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Al-Masyaqqāh Tajlib Al-Taysir Implikasinya dalam Pemikiran dan Perilaku Ekonomi dalam Masyarakat di Era Revolusi Industri 4.0 Hisam Ahyani; Mustofa
Jurnal Hukum Ekonomi Islam Vol. 5 No. 1 (2021): Jurnal Hukum Ekonomi Islam (JHEI)
Publisher : Asosiasi Pengajar dan Peneliti Hukum Ekonomi Islam Indonesia (APPHEISI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.379 KB) | DOI: 10.55577/jhei.v5i1.77

Abstract

The Qawa'id fiqhiyyah al-Masyaqqāh Tajlib al-Taysir is a general foundation in social thinking and behavior that provides guidance for all people and nations in Indonesia, especially in the Era of the Industrial Revolution 4.0 as it is today, to carry out various interactions with each other. The guidance given concerns several aspects of life such as legal, economic, social, political and state aspects, as well as culture to human behavior problems when collided with Islamic economics by understanding the principles contained therein. This research focuses on the study of qawa'id Fiqhiyah al-Masyaqqāh Tajlib al-Taysir, which means Difficulty of Giving Birth to Ease, and its implications for economic thought and behavior in society in the current era, namely the era of the Industrial Revolution 4.0. In this case, the understanding of the difficulty of giving birth to ease is that mutlaq is needed to carry out an ijtihad or renewal of thought. The existence of this fiqh principle, in which the difficulty of giving birth to convenience proves that Islam, with all its tools, pays close attention to human behavior in fulfilling the daily needs of both social and economic needs. This can be proven when Allah SWT allows Muslims to interact and transact with non-Muslims at the same time, even Allah SWT gives flexibility to the mukalaf in determining their economic activities according to their ability levels. However, this almost Qath'i rule, namely masyaqqah is limited by the Shari'a in order to maintain the originality of human benefit from the rules made by the creator. Keywords: Ushul Fiqh, Masyaqqāh, Taysir, Islamic Economics, Industrial Revolution Era 4.0 Abstrak Qawa’id fiqhiyyah al-Masyaqqāh Tajlib al-Taysir merupakan landasan umum dalam pemikiran dan perilaku sosial masyarakat yang memberikan panduan bagi segenap masyarakat dan bangsa di Indonesia khususnya di Era Revolusi Industri 4.0 seperti sekarang ini, untuk melakukan berbagai interaksi dengan sesamanya. Panduan yang diberikan menyangkut beberapa aspek kehidupan semisal aspek hukum, ekonomi, sosial, politik dan kenegaraan, serta budaya sampai pada masalah perilaku manusia jika dibenturkan dengan ekonomi syariah dengan memahami kaidah-kaidah yang terkandung didalamnya. Penelitian ini memfokuskan pada kajian qawa’id Fiqhiyah al-Masyaqqāh Tajlib al-Taysir yang bermakna Kesulitan akan Melahirkan Kemudahan, serta implikasinya dalam pemikiran serta perilaku ekonomi dalam masyarakat di Era sekarang yaitu era Revolusi Industri 4.0. Dalam hal ini, pemahaman terhadap kaidah Kesulitan Melahirkan Kemudahan adalah mutlaq diperlukan untuk melakukan suatu ijtihad atau pembaharuan pemikiran. Hadirnya kaidah fiqh ini, dimana Kesulitan Melahirkan Kemudahan membuktikan bahwa agama Islam dengan segala perangkatnya sangat memperhatikan hal-hal perilaku manusia dalam memenuhi kebutuhan hidup sehari-hari, baik kebutuhan sosial maupun ekonomi. Hal ini dapat dibuktikan ketika Alloh Swt membolehkan kaum Muslimin untuk berinteraksi sekaligus bertransaksi dengan kaum yang non-Muslim, bahkan Alloh Swt memberikan keleluasaan kepada para mukalaf dalam menentukan aktifitas ekonominya yang disesuaikan dengan kadar kemampuannya. Akan tetapi dengan demikian kaidah yang hampir Qath’i ini yaitu masyaqqah dibatasi oleh syariat guna menjaga originalitas kemaslahatan manusia dari aturan yang dibuat oleh sang pencipta. . Kata kunci: Ushul Fiqh, Masyaqqāh, Taysir, Ekonomi Islam, Era Revolusi Industri 4.0
PESONA HERBAL SEBAGAI UPAYA MENGEMBANGKAN ECO-EDUCATION DAN KEWIRAUSAHAAN PRODUK OLAHAN HERBAL Suryadarma, IGP; Widowati, Asri; Mustofa, Mustofa
INOTEKS: Jurnal Inovasi Ilmu Pengetahuan,Teknologi, dan Seni Vol 17, No 1 (2013)
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (896.509 KB) | DOI: 10.21831/ino.v17i1.3093

