Articles
Comparison Of The Effect Of Vitamin E And Rosmarinic Acid On Expression Of P65 NF-KB Subunit In Diabetes Rat
Wahyu Prima;
Nur Samsu;
Husnul Khotimah
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember
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DOI: 10.19184/ams.v6i2.17540
One of the causes of diabetic nephropathy (ND) that have important role is the increase of free radicals due to high levels of glucose which causes oxidative stress. Oxidative stress activates Angiotensin II and the transcription factor of Nuclear Factor kappa B (NFKb). Prevention and slowing down of ND progression is by using antioxidants. The example of antioxidants are Vitamin E and Rosmarinic Acid (RA). Vitamin E is a conventional antioxidant while RA is a potent antioxidant that also has anti-inflammatory effects. This laboratory experimental study aimed to compare the effects of Vitamin E and RA on the expression of NFKb p-65 in glomelurus of type 2 diabetes rats. NFKb expression of p-65 of positive control increased significantly compared to negative controls (p <0.001), Vitamin E and RA were able to reduce NFKb expression compared to positive controls (p = 0.022 and p = 0.001). respectively there was no significant difference between NFKb expression in the Vitamin E group and Rosmarinic acid but RA decreased better than Vitamin E. It can be concluded that AR had a better effect compared to Vitamin E on the decrease in NFKb p-65 expression in glomelurus type 2 diabetes rats. Keyword: Diabetic nephropathy, Nuclear Factor kappa B (NF-Kb), Rosmarinic Acid, Vitamin E
Peningkatan Ekspresi Gen NKG2D Sel-sel NK oleh Brokoli untuk Mencegah Kanker
Diana Krisanti Jasaputra;
Khie Khiong Tjhia;
Ervi Afifah;
Hanna Sari W. Kusuma
Global Medical & Health Communication (GMHC) Vol 5, No 2 (2017)
Publisher : Universitas Islam Bandung
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DOI: 10.29313/gmhc.v5i2.2130
Kanker termasuk kelompok penyakit tidak menular (non-communicable diseases atau NCD) dan penyebab kematian terbesar di dunia. Salah satu faktor yang memengaruhi perkembangan kanker adalah reseptor NKG2D (natural-killer group 2, member D) merupakan kompleks reseptor yang mengaktivasi sel NK dan penting dalam immunosurveilance kanker. Brokoli, sayuran golongan Cruciferae, mengandung glukosinolat dan isotiosianat. Glukosinolat akan dihidrolisis oleh mirosinase (thioglucodase β) dan membentuk senyawa isotiosianat. Senyawa isotiosianat penting untuk mencegah kanker adalah senyawa sulforafan. Tujuan penelitian adalah menilai efek brokoli dalam meningkatkan ekspresi reseptor NKG2D dalam rangka memperbaiki aktivitas sel NK untuk mencegah kanker. Penelitian ini bersifat prospektif eksperimental laboratorium bersifat komparatif yang dilakukan di Laboratorium Aretha Medika Utama pada Februari–Juli 2016. Brokoli di-freeze dryer dan dibuat tepung dua konsentrasi, yaitu 50 μg/mL dan 25 μg/mL. Penelitian diawali dengan perbanyakan sel NK (cell line), kemudian dilanjutkan dengan perlakuan selama 24 jam dan penilaian ekspresi gen NKG2D menggunakan qPCR. Data penelitian ekspresi gen NKG2D dihitung dengan rumus Livak dan dianalisis menggunakan uji ANOVA satu arah dan uji lanjutan Tukey (SPSS 16). Pemberian brokoli konsentrasi 50 μg/mL dan 25 μg/mL meningkatkan level ekspresi gen NKG2D yang mengindikasikan peningkatan aktivitas sel-sel NK. Simpulan penelitian ini adalah pemberian brokoli meningkatkan aktivitas sel-sel NK dalam mencegah dan melawan sel-sel kanker.INCREASED NKG2D GENE EXPRESSION OF NKG CELLS BY BROCCOLI TO PREVENT CANCERCancer is the non-communicable diseases (NCD) and the biggest cause of death in the world. One of the factors that affect cancer development is NKG2D receptors (natural-killer group 2, member D) is a receptor complex that activates NK cells and is important in cancer immunosurveilance. Broccoli, Cruciferae vegetable, contains glucosinolate and isothiocyanate. Glucosinolate will be hydrolysed by the mirosinase (thioglucodase β) and form the isothiocyanate compound. Isothiocyanate compounds essential to prevent cancer are sulforafan compounds. The objective of the study was to assess the effect of broccoli in enhancing NKG2D receptor expression in order to improve NK cell activity to prevent cancer. This experimental study is a comparative true experimental laboratory, conducted in the Aretha Medika Utama in February to July 2016. Broccoli was freeze dryer and made two concentrations of flour, 50 μg/mL and 25 μg/mL. The study begins with multiplication of NK cells (cell line), then continued with treatment for 24 hours and assessment of NKG2D gene expression using qPCR. NKG2D gene expression research data was calculated by Livak formula and analyzed using one-way ANOVA test and Tukey's advanced test (SPSS 16). The administration of broccoli concentrations of 50 μg/mL and 25 μg/mL increased the level of NKG2D gene expression, indicating an increase in NK cell activity. The conclusion of this study is the provision of broccoli increases the activity of NK cells in preventing and fighting cancer cells.
