widayati Ansori, Mukhamad Yusuf Anwar, Muslih Apriani, Hikma ARDIANSYAH, JEFRI Arfiani Nur Arief Agoestanto Arief Budiyanto Arif Budi Setianto Arif Budiman Arina Selawati Arini Arini Aristia, Bella Fevi ariyanti, firda aulia Arum Darmawati Arviyah, Vira Asep Kurniawan Asri Widowati Astuti, Rachma Darma Astuti, Rachmawati Darma Atikah, Ika Audita Nuvriasari Aufa, Mohammad Zidan Aula Ahmad Hafidh Saiful Fikri Awal Syahrani Sirajuddin Ayesa Zahwa Amelia AYU WULANDARI Azizah, Nuryana Elia B. Handoko Purwojatmiko Badrudin Baehaqi Baijuri Bambang Suhartono Baso Intang Sappaile, Baso Intang Basri Basri Bawazier, Lucky Aziza Bayu Prio Septiantoro Bayu Supriyadi Bonartua Hutapea, Edison Brilian, Dion Nicky Buchori, Muhamad Budi Sasomo, Budi Budi Tresnayadi Caesar Ananta Putra, Ihrom Catur Sugiyanto Chairil Anwar Chintyasari, Shaula Curatman, Aang Dadi Mahardi Dafitri, Rizkika Daniel Parenden, Daniel Danny Syamsu W Danto Danto, Danto Daru Wahyuni Dede Nurwahidah Dedy Wijaya Kusuma Desi Suci Handayani Dessy Susanti, Inggit Destita Shari Dewi Sadiah, Dewi Dewi Sulistiyarini Dewi, Wulan Rahma Dhina Fitriastuti Diana Diana Diana Dwi Astuti Djoko Wahyono Donant Alananto Iskandar, Donant Alananto Dwi Ferdiyatmoko Cahya Kumoro Dwi Puryanti Dwi Siswanta Dwi Widiastuti, Dwi Dyah Aryani Perwitasari Edy Turjono Eka Ary Wibawa Eko Budiono Ema Damayanti Emilia Vivi Arsita Emmy Hamidah Encep Taufik Rahman Endah Puji Septisetyani, Endah Puji Endang Darmawan Ending Solehudin Eriek Aristya Pradana Putra Erna Kristin Eti Nurwening Sholikhah Eva Rahmawati Evi Mulyani Evi Sunarti Antu Fadhilah, Putry Fahrezi, Fajar Fahrur Razi Faisal, Agus Faiz, Afiyatul Mahfudloh Fandi Dwi Imaniawan, Fabriyan Faqih, Muhammad Izzatul Faruq, Muhamad Fathur Rozi Fatmawati, Risdiana Andika Fauzi, Ghizela Fineartha Fazila, Nisa Febriana Astuti Febriansah , Rifki Febriyanto, Mohammad Fernanda Al Welery Fezzi Reri Fikri, Aula Ahmad Hafid Saiful Fitranto Arjadi Fredie Irijanto Gigih Hilmiawan Gilang Pratama Gumel, Salisu Gumel, Salisu Muhammad Gunawan Gunawan Gunawan Gusti Nyoman Budiadnyana Hadi, Aminulloh Hadi, Ismanurrahman Hafizah, Noor Haifah, Haifah Haitham Hanifah Yusuf Haqiqi, Adif Farhian Harahap, Arifuddin Muda Hariadi Hariadi Harini, Ika Murti Hariyadi, Ari HARIYANTO HARIYANTO Haryadi Hasan, Zainol Hastadi, Andre Yasip Hayatul Maspufah Heny Ekawati Haryono Heriyanto Heriyanto Herman Cahyo Diartho Heru Agus Cahyanto, Heru Agus Heru Purwanto Hidayat, Agi Attaubah Hidetaka Kawakita Hisam Ahyani Holil Houtman Huddin, Misba I Dewa Putu Pramantara Setiabudi I Nurol Aen Idris, Irma Surya Kumala Idris, M. Manshur IGP Suryadarma Iim Wasliman Iis Nur Asyiah Ika Puspita Sari Ilmiyah, Izzatul Imam Haryono Imam Sujono Indah Purwantini Indah Rahmawati Indra Utama Tanjung Indwiani Astuti Iqmal Tahir Irawan Irawan Irfansyah, Putra Irsyansyah, Irsyansyah Isa, Abdullah Iskandar Iskandar Iskandar Ritonga Isma, Khilyatul Isnaini Maulidatu Nisa Istajib Kulla Himmy Azz Istiqomah, Titis Iswavigra, Dwi Utari izza, Aqidatul Jaenuddin, Jaenuddin Jaka Suwita JAKA WIDADA Jamaludin, Jujun Jastria Pusmarani Jauharotur Rihlah Jayawarsa, A.A. Ketut Jeffry Julianus Jefry Tarantang Jenny Hidayat Jordy Lasmana Putra Jubaedah, Dedah Jumina Jumina Kartono, Munir Kasduni Keisuke Ohto Kennedy, Kennedy Khasanah, Uswatul Khoirul