Abstract

The activity "The Beauty of Herb" is aimed: (1) to improve the understanding of mother and young man about kinds of herb ans its usefulness; (2) to improve the creativity of mother and young man about way of processing of herb; (3) to improve enterpreneurship of mother and young man. The methods used in trouble-shooting covers: nature exploration, discourse, demonstration and practise. Its steps cover: motivation phase, phase training of theory, and phase training of practise. Data are collected by using quesionare and observasion sheet. Argomulyo's mother and young man respond well by involving actively in every activity phase. This training have earned to improve the understanding of participants about herb ang usefulness. Participant have skill process to process the herbs as products which are prospective They also recognize herbs' product as a business opportunity and intend to plant and propagate herb to others as eco-education.Keywords: The Beauty ofHerb, enterpreneurship, and eco-education
Economic Development Theory of Ibnu Khaldun: Interrelation between Justice and Umran al-Alam Mafrudlo, Ahmad Mahfudzi; Mansur, Zuhratul Aini; Mustofa, Mustofa; Janwari, Yadi
Share: Jurnal Ekonomi dan Keuangan Islam Vol. 13 No. 1 (2024)
Publisher : Faculty of Islamic Economics and Business, Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/share.v13i1.20552

Abstract

ABSTRACT – Leading Islamic thinker, Ibn Khaldun, proposed a nuanced theory of economic development that transcends mere material advancement. This theory integrates Islamic principles within a comprehensive framework. This study aims to delve deeper into Ibn Khaldun's economic development theory, focusing on its emphasis on the Islamic way of life and the concept of Umran al-Alam (prospering the earth). A descriptive analysis methodology was employed through a review of existing literature. Ibn Khaldun outlines eight key suggestions and various variables for achieving economic development. Significantly, he underscores the importance of Umran al-Alam, highlighting humanity's responsibility to cultivate the earth. From an Islamic perspective, economic development should prioritize socio-economic justice and maintain a balance between communal well-being and a healthy economy. This study contributes to a more profound understanding of Islamic economic thought and its potential connections to contemporary notions of sustainable development. Further research opportunities lie in exploring the practical applications of Ibn Khaldun's theories within Islamic economic models.==============================================================================================================ABSTRAK – Teori Pembangunan Ekonomi Perspektif Ibnu Khaldun: Interelasi Keadilan dan Umran al-Alam. Pemikir Islam terkemuka, Ibn Khaldun, menawarkan teori pembangunan ekonomi yang lebih bernuansa, tidak sekedar diukur dari sesuatu yang bersifat materi semata-mata. Teori ini mengintegrasikan prinsip-prinsip Islam ke dalam kerangka kerja yang komprehensif. Studi ini bertujuan untuk menggali secara dalam teori pembangunan ekonomi Ibn Khaldun, khususnya pada cara hidup Islami dan konsep "umran al-Alam" (pemakmuran bumi). Kajian ini menggunakan metodologi analisis deskriptif dengan data-data dari sejumlah literatur tersedia. Ibn Khaldun menguraikan delapan komponen inti dan sejumlah variabel untuk mencapai pembangunan ekonomi dimaksud. Ibnu Khaldun menggarisbawahi pentingnya umran al-Alam, yang menyoroti tanggung jawab manusia dalam memakmurkan bumi. Dari perspektif Islam, pembangunan ekonomi harus memprioritaskan keadilan sosial-ekonomi dan menjaga keseimbangan antara kesejahteraan bersama dan sistem ekonomi yang sehat. Studi ini berkontribusi pada pemahaman yang lebih mendalam tentang pemikiran ekonomi Islam dan potensi hubungannya dengan konsep pembangunan berkelanjutan kontemporer. Peluang penelitian lebih lanjut terletak pada eksplorasi aplikasi praktis teori-teori Ibn Khaldun dalam model ekonomi Islam.
Antiplasmodial activity and cytotoxicity of kapur (Harmsiopanax aculeatus) leaf extracts traditionally used for the treatment of malaria in Maluku Turalely, Rachel; Mustofa; Mahardika Agus Wijayanti; Triana Hertiani
Indonesian Journal of Pharmacology and Therapy Vol 1 No 1 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.512