PERANCANGAN VLAN, VTP DAN INTERVLAN ROUTING PADA JARINGAN KOMPUTER STIKOM DINAMIKA BANGSA
Kurniabudi Kurniabudi;
Abdul Rohim
Jurnal Processor Vol 9 No 2 (2014): Processor
Publisher : LPPM STIKOM Dinamika Bangsa
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Pengembangan jaringan komputer harus didasari perencanaan yang baik, salah satunya dengan merencanakan broadcast domain yang baik. Manajemen broadcast domain yang baik dapat meningkatkan performa jaringan. Penelitian ini akan membahas tentang perancangan VLAN dengan implementasi VTP (virtual trunking protocol) dan perutean packet antar VLAN (InterVLAN Routing) pada jaringan komputer STIKOM Dinamika Bangsa. Penelitian ini menggunakan metode studi literatur untuk mempelajari konsep perancangan VLAN, metode requeirement analisys dan metode experiment untuk mensimulasikan rancangan VLAN menggunakan software simulator jaringan
EVALUASI AKTIVITAS ANTIOKSIDAN DAN pH PADA NIRA NIPAH (Nypa fruticans) SELAMA PROSES PRODUKSI SIRUP GULA MERAH
Dhina Aprilia Nurani Widyahapsari;
David Yudianto;
Mohammad Jihad Madiabu;
Ricky Wahyudi
Journal Warta AKAB Vol 44, No 2 (2020): Warta AKAB
Publisher : Politeknik AKA Bogor
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DOI: 10.55075/wa.v44i2.10
Nira nipah sesaat setelah dipanen umumnya memiliki pH mendekati 7 dan akan menurun seiring dengan waktu akibat proses fermentasi. Nilai pH pada nira dapat diasosiasikan dengan aktivitas antioksidan di dalam nira, pH yang tinggi dapat meningkatkan aktivitas antioksidan. Selain pH, suhu merupakan faktor yang berpengaruh terhadap aktivitas antioksidan. Selama proses pemanasan nira menjadi gula merah akan terjadi pembentukan senyawa antioksidan tetapi juga dapat menurunkan jumlah senyawa asam. Penelitian ini dilakukan untuk mengetahui pengaruh suhu dan lama waktu evaporasi terhadap aktivitas antioksidan dan pH nira nipah selama proses produksi sirup gula merah. Evaporasi dilakukan pada suhu 70, 80, 90 dan 100oC kemudian dilakukan sampling setiap 10 menit dan dilakukan analisis nilai brix, aktivitas antioksidan dan pH. Proses sampling dihentikan ketika brix sirup gula merah telah mencapai 65%. Hasil analisis menunjukan bahwa pada semua perlakukan suhu, semakin lama proses evaporasi maka nilai IC50 menunjukan penurunan yang artinya semakin lama proses pemanasan maka aktivitas antioksidan meningkat. Sedangkan nilai pH selama pemanasan cenderung konstan pada kisaran nilai pH 6 untuk semua suhu pemanasan.
