Articles
COVID-19: Analisis in-Silico Struktur Tersier Nsp1 dan Nsp2 pada SARS-CoV-2
Suprianto Suprianto;
I Made Budiarsa
Jurnal Kesehatan Manarang Vol 6 No Khusus (2020): Oktober 2020
Publisher : Politeknik Kesehatan Kemenkes Mamuju
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DOI: 10.33490/jkm.v6iKhusus.269
The spread of the COVID-19 pandemic has captured a lot of attention from the global community. This pandemic was caused by SARS-CoV-2 by producing nonstructural proteins (nsp1-16). This study aims to analyze the tertiary structure of nsp1 and nsp2 in SARS-CoV-2 in-silico. The target proteins nsp1 and nsp2 have access codes YP_009725297.1 and YP_009725298.1 obtained from NCBI. The amino acid composition of nsp1 and nsp2 is 19774.35 Daltons and 70507.81 Daltons, respectively. The nsp1 tertiary structure produces a model structure with a percentage of 64%, 19% disordered area, 42% alpha-helix, 13% beta strand, 92.17% model verification (passed), 74.0% favored region and 6.4% outliers area (stable). The nsp2 tertiary structure produced a model structure with a percentage of 9%, 17% disordered area, 36% alpha-helix, 27% beta strand, 64.29% model verification (failed), 76.0% favored region and 16.4% outliers area (unstable). The stability of nsp1 has very good potential compared to nsp2, the validation of the structure obtained can be the basis for studying the development of the vaccine design for the SARS-CoV-2 virus that causes COVID-19.
A Multi-Criteria Decision-Making Approach for Warehouse Location Selection using TOPSIS
Ira Modifa Tarigan;
Muhammad Ade Kurnia Harahap;
Endang setyawati;
Jimmy Moedjahedy;
Ernie C Avila;
Robbi Rahim
JINAV: Journal of Information and Visualization Vol. 4 No. 1 (2023)
Publisher : PT Mattawang Mediatama Solution
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DOI: 10.35877/454RI.jinav1616
This research makes use of the Method for Order of Preference by Similarity to Ideal Solution, also known as the TOPSIS approach, in order to discover the most suitable site for a company's warehouse. Following the establishment of the criteria for the selection of the warehouse location, weights were allotted to each of the criteria. The min-max method was utilized to do data normalization once it had been collected for each prospective location. After constructing the decision matrix with the weighted normalized values and determining the ideal and non-ideal solutions for each criterion, the results were then presented. Following the calculation of the Euclidean distance between each potential location and the ideal and non-ideal solutions, the TOPSIS formula was used to determine the relative proximity between each of the potential locations. The site of the potential location that was the highest relative closeness to the optimum solution was chosen to be the optimal location for the warehouse. By employing this strategy, the company will be able to make an educated decision regarding the location of their warehouse, which will, in the long run, result in improved operational efficiency and cost savings.
Pembuatan Sumur Resapan dan Biopori untuk Pengendalian Genangan Air Hujan di SMP Negeri 11 Kota Malang
Rahmah Dara Lufira;
Ussy Andawayanti;
Emma Yuliani;
Suwanto Marsudi
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) VOL. 7 NOMOR 1 MARET 2023 JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Publisher : Universitas Muhammadiyah Purwokerto
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DOI: 10.30595/jppm.v7i1.9483
Kegiatan ini mengambil lokasi di SMPN 11– Kota Malang. Di sekolah ini sebelumnya sering dilanda genangan akibat meluapnya saluran drainase serta limpasan permukaan akibat air hujan. Pada pelaksanaannya belum pernah dilakukan penerapan sumur resapan air hujan dilokasi sekolah. Kegiatan pengabdian kepada masyarakat yang dilaksanakan ini adalah membuat 2 (dua) unit sumur resapan air hujan dan biopori untuk menampung komponen air limpasan permukaan yang berasal dari curah hujan. Kegiatan ini Jurusan Teknik Pengairan FTUB bekerja sama dengan akademik SMP Negeri 11 untuk membuat bangunan penanggulanngan Genangan berbasis konservasi. Metode sumur resapan dan biopori ini sangat mudah dilaksanakan dan juga dapat memelihara air tanah serta pemanfaatan daun sisa biopori untuk kompos. Dengan adanya pengabdian kepada masyarakat ini permasalahan genangan di SMP Negeri 11 Kota Malang dapat teratasi pada saat musim hujan.