Abstract

Harmsiopanax aculeatus leaf, locally name kapur, has been use traditionally to treat malaria in Maluku, Indonesia. However, the scientific evidences that support its use are still limited. This study aimed to investigate antiplasmodial activity of H. aculeatus leaf extract and its cytotoxicity on cancer cells line. Three extracts i.e. methanolic, n-hexanic and ethyl acetate extracts were evaluated for their in vitro activity against Plasmodium falciparum FCR3 strain using microscopic method. Cytotoxicity of the extracts on T47D, HeLa and Vero cells lines were determined using MTT assay method. The inhibitory concentration 50% (IC50) against P. falciparum or the cells lines growth was determined using probit analysis. Furthermore, their selectivity index (SI) were determined. The results showed that the methanolic extract was the most active extract with an IC50value of 13.82 μg/mL and the most selective with a SI value of 172.84. The three extracts tested exhibited weak or no cytotoxicity against the cells lines used with IC50 values ranged 101-2388.69 μg/mL. Further study will be conducted to isolate active antiplasmodial compounds from the methanol extract.
Cytotoxicity of ((E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one)) on HeLa cell line Adisty Ridha Damasuri; Eti Nurwening Sholikhah; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 1 No 2 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.606

Abstract

In our previous study, some amino chalcone derivatives have been synthesized and evaluated their cytotoxicity against breast cancer cell line T47D. Among 11 amino chalcone derivatives, ((E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one)) exhibited the most active compound.This study aimed to investigate cytotoxic activity of the ((E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one)) against cervical cell line (HeLa). The cytotoxic activitywas determined using the MTT colorimetric assay. Cisplatin was used as positive control. From this MTT method, inhibitory concentration 50% (IC50) values were determined by probit analysis based on the relationship between log concentrations versus the percentage of cells growth inhibition.The results showed that the IC50 of ((E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one)) and cisplatinwere 22.75 ± 19.13 μg/mL and 14.96±1.08 μg/mL, respectively. In conclusion, the ((E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one)) has moderate cytotoxic activity against HeLa cell line based on National Cancer Institute (NCI) criteria.
Synthesis of 3-carbethoxy-4(3’-chloro-4’-hydroxy) phenyl-but-3-en-2-one and its cytotoxicity evaluation against cancer cell carrying mutant p53 Julianus, Jeffry; Mustofa; Jumina
Indonesian Journal of Pharmacology and Therapy Vol 2 No 1 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1211

Abstract

Overexpression of mutant p53 in cancer cell inactivates the p53 pathways to execute apoptosis and cell cycle arrest. This study aimed to synthesize new kardiena derivative compound, 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one, to reactivate the p53 pathways to execute apoptosis and cell cycle arrest. Characterization of the synthetic compound employing melting point, IR, EI-MS, 1H-NMR, and 13C-NMR spectra revealed 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one was successfully synthesized from 3-chloro-4-hydroxybenzaldehyde and ethyl acetoacetate using dimethylamine as a catalyst. This compound had antiproliferative activity against the WiDr cells which carried mutant p53. Its antiproliferative activity was better than 5’-FU as a reference standard to treat colon cancer. Increasing WiDr cell accumulation in the G2-M phase, the active form of caspase-3, and inducing apoptosis demonstrated the ability of 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one to reactivate p53 pathways to execute apoptosis and cell cycle arrest in cancer cells carrying mutant p53.
Antiplasmodial activity and genome mining study of marine-derived Streptomyces sp. GMY01 Damayanti, Ema; Widada, Jaka; Dinoto, Achmad; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1335

