The "Hepix" smart air filtration system, developed with biomimetic and Internet of Things (IoT) technology, aims to address the urgent issue of poor indoor air quality, particularly in high-mobility urban areas. This system integrates advanced sensors (MQ135 and BME680) and biomimetic filtration inspired by leaf stomata to monitor and filter air pollutants. Tested across three locations—Cilame, Jatinangor, and Cibiru—the system achieved an approximate 24.4% reduction in pollutant levels, as well as stable control of humidity and air pressure. Real-time data is continuously monitored through a mobile and web interface, supported by Google Assistant integration for voice commands. The results demonstrate that "Hepix" effectively improves air quality, offering a practical solution for healthier indoor environments in urban areas.