Analisis Perencanaan Bahan Baku Dengan Menggunakan Metode MRP di PT.XYZ
Sugeng Santoso;
Uli Arta Naibaho;
Ali Nurhasan;
Salachudin Emir
Jurnal Ekonomika dan Bisnis Vol 10 No 1 (2023): Jurnal Ekonomika dan Bisnis UNISS
Publisher : Fakultas Ekonomika dan Bisnis Universitas Selamat Sri
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DOI: 10.51792/jeb.Vol10.Jeb1.253
Permasalahan yang sering terjadi pada perusahaan industri salah satunya terkait persediaan bahan baku. Persediaan bahan baku berkaitan erat dengan proses produksi yang dapat mempercepat atau memperlambat proses tersebut. PT. XYZ adalah salah satu perusahaan yang bergerak di industri makanan frozen food. Peneliti melakukan analisis terhadap model proses bisnis eksisting dan model Material Requirement Planning (MRP) dan transformasi dari kedua model proses bisnis tersebut. Pengolahan data data primer dan data sekunder dilakukan dengan pendekatan model MRP dan menunjukkan bahwa dengan metode Lot for Lot memberikan penghematan biaya pemesanan dan pembelian bahan baku serta memberikan penghematan biaya persediaan bahan baku selama periode bulan Januari 2020 - Desember 2021. Kebutuhan Bill of Material juga lebih terkendali menggunakan model sistem MRP.
COMPARISON OF EARLY CHILDHOOD EDUCATION PLAY ENVIRONMENT DESIGN MANAGEMENT AT RA BABUSSALAM AND RA RAUDHATUL HASANAH SUNGGAL SUB-DISTRICT MEDAN SUNGGAL SUB-DISTRICT MEDAN CITY
Rahayu Dwi Utami;
Novalinda Novalinda;
Putri Utami
Proceeding International Seminar of Islamic Studies INSIS 5 (March 2023)
Publisher : Proceeding International Seminar of Islamic Studies
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Early Childhood Education play environment design management is expected to design an early childhood education play environment well with the aim of educational achievement in the school environment. The Early Childhood Education play environment needs to be arranged in such a way that this will have a major impact on the growth and development of early childhood so that children have the readiness to continue to the next education, the precise arrangement of indoor and outdoor display set plans. Although the activity of designing indoor and outdoor appearances. The fantasy world of early childhood has a major influence on the optimal development of religious and moral values, language, cognitive, social-emotional, and physical motor. The purpose of this study was to find out how the management of the design of the play environment of early childhood education in RA Babussalam and RA Raudhatul Jannah. This research uses qualitative methods. Data collection techniques are carried out through interviews, observation, documentation research and triangulation. The results of this study show that the management of early childhood education environment design both indoor and outdoor in RA Babussalam and RA Raudhatul Hasanah is still not carried out properly. Because it adjusts the condition of the school with a building that is not so spacious. Therefore, not all facilities have been realized. However, the functions of planning, organizing, mobilizing and supervising are carried out by the institution. The utilization of indoor and outdoor facilities at RA Babussalam and RA Raudhatul Hasanah is quite maximal. Where the learning process always utilizes existing facilities. That way also maintain and take good care of the facilities that have been owned.