Abstract

High resistance to chloroquine in most malaria-endemic area in the world leads to the need for new antimalaria drugs. Marine bacterium Streptomyces is the source for potential new antimalarial molecules. This research aimed to investigate antiplasmodial activity of marine-derived of Streptomyces sp. GMY01 and to identify potential active compounds using genome mining study. In vitro antiplasmodial activity assays using flow cytometry method showed that the ethyl acetate extract of this bacterium had high antiplasmodial activity (IC50 value of 1.183 µg/mL) on Plasmodium falciparum FCR3. Genome mining analysis of whole-genome sequences using antiSMASH 6.0 beta version revealed that Streptomyces sp. GMY01 had 28 biosynthetic gene clusters (BGCs), including the genes encoding polyketide synthase, non-ribosomal peptide synthetase, terpene, lanthipeptide, bacteriocin, butyrolactone, ectoin, siderophore, and others. The known BGCs were predicted to be involved in the production of known compounds from gene clusters ranged from 5 to 100% similarity. Ongoing purification and elucidation of the structures will allow identification of the active compounds produced by marine-derived Streptomyces sp. GMY01.
Antimicrobial activity of Pycnarrhena cauliflora (Miers.) Diels. methanol extract Eti Nurwening Sholikhah; Maulina Diah; Mustofa; Masriani; Susi Iravati; Samekto Wibowo
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1656

Abstract

Pycnarrhena cauliflora (Miers.) Diels., local name sengkubak, is one of indigenous plants from West Kalimantan that has been used as natural flavor. Pycnorrhena cauliflora is one of species of Menispermaceae family which is rich in bisbenzylisoquinoline alkaloids. This alkaloids are known to have various biological activities including antiprotozoal, antiplasmodial, antifungal and antibacterial activities. This study aimed to investigate antimicrobial activity of the P. cauliflora (Miers.) Diels. methanolic extracts against gram-positive and gram-negative bacteria. The methanolic extract of P. cauliflora (Miers.) Diels., root, leaf and stem were prepared by maceration. The disk-diffusion method was then used to determine the antimicrobial activity of the extracts against Streptococcus pyogenes, S. mutants, Staphylococcus aureus, S. epidermidis, Salmonella typhi, Shigella flexneri, Pseudomonas aeruginosa and Escherichia coli after 18-24 h incubation at 37 oC. Amoxicillin was used as positive control for gram-positive bacteria and ciprofloxacin was used as gram-negative bacteria. The inhibition zones were then measured in mm. Analysis were conducted in duplicates. The results showed in general the methanolic extracts of P. cauliflora (Miers.) Diels. root (inhibition zone diameter= 10-23 mm) were more active than that leaf (0-15 mm) and stem (0-17 mm) extracts against gram-positive bacteria. The zone inhibition diameter of amoxicillin as positive control was 8-42 mm. In addition, the methanolic extracts of P. cauliflora (Miers.) Diels. root (12-17 mm) were also more active than that leaf (0-12 mm) and stem (0-12 mm) extracts against gram-negative bacteria. The zone inhibition diameter of ciprofloxacin as positive control was 33-36 mm. In conclusion, the methanolic extract of P. caulifloria (Miers.) Diels. root is the most extract active against both gram-positive and gram-negative bacteria. Further study will be focused to isolate active compounds in the methanolic extract of the root.
The effect of Centella asiatica L. Urban. and Curcuma longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity Gofir, Abdul; Ar Rochmah, Mawaddah; Wibowo, Samekto; Hakimi, Mohammad; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1765