Fata, Khoirul Khoirun Nisa Khotib Khotib Khotib, Khotib Khusniyah, Siti Alfitrotul Kistiananingsih, Isti Kristian Selleng Kuncoro, Prasetyo Tri Kurani Mega Asteroid Kurnaesih, Uun Kurnia, Heri Kushariyadi Kushariyadi Kusuma, Nurul Rahmah Kusumasari, Dyah Kusumawati, Nyimas Inda Latif, Lita Asyriati Leo Soemardji Lilia Pasca Riani Listini Listini, Listini Lorettha Wijaya Losina Purnastuti Luluk Faridah Lutfiyani, Intan Qori M Rusdi M, Nurdiana M. Satrio Setia Budi Ma'ruf, Attabik Hasan Madani, Arya Indra Mafrudlo, Ahmad Mahfudzi Maftuh, Abdullah Maghfiroh, Annisatul Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahmudah, Himmatunnisak Maimun Sholeh Makki, Hali Malasari, Putri Nur Mansur, Zuhratul Aini Marhadi Saputro Mariani, Scholastika Marlinda, Dwi Marstyawan Marstyawan Mar’atullatifah, Yulaikha Maslachah, Cholilatul Masriani . Masrid Pikoli Maulina Diah Mawaddah Ar-Rochmah Mayasari, Dwika Maywan Hariono Medi, Gery Meirina Suci Ridha Melia, Anissa Dwi Melia, Annisa Dwi Meti Fatimah Mintarsih, Betty Mintarsih, Betty Misba Huddin Mislan Moh. As’ad Mohamad, Roni Mohammad Hakimi Muadib, Ihwanul Mubarika Mubarika Muchsin Muchsin Muflikhah, Khusnul Mufrida, Farah Fergi Muhammad Dala Rizfie Muhammad Fajar Muhammad Idham Darussalam Mardjan Muhammad Nur, Hidayat Muhammad Nurkholis Kholik Muharir, Muharir Muharromah, Gabriele Lailatul Mukammilah, Mukammilah Mukhlas, Oyo Sunaryo Mulyadi Mulyadi Mulyani Surendra Mulyono Mulyono Mumtaza, Alif Nafiatul Mun'im, Muhammad Hasan Munawar, Agus Muqoddaroh, Fadillatul Mursalim Mursalim mursid, fadillah Musaiyadi Musaiyadi Musawir, Musawir Musriatun Napiah Musri’ah, Musri’ah Mustofa, Ismail Muthi Ikawati Mutmainah, Naeli Muvita Rina Wati Nafi'ah, Nafi'ah Nahadia, Risna Nasiruddin, Atsir Faris Nasrudin Natasyah Asviana Naufal, Ahmad Maulidin Nazudin, Nazudin Nenden Susilowati NETTI KARIANI MENDOFA Ngadiyono Ngadiyono, Ngadiyono Nico Frederick Nisa, Shinta Khoirun Nisak, Sayida Khoiratun Nita Kusumawardani Nita Suleman Nofia Sari, Okta Noval Cahyo Triyanto Noventi, Iis Novita Carolia Nugraha, Raffy Ave Nur Fadillah, Nur Nur Rochmat Nur Sakinah Nur Signa Aini Gumilas Nuraini El Fajri Nurfaizah, Ani Nurhayati Nurhayati Nurhayati, Is Nuriman Nuriman, Agus Nurkolis Nurkolis, Nurkolis Nurmaulida, Regita Okti Nurrohman Nurrohman Nursari, Nina Nursyahira, Kasandra NURUL FAIZAH Nurul Hidayah Almubarokah Nuryani Nuryani Oktaviyah, Dayanti Paisal, M. Pakaya, Renaldi Pamudji, Rama Adistya Nurcahya Pamuraharjo, Hemi Pangestu, Herwindu Danu Parwanti, Sri Pasai, Muda Wali Samudra Pekerti UA, Pekerti Permatasari, Armita Pertiwi, Rini Wahyuning Phebe Hendra Piarah, Wahyu Haryadi Prabowo, Arif Agung Pranidya, Cici Dwi Prasetya, Dimas Prasetyo, Deny Prastiyo, Rian Pratama, Dinar Rezky Prihatin Oktivasari Probosuseno Probosuseno, Probosuseno Purwandari, Elce Purwanti, Nunik Puspa, Eka Septariana Puspasari, Novela Putri Puspitaningrum, Yuliastuti Putra, Haris Maiza Putri, Depi Putri, Nadia Tiara Putri, Vanesa Adelia Qodariyah, Niyar Ana R, Agam Bahtiar Rachel Turalely Rachmawati, Silvia Raharjo, Mugi Rahayu, Dewi Widiana Rahim, Abd Rahmadanti, Putri Rahmah, Suqya Rahmani, Mawardi Rahmani, Mawardi Rahmat Dani Rahmatulloh, Asep Rahmawati, Indriyani Dwi Rahmawati, Lilik Ratna Asmah Susidarti Ratna Asmah Susidarti Ratna Dewi Kusumaningtyas