Pengaruh Bank Sampah Terhadap Pemberdayaan Ibu Rumah Tangga (Studi Kasus di Bank Sampah Kurabu Kota Padang Panjang)
Anno Suliza;
Fery Andrianus;
Chairul Chairul
Jurnal Ekonika : Jurnal Ekonomi Universitas Kadiri Vol. 5 No. 2 (2020): September 2020
Publisher : Fakultas Ekonomi Universitas Kadiri
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DOI: 10.30737/ekonika.v5i2.673
Waste Bank is a waste management based recycling management program that is driven by the active role and participation of members or customers. The community group with the status of Housewives are considered to have more potential resources for activities in the Waste Bank, while customer empowerment is the main indicator of the success of the program. The city of Padang Panjang still has a high final waste disposal ratio despite having a Waste Bank. The research objective is to analyze several variables so that they can influence the empowerment of Housewives. The number of respondents was 74 people taken by purposive sampling from the Kurabu Waste Bank in the city of Padang Panjang. The results of the analysis by the SEM-PLS method showed that there was a significant influence on education about the knowledge of resource utilization and the growth of an attitude of caring for the environment towards empowering customers who were housewives. Bank Sampah merupakan program manajemen pengelolaan persampahan berbasis daur ulang yang digerakkan oleh peran dan partisipasi aktif anggota atau nasabahnya. Kelompok masyarakat berstatus Ibu Rumah Tangga (IRT) dinilai memiliki potensi sumber daya yang lebih untuk berkegiatan di Bank Sampah, sedangkan pemberdayaan nasabah menjadi indikator utama keberhasilan program tersebut. Kota Padang Panjang masih mempunyai rasio beban buangan akhir sampah yang cukup tinggi meskipun telah memiliki Bank Sampah. Tujuan penelitian untuk menganalisis beberapa variabel sehingga dapat mempengaruhi pemberdayaan Ibu Rumah Tangga. Jumlah responden sebanyak 74 orang diambil dengan purposive sampling dari Bank Sampah Kurabu di Kota Padang Panjang. Hasil analisis dengan metode SEM-PLS menunjukkan terdapat pengaruh signifikan dari edukasi tentang pengetahuan pemanfaatan sumber daya dan penumbuhan sikap peduli lingkungan terhadap pemberdayaan nasabah yang berstatus Ibu Rumah Tangga.
English: Bahasa Indonesia
Ira Prima Sari;
Fitri April Yanti;
Dian Imam Saefullah;
Bagus Tri Yunianto
Journal of Sustainability Science and Technology Vol. 1 No. 1 (2021)
Publisher : Universitas Lampung
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DOI: 10.23960/josst.v1i1.8
Borax is a chemical substance that is prohibited from being used as a food additive because of its toxic nature. However, the use of borax is still widely found, one of which is meatballs the most. This study aims to identify the borax content in meatballs. Samples were taken from Ciroyom Market, Bandung City, Indonesia using total sampling and obtained as many as 10 samples of meatballs. The samples were analyzed qualitatively by observing physical conditions and testing using BaCl2 solution. Meanwhile, quantitative analysis was carried out using a UV-Vis spectrophotometer at a wavelength of 428 nm. The results of the analysis showed that all samples were indicated to contain borax. Even the quantitative test using UV-Vis spectrophotometer showed that the highest borax content was found in sample 10, which was 3.672,9 µg/ml.
The Role of Corticosteroids in the Management of Drug Allergy: A Narrative Literature Review
Rivani Sintia Suratman;
Rudy Afriant;
Roza Mulyana;
Saptino Miro;
Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher
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DOI: 10.37275/bsm.v7i2.773
Drug allergy is an adverse drug reaction that occurs through an immune reaction that occurs through IgE or a rapid hypersensitivity reaction with various mechanisms and clinical presentations. One of the therapeutic modalities for drug allergies is corticosteroids. In allergic processes, corticosteroids can suppress the production and effects of humoral factors involved in the inflammatory response, inhibit the migration of leukocytes to sites of inflammation, and interfere with the function of endothelial cells, granulocytes, mast cells, and fibroblasts. This literature review aimed to describe the role of corticosteroids in the management of drug allergies. Corticosteroids are used very widely in the treatment of various allergic diseases because of their strong anti-inflammatory properties. Corticosteroids inhibit the synthesis of a number of cytokines, such as the interleukins IL-1 to IL-6, tumor necrosis factor-α (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF). In conclusion, corticosteroids are one of the therapeutic modalities in various manifestations of drug allergies. Every drug allergy gets the anti-inflammatory effects of corticosteroids with different choices, routes, and doses for each manifestation.