Abstract

Post-stroke cognitive impairment involves memory, visuoconstructional, and spatial dysfunctions. Centella asiatica L. Urban. and Curcuma longa L. are both well-known herbs in South and South-East Asia countries that are believed to possess neuroprotective properties as memory enhancers. This study aimed to investigate the effects of C. asiatica L. Urban. and C. longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity. Twenty-five Wistar rats underwent transient bilateral common carotid artery occlusion. Y-maze pre-test was performed 24 h after the occlusion. The rats were then divided into five groups i.e. Group 1 received NaCMC dilution, Group 2 received donepezil 0. 7 mg/kg BW/day, and Groups 3, 4, and 5 received the extracts combination with dose of 59; 118; and 236 mg/kg BW/day, respectively. Y-maze post-test was performed 24 h after the last dose had been given. Spontaneous alternation behavior was used as the indicator of working memory measurement. The fixed-dose method according to OECD Guideline was used to estimate the LD50 in acute toxicity testing on Wistar rats. There was a significant difference in the delta spontaneous alternation percentage among groups tested (p<0. 05). Group 1 had significant difference with any other group (compared to Groups 2 to 5; p<0.05). No significant difference could be found between groups of the extracts combination and donepezil group suggesting that the effect is not more inferior nor dose-dependent in improving memory performance. The extracts combination at a single dose of 2000 mg/kg BW did not show related signs of toxicity or mortality in any of the rats during the 14-day observation period. In conclusion, the C. asiatica L. Urban. and C. longa L. extracts combination can improve performance of memory on stroke model animal. According to Globally Harmonized Classification System, the extracts combination can be classified as Category 5/unclassified.
Liposome as carrier therapy for Alzheimer’s disease Anggraeni, Andi Sri Dewi; Arsita, Emilia Vivi; Suwarman, Adika; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2315

Abstract

Alzheimer's disease (AD) is the most common type of dementia. Approximately 50 million people suffer from Alzheimer's and it is expected to increase more than 100 million by 2050. According to the Diagnostic and Statistical Manual of Mental Disorders V (DSM-V), the diagnosis of AD has an onset of memory impairment and cognitive decline. Effective treatment of AD is a major challenge in the field of pharmacy and science due to the restriction from blood brain barrier (BBB). This causes poor access to pills or oral administration. Liposome as a part of nanoparticle showed to be a potential AD treatment because of its biocompatibility, flexibility, and capability to carry various therapeutic molecules across the BBB and into brain cells. Several types of liposomes provide varied therapy effect. Some factors which determine liposomes effectiveness are its structure, mechanism of action; formed; and delivery, and its preparation method. This article reviewed liposomes characteristics which has potency as carrier therapy for AD.
Co-Authors -, Nasiri A Halim A. Fitriani Abas, Rizan Abdilah, Ulil Absor Faiq Abdul Gofir Abdul Hakim, Al Hasan Abdul Kholik Abdul Manaf Ali, Abdul Manaf Abdul Rokhim Abdul Wahid Arohman Abdullah, Rizky Achmad Dinoto Achmad Sehan Ade Nur Rohim Ade Setiawan Adi Putranto, Hanafi Adika Suwarman Adisty Ridha Damasuri Aditama, Wahyu Aditia Dhani Mustofa Afib Rulyansah Agus Faisal Asyha Agus Luthfi Agus Pahrudin agus prasetyo aji Agus Sugiarto Agussalim Agussalim, Agussalim Agustin HP, Agustin Agustina, Feny Rizki Eka Ahmad Asrof Fitri Ahmad Hamim Sadewa Ahmad Khoirul Fata Ahmad Nouvel - AMIK BSI Purwokerto Ahmad Nouvel - AMIK BSI Purwokerto Ahmad Syaifuddin Romli Akhmad Akbar Susamto Akhwani Akhwani Akhwani, Akhwani Akrom, Akrom Akuba, Syamsu Al Hakim, Mahathir Muhammad Alatas, Haidar Alexis Valentin, Alexis Alfi Yasmina Alfinatus Zayyinah Alfiyah, Viny Ali Djamhuri Ali Ghufron Mukti Ali Muhson alimin alimin aliyah, faridatul Almubarokah, Nurul Hidayah Almurni, Muhammad Furqon Amri, Aini Nurul Andayani, Tri M. 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