Refson Refson, Refson Reni Nurjasmi, Reni Retikasari, Frysca Virnanda Retno Murwanti Retno Wahyuningrum Rian Byhaqi Rias Gesang Kinanti Ridwan, Ahmad Hasan Ridwan, Vicky Bahru Rifky, Rifky Riyansyah Rizfie, Muhammad Dala Rofiq Sunaryanto Rohimah, Titi Rohma, Adelia Nur Rohmah, Ainun Roni Mohammad Royhan, Royhan Rukmana, Andi Rulyansyah, Afib Ruslin Hadanu Rusmana, Najwa Rokhan Rustan Hatib S Mursiti S Siswanto Sabirin Matsjeh Saepul Nugraha Safarudin, Muhamad Sigid Safitri, Anggi Safitri, Erica Meilia Said, Andika Pratama Said, Moch Imron Salim, Helmi Agus Salsabila Imarotul Maftuhah Salsabila, Anisah Fithriyyah Samekto Wibowo Samekto Wibowo Samsul Arifin Saptono Saputri, Adinda Rizky Eka Saputri, Ginandjar Zukhruf Sari, Elisa Mardita Sari, Nurita Sari, Rosyidah Hikmah Sariman, Farid sarwo edy Satria Wati Pade Satrio Ardyantoro Sejati, Hiro Selirowangi, Nisaul Barokati Seto, Bayu Setyawan A, Setyawan Setyo Rini, Asih Shalsabila Azzahra Sherin Ramadhania Shinta Ayu Lestari Shodiq, Achmad Shofwatun Hasna Shukatin, Shukatin Sidiq, Sidiq Sinensis, Rizki Amelia Sinta Suleman Siradjuddin Haluti, Siradjuddin Sirotjuddin, M. Siti Aimah Siti Hamidah Siti Maghfirotun Amin Siti Maimunah Siti Musyrifah, Siti Siti Rahimah Siti Rodhiyah, Siti Siti Romlah Sitti Ayu Suhartina Yahya Sja'bani, Mochammad Soedjono Aswin Soedrijanto, Angky Sofiana, Elda Sofiana, Nabila Okta Sonny Taufan Sri Handayani Sri Hartatik Sri Haryanti Sri Juari Santosa SRI RAHAYU Staddal, Iqrima Subaidi Subyanto, Subyanto Suharyanto H. Soro Suherli, Ian Rakhmawan Sukanta, Deris Samba Pordi Sukari, Mohd. Aspollah Sukari, Mohd. Aspollah Sukidjo . Sulaeman Sumarta Sumbodo, Mugiatno Sun, Suny Sunanto Sunanto Sunarti Sunarti Sunaryati Supendi, Dede Supriatini Supriatini Supriatini, Supriatini Supriyanto Supriyanto Supriyanto Surismiati Surismiati Suriyana Suriyana Suryani Suryani Susanti , Yuli Susi Iravati Susiana Candrawati Susy Yunita Prabawati Sutirman Sutirman Suwarman, Adika Suyahman Suyahman Suyanto Suyanto Syamsul Ghufron Syarief, Ali TAUFIK ROHMAN, TAUFIK Thina Oktarina Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tonny Ari Wibowo Tresna Dewi Tri Cahayati, Ulinnuha Triana Hertiani Triana Kusumaningsih Tryono, Agus Tsaabitah Jihaan Sabrina Tsumu, Dhatu A Udi, Moh. Usni Putri, Saifa Utami, Satiti Vadlya, Vadlya Maarif Vero Ferdinand Putra Suseno VIKTARIA, Venansi Wachda, Mazayatun Nissa’ul Wahyono Wahyono Wahyuni, Ane Tika Wahyuni, Fina Tri Wahyuningsih, Fetri Warang, Japri Yusrifal Wardani, NIta Kusuma Wasliman, Eva Dianawati Whan Augustin Ainul Amri Wicaksono, Ardy Wicaksono, Nicky Gilang Widya Asmara Wijaya, Rahman Benta Wina Libyawati, Wina Wisesa, Sindhu Wiwiek Fatchurohmah, Wiwiek Wiwik Cahyaningrum Woro Rukmi Pratiwi Wulan Rahma Dewi Wulandari, Friska Tri Wulansari, Rahmawati Wuni Sapoan, A’is Mulie Yadi Janwari Yamin , Muhammad Yanti Dwi Astuti, Yanti Dwi Yanuar, Rahmat Yasri Rahmawati Yayi Suryo Prabandari Yayuk Dwi Rahayu, Yayuk Dwi Yoga Prihastomo Yoga Prihastomo Yohandri Bow Yuli Asmi Rahman Yuliansah Yuliansah Yumna, Isna Aulia Yunianto Agung Nugroho Yuniarti, Angger Styo Yusman, Nurjannah Zahroh, Fatimatus Zainuddin, Faiz Zainuri Zainuri, Zainuri Zakiyah, Makhshushi Zikri Marifatullah Zuhratul Aini Mansur Zulaela Zulaela, Zulaela Zulkaisni, Zulkaisni Zuryati Djafar