The Effect of Acceptance and Commitment Therapy on The Quality of Life of Post Stroke Patients in Aloei Saboe Hospital
Fatmawati Mohamad1, Wenny Ino Ischak1, Heni Panai1, Hafni Van Gobel1, Yusrin Aswad1, Rini Fahriani Z
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd
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DOI: 10.37506/ijfmt.v14i2.3508
Quality of life is a global concept that emphasizes dimensions of health status including finance, housing, and work. The quality of life of post-stroke sufferers can experience disturbances or obstacles due to physical disabilities, cognition, psychological and social disorders. The purpose of this study was to determine the effect of ACT interventions on changes in the quality of life of post-stroke patients at Aloe Saboe Hospital. The method used in this research is quasi-experimental research method pre-posttest with the control group. The sampling technique used was the purposive sampling technique. The number of samples studied was 60 respondents divided into the experimental group (ACT Therapy and health education) and the control group (health education). The variables used are independent variables namely ACT therapy and the dependent variable is the quality of life of patients after stroke. Based on the results of the analysis, there is an effect of ACT intervention on improving quality of life in post-stroke patients as evidenced by the results of t count = -9.015, then the Significant value is 0,000. This shows that the value of p <0.05 then Ho is rejected, so the research hypothesis is proven that there is an effect of ACT therapy on the quality of life of post-stroke patients at Aloei Saboe Hospital, Gorontalo City.
HUBUNGAN KEMANDIRIAN BELAJAR TERHADAP HASIL BELAJAR MEKANIKA TEKNIK II PADA MAHASISWA PROGRAM STUDI PENDIDIKAN TEKNIK BANGUNAN UNIVERSITAS NEGERI JAKARTA
Dedi Hariyanto;
R Eka Murtinugraha;
Tuti Iriani
Jurnal Pensil : Pendidikan Teknik Sipil Vol 1 No 1 (2012): Jurnal Pensil : Pendidikan Teknik Sipil
Publisher : LPPM Universitas Negeri Jakarta
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DOI: 10.21009/jpensil.v1i1.6729
The aim of this research knows the relationship between self-learning and learning output of the Mechanics of Structure II subject for the students of Building Engineering Education Program Department of Civil Engineering State University of Jakarta in June 2011 which involved 50 students as the sample of this research. The result shows that students have less initiative in utilizing the facilities served in the library, self-learning at home, learning sources, practicing in the class, and having some handouts. Discussion between students is the only indicator demonstrating that the student initiative is quite good. Unfortunately, the interest of the students regarding this subject is very low. Learning output of the Mechanics of Structure II can be categorized as worst. The reasons are the students have no confidence in preparing the materials before the test and lean on other party during the test. The student’s responsibility in using the method and media for learning this subject is good even though the students just count on the lecture notes given by the lecturers during the course. But, the allocation time and readiness aspect shows that the student’s responsibility is minus because they don’t allocate much time to digest the subject and have the tendency of studying close to the deadline. Generally, the motivation and concentration of the students in learning is high. But, in allocating more time to digest the subject is lack.
Peningkatan Prestasi Belajar PAI Dan Budi Pekerti Materi Mengenal Nama Rasul Alloh Dan Ulul Azmi Melalui Metode Index Card Match Pada Siswa
DEDEH KURNIASIH
UNISAedu : Jurnal Ilmiah Ilmu Pendidikan Vol 5 No 4 (2021): UNISAedu Vol. 5 No. 4 2021
Publisher : LPPM Universitas Islam Al-Ihya Kuningan
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DOI: 10.2021/unisaedu.v5i4.2
Tujuan peneitian ini adalh untuk meningkatan aktivitas dan hasil belajar siswa SD Negeri Sinarsaluyu dengan menerapkan model ICM (Index Card Match) pada pelajaran Pendidikan Agama Islam. Penelitian ini merupakan penelitian tindakan kelas, yang dilakukan dalam 2 siklus dengan tiap siklusnya terdiri dari perencanaan, pelaksanaan, pengamatan, dan repleksi. Penelitian ini dilakukan pada 38 siswa kelas V SD Negeri Sinarsaluyu. Sumber data berasal dari guru dan siswa serta proses pembelajaran. Pengumpulan data berasal dari hasil tes, wawancara, pengamatan, serta quisioner. Dari hasil selama proses penelitian didapatkan aktivitas kinerja guru meningkat dari 62.5% menjadi 79.5% pada pra siklus, kemudian menjadi 82.31 pada siklus I, dan hasil pengembangan aktivitas belajar siswa pada pra siklus adalah 65.79% menjadi 73.69% dan menjadi 81.37% pada siklus II. Berdasarkan hasil penelitian dan diskusi, dapat ditarik kesimpulan bahwa proses pembelajaran menggunakan ICM dapat meingkatkan hasil dan aktivitas proses pembelajaran di kelas V SD Negeri Sinarsaluyu.