GAMBARAN PERILAKU MASYARAKAT TERHADAP GIGITAN HEWANPENULAR RABIES (GHPR) DI KABUPATEN KONAWE SELATAN
Abas Abas;
Yasnani Yasnani;
Siti Rabbani Karimuna
Jurnal Kesehatan Lingkungan Universitas Halu Oleo Vol 2, No 4 (2022): Jurnal Kesehatan Lingkungan Universitas Halu Oleo
Publisher : FKM Universitas Halu Oleo
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DOI: 10.37887/jkl-uho.v2i4.27407
Rabies merupakan penyakit zoonosis yang menyerang sistem saraf pusat sehingga dapat berakibat fatal. Menurut Word Health Organization(2017), Rabies menyebabkan kematian lebih dari 59.000 orang atau hampir 1 kematian setiap 9 menit di seluruh dunia. Berdasarkan Hasil Penyelidikan epidemiologi yang dilakukan oleh tim terpadu dari Ditjen P2P Kementerian Kesehatan dan Ditjen PKH Kementerian Pertanian terkait dugaan adanya Kejadian Luar Biasa (KLB) Rabies pada tanggal 17-20 Januari 2019 ditemukan 192 kasus Gigitan Hewan Penular Rabies dan 2 Kasus kematian pada manusia karena rabies Lyssa (Kemenkes, 2019). Di Kabupaten Konawe Selatan Tahun 2021 data kasus GHPR (Gigitan Hewan Penular Rabies) pada bulan Januari-April sebanyak 58 kasus. Tujuan penelitian ini adalah untuk mengetahui Gambaran Perilaku Masyarakat Terhadap Gigitan Hewan Penular Rabies (GHPR) Di Kabupaten Konawe Selatan Tahun 2021. Penelitian ini merupakan penelitian deskriptif observasional. Penelitian ini menggunakan teknik pengambilan sampel Exchaustive Sampling. Populasi dalam penelitian ini berjumlah 58 responden. Sampel dalam penelitian ini adalah seluruh populasi. Hasil penelitian ini menunjukkan bahwa Pengetahuan Masyarakat sebagian besar kurang yaitu 47 (81,0%), Sikap Masyarakat tergolong baik yaitu 40 (69,0%) dan Tindakan Masyarakat Kurang 58 (100%). Kesimpulan dari penelitian ini yaitu menggambarkan pengetahuan masyarakat dan tindakan masyarakat yang kurang baik.
KINERJA KOMITE SEKOLAH DALAM RANGKA MENINGKATKAN MUTU PENDIDIKAN DI SDIT AL-AZHAR 2 KECAMATAN SEKUPANG KOTA BATAM PROVINSI KEPULAUAN RIAU
jurnalmap map;
Anita ÔÇì;
Indra Prasetyo;
Sri Mulyani
MAP (Jurnal Manajemen dan Administrasi Publik) Vol 2 No 02 (2019): MAP (Jurnal Manajemen dan Administrasi Publik)
Publisher : Program Pascasarjana Universitas Wijaya Putra Surabaya
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DOI: 10.37504/map.v2i02.189
ABSTRACT The aim of this research is to know and analyze the role of cominte school in order to improve the quality of education in SDIT Al-Azhar 2 Batam as an educational institution that has formed a school committee. The school committee's performance is 1). As an Advisory Agency, (2) supporting agency, (3) Controlling Agency, and (4) Mediator agency. The results of the study and data analysis explained that the performance of the school committee of Al-Azhar 2 Batam SDIT in order to improve the quality of education has not been seen to be optimal due to communication that has not gone well between the school and the school committee as work partners. The efforts made to maintain conditions become more is to improve communication, coordination, socialization by creating new agendas for committees and school parties, and involving school citizens namely guardians to play an active role in supporting educational activities in SDIT Al-Azhar 2 Batam Sekupang District, Batam City Riau Islands province. Keywords: School committee, role and quality