DEVELOPING WEB-BASED MEDIA TO PROMOTE STUDENTS 'INITIAL CRAFTS
Tina Amalia;
Ivan Hanavi;
Yuliatri Sastrawijaya;
Jarudin Jarudin
JURNAL SISFOTEK GLOBAL Vol 11, No 1 (2021): JURNAL SISFOTEK GLOBAL
Publisher : Institut Teknologi dan Bisnis Bina Sarana Global
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DOI: 10.38101/sisfotek.v11i1.345
Training entrepreneurs is very important to equip students' skills in community life. The students' products in this aspect of handicrafts have been promoted by displaying them in glass cabinets.. Some works are sold directly by students to friends who are interested in buying handicraft products produced. Works that have long been displayed in glass cabinets are usually discarded and replaced by students' work the following year. This is unfortunate because there is no media promotion of students' handicrafts, the purpose of this research is to develop web-based promotional media to promote students' pre-work handicrafts. The method used in this research is by kuantitativ research and development approach. The instrument used kuesioane with a scale of five options liker. Involving 60 participants in product trials divided into two groups, three expert teams for product validation and 57 participants for product trials. The results of the study based on the validation team that the media is feasible to be used as a means of promotion of student handicraft products, while the results of the trial that web-based media is effective to promote the results of student pre-work handicrafts. Kesimpulnya that the products produced can be used as a means of conveying information to the wider community both nationally and globally indefinitely. The implication of this study is to facilitate marketing regardless of the level of the economy in all directions.
PENGARUH LIKUIDITAS, LEVERAGE DAN PROFITABILITAS TERHADAP FINANCIAL DISTRESS (Z-SCORE) PERUSAHAAN PROPERTY, REAL ESTATE, DAN MANUFAKTUR PERIODE 2014-2016
Eveline Kusuma;
Sumani Sumani
Jurnal Manajemen Vol 14 No 1 (2017): Jurnal Manajemen
Publisher : Fakultas Ekonomi dan Bisnis Universitas Katolik Indonesia Atma Jaya
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DOI: 10.25170/jm.v14i1.794
This study aims to reexamine the influence of liquidity ratio, leverage ratio and profitability ratio on financial distress conducted on property, real estate and manufacturing companies listed on the Indonesia Stock Exchange period 2014-2016. This is because the property, real estate and manufacturing industries in the 2014-2016 period show symptoms of ups and downs as a result of economic movement in Indonesia. The research was conducted by measuring the level of financial distress formulated by Altman (1968) that is Z-score model, followed by calculating liquidity ratio represented by current ratio, leverage ratio represented by debt ratio and profitability ratio represented return on assets. Data processing using Eviews. The results obtained from this research is the ratio of leverage represented debt ratio, significantly have an effect to financial distress, while the other two ratios are not significant.
ANALISIS PENGARUH LIKUIDITAS, LEVERAGE, AKTIVITAS, PROFITABILITAS, DAN GROWTH TERHADAP KEBIJAKAN DIVIDEN EMITEN YANG TERDAFTAR PADA INDEKS LQ-45 PERIODE 2011-2013
Hengky Sulaiman;
Sumani Sumani
Jurnal Manajemen Vol 13 No 2 (2016): Jurnal Manajemen
Publisher : Fakultas Ekonomi dan Bisnis Universitas Katolik Indonesia Atma Jaya
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DOI: 10.25170/jm.v13i2.804
Dividend is component of return that investor gain on stock investment. On other side, dividend policy ismajor cash outlay for the company. The research goal is to reveal the factor that significantly influence thedividend policy, which can be used to maximize the investor’s return and provides guidance for thecompany in determining dividend policy.The research used sixteen company listed on LQ-45 Indexes during 2011-2013 by using panel dataanalysis. The research shows that activity and growth significantly affect the dividend policy whileliquidity, leverage, and profitability insignificantly affect the dividend policy.